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Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection

https://doi.org/10.3390/molecules23020474

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Neurodegenerative Disorders

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Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes

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Enhanced anti-fibrogenic effects of novel oridonin derivative CYD0692 in hepatic stellate cells

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Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells

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Molecular Insight in the Multifunctional Effects of Oridonin

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Correlations of synaptic and pathological markers with cognition of the elderly

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Oridonin induces G2/M arrest and apoptosis via activating ERK–p53 apoptotic pathway and inhibiting PTK–Ras–Raf–JNK survival pathway in murine fibrosarcoma L929 cells

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Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer therapeutics

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A new oridonin analog suppresses triple-negative breast cancer cells and tumor growth via the induction of death receptor 5

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Natural products: An evolving role in future drug discovery

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The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents

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Synthesis of spirolactone-type diterpenoid derivatives from kaurene-type oridonin with improved antiproliferative effects and their apoptosis-inducing activity in human hepatoma Bel-7402 cells

inferredcites →https://doi.org/10.1016/j.ejmech.2013.04.012openalex-snapshot

Enmein-type diterpenoid analogs from natural kaurene-type oridonin: Synthesis and their antitumor biological evaluation

inferredcites →https://doi.org/10.1016/j.ejmech.2016.06.015openalex-snapshot

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Anti-inflammatory effects of 27 selected terpenoid compounds tested through modulating Th1/Th2 cytokine secretion profiles using murine primary splenocytes

inferredcites →https://doi.org/10.1016/j.ijbiomac.2012.01.024openalex-snapshot

In vitro and in vivo evaluation of oridonin-loaded long circulating nanostructured lipid carriers

inferredcites →https://doi.org/10.1016/j.ijpharm.2007.12.016openalex-snapshot

Studies on pharmacokinetics and tissue distribution of oridonin nanosuspensions

inferredcites →https://doi.org/10.1016/j.ijpharm.2007.12.026openalex-snapshot

Preparation and evaluation of self-microemulsifying drug delivery system of oridonin

inferredcites →https://doi.org/10.1016/j.ijpharm.2008.08.009openalex-snapshot

Optimization and in situ intestinal absorption of self-microemulsifying drug delivery system of oridonin

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Galactosylated chitosan nanoparticles for hepatocyte-targeted delivery of oridonin

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Synthesis, characterization, in vitro and in vivo evaluation of PEGylated oridonin conjugates

inferredcites →https://doi.org/10.1016/j.intimp.2007.03.001openalex-snapshot

Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra

inferredcites →https://doi.org/10.1016/j.intimp.2009.01.002openalex-snapshot

Multiple-modulation effects of Oridonin on the production of proinflammatory cytokines and neurotrophic factors in LPS-activated microglia

inferredcites →https://doi.org/10.1016/j.jss.2014.03.036openalex-snapshot

Oridonin inhibits hepatic stellate cell proliferation and fibrogenesis

inferredcites →https://doi.org/10.1016/j.jss.2015.07.042openalex-snapshot

Enhanced effects of novel oridonin analog CYD0682 for hepatic fibrosis

inferredcites →https://doi.org/10.1016/j.mcn.2007.06.004openalex-snapshot

Creating a neurogenic environment: The role of BDNF and FGF2

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Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways

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Formal synthesis of semiaquilegin A

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The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis

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Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide

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Association of interleukin-1β polymorphisms with idiopathic Parkinson's disease

inferredcites →https://doi.org/10.1021/acs.jmedchem.6b00408openalex-snapshot

Probing the Anticancer Action of Oridonin with Fluorescent Analogues: Visualizing Subcellular Localization to Mitochondria

inferredcites →https://doi.org/10.1021/acs.jmedchem.6b01652openalex-snapshot

A Novel Potent Anticancer Compound Optimized from a Natural Oridonin Scaffold Induces Apoptosis and Cell Cycle Arrest through the Mitochondrial Pathway

