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Glutamine deficiency shifts the asthmatic state toward neutrophilic airway inflammation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1006/abbi.2000.2168openalex-snapshot
Leukotriene B4: Metabolism and Signal Transduction
inferredcites →https://doi.org/10.1006/mgme.1999.2857openalex-snapshot
Glutamine, as a Precursor of Glutathione, and Oxidative Stress
inferredcites →https://doi.org/10.1007/bf00634379openalex-snapshot
The haematological, biochemical and immunological profile of athletes suffering from the overtraining syndrome
inferredcites →https://doi.org/10.1007/s001340000703openalex-snapshot
Plasma glutamine depletion and patient outcome in acute ICU admissions
inferredcites →https://doi.org/10.1016/0261-5614(94)90003-5openalex-snapshot
Glutamine and the immune system
inferredcites →https://doi.org/10.1016/j.anai.2016.05.016openalex-snapshot
Characterization of asthma endotypes: implications for therapy
inferredcites →https://doi.org/10.1016/j.bbamcr.2015.12.017openalex-snapshot
Glutamine transporters in mammalian cells and their functions in physiology and cancer
inferredcites →https://doi.org/10.1016/j.bbrep.2016.05.011openalex-snapshot
Glutamine up-regulates MAPK phosphatase-1 induction via activation of Ca 2+ → ERK cascade pathway
inferredcites →https://doi.org/10.1016/j.jaci.2004.09.038openalex-snapshot
Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound
inferredcites →https://doi.org/10.1016/j.jaci.2005.05.034openalex-snapshot
TNF-α induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A2 activation
inferredcites →https://doi.org/10.1016/j.jaci.2007.02.042openalex-snapshot
Noneosinophilic asthma: A distinct clinical and pathologic phenotype
inferredcites →https://doi.org/10.1016/j.jaci.2013.08.041openalex-snapshot
Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation
inferredcites →https://doi.org/10.1016/j.jaip.2017.04.038openalex-snapshot
Biologic Therapy and Novel Molecular Targets of Severe Asthma
inferredcites →https://doi.org/10.1016/j.jaip.2019.11.006openalex-snapshot
T2-“Low” Asthma: Overview and Management Strategies
inferredcites →https://doi.org/10.1016/j.jid.2018.02.036openalex-snapshot
GPCR Kinase (GRK)-2 Is a Key Negative Regulator of Itch: l-Glutamine Attenuates Itch via a Rapid Induction of GRK2 in an ERK-Dependent Way
inferredcites →https://doi.org/10.1016/j.mrgentox.2008.09.017openalex-snapshot
Oxidative stress in environmental-induced carcinogenesis
inferredcites →https://doi.org/10.1016/j.prostaglandins.2021.106539openalex-snapshot
Role of arachidonic cascade in COVID-19 infection: A review
inferredcites →https://doi.org/10.1016/j.yjmcc.2020.05.007openalex-snapshot
p38 MAPK inhibition: A promising therapeutic approach for COVID-19
inferredcites →https://doi.org/10.1016/s0021-9258(17)44306-7openalex-snapshot
Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system.
inferredcites →https://doi.org/10.1016/s0021-9258(18)46028-0openalex-snapshot
Oxidative modification of Escherichia coli glutamine synthetase. Decreases in the thermodynamic stability of protein structure and specific changes in the active site conformation.
inferredcites →https://doi.org/10.1016/s0140-6736(05)66630-5openalex-snapshot
Obesity, cigarette smoking, and telomere length in women
inferredcites →https://doi.org/10.1016/s0952-7915(96)80131-2openalex-snapshot
Mitogen-activated protein kinase cascades and regulation of gene expression
inferredcites →https://doi.org/10.1017/s1740925x11000093openalex-snapshot
Roles of glutamine in neurotransmission
inferredcites →https://doi.org/10.1038/jid.2012.373openalex-snapshot
Glutamine Suppresses DNFB-Induced Contact Dermatitis by Deactivating p38 Mitogen–Activated Protein Kinase via Induction of MAPK Phosphatase-1
inferredcites →https://doi.org/10.1038/s41467-020-17181-wopenalex-snapshot
Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth
inferredcites →https://doi.org/10.1042/bj20100323openalex-snapshot
Mechanisms and functions of p38 MAPK signalling
inferredcites →https://doi.org/10.1046/j.1471-4159.1997.68062451.xopenalex-snapshot
Oxidatively Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Label Incorporation Kinetics: Relevance to Alzheimer's Disease
inferredcites →https://doi.org/10.1073/pnas.0510965103openalex-snapshot
Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
inferredcites →https://doi.org/10.1074/jbc.m109.028381openalex-snapshot
Inhibition of NF-κB-dependent Transcription by MKP-1
inferredcites →https://doi.org/10.1084/jem.20021340openalex-snapshot
Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen
inferredcites →https://doi.org/10.1084/jem.20051753openalex-snapshot
Dual specificity phosphatase 1 (DUSP1) regulates a subset of LPS-induced genes and protects mice from lethal endotoxin shock
inferredcites →https://doi.org/10.1084/jem.20051794openalex-snapshot
MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a003185openalex-snapshot
Leukotriene Receptors: Classification, Gene Expression, and Signal Transduction
inferredcites →https://doi.org/10.1097/01.shk.0000194041.18699.6fopenalex-snapshot
GLUTAMINE INHIBITS LIPOPOLYSACCHARIDE-INDUCED CYTOPLASMIC PHOSPHOLIPASE A2 ACTIVATION AND PROTECTS AGAINST ENDOTOXIN SHOCK IN MOUSE
inferredcites →https://doi.org/10.1111/all.13985openalex-snapshot
Mechanisms and therapeutic strategies for non‐T2 asthma
inferredcites →https://doi.org/10.1111/all.15121openalex-snapshot
Glutamine deficiency shifts the asthmatic state toward neutrophilic airway inflammation
inferredcites →https://doi.org/10.1111/cei.12585openalex-snapshot
Mechanism of glutamine inhibition of cytosolic phospholipase a2 (cPLA2): Evidence of physical interaction between glutamine-Induced mitogen-activated protein kinase phosphatase-1 and cPLA2
inferredcites →https://doi.org/10.1111/j.1365-2222.2007.02900.xopenalex-snapshot
Glutamine preferentially inhibits T‐helper type 2 cell‐mediated airway inflammation and late airway hyperresponsiveness through the inhibition of cytosolic phospholipase A2 activity in a murine asthma model
inferredcites →https://doi.org/10.1124/pr.116.012518openalex-snapshot
Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease
inferredcites →https://doi.org/10.1136/thx.2006.073429openalex-snapshot
Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
inferredcites →https://doi.org/10.1155/2013/793505openalex-snapshot
The Involvement of Phospholipases A 2 in Asthma and Chronic Obstructive Pulmonary Disease
inferredcites →https://doi.org/10.1159/000452103openalex-snapshot
Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation
inferredcites →https://doi.org/10.1165/rcmb.2007-0014ocopenalex-snapshot
Corticosteroids Reduce IL-6 in ASM Cells via Up-Regulation of MKP-1
inferredcites →https://doi.org/10.1165/rcmb.2012-0492tropenalex-snapshot
The Neutrophil in Chronic Obstructive Pulmonary Disease. Too Little, Too Late or Too Much, Too Soon?
inferredcites →https://doi.org/10.1172/jci0214869openalex-snapshot
Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo
inferredcites →https://doi.org/10.1172/jci14869openalex-snapshot
Transcellular biosynthesis contributes to the production of leukotrienes during inflammatory responses in vivo
inferredcites →https://doi.org/10.1183/20734735.008115openalex-snapshot
Clinical asthma phenotypes in the real world: opportunities and challenges
inferredcites →https://doi.org/10.1183/23120541.00088-2015openalex-snapshot
Leukotriene B4 levels in sputum from asthma patients
inferredcites →https://doi.org/10.1186/1471-2458-12-204openalex-snapshot
Global asthma prevalence in adults: findings from the cross-sectional world health survey
inferredcites →https://doi.org/10.1194/jlr.r057588openalex-snapshot
Cytosolic phospholipase A2: physiological function and role in disease
inferredcites →https://doi.org/10.1378/chest.08-2782openalex-snapshot
Leukotriene B 4 Contributes to Exhaled Breath Condensate and Sputum Neutrophil Chemotaxis in COPD
inferredcites →https://doi.org/10.3390/ijms20112710openalex-snapshot
Dual-Specificity Phosphatases in Immunity and Infection: An Update
inferredcites →https://doi.org/10.3390/nu10030288openalex-snapshot
l-Glutamine Attenuates DSS-Induced Colitis via Induction of MAPK Phosphatase-1
inferredcites →https://doi.org/10.4049/jimmunol.0900043openalex-snapshot
Glutamine Protects Mice from Lethal Endotoxic Shock via a Rapid Induction of MAPK Phosphatase-1
inferredcites →https://doi.org/10.4049/jimmunol.1201599openalex-snapshot
Glutamine Suppresses Airway Neutrophilia by Blocking Cytosolic Phospholipase A2 via an Induction of MAPK Phosphatase-1
inferredcites →https://doi.org/10.4049/jimmunol.176.3.1899openalex-snapshot
Essential Role of MAPK Phosphatase-1 in the Negative Control of Innate Immune Responses
inferredcites →https://doi.org/10.4049/jimmunol.178.8.5375openalex-snapshot
Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4773660openalex-extracted
Chronic Pm2.5 Exposure Disrupts Intestinal Barrier Integrity Via Microbial Dysbiosis-Triggered Tlr2/5-Myd88-Nlrp3 Inflammasome Activation
inferred← citeshttps://doi.org/10.1007/s11882-022-01058-7openalex-snapshot
