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Chronic Exposure to 6-Ppd Quinone at Environmentally Relevant Concentrations Causes Neurotoxicity by Affecting Dopaminergic, Serotonergic, Glutamatergic, and Gabaergic Neuronal Systems in Caenorhabditis Elegans

https://doi.org/10.2139/ssrn.4688983
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Molecular Toxicology in Caenorhabditis elegans
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Toxicology at Environmentally Relevant Concentrations in Caenorhabditis elegans
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The Tire Wear Compounds 6PPD-Quinone and 1,3-Diphenylguanidine in an Urban Watershed
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Disruption of dopamine metabolism by exposure to 6-PPD quinone in Caenorhabditis elegans
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Alteration in Wnt signaling mediates induction of transgenerational toxicity of polystyrene nanoplastics in C. elegans
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Loss of mammalian glutaminase orthologs impairs sperm function in Caenorhabditis elegans
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Chronic exposure to UV-aged microplastics induces neurotoxicity by affecting dopamine, glutamate, and serotonin neurotransmission in Caenorhabditis elegans
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Toxicological effects of 6PPD and 6PPD quinone in zebrafish larvae
inferredcites →https://doi.org/10.1016/j.jhazmat.2022.130543openalex-extracted
Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans
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6PPD and its metabolite 6PPDQ induce different developmental toxicities and phenotypes in embryonic zebrafish
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Tire-rubber related pollutant 6-PPD quinone: A review of its transformation, environmental distribution, bioavailability, and toxicity
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Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes
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MPMT-OX up-regulates GABAergic transmission and protects against seizure-like behavior in Caenorhabditis elegans
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Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network
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Toxicity comparison between pristine and sulfonate modified nanopolystyrene particles in affecting locomotion behavior, sensory perception, and neuronal development in Caenorhabditis elegans
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Trans-generational effect of neurotoxicity and related stress response in Caenorhabditis elegans exposed to tetrabromobisphenol A
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Size-dependent transgenerational toxicity induced by nanoplastics in nematode Caenorhabditis elegans
inferredcites →https://doi.org/10.1016/j.scitotenv.2022.160591openalex-extracted
Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.161836openalex-extracted
Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.164842openalex-extracted
Four-week repeated exposure to tire-derived 6-PPD quinone causes multiple organ injury in male BALB/c mice
inferredcites →https://doi.org/10.1016/j.scitotenv.2023.165874openalex-extracted
Photoaged microplastics induce neurotoxicity associated with damage to serotonergic, glutamatergic, dopaminergic, and GABAergic neuronal systems in Caenorhabditis elegans
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Environmentally persistent free radicals on photoaged nanopolystyrene induce neurotoxicity by affecting dopamine, glutamate, serotonin and GABA in Caenorhabditis elegans
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Abiotic oxidative transformation of 6-PPD and 6-PPD quinone from tires and occurrence of their products in snow from urban roads and in municipal wastewater
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C. elegans Locomotory Rate Is Modulated by the Environment through a Dopaminergic Pathway and by Experience through a Serotonergic Pathway
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Assessment of locomotion behavioral defects induced by acute toxicity from heavy metal exposure in nematode Caenorhabditis elegans
inferredcites →https://doi.org/10.1021/acs.est.1c02723openalex-extracted
Organic Markers of Tire and Road Wear Particles in Sediments and Soils: Transformation Products of Major Antiozonants as Promising Candidates
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New Evidence of Rubber-Derived Quinones in Water, Air, and Soil
inferredcites →https://doi.org/10.1021/acs.est.1c07451openalex-extracted
Concentrations of Tire Additive Chemicals and Tire Road Wear Particles in an Australian Urban Tributary
inferredcites →https://doi.org/10.1021/acs.est.2c08644openalex-extracted
Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Causes Abnormal Locomotion Behaviors and Neurodegeneration in Caenorhabditis elegans
inferredcites →https://doi.org/10.1021/acs.estlett.1c00148openalex-extracted
Occurrence of Substituted p -Phenylenediamine Antioxidants in Dusts
inferredcites →https://doi.org/10.1021/acs.estlett.1c00682openalex-extracted
Occurrences of Tire Rubber-Derived Contaminants in Cold-Climate Urban Runoff
inferredcites →https://doi.org/10.1021/acs.estlett.1c00794openalex-extracted
A Direct Mass Spectrometry Method for the Rapid Analysis of Ubiquitous Tire-Derived Toxin N -(1,3-Dimethylbutyl)- N ′-phenyl- p -phenylenediamine Quinone (6-PPDQ)
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6PPD-Quinone: Revised Toxicity Assessment and Quantification with a Commercial Standard
inferredcites →https://doi.org/10.1021/acs.estlett.2c00193openalex-extracted
Widespread N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine Quinone in Size-Fractioned Atmospheric Particles and Dust of Different Indoor Environments
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First Report on the Occurrence of N -(1,3-Dimethylbutyl)- N ′-phenyl- p -phenylenediamine (6PPD) and 6PPD-Quinone as Pervasive Pollutants in Human Urine from South China
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Environmental Occurrence and Toxicity of 6PPD Quinone, an Emerging Tire Rubber-Derived Chemical: A Review
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Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans
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MPA-capped CdTe quantum dots exposure causes neurotoxic effects in nematode Caenorhabditis elegans by affecting the transporters and receptors of glutamate, serotonin and dopamine at the genetic level, or by increasing ROS, or both
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Caenorhabditis elegans Glutamate Transporters Influence Synaptic Function and Behavior at Sites Distant from the Synapse
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Toxicity Testing of Neurotoxic Pesticides inCaenorhabditis elegans
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THE GENETICS OF CAENORHABDITIS ELEGANS
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Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
inferredcites →https://doi.org/10.1126/science.abd6951openalex-extracted
A ubiquitous tire rubber–derived chemical induces acute mortality in coho salmon
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LAMP5 in presynaptic inhibitory terminals in the hindbrain and spinal cord: a role in startle response and auditory processing
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Plasticity of Chemotaxis Revealed by Paired Presentation of A Chemoattractant and Starvation in the Nematode Caenorhabditis Elegans
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Dopamine Signaling Is Essential for Precise Rates of Locomotion by C. elegans
inferredcites →https://doi.org/10.1371/journal.pone.0077779openalex-extracted
Serotonin Control of Thermotaxis Memory Behavior in Nematode Caenorhabditis elegans
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The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons
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Transmissions of serotonin, dopamine, and glutamate are required for the formation of neurotoxicity from Al2O3-NPs in nematodeCaenorhabditis elegans
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Structurally and Morphologically Distinct Pathological Tau Assemblies Differentially Affect GVB Accumulation
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Transcriptome Analysis of C. elegans Reveals Novel Targets for DON Cytotoxicity
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Caenorhabditis elegans as a Biological Model for Multilevel Biomarker Analysis in Environmental Toxicology and Risk Assessment
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