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Promising influences ofScutellaria baicalensisand its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review

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2 of the 132 references listed on this page are in the Retraction Watch database as retracted (export 2026-11-11): 10.1002/jcb.27095 (notice 2021-02-08), 10.1016/j.yexmp.2019.01.002 (notice 2022-07-06).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/2211-5463.12180openalex-snapshot

Activation of PPAR γ by baicalin attenuates pulmonary hypertension in an infant rat model by suppressing HMGB 1/ RAGE signaling

inferredcites →https://doi.org/10.1002/food.200300382openalex-snapshot

Influence of bioflavonoids from the radix extract of Scutellaria baicalensis on the level of serum lipids, and the development of laboratory rats fed with fresh and oxidized fats

inferredcites →https://doi.org/10.1002/jcb.27095openalex-snapshot

Retracted: Baicalin prevents tumor necrosis factor‐α−induced apoptosis and dysfunction of pancreatic β‐cell line Min6 via upregulation of miR‐205

inferredcites →https://doi.org/10.1002/jsfa.8134openalex-snapshot

Saffron: a promising natural medicine in the treatment of metabolic syndrome

inferredcites →https://doi.org/10.1002/mc.22220openalex-snapshot

Asiatic acid induces endoplasmic reticulum stress and apoptotic death in glioblastoma multiforme cells both in vitro and in vivo

inferredcites →https://doi.org/10.1002/ptr.2937openalex-snapshot

Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway

inferredcites →https://doi.org/10.1002/ptr.4691openalex-snapshot

Extracts of Scutellaria baicalensis Reduced Body Weight and Blood Triglyceride in db/db Mice

inferredcites →https://doi.org/10.1002/ptr.5570openalex-snapshot

Grapes (Vitis vinifera) as a Potential Candidate for the Therapy of the Metabolic Syndrome

inferredcites →https://doi.org/10.1002/ptr.5805openalex-snapshot

Effects of Avocado (Persea americana)on Metabolic Syndrome: A Comprehensive Systematic Review

inferredcites →https://doi.org/10.1002/ptr.6565openalex-snapshot

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

inferredcites →https://doi.org/10.1007/s00125-017-4342-zopenalex-snapshot

The mechanisms of action of metformin

inferredcites →https://doi.org/10.1007/s10495-013-0946-zopenalex-snapshot

Inhibition of 12/15 lipoxygenase by baicalein reduces myocardial ischemia/reperfusion injury via modulation of multiple signaling pathways

inferredcites →https://doi.org/10.1007/s11239-013-1026-5openalex-snapshot

Thrombin generation and atherosclerosis

inferredcites →https://doi.org/10.1007/s11418-018-1199-5openalex-snapshot

Scutellaria baicalensis regulates FFA metabolism to ameliorate NAFLD through the AMPK-mediated SREBP signaling pathway

inferredcites →https://doi.org/10.1007/s40199-019-00238-7openalex-snapshot

Pharmacology of dipeptidyl peptidase-4 inhibitors and its use in the management of metabolic syndrome: a comprehensive review on drug repositioning

inferredcites →https://doi.org/10.1007/s40618-015-0313-8openalex-snapshot

A review on the effects of Allium sativum (Garlic) in metabolic syndrome

inferredcites →https://doi.org/10.1016/j.ajpath.2013.01.010openalex-snapshot

Biological Relevance of Inflammation and Oxidative Stress in the Pathogenesis of Arterial Diseases

inferredcites →https://doi.org/10.1016/j.biopha.2016.06.046openalex-snapshot

Anti-atherosclerotic potential of baicalin mediated by promoting cholesterol efflux from macrophages via the PPARγ-LXRα-ABCA1/ABCG1 pathway

inferredcites →https://doi.org/10.1016/j.biopha.2017.12.024openalex-snapshot

Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the NF-κB and p38 MAPK signaling pathways

inferredcites →https://doi.org/10.1016/j.biopha.2018.10.154openalex-snapshot

Baicalein stimulates fibroblast growth factor 21 expression by up-regulating retinoic acid receptor-related orphan receptor α in C2C12 myotubes

inferredcites →https://doi.org/10.1016/j.biopha.2018.12.086openalex-snapshot

Baicalin relaxes vascular smooth muscle and lowers blood pressure in spontaneously hypertensive rats

inferredcites →https://doi.org/10.1016/j.bmc.2017.08.013openalex-snapshot

The design and synthesis of a novel compound of berberine and baicalein that inhibits the efficacy of lipid accumulation in 3T3-L1 adipocytes