Immune Metabolism in TH2 Responses: New Opportunities to Improve Allergy Treatment — Cell Type-Specific Findings (Part 2)
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116187openalex-snapshot
Targeting reprogrammed metabolism as a therapeutic approach for respiratory diseases
inferred← citeshttps://doi.org/10.1016/j.bcp.2025.117443openalex-snapshot
Targeting glutamine catabolism suppresses eosinophil expansion and activation to alleviate allergic airway inflammation
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117701openalex-snapshot
TTC3-mediated ubiquitination of APPL1 is suppression involved in the anti-asthmatic effects of the substance P receptor antagonist WIN62577
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117518openalex-snapshot
METTL16 controls airway inflammations in smoking-induced COPD via regulating glutamine metabolism
inferred← citeshttps://doi.org/10.1016/j.envres.2024.119415openalex-snapshot
Chronic PM2.5 exposure disrupts intestinal barrier integrity via microbial dysbiosis-triggered TLR2/5-MyD88-NLRP3 inflammasome activation
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113316openalex-snapshot
Dietary glutamine supplementation improves both Th1 and Th17 responses via CARD11-mTORC1 pathway in murine model of atopic dermatitis
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108612openalex-snapshot
Pathological and pharmacological functions of the metabolites of polyunsaturated fatty acids mediated by cyclooxygenases, lipoxygenases, and cytochrome P450s in cancers
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103335openalex-snapshot
Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization
inferred← citeshttps://doi.org/10.1021/acsptsci.5c00205openalex-snapshot
α, δ- N -Acetyl-glutamine Suppresses Neutrophilic Airway Inflammation by Activating the G Protein-Coupled Receptor/Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Phosphatase 1 Pathway
inferred← citeshttps://doi.org/10.1038/s41392-026-02981-1openalex-snapshot
Glutamine metabolism in health and disease
inferred← citeshttps://doi.org/10.1038/s41398-024-02846-7openalex-snapshot
Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation
inferred← citeshttps://doi.org/10.1038/s41598-026-38440-8openalex-snapshot
Multi-omics insights into Shenling Baizhu Powder’s amelioration of murine asthma through gut microbiota and Glutamine-GLS1 pathway
inferred← citeshttps://doi.org/10.1111/febs.70119openalex-snapshot
Glutamine limits NLRP3 inflammasome activation and pyroptosis in macrophages by sustaining the IRG1 /itaconate axis
inferred← citeshttps://doi.org/10.1152/ajplung.00181.2022openalex-snapshot
Inhibition of glutaminase 1 activity reverses airway hyperresponsiveness and decreases IL-1β+ M1s and IL-17 producing ILC3s in high-fat diet-fed obese mice
inferred← citeshttps://doi.org/10.1186/s10020-025-01099-4openalex-snapshot
Harnessing amino acid pathways to influence myeloid cell function in tumor immunity
inferred← citeshttps://doi.org/10.1186/s13578-024-01322-5openalex-snapshot
Multi-omics landscape of childhood simple obesity: novel insights into pathogenesis and biomarkers discovery
inferred← citeshttps://doi.org/10.15616/bsl.2021.27.4.223openalex-snapshot
Glutamine Inhibits TNF-α-induced Cytosolic Phospholipase A2 Activation via Upregulation of MAPK Phosphatase-1
inferred← citeshttps://doi.org/10.2147/dmso.s471711openalex-snapshot
Glutaminolysis is a Potential Therapeutic Target for Kidney Diseases
inferred← citeshttps://doi.org/10.3389/ebm.2026.10755openalex-snapshot
L-Glutamine attenuates peritoneal fibrosis developed in 5-Fluorouracil-treated mice
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1221530openalex-snapshot
Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy
inferred← citeshttps://doi.org/10.3389/fphar.2022.978421openalex-snapshot
Guominkang formula alleviate inflammation in eosinophilic asthma by regulating immune balance of Th1/2 and Treg/Th17 cells
inferred← citeshttps://doi.org/10.3389/fphar.2023.1096309openalex-snapshot
Glutamine ameliorates hyperoxia-induced hippocampal damage by attenuating inflammation and apoptosis via the MKP-1/MAPK signaling pathway in neonatal rats
inferred← citeshttps://doi.org/10.3390/ijms25095034openalex-snapshot
Interleukin-13 Treatment of Living Lung Tissue Model Alters the Metabolome and Proteome—A Nano-DESI MS Metabolomics and Shotgun Proteomics Study
inferred← citeshttps://doi.org/10.4103/1673-5374.346460openalex-snapshot
Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma
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