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Natural Products as Sources of New Drugs from 1981 to 2014

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Discovery of Multitarget-Directed Ligands against Alzheimer’s Disease through Systematic Prediction of Chemical–Protein Interactions

inferredcites →https://doi.org/10.1021/jm400367nopenalex-snapshot

Novel Nitrogen-Enriched Oridonin Analogues with Thiazole-Fused A-Ring: Protecting Group-Free Synthesis, Enhanced Anticancer Profile, and Improved Aqueous Solubility

inferredcites →https://doi.org/10.1021/jm401248xopenalex-snapshot

Oridonin Ring A-Based Diverse Constructions of Enone Functionality: Identification of Novel Dienone Analogues Effective for Highly Aggressive Breast Cancer by Inducing Apoptosis

inferredcites →https://doi.org/10.1021/ol0531379openalex-snapshot

Bisrubescensins A−C: Three New Dimeric ent-Kauranoids Isolated from Isodon rubescens

inferredcites →https://doi.org/10.1021/ol4015865openalex-snapshot

Overcoming Synthetic Challenges of Oridonin A-Ring Structural Diversification: Regio- and Stereoselective Installation of Azides and 1,2,3-Triazoles at the C-1, C-2, or C-3 Position

inferredcites →https://doi.org/10.1038/cddis.2017.121openalex-snapshot

Targeting 3-phosphoinositide-dependent protein kinase 1 associated with drug-resistant renal cell carcinoma using new oridonin analogs

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The evolving role of natural products in drug discovery

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inferredcites →https://doi.org/10.1039/c19670000252openalex-snapshot

Oridonin, a new diterpenoid from Isodon species

inferredcites →https://doi.org/10.1039/c1ob05611eopenalex-snapshot

Synthesis and revision of stereochemistry of rubescensin S

inferredcites →https://doi.org/10.1039/c4ob01040jopenalex-snapshot

ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels–Alder reactions: synthesis of dihydropyran-fused diterpenoids

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Discovery of neuroprotective compounds by machine learning approaches

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Oridonin induced A375-S2 cell apoptosis VIA BAX-regulated caspase pathway activation, dependent on the cytochromeC/CASPASE-9 apoptosome

inferredcites →https://doi.org/10.1083/jcb.200209011openalex-snapshot

BDNF-induced TrkB activation down-regulates the K+–Cl− cotransporter KCC2 and impairs neuronal Cl− extrusion

inferredcites →https://doi.org/10.1097/00005072-199708000-00011openalex-snapshot

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

inferredcites →https://doi.org/10.1097/cad.0000000000000329openalex-snapshot

Inhibition of nuclear factor κB transcription activity drives a synergistic effect of cisplatin and oridonin on HepG2 human hepatocellular carcinoma cells

inferredcites →https://doi.org/10.1111/1751-2980.12314openalex-snapshot

Oridonin derivative ameliorates experimental colitis by inhibiting activated T‐cells and translocation of nuclear factor‐kappa B

inferredcites →https://doi.org/10.1111/j.1745-7254.2006.00440.xopenalex-snapshot

Pharmacokinetic behaviors and oral bioavailability of oridonin in rat plasma

inferredcites →https://doi.org/10.1111/j.1745-7254.2007.00667.xopenalex-snapshot

Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line

inferredcites →https://doi.org/10.1111/jcmm.12124openalex-snapshot

Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis

inferredcites →https://doi.org/10.1111/jgh.12710openalex-snapshot

Oridonin's therapeutic effect: Suppressing T h1/ T h17 simultaneously in a mouse model of C rohn's disease

inferredcites →https://doi.org/10.1124/mol.105.012765openalex-snapshot

Novel Mechanism of Inhibition of Nuclear Factor-κB DNA-Binding Activity by Diterpenoids Isolated from Isodon rubescens

inferredcites →https://doi.org/10.1146/annurev-pharmtox-011112-140320openalex-snapshot