inferredcites →https://doi.org/10.1016/j.carpath.2014.12.004openalex-snapshot

Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells

inferredcites →https://doi.org/10.1016/j.cell.2015.03.008openalex-snapshot

The Hunger Genes: Pathways to Obesity

inferredcites →https://doi.org/10.1016/j.cmet.2004.12.003openalex-snapshot

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

inferredcites →https://doi.org/10.1016/j.cyto.2007.02.015openalex-snapshot

Kidney and splanchnic handling of Interleukin-6 in humans

inferredcites →https://doi.org/10.1016/j.diabres.2014.04.006openalex-snapshot

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

inferredcites →https://doi.org/10.1016/j.diabres.2018.02.023openalex-snapshot

IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045

inferredcites →https://doi.org/10.1016/j.ejmech.2017.09.049openalex-snapshot

Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells

inferredcites →https://doi.org/10.1016/j.ejphar.2012.09.043openalex-snapshot

Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats

inferredcites →https://doi.org/10.1016/j.ejphar.2014.06.039openalex-snapshot

Baicalin and geniposide attenuate atherosclerosis involving lipids regulation and immunoregulation in ApoE−/− mice

inferredcites →https://doi.org/10.1016/j.ejphar.2017.07.041openalex-snapshot

Baicalin attenuates in vivo and in vitro hyperglycemia-exacerbated ischemia/reperfusion injury by regulating mitochondrial function in a manner dependent on AMPK

inferredcites →https://doi.org/10.1016/j.ejphar.2019.04.005openalex-snapshot

Baicalein improves glucose metabolism in insulin resistant HepG2 cells

inferredcites →https://doi.org/10.1016/j.ejphar.2020.173103openalex-snapshot

The mechanisms of baicalin ameliorate obesity and hyperlipidemia through a network pharmacology approach

inferredcites →https://doi.org/10.1016/j.fitote.2009.04.001openalex-snapshot

Anti-diabetic effect of American ginseng may not be linked to antioxidant activity: Comparison between American ginseng and Scutellaria baicalensis using an ob/ob mice model

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2014.06.002openalex-snapshot

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function

inferredcites →https://doi.org/10.1016/j.hfc.2018.02.003openalex-snapshot

Pulmonary Arterial Hypertension

inferredcites →https://doi.org/10.1016/j.ijcard.2016.11.182openalex-snapshot

Emerging roles and mechanisms of long noncoding RNAs in atherosclerosis

inferredcites →https://doi.org/10.1016/j.intimp.2014.02.037openalex-snapshot

Oral administration of baicalin and geniposide induces regression of atherosclerosis via inhibiting dendritic cells in ApoE-knockout mice

inferredcites →https://doi.org/10.1016/j.intimp.2015.01.009openalex-snapshot

Therapeutic effects of baicalin on monocrotaline-induced pulmonary arterial hypertension by inhibiting inflammatory response

inferredcites →https://doi.org/10.1016/j.it.2011.07.001openalex-snapshot

How dendritic cells shape atherosclerosis

inferredcites →https://doi.org/10.1016/j.jacc.2004.02.033openalex-snapshot

Pathologic assessment of vasculopathies in pulmonary hypertension

inferredcites →https://doi.org/10.1016/j.jchromb.2004.06.045openalex-snapshot

Separation methods used for Scutellaria baicalensis active components

inferredcites →https://doi.org/10.1016/j.jhep.2011.08.025openalex-snapshot

The interaction of hepatic lipid and glucose metabolism in liver diseases

inferredcites →https://doi.org/10.1016/j.jsbmb.2015.04.014openalex-snapshot

Cholesterol homeostasis in cardiovascular disease and recent advances in measuring cholesterol signatures

inferredcites →https://doi.org/10.1016/j.mce.2012.06.002openalex-snapshot

Baicalein, a natural product, selectively activating AMPKα2 and ameliorates metabolic disorder in diet-induced mice

inferredcites →https://doi.org/10.1016/j.mce.2017.03.027openalex-snapshot

Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway

inferredcites →https://doi.org/10.1016/j.phymed.2018.09.024openalex-snapshot

Medicinal plants in treatment of hypertriglyceridemia: A review based on their mechanisms and effectiveness

inferredcites →https://doi.org/10.1016/j.yexmp.2019.01.002openalex-snapshot

RETRACTED: Baicalin protects human retinal pigment epithelial cell lines against high glucose-induced cell injury by up-regulation of microRNA-145

