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Rhodesain Inhibitors on the Edge of Reversibility-Irreversibility

https://doi.org/10.2139/ssrn.4781829
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inferredcites →https://doi.org/10.1002/chem.202100892openalex-extracted
Elucidating the Dual Mode of Action of Dipeptidyl Enoates in the Inhibition of Rhodesain Cysteine Proteases
inferredcites →https://doi.org/10.1002/cmdc.202300160openalex-extracted
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α‐Fluorovinylsulfones and α‐Sulfonates as Potential Immunomodulators in Cancer
inferredcites →https://doi.org/10.1002/cssc.202101635openalex-extracted
Recent Progress and Emerging Technologies towards a Sustainable Synthesis of Sulfones
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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
inferredcites →https://doi.org/10.1016/0263-7855(96)00018-5openalex-extracted
VMD: Visual molecular dynamics
inferredcites →https://doi.org/10.1016/j.drudis.2023.103799openalex-extracted
The expanding repertoire of covalent warheads for drug discovery
inferredcites →https://doi.org/10.1016/j.ejmech.2022.115021openalex-extracted
Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors
inferredcites →https://doi.org/10.1016/j.ijpara.2012.03.009openalex-extracted
Trypanosoma brucei: Chemical evidence that cathepsin L is essential for survival and a relevant drug target
inferredcites →https://doi.org/10.1016/s0040-4039(00)89719-1openalex-extracted
Torsional strain involving partial bonds. The stereochemistry of the lithium aluminium hydride reduction of some simple open-chain ketones
inferredcites →https://doi.org/10.1016/s0045-2068(02)00009-3openalex-extracted
pH Dependence of inhibitors targeting the occluding loop of cathepsin B
inferredcites →https://doi.org/10.1016/s0140-6736(09)60829-1openalex-extracted
Human African trypanosomiasis
inferredcites →https://doi.org/10.1016/s0166-6851(01)00368-1openalex-extracted
Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense
inferredcites →https://doi.org/10.1017/s0031182020000645openalex-extracted
Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases
inferredcites →https://doi.org/10.1021/acs.jcim.1c00203openalex-extracted
AutoDock Vina 1.2.0: New Docking Methods, Expanded Force Field, and Python Bindings
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c01002openalex-extracted
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure–Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies
inferredcites →https://doi.org/10.1021/acsmedchemlett.6b00276openalex-extracted
Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain
inferredcites →https://doi.org/10.1021/jacs.6b03052openalex-extracted
Quantum Chemical-Based Protocol for the Rational Design of Covalent Inhibitors
inferredcites →https://doi.org/10.1021/jm00017a002openalex-extracted
Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors
inferredcites →https://doi.org/10.1038/d41573-021-00140-5openalex-extracted
FDA approves first all-oral sleeping sickness drug
inferredcites →https://doi.org/10.1126/science.abb3405openalex-extracted
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
inferredcites →https://doi.org/10.1515/9783110468755-002openalex-extracted
1.2 Designing Covalent Inhibitors: A Medicinal Chemistry Challenge
inferredcites →https://doi.org/10.2174/1389557515666160509125243openalex-extracted
The Inhibition of Cysteine Proteases Rhodesain and TbCatB: A Valuable Approach to Treat Human African Trypanosomiasis
inferredcites →https://doi.org/10.2174/156802610790725498openalex-extracted
Enzyme Kinetics and Hit Validation in Fluorimetric Protease Assays
inferredcites →https://doi.org/10.3390/ijms24087226openalex-extracted
Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors—A Comprehensive Reactivity and Selectivity Study
inferredcites →https://doi.org/10.3390/molecules25092064openalex-extracted
Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases—Studies on Inhibition Mechanism and Kinetics
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