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Synthesis and Biological Evaluation of Tacrine-Diterpenoid Alkaloid Hybrids as Multifunctional Agents Against Alzheimer's Disease

https://doi.org/10.2139/ssrn.4741157
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inferredcites →https://doi.org/10.1002/cbic.201402718openalex-extracted
Tools of the Trade: Investigations into Design Strategies of Small Molecules to Target Components in Alzheimer's Disease
inferredcites →https://doi.org/10.1002/pro.5560020312openalex-extracted
Thioflavine T interaction with synthetic Alzheimer's disease β ‐amyloid peptides: Detection of amyloid aggregation in solution
inferredcites →https://doi.org/10.1002/ptr.7099openalex-extracted
Natural products: A lead for drug discovery and development
inferredcites →https://doi.org/10.1007/s00018-014-1706-0openalex-extracted
Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease
inferredcites →https://doi.org/10.1007/s10517-018-4087-9openalex-extracted
Correction of Cholinergic Abnormalities in Mnestic Processes with Diterpene Alkaloid Songorine
inferredcites →https://doi.org/10.1016/0006-2952(61)90145-9openalex-extracted
A new and rapid colorimetric determination of acetylcholinesterase activity
inferredcites →https://doi.org/10.1016/j.ejmech.2013.01.029openalex-extracted
Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors
inferredcites →https://doi.org/10.1016/j.ejmech.2013.03.051openalex-extracted
Design, synthesis and evaluation of novel tacrine–coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.ejmech.2016.07.043openalex-extracted
Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX
inferredcites →https://doi.org/10.1016/j.ejmech.2018.01.028openalex-extracted
Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids
inferredcites →https://doi.org/10.1016/j.neulet.2012.04.067openalex-extracted
The newly identified K+ channel blocker talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons
inferredcites →https://doi.org/10.1016/s0140-6736(76)91936-xopenalex-extracted
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
inferredcites →https://doi.org/10.1021/acs.chemrev.8b00138openalex-extracted
Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c00048openalex-extracted
Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c00160openalex-extracted
Discovery of Novel Tacrine–Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer’s Disease
inferredcites →https://doi.org/10.1021/acs.jnatprod.0c01111openalex-extracted
Isolation, Structure Elucidation, Semi-Synthesis, and Structural Modification of C19-Diterpenoid Alkaloids from Aconitum apetalum and Their Neuroprotective Activities
inferredcites →https://doi.org/10.1021/acschemneuro.1c00184openalex-extracted
Phenothiazine-Tacrine Heterodimers: Pursuing Multitarget Directed Approach in Alzheimer’s Disease
inferredcites →https://doi.org/10.1021/acschemneuro.9b00120openalex-extracted
Tacrine–Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer’s Disease
inferredcites →https://doi.org/10.1021/acsomega.1c03103openalex-extracted
Pd-Catalyzed Direct Modification of an Anti-Alzheimer’s Disease Drug: Synthesis and Biological Evaluation of α-Aryl Donepezil Analogues
inferredcites →https://doi.org/10.1021/jm501195eopenalex-extracted
Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor
inferredcites →https://doi.org/10.1021/jm7009364openalex-extracted
Multi-target-Directed Ligands To Combat Neurodegenerative Diseases
inferredcites →https://doi.org/10.1073/pnas.90.20.9649openalex-extracted
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
inferredcites →https://doi.org/10.1080/14756366.2016.1210139openalex-extracted
Novel multitarget-directed tacrine derivatives as potential candidates for the treatment of Alzheimer’s disease
inferredcites →https://doi.org/10.1080/14756366.2018.1430691openalex-extracted
Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease
inferredcites →https://doi.org/10.1248/cpb.c15-00742openalex-extracted
Medicinal Chemistry Focusing on Aggregation of Amyloid-β
inferredcites →https://doi.org/10.1360/aps050046openalex-extracted
A pharmacophylogenetic study of Aconitum L. (Ranunculaceae) from China
inferredcites →https://doi.org/10.2147/ijn.s236922openalex-extracted
Rhynchophylline Loaded-mPEG-PLGA Nanoparticles Coated with Tween-80 for Preliminary Study in Alzheimer’s Disease
inferredcites →https://doi.org/10.2174/15680266113139990135openalex-extracted
The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics
inferredcites →https://doi.org/10.2174/1874104501711010024openalex-extracted
Tacrine, Trolox and Tryptoline as Lead Compounds for the Design and Synthesis of Multi-target Agents for Alzheimer’s Disease Therapy
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