inferredcites →https://doi.org/10.1016/s0140-6736(05)61032-xopenalex-snapshot

Type 2 diabetes: principles of pathogenesis and therapy

inferredcites →https://doi.org/10.1016/s0163-7258(02)00236-xopenalex-snapshot

LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis

inferredcites →https://doi.org/10.1016/s0378-8741(02)00370-7openalex-snapshot

Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose

inferredcites →https://doi.org/10.1016/s0895-7061(96)00488-8openalex-snapshot

Elevated 12-Lipoxygenase Activity in the Spontaneously Hypertensive Rat

inferredcites →https://doi.org/10.1016/s0895-7061(97)90519-7openalex-snapshot

Elevated 12-lipoxygenase activity in the spontaneously hypertensive rat*1

inferredcites →https://doi.org/10.1016/s1357-2725(03)00195-xopenalex-snapshot

Damage to the structure of erythrocyte plasma membranes in patients with type-2 hypercholesterolemia

inferredcites →https://doi.org/10.1016/s1875-5364(15)30006-6openalex-snapshot

Determination of α-glucosidase inhibitors from ScutScutellaria baicalensis using liquid chromatography with quadrupole time of flight tandem mass spectrometry coupled with centrifugal ultrafiltration

inferredcites →https://doi.org/10.1038/aps.2009.150openalex-snapshot

Long-term baicalin administration ameliorates metabolic disorders and hepatic steatosis in rats given a high-fat diet

inferredcites →https://doi.org/10.1038/hr.2016.35openalex-snapshot

Hypertension as an autoimmune and inflammatory disease

inferredcites →https://doi.org/10.1038/nature11552openalex-snapshot

Functional interactions between the gut microbiota and host metabolism

inferredcites →https://doi.org/10.1038/nrendo.2017.91openalex-snapshot

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

inferredcites →https://doi.org/10.1038/nrm2066openalex-snapshot

Adipocyte differentiation from the inside out

inferredcites →https://doi.org/10.1038/nrneph.2009.184openalex-snapshot

An update on the lipid nephrotoxicity hypothesis

inferredcites →https://doi.org/10.1053/j.gastro.2008.12.031openalex-snapshot

Roles of Infection, Inflammation, and the Immune System in Cholesterol Gallstone Formation

inferredcites →https://doi.org/10.1055/s-2004-826168openalex-snapshot

The Development of Beta-cell Mass: Recent Progress and Potential Role of GLP-1

inferredcites →https://doi.org/10.1056/nejmra1514009openalex-snapshot

Mechanisms, Pathophysiology, and Management of Obesity

inferredcites →https://doi.org/10.1073/pnas.1801745115openalex-snapshot

Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis

inferredcites →https://doi.org/10.1080/13880209.2018.1492620openalex-snapshot

A comprehensive review on phytochemistry, pharmacology, and flavonoid biosynthesis ofScutellaria baicalensis

inferredcites →https://doi.org/10.1089/jmf.2006.9.145openalex-snapshot

Baicalein Inhibits Adipocyte Differentiation by Enhancing COX-2 Expression

inferredcites →https://doi.org/10.1093/ajh/hpu194openalex-snapshot

Baicalein Attenuates Angiotensin II-Induced Cardiac Remodeling via Inhibition of AKT/mTOR, ERK1/2, NF-κB, and Calcineurin Signaling Pathways in Mice

inferredcites →https://doi.org/10.1093/jn/130.12.3122sopenalex-snapshot

Adipocyte Differentiation and Gene Expression

inferredcites →https://doi.org/10.1093/nutrit/nux014openalex-snapshot

Lifestyle recommendations for the prevention and management of metabolic syndrome: an international panel recommendation

inferredcites →https://doi.org/10.1096/fj.10-172981openalex-snapshot

Wnt1 is a proangiogenic molecule, enhances human endothelial progenitor function, and increases blood flow to ischemic limbs in a HGF‐dependent manner

inferredcites →https://doi.org/10.1097/hco.0000000000000408openalex-snapshot

Management of hypertension in 2017

inferredcites →https://doi.org/10.1101/gad.177857.111openalex-snapshot

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

inferredcites →https://doi.org/10.1111/1753-0407.12313openalex-snapshot

Altered profile of serum microRNAs in pancreatic cancer‐associated new‐onset diabetes mellitus

inferredcites →https://doi.org/10.1111/j.1365-2362.1994.tb02418.xopenalex-snapshot

