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Pinocembrin flavanone inhibits cell viability in PC-3 human prostate cancer by inducing cellular apoptosis, ROS production and cell cycle arrest

https://doi.org/10.2478/acph-2021-0042
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.2015.8033openalex-snapshot
Prostate Cancer Screening
inferredcites →https://doi.org/10.1002/cbdv.201000367openalex-snapshot
New Flavanones from the Leaves of Cryptocarya chinensis and Their Antituberculosis Activity
inferredcites →https://doi.org/10.1002/mc.20272openalex-snapshot
Pinocembrin triggers Bax‐dependent mitochondrial apoptosis in colon cancer cells
inferredcites →https://doi.org/10.1007/bf02977330openalex-snapshot
Anti-asthmatic action of quercetin and rutin in conscious guinea-pigs challenged with aerosolized ovalbumin
inferredcites →https://doi.org/10.1007/s12035-015-9125-2openalex-snapshot
The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications
inferredcites →https://doi.org/10.1016/j.canlet.2018.05.026openalex-snapshot
Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells
inferredcites →https://doi.org/10.1016/j.ejphar.2008.06.071openalex-snapshot
Pinocembrin prevents glutamate-induced apoptosis in SH-SY5Y neuronal cells via decrease of bax/bcl-2 ratio
inferredcites →https://doi.org/10.1016/j.fct.2008.09.062openalex-snapshot
Antioxidant and antimicrobial effects of phenolic compounds extracts of Northeast Portugal honey
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2019.01.039openalex-snapshot
Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage
inferredcites →https://doi.org/10.1016/j.neuint.2009.09.015openalex-snapshot
Functional activation of monoamine transporters by luteolin and apigenin isolated from the fruit of Perilla frutescens (L.) Britt
inferredcites →https://doi.org/10.1016/j.phytochem.2012.01.007openalex-snapshot
Anti-inflammatory flavonoids from Cryptocarya chingii
inferredcites →https://doi.org/10.1016/j.taap.2007.03.016openalex-snapshot
(Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture
inferredcites →https://doi.org/10.1016/s0014-827x(01)01111-9openalex-snapshot
Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat
inferredcites →https://doi.org/10.1016/s0031-9422(00)00235-1openalex-snapshot
Advances in flavonoid research since 1992
inferredcites →https://doi.org/10.1016/s0140-6736(05)80091-1openalex-snapshot
Chinese herbal medicines revisited: a Hong Kong perspective
inferredcites →https://doi.org/10.1016/s1875-5364(12)60009-0openalex-snapshot
Phenols and flavonoids from the aerial part of Euphorbia hirta
inferredcites →https://doi.org/10.1021/np50081a012openalex-snapshot
Isolation of Potential Cancer Chemopreventive Agents from Eriodictyon californicum
inferredcites →https://doi.org/10.1039/c004698copenalex-snapshot
The biological potential of flavones
inferredcites →https://doi.org/10.1093/oxfordjournals.aje.a009698openalex-snapshot
Asymptomatic Incidence and Duration of Prostate Cancer
inferredcites →https://doi.org/10.1155/2013/379850openalex-snapshot
Pinocembrin: A Novel Natural Compound with Versatile Pharmacological and Biological Activities
inferredcites →https://doi.org/10.2174/138955707779317830openalex-snapshot
Biological Fingerprinting Analysis of Traditional Chinese Medicines with Targeting ADME/Tox Property for Screening of Bioactive Compounds by Chromatographic and MS Methods
inferredcites →https://doi.org/10.3322/caac.21387openalex-snapshot
Cancer statistics, 2017
inferredcites →https://doi.org/10.3329/bjp.v8i3.14795openalex-snapshot
Antiproliferative and apoptotic effects of pinocembrin in human prostate cancer cells
inferredcites →https://doi.org/10.3724/sp.j.1009.2012.00040openalex-snapshot
Phenols and flavonoids from the aerial part of Euphorbia hirta

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.5362205openalex-extracted
Network Pharmacology-Guided Discovery and Computational Validation of Pinocembrin-Based Anticancer Inhibitors Targeting Mmp9, Tp53, and Hif1α Through Molecular Docking, Admet Profiling, and Molecular Dynamics Simulations
