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2-Aminopyridine Chemicals Kill Pc-3 Prostate Cancer Cells Via Activation of Ampk and Indirect Inhibition of the Mtor Pathway

https://doi.org/10.2139/ssrn.4821602
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Outgoing claims: the papers this work cites, builds on, or argues with.

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The interplay of ROS and the PI3K/Akt pathway in autophagy regulation
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A simple colorimetric experiment using mammalian cell culture to study metabolism
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Cancer statistics for the year 2020: An overview
inferredcites →https://doi.org/10.1002/jcla.24332openalex-snapshot
The expression and significance of p4E‐BP1/4E‐BP1 in prostate cancer
inferredcites →https://doi.org/10.1002/prp2.149openalex-snapshot
Analysis of drug combinations: current methodological landscape
inferredcites →https://doi.org/10.1016/j.abb.2005.06.015openalex-snapshot
Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells
inferredcites →https://doi.org/10.1016/j.bbabio.2009.06.003openalex-snapshot
Hypoxia and the metabolic phenotype of prostate cancer cells
inferredcites →https://doi.org/10.1016/j.bbrc.2012.11.030openalex-snapshot
Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells
inferredcites →https://doi.org/10.1016/j.bmcl.2017.07.061openalex-snapshot
Novel anti-prostate cancer scaffold identified by the combination of in silico and cell-based assays targeting the PI3K-AKT-mTOR pathway
inferredcites →https://doi.org/10.1016/j.drudis.2015.01.002openalex-snapshot
Extending kinome coverage by analysis of kinase inhibitor broad profiling data
inferredcites →https://doi.org/10.1016/j.eururo.2023.04.021openalex-snapshot
2022 Update on Prostate Cancer Epidemiology and Risk Factors—A Systematic Review
inferredcites →https://doi.org/10.1016/j.tcb.2019.02.004openalex-snapshot
Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis
inferredcites →https://doi.org/10.1038/nature14107openalex-snapshot
SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
inferredcites →https://doi.org/10.1038/ncb2204openalex-snapshot
Lysosomal positioning coordinates cellular nutrient responses
inferredcites →https://doi.org/10.1038/nmeth.2019openalex-snapshot
Fiji: an open-source platform for biological-image analysis
inferredcites →https://doi.org/10.1038/s41388-021-01810-9openalex-snapshot
The role of the p90 ribosomal S6 kinase family in prostate cancer progression and therapy resistance
inferredcites →https://doi.org/10.1038/s41580-022-00547-xopenalex-snapshot
New insights into activation and function of the AMPK
inferredcites →https://doi.org/10.1038/s41598-018-23847-9openalex-snapshot
Discrimination between the human prostate normal and cancer cell exometabolome by GC-MS
inferredcites →https://doi.org/10.1038/s41598-019-46163-2openalex-snapshot
Reversine exhibits antineoplastic activity in JAK2V617F-positive myeloproliferative neoplasms
inferredcites →https://doi.org/10.1038/s42255-019-0157-1openalex-snapshot
mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress
inferredcites →https://doi.org/10.1126/science.1257132openalex-snapshot
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
inferredcites →https://doi.org/10.1159/000519861openalex-snapshot
Metastatic Prostate Cancer: Treatment Options
inferredcites →https://doi.org/10.14740/wjon1191openalex-snapshot
Epidemiology of Prostate Cancer
inferredcites →https://doi.org/10.18632/oncotarget.10150openalex-snapshot
Cytoplasmic vacuolization in cell death and survival
inferredcites →https://doi.org/10.2478/acph-2021-0042openalex-snapshot
Pinocembrin flavanone inhibits cell viability in PC-3 human prostate cancer by inducing cellular apoptosis, ROS production and cell cycle arrest
inferredcites →https://doi.org/10.3389/fphar.2021.728054openalex-snapshot
Advanced Therapeutic Options for Treatment of Metastatic Castration Resistant Prostatic Adenocarcinoma
inferredcites →https://doi.org/10.3390/cells12040659openalex-snapshot
Doxorubicin—An Agent with Multiple Mechanisms of Anticancer Activity
inferredcites →https://doi.org/10.3390/ijms222312827openalex-snapshot
The MTT Assay: Utility, Limitations, Pitfalls, and Interpretation in Bulk and Single-Cell Analysis
inferredcites →https://doi.org/10.3892/ijo.2021.5263openalex-snapshot
Targeting the mTOR pathway using novel ATP‑competitive inhibitors, Torin1, Torin2 and XL388, in the treatment of glioblastoma
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