Role of Nrf2 in Oxidative Stress and Toxicity

inferredcites →https://doi.org/10.1146/annurev.neuro.22.1.219openalex-snapshot

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

inferredcites →https://doi.org/10.1146/annurev.pharmtox.46.120604.141046openalex-snapshot

Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

inferredcites →https://doi.org/10.1155/2013/484613openalex-snapshot

Role of Redox Signaling in Neuroinflammation and Neurodegenerative Diseases

inferredcites →https://doi.org/10.1158/1535-7163.mct-04-0277openalex-snapshot

Oridonin, a diterpenoid purified fromRabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways

inferredcites →https://doi.org/10.1159/000365571openalex-snapshot

Recent Research Progress in and Future Perspective on Treatment of Parkinson's Disease

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The Treatment Strategies for Neurodegenerative Diseases by Integrative Medicine

inferredcites →https://doi.org/10.1177/019262330002800104openalex-snapshot

Microglial Response to Brain Injury: A Brief Synopsis

inferredcites →https://doi.org/10.1182/blood-2006-06-032250openalex-snapshot

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo

inferredcites →https://doi.org/10.1186/1471-2407-14-217openalex-snapshot

Oridonin induces apoptosis and cell cycle arrest of gallbladder cancer cells via the mitochondrial pathway

inferredcites →https://doi.org/10.1186/1749-8546-6-27openalex-snapshot

Anti-cancer natural products isolated from chinese medicinal herbs

inferredcites →https://doi.org/10.1212/01.wnl.0000344650.95823.03openalex-snapshot

Donepezil treatment of patients with MCI

inferredcites →https://doi.org/10.1212/wnl.0b013e3181bd6c25openalex-snapshot

DONEPEZIL TREATMENT OF PATIENTS WITH MCI: A 48-WEEK RANDOMIZED, PLACEBO- CONTROLLED TRIAL

inferredcites →https://doi.org/10.1212/wnl.56.1.127openalex-snapshot

Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease

inferredcites →https://doi.org/10.1248/bpb.29.1873openalex-snapshot

Fas/FasL Signaling Allows Extracelluar-Signal Regulated Kinase to Regulate Cytochrome c Release in Oridonin-Induced Apoptotic U937 Cells

inferredcites →https://doi.org/10.1248/cpb.24.2118openalex-snapshot

The antitumor and antibacterial activity of the Isodon diterpenoids.

inferredcites →https://doi.org/10.1254/jphs.91.267openalex-snapshot

Brain-Derived Neurotrophic Factor/TrkB Signaling in Memory Processes

inferredcites →https://doi.org/10.1254/jphs.fp0070336openalex-snapshot

Oridonin Induced Autophagy in Human Cervical Carcinoma HeLa Cells Through Ras, JNK, and P38 Regulation

inferredcites →https://doi.org/10.1254/jphs.fp0072079openalex-snapshot

Caspase Inhibition Augmented Oridonin-Induced Cell Death in Murine Fibrosarcoma L929 by Enhancing Reactive Oxygen Species Generation

inferredcites →https://doi.org/10.1254/jphs.fpj04008xopenalex-snapshot

Cytochrome c Release From Oridonin-Treated Apoptotic A375-S2 Cells Is Dependent on p53 and Extracellular Signal-Regulated Kinase Activation

