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Unraveling the Potential Mechanisms of Bupleuri Radix-Scutellariae Radix Herb Pair on Non-Alcoholic Fatty Liver Disease by Integrated Transcriptomics, Metabolomics, and Network Pharmacology

https://doi.org/10.2139/ssrn.5378837
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Outgoing claims: the papers this work cites, builds on, or argues with.

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A lipidomic analysis of nonalcoholic fatty liver disease
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Global burden of NAFLD and chronic liver disease among adolescents and young adults
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Triglyceride Metabolism in the Liver
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Promising influences ofScutellaria baicalensisand its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review
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Activity measurements of acyl‐CoA oxidases in human liver
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Mechanisms of hepatic triglyceride accumulation in non-alcoholic fatty liver disease
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PPARα-Deficient ob/ob Obese Mice Become More Obese and Manifest Severe Hepatic Steatosis Due to Decreased Fatty Acid Oxidation
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Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease
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Bupleuri radix extract ameliorates impaired lipid metabolism in high-fat diet-induced obese mice via gut microbia-mediated regulation of FGF21 signaling pathway
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The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
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Recent advances in Scutellariae radix: A comprehensive review on ethnobotanical uses, processing, phytochemistry, pharmacological effects, quality control and influence factors of biosynthesis
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A comprehensive review of bupleuri radix and its bioactive components： with a major focus on treating chronic liver diseases
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Integrative transcriptomics and lipidomics unravels the amelioration effects of Radix Bupleuri on non-alcoholic fatty liver disease
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Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease
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A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
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MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans
inferredcites →https://doi.org/10.1016/j.jhep.2021.04.013openalex-snapshot
Hepatic lipidomic remodeling in severe obesity manifests with steatosis and does not evolve with non-alcoholic steatohepatitis
inferredcites →https://doi.org/10.1016/j.jhep.2023.10.042openalex-snapshot
Pharmacologic inhibition of lipogenesis for the treatment of NAFLD
inferredcites →https://doi.org/10.1016/j.jnutbio.2022.109224openalex-snapshot
Fructose impairs fat oxidation: Implications for the mechanism of western diet-induced NAFLD
inferredcites →https://doi.org/10.1016/j.phrs.2023.107033openalex-snapshot
Baicalin circumvents anti-PD-1 resistance by regulating the gut microbiota metabolite short-chain fatty acids
inferredcites →https://doi.org/10.1016/j.phymed.2018.09.174openalex-snapshot
A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins
inferredcites →https://doi.org/10.1016/s0140-6736(20)32511-3openalex-snapshot
Non-alcoholic fatty liver disease
inferredcites →https://doi.org/10.1016/s2468-1253(22)00317-xopenalex-snapshot
Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1021/acs.accounts.6b00435openalex-snapshot
The Ins and Outs of Lipid Flip-Flop
inferredcites →https://doi.org/10.1021/acs.jafc.1c04194openalex-snapshot
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis
inferredcites →https://doi.org/10.1038/nrendo.2017.91openalex-snapshot
SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology
inferredcites →https://doi.org/10.1038/nrgastro.2013.183openalex-snapshot
NAFLD, NASH and liver cancer
inferredcites →https://doi.org/10.1038/nrgastro.2017.32openalex-snapshot
Lipid droplets and liver disease: from basic biology to clinical implications
inferredcites →https://doi.org/10.1038/s41467-024-48471-2openalex-snapshot
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling
inferredcites →https://doi.org/10.1038/s41574-023-00809-4openalex-snapshot
The role of ChREBP in carbohydrate sensing and NAFLD development
inferredcites →https://doi.org/10.1038/s41575-021-00472-yopenalex-snapshot
Dietary carbohydrates and fats in nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1038/s41591-018-0104-9openalex-snapshot
Mechanisms of NAFLD development and therapeutic strategies
inferredcites →https://doi.org/10.1042/0264-6021:3560899openalex-snapshot
Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886
inferredcites →https://doi.org/10.1074/jbc.271.40.24698openalex-snapshot
Hepatocellular and Hepatic Peroxisomal Alterations in Mice with a Disrupted Peroxisomal Fatty Acyl-coenzyme A Oxidase Gene
inferredcites →https://doi.org/10.1074/jbc.m211062200openalex-snapshot
A Thyroid Hormone Response Unit Formed between the Promoter and First Intron of the Carnitine Palmitoyltransferase-Iα Gene Mediates the Liver-specific Induction by Thyroid Hormone
inferredcites →https://doi.org/10.1074/jbc.m310130200openalex-snapshot
Functional and Structural Basis of Carnitine Palmitoyltransferase 1A Deficiency
inferredcites →https://doi.org/10.1093/bib/bbad518openalex-snapshot
Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine
inferredcites →https://doi.org/10.1097/hep.0000000000000004openalex-snapshot
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
inferredcites →https://doi.org/10.1097/hep.0000000000000375openalex-snapshot
Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis
inferredcites →https://doi.org/10.1111/obr.12407openalex-snapshot
Obesity is an independent risk factor for non‐alcoholic fatty liver disease: evidence from a meta‐analysis of 21 cohort studies
inferredcites →https://doi.org/10.1146/annurev.bi.64.070195.001531openalex-snapshot
EUKARYOTIC PHOSPHOLIPID BIOSYNTHESIS
inferredcites →https://doi.org/10.1146/annurev.biochem.74.082803.133329openalex-snapshot
Biochemistry of Mammalian Peroxisomes Revisited
inferredcites →https://doi.org/10.1152/ajpendo.00064.2004openalex-snapshot
Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population
inferredcites →https://doi.org/10.1161/01.cir.98.19.2088openalex-snapshot
Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism
inferredcites →https://doi.org/10.1210/er.2018-00064openalex-snapshot
Molecular Actions of PPARα in Lipid Metabolism and Inflammation
inferredcites →https://doi.org/10.2139/ssrn.4597306openalex-snapshot
Baicalin Circumvents Anti-Pd-1 Resistance by Regulating the Gut Microbiota Metabolite Short-Chain Fatty Acids
inferredcites →https://doi.org/10.3350/cmh.2018.0114openalex-snapshot
Carnitine palmitoyl transferase 1A deficiency in an adult with recurrent severe steato hepatitis aggravated by high pathologic or physiologic demands: A roller-coaster for internists
inferredcites →https://doi.org/10.3389/fphar.2023.1160440openalex-snapshot
Mitochondrial CPT1A: Insights into structure, function, and basis for drug development
inferredcites →https://doi.org/10.3390/ijms21062061openalex-snapshot
PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice
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