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The Epigenetic Roles of Bet Inhibitors Jq1 and I-Bet726 in Regulating Inflammation and Treatment for Experimental Autoimmune Encephalomyelitis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Animal Models of Multiple Sclerosis

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Toll-Like Receptors: Linking Innate and Adaptive Immunity

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Monocyte-Derived Dendritic Cells as Antigen-Presenting Cells in T-Cell Proliferation and Cytokine Production

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Monocyte-Derived Dendritic Cells as Antigen-Presenting Cells in T-Cell Proliferation and Cytokine Production

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The role of IL-17 in CNS diseases

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Nicotine Stimulated Dendritic Cells Could Achieve Anti-Tumor Effects in Mouse Lung and Liver Cancer

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Coffee and autoimmunity: More than a mere hot beverage!

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A review of the evidence for a natalizumab exit strategy for patients with multiple sclerosis

inferredcites →https://doi.org/10.1016/j.bbadis.2010.07.007openalex-extracted

Inflammation, demyelination, and degeneration — Recent insights from MS pathology

inferredcites →https://doi.org/10.1016/j.brainres.2022.147904openalex-extracted

The pathogenesis of amyotrophic lateral sclerosis: Mitochondrial dysfunction, protein misfolding and epigenetics

inferredcites →https://doi.org/10.1016/j.cell.2012.02.013openalex-extracted

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

inferredcites →https://doi.org/10.1016/j.cell.2020.02.041openalex-extracted

Toll-like Receptors and the Control of Immunity

inferredcites →https://doi.org/10.1016/j.coi.2014.11.001openalex-extracted

Defining dendritic cells

inferredcites →https://doi.org/10.1016/j.cytogfr.2016.03.013openalex-extracted

IFN-β differentially regulates the function of T cell subsets in MS and EAE

inferredcites →https://doi.org/10.1016/j.immuni.2010.03.004openalex-extracted

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

inferredcites →https://doi.org/10.1016/j.immuni.2013.08.016openalex-extracted

Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20

inferredcites →https://doi.org/10.1016/j.immuni.2015.10.017openalex-extracted

Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System

inferredcites →https://doi.org/10.1016/j.jaut.2017.06.001openalex-extracted

Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity

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Development of autoantibodies precedes clinical manifestations of autoimmune diseases: A comprehensive review

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Genome-wide DNA methylation profiling identifies epigenetic changes in CD4+ and CD14+ cells of multiple sclerosis patients

inferredcites →https://doi.org/10.1016/j.neuron.2022.03.017openalex-extracted

Immune genes outside immune cells for multiple sclerosis

inferredcites →https://doi.org/10.1016/j.smim.2009.08.003openalex-extracted

Genetics and pathogenesis of multiple sclerosis

inferredcites →https://doi.org/10.1016/j.vaccine.2005.10.027openalex-extracted

Analysis of costimulatory molecule expression on antigen-specific T and B cells during the induction of adjuvant-induced Th1 and Th2 type responses

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Dendritic Cells

inferredcites →https://doi.org/10.1016/s0140-6736(08)61620-7openalex-extracted

Multiple sclerosis

inferredcites →https://doi.org/10.1021/jm5010539openalex-extracted

The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

inferredcites →https://doi.org/10.1038/nature10509openalex-extracted

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

inferredcites →https://doi.org/10.1038/ni.3347openalex-extracted

Epigenetic regulation of the expression of Il12 and Il23 and autoimmune inflammation by the deubiquitinase Trabid

inferredcites →https://doi.org/10.1038/ni1010openalex-extracted

Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways

inferredcites →https://doi.org/10.1038/nn.3505openalex-extracted

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

inferredcites →https://doi.org/10.1073/pnas.1615601114openalex-extracted

BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice

inferredcites →https://doi.org/10.1084/jem.20130376openalex-extracted

BET bromodomain inhibition suppresses TH17-mediated pathology

inferredcites →https://doi.org/10.1093/brain/awx154openalex-extracted

Cell-based therapeutic strategies for multiple sclerosis

inferredcites →https://doi.org/10.1093/intimm/dxw045openalex-extracted

The role of α4 integrin in Theiler’s murine encephalomyelitis virus (TMEV)-induced demyelinating disease: an infectious animal model for multiple sclerosis (MS)

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Innate and adaptive dendritic cell responses to immunotherapy

inferredcites →https://doi.org/10.1097/wco.0b013e328346c226openalex-extracted

Experimental models of multiple sclerosis

inferredcites →https://doi.org/10.1097/wnf.0b013e3181cbf825openalex-extracted

Mechanism of Action of Oral Fingolimod (FTY720) in Multiple Sclerosis

inferredcites →https://doi.org/10.1111/imr.12192openalex-extracted

Macrophages in intestinal homeostasis and inflammation

inferredcites →https://doi.org/10.1126/science.aav7188openalex-extracted

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

inferredcites →https://doi.org/10.1136/jnnp-2018-319831openalex-extracted

Comparison of fingolimod, dimethyl fumarate and teriflunomide for multiple sclerosis

inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-0028openalex-extracted

Ex vivoNicotine Stimulation Augments the Efficacy of Therapeutic Bone Marrow–Derived Dendritic Cell Vaccination

inferredcites →https://doi.org/10.1158/2159-8290.cd-12-0418openalex-extracted

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

inferredcites →https://doi.org/10.1159/000364945openalex-extracted

M1 and M2 Macrophages: The Chicken and the Egg of Immunity

inferredcites →https://doi.org/10.1182/blood-2014-08-598037openalex-extracted

BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice

inferredcites →https://doi.org/10.1186/1471-2172-7-17openalex-extracted

Regulatory role of pro-Th1 and pro-Th2 cytokines in modulating the activity of Th1 and Th2 cells when B cell and macrophages are used as antigen presenting cells

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BRD4 and Cancer: going beyond transcriptional regulation

inferredcites →https://doi.org/10.1681/asn.2015080910openalex-extracted

Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage

inferredcites →https://doi.org/10.2147/ijgm.s356877openalex-extracted

Epigenetic Modifications in the Pathogenesis of Systemic Sclerosis

inferredcites →https://doi.org/10.2353/ajpath.2008.070690openalex-extracted

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

inferredcites →https://doi.org/10.3390/biomedicines10030606openalex-extracted

The Forgotten Brother: The Innate-like B1 Cell in Multiple Sclerosis

inferredcites →https://doi.org/10.3892/ijmm.2014.1632openalex-extracted

Nicotine exerts neuroprotective effects against β-amyloid-induced neurotoxicity in SH-SY5Y cells through the Erk1/2-p38-JNK-dependent signaling pathway

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Studies Using Antigen-Presenting Cells Lacking Expression of Both B7-1 (CD80) and B7-2 (CD86) Show Distinct Requirements for B7 Molecules During Priming Versus Restimulation of Th2 But Not Th1 Cytokine Production

inferredcites →https://doi.org/10.4049/jimmunol.177.1.566openalex-extracted

IL-17 Plays an Important Role in the Development of Experimental Autoimmune Encephalomyelitis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1186/s12950-026-00489-7openalex-snapshot

Bromodomain-containing protein 4 in inflammatory diseases: molecular mechanisms and therapeutic potential

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