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Activation of Phosphoinositide 3-Kinase, Protein Kinase C, and Extracellular Signal-Regulated Kinase Is Required for Oridonin-Enhanced Phagocytosis of Apoptotic Bodies in Human Macrophage-Like U937 Cells

inferredcites →https://doi.org/10.1289/ehp.11464openalex-snapshot

Oridonin Confers Protection against Arsenic-Induced Toxicity through Activation of the Nrf2-Mediated Defensive Response

inferredcites →https://doi.org/10.1371/journal.pone.0104745openalex-snapshot

Oridonin Attenuates Aβ1–42-Induced Neuroinflammation and Inhibits NF-κB Pathway

inferredcites →https://doi.org/10.1371/journal.pone.0151397openalex-snapshot

Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease

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Microglial Activation and Dopaminergic Cell Injury: AnIn VitroModel Relevant to Parkinson's Disease

inferredcites →https://doi.org/10.18632/oncotarget.10863openalex-snapshot

Targeting XBP1-mediated β-catenin expression associated with bladder cancer with newly synthetic Oridonin analogues

inferredcites →https://doi.org/10.18632/oncotarget.8033openalex-snapshot

Oridonin, a novel lysine acetyltransferases inhibitor, inhibits proliferation and induces apoptosis in gastric cancer cells through p53- and caspase-3-mediated mechanisms

inferredcites →https://doi.org/10.18926/amo/31960openalex-snapshot

A comparison of the signal pathways between the TNF alpha- and oridonin-induced murine L929 fibrosarcoma cell death.

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Oridonin nanosuspension was more effective than free oridonin on G2/M cell cycle arrest and apoptosis in the human pancreatic cancer PANC-1 cell line

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Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

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Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound

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Intracellular Glutathione Depletion by Oridonin Leads to Apoptosis in Hepatic Stellate Cells

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Neuroprotective and Cognitive Enhancement Potentials of Angelica gigas Nakai Root: A Review

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Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells

inferredcites →https://doi.org/10.3892/ijo.23.4.1187openalex-snapshot

Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells

inferredcites →https://doi.org/10.3892/ijo.26.3.579openalex-snapshot

The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage

inferredcites →https://doi.org/10.3892/or_00000903openalex-snapshot

Oridonin induces G2/M cell cycle arrest and apoptosis through MAPK and p53 signaling pathways in HepG2 cells

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A novel ent-kaurane diterpenoid analog, DN3, selectively kills human gastric cancer cells via acting directly on mitochondria

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2′,4′-Dihydroxy-6′‑methoxy-3′,5′-dimethylchalcone and its amino acid-conjugated derivatives induce G0/G1 cell cycle arrest and apoptosis via BAX/BCL2 ratio upregulation and in silico insight in SiHa cell lines

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Hydroxypropyl-β-cyclodextrin/Oridonin and Trehalose loaded nanovesicles attenuate foam cells formation and regulate the inflammation

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inferred← citeshttps://doi.org/10.1016/j.genrep.2020.100655openalex-snapshot

Zataria multiflora methanolic extract has antitumor properties on U266 multiple myeloma cell line

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.126623openalex-snapshot

Biomacromolecule-based nanocarrier strategies to deliver plant-derived bioactive components for cancer treatment: A recent review

inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108387openalex-snapshot

Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide

inferred← citeshttps://doi.org/10.1016/j.intimp.2025.115388openalex-snapshot

Oridonin alleviates SiNPs-induced pulmonary fibrosis by inhibiting pyroptosis via IRE1α-XBP1s-NLRP3 pathway

inferred← citeshttps://doi.org/10.1016/j.jep.2020.113383openalex-snapshot

Studying CNS effects of Traditional Chinese Medicine using zebrafish models

inferred← citeshttps://doi.org/10.1016/j.jep.2026.122452openalex-snapshot

Isodon rosthornii accelerates wound healing via dual antimicrobial activity and NF-κB/MAPK suppression

inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2021.112142openalex-snapshot

