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Chronic Pm2.5 Exposure Disrupts Intestinal Barrier Integrity Via Microbial Dysbiosis-Triggered Tlr2/5-Myd88-Nlrp3 Inflammasome Activation

https://doi.org/10.2139/ssrn.4773660
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Long-term Air Pollution Exposure and Acceleration of Atherosclerosis and Vascular Inflammation in an Animal Model
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PM2.5 Exposure Induces Inflammatory Response in Macrophages via the TLR4/COX-2/NF-κB Pathway
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FHA domain of AGGF1 is essential for its nucleocytoplasmic transport and angiogenesis
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Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring
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Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease
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Fine particulate matter-induced cardiovascular injury is associated with NLRP3 inflammasome activation in Apo E-/- mice
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Exposure to concentrated ambient PM2.5 (CAPM) induces intestinal disturbance via inflammation and alternation of gut microbiome
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Subchronic exposure to concentrated ambient PM2.5 perturbs gut and lung microbiota as well as metabolic profiles in mice
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Phenylalanine- and leucine-defined metabolic types identify high mortality risk in patients with severe infection
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Combined exposure of fine particulate matter and high-fat diet aggravate the cardiac fibrosis in C57BL/6J mice
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Biomarkers for the adverse effects on respiratory system health associated with atmospheric particulate matter exposure
inferredcites →https://doi.org/10.1016/j.jhazmat.2022.128653openalex-extracted
PM2.5 induced weight loss of mice through altering the intestinal microenvironment: Mucus barrier, gut microbiota, and metabolic profiling
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Gut barrier disruption and chronic disease
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Intermediates of Metabolism: From Bystanders to Signalling Molecules
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Shp2 regulates PM2.5-induced airway epithelial barrier dysfunction by modulating ERK1/2 signaling pathway
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Glutamine Metabolism in Cancer: Understanding the Heterogeneity
inferredcites →https://doi.org/10.1016/s0016-5085(00)70417-3openalex-extracted
Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, RAF-independent mechanism
inferredcites →https://doi.org/10.1021/acs.est.5b01236openalex-extracted
Addressing Global Mortality from Ambient PM2.5
inferredcites →https://doi.org/10.1038/mi.2015.40openalex-extracted
Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
inferredcites →https://doi.org/10.1038/nature08821openalex-extracted
A human gut microbial gene catalogue established by metagenomic sequencing
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Fast and sensitive protein alignment using DIAMOND
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From Krebs to clinic: glutamine metabolism to cancer therapy
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Seasonal variations in cardiovascular disease
inferredcites →https://doi.org/10.1038/s41579-018-0036-xopenalex-extracted
Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
inferredcites →https://doi.org/10.1038/s41586-023-05874-3openalex-extracted
Lung adenocarcinoma promotion by air pollutants
inferredcites →https://doi.org/10.1038/s41598-020-61972-6openalex-extracted
Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity
inferredcites →https://doi.org/10.1038/s41598-020-67971-xopenalex-extracted
Plasma phenylalanine and glutamine concentrations correlate with subsequent hepatocellular carcinoma occurrence in liver cirrhosis patients: an exploratory study
inferredcites →https://doi.org/10.1038/s42255-022-00558-0openalex-extracted
The gut microbial metabolite formate exacerbates colorectal cancer progression
inferredcites →https://doi.org/10.1038/srep42906openalex-extracted
Ambient Ultrafine Particle Ingestion Alters Gut Microbiota in Association with Increased Atherogenic Lipid Metabolites
inferredcites →https://doi.org/10.1053/j.gastro.2019.05.010openalex-extracted
RNA-Binding Protein HuR Regulates Paneth Cell Function by Altering Membrane Localization of TLR2 via Post-transcriptional Control of CNPY3
inferredcites →https://doi.org/10.1053/j.gastro.2022.07.051openalex-extracted
Histone Deacetylase Inhibition by Gut Microbe-Generated Short-Chain Fatty Acids Entrains Intestinal Epithelial Circadian Rhythms
inferredcites →https://doi.org/10.1073/pnas.1231488100openalex-extracted
Mast cells disrupt epithelial barrier function during enteric nematode infection
inferredcites →https://doi.org/10.1073/pnas.1803222115openalex-extracted
Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter
inferredcites →https://doi.org/10.1073/pnas.1908128116openalex-extracted
Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species
inferredcites →https://doi.org/10.1073/pnas.2025070118openalex-extracted
METTL3-dependent N 6 -methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium
inferredcites →https://doi.org/10.1080/17474124.2017.1343143openalex-extracted
The intestinal barrier: a fundamental role in health and disease
inferredcites →https://doi.org/10.1084/jem.20071262openalex-extracted
Molecular mechanism of mast cell–mediated innate defense against endothelin and snake venom sarafotoxin
inferredcites →https://doi.org/10.1089/ars.2019.8015openalex-extracted
Particulate Matter Induces Tissue OxInflammation: From Mechanism to Damage
inferredcites →https://doi.org/10.1093/bioinformatics/btl158openalex-extracted
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
inferredcites →https://doi.org/10.1093/bioinformatics/btv033openalex-extracted
MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph
inferredcites →https://doi.org/10.1093/infdis/jit539openalex-extracted
Helicobacter pullorum Cytolethal Distending Toxin Targets Vinculin and Cortactin and Triggers Formation of Lamellipodia in Intestinal Epithelial Cells
inferredcites →https://doi.org/10.1093/toxsci/kfr211openalex-extracted
Long-term Exposure to Ambient Fine Particulate Pollution Induces Insulin Resistance and Mitochondrial Alteration in Adipose Tissue
inferredcites →https://doi.org/10.1111/all.15121openalex-extracted
Glutamine deficiency shifts the asthmatic state toward neutrophilic airway inflammation
inferredcites →https://doi.org/10.1128/aem.00052-19openalex-extracted
Clostridium scindens ATCC 35704: Integration of Nutritional Requirements, the Complete Genome Sequence, and Global Transcriptional Responses to Bile Acids
inferredcites →https://doi.org/10.1136/gut.2007.143172openalex-extracted
The significance of the gut barrier in disease: Figure 1
inferredcites →https://doi.org/10.1161/circulationaha.108.799015openalex-extracted
Ambient Air Pollution Exaggerates Adipose Inflammation and Insulin Resistance in a Mouse Model of Diet-Induced Obesity
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Principles for Valid Histopathologic Scoring in Research
inferredcites →https://doi.org/10.1186/s12989-018-0264-2openalex-extracted
Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice
inferredcites →https://doi.org/10.1186/s40779-017-0122-9openalex-extracted
Interaction between the gut microbiome and mucosal immune system
inferredcites →https://doi.org/10.1194/jlr.m038869openalex-extracted
Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens
inferredcites →https://doi.org/10.1289/ehp.1307823openalex-extracted
Association between Ambient Air Pollution and Diabetes Mellitus in Europe and North America: Systematic Review and Meta-Analysis
inferredcites →https://doi.org/10.1371/journal.pbio.1002202openalex-extracted
Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions
inferredcites →https://doi.org/10.1371/journal.pcbi.1004957openalex-extracted
MEGAN Community Edition - Interactive Exploration and Analysis of Large-Scale Microbiome Sequencing Data
inferredcites →https://doi.org/10.1371/journal.pone.0087796openalex-extracted
Disrupted Intestinal Microbiota and Intestinal Inflammation in Children with Cystic Fibrosis and Its Restoration with Lactobacillus GG: A Randomised Clinical Trial
inferredcites →https://doi.org/10.1371/journal.pone.0195310openalex-extracted
Mice harboring pathobiont-free microbiota do not develop intestinal inflammation that normally results from an innate immune deficiency
inferredcites →https://doi.org/10.15252/msb.20145645openalex-extracted
Potential of fecal microbiota for early‐stage detection of colorectal cancer
inferredcites →https://doi.org/10.2147/jir.s407521openalex-extracted
TLR5 Signaling in the Regulation of Intestinal Mucosal Immunity
inferredcites →https://doi.org/10.3389/fmicb.2017.00604openalex-extracted
Helicobacter pullorum: An Emerging Zoonotic Pathogen
inferredcites →https://doi.org/10.3389/fonc.2020.00559openalex-extracted
Expression and Significance of MyD88 in Patients With Gastric Cardia Cancer in a High-Incidence Area of China
inferredcites →https://doi.org/10.3389/fphar.2019.00451openalex-extracted
MicroRNA Post-transcriptional Regulation of the NLRP3 Inflammasome in Immunopathologies
inferredcites →https://doi.org/10.3389/fphys.2015.00294openalex-extracted
Fine particulate matter in acute exacerbation of COPD
inferredcites →https://doi.org/10.4103/0971-5916.162091openalex-extracted
Alterations of mucosal microbiota in the colon of patients with inflammatory bowel disease revealed by real time polymerase chain reaction amplification of 16S ribosomal ribonucleic acid
inferredcites →https://doi.org/10.4161/gmic.27251openalex-extracted
Air pollution effects on the gut microbiota
inferredcites →https://doi.org/10.4168/aair.2020.12.1.56openalex-extracted
Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells
inferredcites →https://doi.org/10.5217/ir.2014.12.2.90openalex-extracted
Lipopolysaccharide: Basic Biochemistry, Intracellular Signaling, and Physiological Impacts in the Gut
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TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury
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