inferred← citeshttps://doi.org/10.1007/978-3-031-99601-6_5openalex-snapshot
Anticancer Potential of Flavanones
inferred← citeshttps://doi.org/10.1016/j.bbagen.2023.130340openalex-snapshot
Narirutin downregulates lipoxygenase-5 expression and induces G0/G1 arrest in triple-negative breast carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.09.178openalex-snapshot
Apoptosis of hepatocellular carcinoma HepG2 cells induced by seleno-ovalbumin (Se-OVA) via mitochondrial pathway
inferred← citeshttps://doi.org/10.1016/j.prenap.2024.100046openalex-snapshot
Review on the pharmacological properties of lemongrass (Cymbopogon citratus) as a promising source of bioactive compounds
inferred← citeshttps://doi.org/10.1021/acs.iecr.4c02301openalex-snapshot
Efficient Leaching of Pinocembrin from Eucalyptus Leaves Using Aqueous-Based Leaching Systems
inferred← citeshttps://doi.org/10.1039/d2nj00716aopenalex-snapshot
Ovalbumin-coated Fe 3 O 4 nanoparticles as a nanocarrier for chlorogenic acid to promote the anticancer efficacy on MDA-MB-231 cells
inferred← citeshttps://doi.org/10.1055/a-2899-3112openalex-snapshot
Phytochemicals to Pharmacology: Potential Cytotoxic and Tumor Inhibitory Activity of Elaeocarpus ganitrus Extract in Preclinical Models
inferred← citeshttps://doi.org/10.11606/t.82.2023.tde-04072024-113704openalex-snapshot
Ensaios celulares aplicados para o estudo de inibidores de cisteíno proteases e de biomateriais
inferred← citeshttps://doi.org/10.1186/s12935-026-04352-wopenalex-snapshot
Pinocembrin, an anticancer dihydroxyflavanone: from chemistry to cellular interactions and synergistic prospects
inferred← citeshttps://doi.org/10.1208/s12249-022-02427-1openalex-snapshot
Preparation of Pinocembrin-Loaded F127/MPEG-PDLLA Polymer Micelles and Anti-Osteoporotic Activity
inferred← citeshttps://doi.org/10.1371/journal.pone.0266044openalex-snapshot
Induction of apoptosis in human colorectal cancer cells by nanovesicles from fingerroot (Boesenbergia rotunda (L.) Mansf.)
inferred← citeshttps://doi.org/10.2139/ssrn.4821602openalex-snapshot
2-Aminopyridine Chemicals Kill Pc-3 Prostate Cancer Cells Via Activation of Ampk and Indirect Inhibition of the Mtor Pathway
inferred← citeshttps://doi.org/10.26538/tjnpr/v9i7.3openalex-snapshot
Goniothalamus macrophyllus: A Comprehensive Review of Its Phytochemistry, Pharmacological Activities, and Therapeutic Potential
inferred← citeshttps://doi.org/10.3389/fphar.2025.1710923openalex-snapshot
Mitochondrial involvement in PC: improving therapeutic strategies
inferred← citeshttps://doi.org/10.3390/biom15091325openalex-snapshot
Pinocembrin Downregulates Vascular Smooth Muscle Cells Proliferation and Migration Leading to Attenuate Neointima Formation in Balloon-Injured Rats
inferred← citeshttps://doi.org/10.3390/ijms27020885openalex-snapshot
Prostate Cancer, JAK/STAT3 Dysregulation, and Flavonoids: Is There a Possible Link?
inferred← citeshttps://doi.org/10.3390/ijms27073074openalex-snapshot
Recent Progress on Polyphenols of Malaysian Honey and Their Molecular Mechanism Pathways in Cancer—A Comprehensive Review
inferred← citeshttps://doi.org/10.3390/ma15155166openalex-snapshot
Synthesis and Anticancer Activity of Bagasse Xylan/Resveratrol Graft-Esterified Composite Nanoderivative
inferred← citeshttps://doi.org/10.3390/molecules26164779openalex-snapshot
Anastatin Derivatives Alleviate Myocardial Ischemia-Reperfusion Injury via Antioxidative Properties
inferred← citeshttps://doi.org/10.3390/polym13132084openalex-snapshot
Synthesis and Biological Evaluation of a Novel Glycidyl Metharcylate/Phaytic Acid-Based on Bagasse Xylan Composite Derivative
inferred← citeshttps://doi.org/10.34172/jhp.2024.48225openalex-snapshot
Effect of pinocembrin on thymocyte proliferation and death
inferred← citeshttps://doi.org/10.5493/wjem.v15.i4.110482openalex-snapshot
Pinocembrin as a novel anti-cancer agent: Exploring preclinical evidence along with therapeutic potential
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