Ultraviolet-B mediated biochemical and metabolic responses of a medicinal plant Adhatoda vasica Nees. at different growth stages

inferred← citeshttps://doi.org/10.1016/j.jss.2018.06.040openalex-snapshot

Antifibrosis Effect of Novel Oridonin Analog CYD0618 Via Suppression of the NF-κB Pathway

inferred← citeshttps://doi.org/10.1016/j.matpr.2021.09.505openalex-snapshot

Phytochemicals used as inhibitors in the treatment of ovarian cancer: A Mini-review

inferred← citeshttps://doi.org/10.1016/j.mce.2024.112419openalex-snapshot

Oridonin attenuates diabetic retinopathy progression by suppressing NLRP3 inflammasome pathway

inferred← citeshttps://doi.org/10.1016/j.omto.2021.08.008openalex-snapshot

Multiple targeted self-emulsifying compound RGO reveals obvious anti-tumor potential in hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2023.108479openalex-snapshot

Signaling pathways driving ocular malignancies and their targeting by bioactive phytochemicals

inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105710openalex-snapshot

Phytochemical inhibitors of the NLRP3 inflammasome for the treatment of inflammatory diseases

inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155179openalex-snapshot

The bioavailability enhancement and insight into the action mechanism of poorly soluble natural compounds from co-crystals preparation: Oridonin as an example

inferred← citeshttps://doi.org/10.1016/j.semcancer.2021.11.006openalex-snapshot

Anticancer natural products targeting immune checkpoint protein network

inferred← citeshttps://doi.org/10.1016/j.tet.2020.131351openalex-snapshot

Use of the Hosomi-Sakurai allylation in natural product total synthesis

inferred← citeshttps://doi.org/10.1016/j.tet.2024.133918openalex-snapshot

Natural product-inspired molecules for covalent inhibition of SHP2 tyrosine phosphatase

inferred← citeshttps://doi.org/10.1016/j.tice.2021.101514openalex-snapshot

Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation

inferred← citeshttps://doi.org/10.1016/s1875-5364(22)60214-0openalex-snapshot

Biosynthesis and regulation of diterpenoids in medicinal plants

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00504openalex-snapshot

Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01514openalex-snapshot

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00200openalex-snapshot

Dehydrohispanolone Derivatives Attenuate the Inflammatory Response through the Modulation of Inflammasome Activation

inferred← citeshttps://doi.org/10.1021/acs.orglett.0c02920openalex-snapshot

Syntheses of Skeletally Diverse Tetracyclic Isodon Diterpenoid Scaffolds Guided by Dienyne Radical Cyclization Logic

inferred← citeshttps://doi.org/10.1021/acsomega.1c07186openalex-snapshot

Binding Studies of the Prodrug HAO472 to SARS-Cov-2 Nsp9 and Variants

inferred← citeshttps://doi.org/10.1021/jacs.9b12034openalex-snapshot

Total Synthesis of (−)-Oridonin: An Interrupted Nazarov Approach

inferred← citeshttps://doi.org/10.1038/s41420-021-00697-5openalex-snapshot

Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis

inferred← citeshttps://doi.org/10.1038/s41598-020-70236-2openalex-snapshot

Effect of kaempferol on the transgenic Drosophila model of Parkinson’s disease

inferred← citeshttps://doi.org/10.1039/d0ra06106aopenalex-snapshot

Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior

inferred← citeshttps://doi.org/10.1039/d2np00042copenalex-snapshot

Dearomative logic in natural product total synthesis

inferred← citeshttps://doi.org/10.1039/d4qo02276aopenalex-snapshot

Recent advances on electrocyclic reactions in complex natural product synthesis: an update

inferred← citeshttps://doi.org/10.1039/d6md00432fopenalex-snapshot

Synthesis and biological evaluation of oridonin derivatives as antiproliferative agents against colorectal cancer

inferred← citeshttps://doi.org/10.1055/a-0953-6738openalex-snapshot

Molecular Targets Involved in the Neuroprotection Mediated by Terpenoids

inferred← citeshttps://doi.org/10.1080/03639045.2025.2596294openalex-snapshot

Oridonin-loaded liposomes targeting lung cancer: formulation and delivery in vitro and in vivo

