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Oridonin Alleviates Cerebral Ischemic-Reperfusion (I/R) Injury by Covalently Binding with Hmgb1 and Inhibiting Hmgb1/Tlr4/Myd88/Nf-Κb Signaling Pathway

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/brb3.2987openalex-snapshot
HMGB1, angel or devil, in ischemic stroke
inferredcites →https://doi.org/10.1002/ptr.7518openalex-snapshot
Oridonin relieves depressive‐like behaviors by inhibiting neuroinflammation and autophagy impairment in rats subjected to chronic unpredictable mild stress
inferredcites →https://doi.org/10.1007/s12975-024-01258-5openalex-snapshot
HMGB1: A New Target for Ischemic Stroke and Hemorrhagic Transformation
inferredcites →https://doi.org/10.1007/s40268-015-0102-zopenalex-snapshot
Molecular Insight in the Multifunctional Effects of Oridonin
inferredcites →https://doi.org/10.1016/bs.apcsb.2016.10.001openalex-snapshot
HMGB1 Protein
inferredcites →https://doi.org/10.1016/j.jfda.2016.05.008openalex-snapshot
Simultaneous characterization and quantification of 17 main compounds in Rabdosia rubescens by high performance liquid chromatography
inferredcites →https://doi.org/10.1016/j.jphs.2019.04.006openalex-snapshot
Anti-HMGB1 monoclonal antibody therapy for a wide range of CNS and PNS diseases
inferredcites →https://doi.org/10.1016/j.jstrokecerebrovasdis.2017.05.033openalex-snapshot
Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke
inferredcites →https://doi.org/10.1016/j.pharmthera.2020.107695openalex-snapshot
Natural medicine in neuroprotection for ischemic stroke: Challenges and prospective
inferredcites →https://doi.org/10.1016/j.phrs.2016.06.031openalex-snapshot
HMGB1 as biomarker and drug target
inferredcites →https://doi.org/10.1016/s1474-4422(19)30078-xopenalex-snapshot
Global brain inflammation in stroke
inferredcites →https://doi.org/10.1021/acs.jmedchem.4c00211openalex-snapshot
Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers
inferredcites →https://doi.org/10.1038/nrrheum.2011.222openalex-snapshot
HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
inferredcites →https://doi.org/10.1038/s41392-023-01688-xopenalex-snapshot
Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
inferredcites →https://doi.org/10.1038/s41401-022-00995-3openalex-snapshot
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy
inferredcites →https://doi.org/10.1038/s41577-023-00894-6openalex-snapshot
The multifunctional protein HMGB1: 50 years of discovery
inferredcites →https://doi.org/10.1039/d3cc00577aopenalex-snapshot
Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1
inferredcites →https://doi.org/10.1080/01616412.2018.1497254openalex-snapshot
Association of circulating blood HMGB1 levels with ischemic stroke: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1089/ars.2015.6397openalex-snapshot
HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke
inferredcites →https://doi.org/10.1089/neu.2021.0466openalex-snapshot
Oridonin Ameliorates Traumatic Brain Injury-Induced Neurological Damage by Improving Mitochondrial Function and Antioxidant Capacity and Suppressing Neuroinflammation through the Nrf2 Pathway
inferredcites →https://doi.org/10.1111/jcmm.12124openalex-snapshot
Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis
inferredcites →https://doi.org/10.1111/jcmm.16923openalex-snapshot
Oridonin prevents oxidative stress‐induced endothelial injury via promoting Nrf‐2 pathway in ischaemic stroke
inferredcites →https://doi.org/10.1146/annurev-immunol-030409-101323openalex-snapshot
HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection
inferredcites →https://doi.org/10.1161/circresaha.120.317596openalex-snapshot
tPA Mobilizes Immune Cells That Exacerbate Hemorrhagic Transformation in Stroke
inferredcites →https://doi.org/10.1186/s10020-023-00717-3openalex-snapshot
HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases
inferredcites →https://doi.org/10.1186/s12974-021-02216-wopenalex-snapshot
Celastrol exerts a neuroprotective effect by directly binding to HMGB1 protein in cerebral ischemia–reperfusion
inferredcites →https://doi.org/10.1212/wnl.0000000000012781openalex-snapshot
Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions
inferredcites →https://doi.org/10.15252/emmm.202216269openalex-snapshot
Systemic inflammation after stroke: implications for post‐stroke comorbidities
inferredcites →https://doi.org/10.2147/jir.s477415openalex-snapshot
Elevated Serum HMGB1 Levels and Their Association with Recurrence of Acute Ischaemic Stroke
inferredcites →https://doi.org/10.2174/1567201813666160808111933openalex-snapshot
Review: Therapeutic Targeting of HMGB1 in Stroke
inferredcites →https://doi.org/10.3389/fnins.2020.557170openalex-snapshot
Neuroprotective Effect of Oridonin on Traumatic Brain Injury via Inhibiting NLRP3 Inflammasome in Experimental Mice
inferredcites →https://doi.org/10.3389/fphar.2021.645824openalex-snapshot
Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity
inferredcites →https://doi.org/10.3389/fphys.2015.00093openalex-snapshot
Oxidative stress-mediated HMGB1 biology
inferredcites →https://doi.org/10.3390/brainsci12111580openalex-snapshot
The Association between High Mobility Group Box 1 and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients
inferredcites →https://doi.org/10.3390/brainsci14040328openalex-snapshot
Natural Compounds Oridonin and Shikonin Exhibit Potentially Beneficial Regulatory Effects on Select Functions of Microglia
inferredcites →https://doi.org/10.3390/cells10123323openalex-snapshot
Post-Translational Modification of HMGB1 Disulfide Bonds in Stimulating and Inhibiting Inflammation
inferredcites →https://doi.org/10.3390/ijms21134609openalex-snapshot
HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities
inferredcites →https://doi.org/10.3390/ijms23105796openalex-snapshot
The Development of Novel Drug Treatments for Stroke Patients: A Review
inferredcites →https://doi.org/10.3390/molecules23020474openalex-snapshot
Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection
inferredcites →https://doi.org/10.34133/research.0459openalex-snapshot
Dihydroartemisinin Regulated the MMP-Mediated Cellular Microenvironment to Alleviate Rheumatoid Arthritis
inferredcites →https://doi.org/10.4049/jimmunol.1402609openalex-snapshot
The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release
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