inferred← citeshttps://doi.org/10.1080/0886022x.2024.2347462openalex-snapshot

Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway

inferred← citeshttps://doi.org/10.1080/08927014.2021.1971655openalex-snapshot

Screening of natural compounds identifies ferutinin as an antibacterial and anti-biofilm compound

inferred← citeshttps://doi.org/10.1080/10837450.2024.2315460openalex-snapshot

Oridonin loaded peptide nanovesicles alleviate nonalcoholic fatty liver disease in mice

inferred← citeshttps://doi.org/10.1080/14728222.2021.1887141openalex-snapshot

The Nrf2 pathway in psychiatric disorders: pathophysiological role and potential targeting

inferred← citeshttps://doi.org/10.1093/jpp/rgac009openalex-snapshot

The application of natural compounds in uveal melanoma drug discovery

inferred← citeshttps://doi.org/10.1093/jpp/rgad025openalex-snapshot

Oridonin inhibits Hela cell proliferation via downregulation of glutathione metabolism: a new insight from metabolomics

inferred← citeshttps://doi.org/10.1097/fjc.0000000000001523openalex-snapshot

Colchicine Leads the Charge in Post-percutaneous Coronary Intervention Anti-inflammatory Defense

inferred← citeshttps://doi.org/10.1097/hm9.0000000000000181openalex-snapshot

Oridonin mitigates cerebral ischemic–reperfusion injury via covalent binding to HMGB1 and inhibiting the HMGB1/TLR4/MyD88/NF-κB signaling pathway

inferred← citeshttps://doi.org/10.1111/bph.70160openalex-snapshot

Modulating G6PD/PGD to overcome FSP1/DHODH‐mediated ferroptosis defence: A novel oridonin derivative suppresses liver cancer

inferred← citeshttps://doi.org/10.1111/cbdd.70222openalex-snapshot

Exploring the Therapeutic Potential of Oridonin in the Treatment of Laryngeal Cancer: A Comprehensive Strategy Involving Network Pharmacology, Molecular Docking, Dynamic Simulation, and Experimental Verification

inferred← citeshttps://doi.org/10.1111/imr.12839openalex-snapshot

Inflammasomes contributing to inflammation in arthritis

inferred← citeshttps://doi.org/10.1155/2022/3002962openalex-snapshot

Oridonin Attenuates Cisplatin‐Induced Acute Kidney Injury via Inhibiting Oxidative Stress, Apoptosis, and Inflammation in Mice

inferred← citeshttps://doi.org/10.1186/s12951-024-02574-6openalex-snapshot

Glutathione-depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy

inferred← citeshttps://doi.org/10.12659/msm.921114openalex-snapshot

Oridonin Alleviates IRI-Induced Kidney Injury by Inhibiting Inflammatory Response of Macrophages via AKT-Related Pathways

inferred← citeshttps://doi.org/10.1590/fst.110222openalex-snapshot

Antimicrobial activity of oridonin

inferred← citeshttps://doi.org/10.21037/atm-21-2630openalex-snapshot

Oridonin induces autophagy-mediated cell death in pancreatic cancer by activating the c-Jun N-terminal kinase pathway and inhibiting phosphoinositide 3-kinase signaling

inferred← citeshttps://doi.org/10.21037/tcr-20-3042openalex-snapshot

Preventive and therapeutic effect of intraportal oridonin on BALb/c nude mice hemispleen model of colon cancer liver metastasis

inferred← citeshttps://doi.org/10.21037/tcr.2019.08.25openalex-snapshot

Wnt/β-catenin signaling pathway is involved in induction of apoptosis by oridonin in colon cancer COLO205 cells

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3780719/v1openalex-snapshot

Glutathione-depleting liposome adjuvant for augmenting the efficacy of a Glutathione covalent inhibitor oridonin for acute myeloid leukemia therapy

inferred← citeshttps://doi.org/10.2139/ssrn.5226089openalex-snapshot

Oridonin Alleviates Cerebral Ischemic-Reperfusion (I/R) Injury by Covalently Binding with Hmgb1 and Inhibiting Hmgb1/Tlr4/Myd88/Nf-Κb Signaling Pathway

inferred← citeshttps://doi.org/10.2147/jir.s568133openalex-snapshot

Mechanisms of Macrophage Polarization Regulated by Oridonin: A Review

inferred← citeshttps://doi.org/10.2147/ott.s220401openalex-snapshot

The inhibitory effect of oridonin on colon cancer was mediated by deactivation of TGF-β1/Smads-PAI-1 signaling pathway in vitro and vivo

inferred← citeshttps://doi.org/10.2147/ott.s262022openalex-snapshot

AMPK/mTOR/ULK1 Axis-Mediated Pathway Participates in Apoptosis and Autophagy Induction by Oridonin in Colon Cancer DLD-1 Cells

inferred← citeshttps://doi.org/10.2174/0113892010304266240507050825openalex-snapshot

Exploring Therapeutic Frontiers: Unveiling the Potential of Natural Diterpenoid Derivatives in Addressing Neurological Disorders

inferred← citeshttps://doi.org/10.2174/0115680266362594250527112018openalex-snapshot

Novel Nanoformulations to Overcome Obstacles in Herbal Drug Delivery for Alzheimer's Disease

inferred← citeshttps://doi.org/10.2174/1389201024666230821110116openalex-snapshot

The Natural Product Oridonin as an Anticancer Agent: Current Achievements and Problems

inferred← citeshttps://doi.org/10.2174/1573401315666190801120306openalex-snapshot

Optimizing Modifiable and Lifestyle-related Factors in the Prevention of Dementia Disorders with Special Reference to Alzheimer, Parkinson and Autism Diseases

inferred← citeshttps://doi.org/10.2174/1874467216666221130163634openalex-snapshot

Research Progress and Future Development Potential of Oridonin in Pharmacological Activities

inferred← citeshttps://doi.org/10.23750/abm.v94i2.14003openalex-snapshot

Oridonin supplementation in rabbits may help to improve the outcome of induced atherosclerosis via autophagy induction.

inferred← citeshttps://doi.org/10.26538/tjnpr/v8i4.1openalex-snapshot

Oridonin: A Mini Review on the Anti-Cancer, Anti-Inflammatory, Cardioprotective, Hepatoprotective, Renoprotective and Lung Protective Properties

inferred← citeshttps://doi.org/10.30699/jambs.26.119.43openalex-snapshot

The Antitumoral Activity of Zataria Multiflora Methanolic Extract on Acute Promyelocytic Leukemia Cell Line; NB4

inferred← citeshttps://doi.org/10.3233/jad-210660openalex-snapshot

The NLRP3 Inflammasome in the Pathogenesis and Treatment of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.32350/bsr.71.iiopenalex-snapshot

Molecular Mechanisms Underlying Anticancer and Anti-Inflammatory Activities of Oridonin in Oral Squamous Cell Carcinoma

inferred← citeshttps://doi.org/10.3389/fchem.2023.1066280openalex-snapshot

Recent advances in oridonin derivatives with anticancer activity

inferred← citeshttps://doi.org/10.3389/fcimb.2021.630812openalex-snapshot

Eryptosis and Malaria: New Experimental Guidelines and Re-Evaluation of the Antimalarial Potential of Eryptosis Inducers

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1568722openalex-snapshot

The NLRP3 inflammasome: a therapeutic target of phytochemicals in treating atherosclerosis (a systematic review)

inferred← citeshttps://doi.org/10.3389/fnagi.2022.879021openalex-snapshot

The NLRP3 Inflammasome Pathway: A Review of Mechanisms and Inhibitors for the Treatment of Inflammatory Diseases

inferred← citeshttps://doi.org/10.3389/fonc.2025.1606325openalex-snapshot

Research progress and molecular mechanism of oridonin in the treatment of malignant melanoma

inferred← citeshttps://doi.org/10.3389/fphar.2022.888247openalex-snapshot

Oridonin Delays Aging Through the AKT Signaling Pathway

inferred← citeshttps://doi.org/10.3389/fphar.2025.1539886openalex-snapshot

Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury

inferred← citeshttps://doi.org/10.3389/ftox.2026.1821778openalex-snapshot

Oridonin attenuates diclofenac-induced organ damage by suppressing endoplasmic reticulum stress and inflammasome activation

inferred← citeshttps://doi.org/10.3390/cancers13112678openalex-snapshot

Multiple Myeloma Inhibitory Activity of Plant Natural Products

inferred← citeshttps://doi.org/10.3390/cells9061451openalex-snapshot

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

inferred← citeshttps://doi.org/10.3390/ijms21197186openalex-snapshot

Bioactive Ent-Kaurane Diterpenes Oridonin and Irudonin Prevent Cancer Cells Migration by Interacting with the Actin Cytoskeleton Controller Ezrin

inferred← citeshttps://doi.org/10.3390/ijms24098162openalex-snapshot

Portrayal of NLRP3 Inflammasome in Atherosclerosis: Current Knowledge and Therapeutic Targets

inferred← citeshttps://doi.org/10.3390/ijms27156835openalex-snapshot

Oridonin Suppresses Bladder Cancer Growth and Metastasis by Inducing S-Phase Arrest and Apoptosis

inferred← citeshttps://doi.org/10.3390/ma15030804openalex-snapshot

Applications of Phyto-Nanotechnology for the Treatment of Neurodegenerative Disorders

inferred← citeshttps://doi.org/10.3390/molecules25020332openalex-snapshot

Solubility and Bioavailability Enhancement of Oridonin: A Review

inferred← citeshttps://doi.org/10.3390/molecules29112643openalex-snapshot

Synthesis and Application of a pH-Responsive Functional Metal–Organic Framework: In Vitro Investigation for Delivery of Oridonin in Cancer Therapy

inferred← citeshttps://doi.org/10.3390/pathogens12060799openalex-snapshot

Oridonin Inhibits Mycobacterium marinum Infection-Induced Oxidative Stress In Vitro and In Vivo

inferred← citeshttps://doi.org/10.3390/ph15070825openalex-snapshot

Dehydroisohispanolone as a Promising NLRP3 Inhibitor Agent: Bioevaluation and Molecular Docking

inferred← citeshttps://doi.org/10.3892/ijo.2018.4527openalex-snapshot

Anticancer effects of oridonin on colon cancer are mediated via BMP7/p38 MAPK/p53 signaling

inferred← citeshttps://doi.org/10.4018/979-8-3693-5908-2.ch004openalex-snapshot

Autophagy Pathways in Major Depressive Disorder

inferred← citeshttps://doi.org/10.4018/979-8-3693-6972-2.ch007openalex-snapshot

Terpenes in Treatment of Ovarian Cancer

inferred← citeshttps://doi.org/10.4314/tjpr.v20i3.13openalex-snapshot

Oridonin ameliorates depressive-like behaviors induced by chronic unpredictable mild stress in mice via TXNIP/NLRP3 signaling pathway

inferred← citeshttps://doi.org/10.52711/0974-360x.2025.00497openalex-snapshot

The Treatment of Neurological Disease via Green Metallic Nanoparticles

inferred← citeshttps://doi.org/10.6023/cjoc202108029openalex-snapshot

Asymmetric Synthesis of AB Rings in ent-Kaurene Carbon Framework

inferred← citeshttps://doi.org/10.6084/m9.figshare.25929057openalex-snapshot

Additional file 1 of Glutathione-depleting Liposome Adjuvant for Augmenting the Efficacy of a Glutathione Covalent Inhibitor Oridonin for Acute Myeloid Leukemia Therapy

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