Significance of testing platelet functions in vitro

inferredcites →https://doi.org/10.1111/j.1467-789x.2009.00642.xopenalex-snapshot

Regulatory enzymes of mitochondrial β‐oxidation as targets for treatment of the metabolic syndrome

inferredcites →https://doi.org/10.1111/jphp.13129openalex-snapshot

Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology

inferredcites →https://doi.org/10.1142/s0192415x08005953openalex-snapshot

Scutellaria baicalensis Enhances the Anti-Diabetic Activity of Metformin in Streptozotocin-Induced Diabetic Wistar Rats

inferredcites →https://doi.org/10.1142/s0192415x18500404openalex-snapshot

Baicalein Ameliorates Pulmonary Arterial Hypertension Caused by Monocrotaline through Downregulation of ET-1 and ETAR in Pneumonectomized Rats

inferredcites →https://doi.org/10.1152/ajpcell.00529.2004openalex-snapshot

Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus

inferredcites →https://doi.org/10.1152/ajpendo.00116.2005openalex-snapshot

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle

inferredcites →https://doi.org/10.1152/ajpendo.00221.2019openalex-snapshot

Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation

inferredcites →https://doi.org/10.1152/physrev.00045.2011openalex-snapshot

Mechanisms of Diabetic Complications

inferredcites →https://doi.org/10.1152/physrev.1977.57.2.313openalex-snapshot

Renin-angiotensin system: biochemistry and mechanisms of action.

inferredcites →https://doi.org/10.1155/2014/846742openalex-snapshot

Baicalein Protects against Type 2 Diabetes via Promoting Isletβ-Cell Function in Obese Diabetic Mice

inferredcites →https://doi.org/10.1155/2018/2164345openalex-snapshot

In VitroInhibition ofα‐Amylase andα‐Glucosidase by Extracts fromPsiadia punctulataandMeriandra bengalensis

inferredcites →https://doi.org/10.1155/2019/1531567openalex-snapshot

Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials

inferredcites →https://doi.org/10.1155/2019/2187306openalex-snapshot

Baicalin Protects against Thrombin-Induced Cell Injury in Human Umbilical Vein Endothelial Cells

inferredcites →https://doi.org/10.1155/2020/1343969openalex-snapshot

Role of Baicalin and Liver X Receptor Alpha in the Formation of Cholesterol Gallstones in Mice

inferredcites →https://doi.org/10.1159/000374037openalex-snapshot

Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway

inferredcites →https://doi.org/10.1159/000488828openalex-snapshot

Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia

inferredcites →https://doi.org/10.1161/atvbaha.108.179705openalex-snapshot

Inflammation in Atherosclerosis

inferredcites →https://doi.org/10.1161/atvbaha.110.215459openalex-snapshot

Oral Administration of an Active Form of Vitamin D 3 (Calcitriol) Decreases Atherosclerosis in Mice by Inducing Regulatory T Cells and Immature Dendritic Cells With Tolerogenic Functions

inferredcites →https://doi.org/10.1161/circresaha.109.210781openalex-snapshot

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

inferredcites →https://doi.org/10.1161/circresaha.110.223545openalex-snapshot

Oxidative Stress and Diabetic Complications

inferredcites →https://doi.org/10.1161/circresaha.115.306300openalex-snapshot

MicroRNA Regulation of Atherosclerosis

inferredcites →https://doi.org/10.1161/circulationaha.105.539528openalex-snapshot

Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus

inferredcites →https://doi.org/10.1161/circulationaha.109.907121openalex-snapshot

Early Atherosclerosis Exhibits an Enhanced Procoagulant State

inferredcites →https://doi.org/10.1161/circulationaha.114.008777openalex-snapshot

Proteomic Analysis Implicates Translationally Controlled Tumor Protein as a Novel Mediator of Occlusive Vascular Remodeling in Pulmonary Arterial Hypertension

inferredcites →https://doi.org/10.1177/153537020523001107openalex-snapshot

Molecular Aspects of Arterial Smooth Muscle Contraction: Focus on Rho

inferredcites →https://doi.org/10.1186/s12929-017-0359-3openalex-snapshot

Baicalin attenuates chronic hypoxia-induced pulmonary hypertension via adenosine A2A receptor-induced SDF-1/CXCR4/PI3K/AKT signaling

inferredcites →https://doi.org/10.1186/s13065-018-0445-yopenalex-snapshot

Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure–activity relationship of its eight flavonoids by a refined assign-score method

inferredcites →https://doi.org/10.11909/j.issn.1671-5411.2016.10.013openalex-snapshot

Baicalin and geniposide inhibit the development of atherosclerosis by increasing Wnt1 and inhibiting dickkopf-related protein-1 expression.

inferredcites →https://doi.org/10.1248/bpb.b19-00196openalex-snapshot

Baicalin Suppresses the Proliferation and Migration of Ox-LDL-VSMCs in Atherosclerosis through Upregulating miR-126-5p

inferredcites →https://doi.org/10.1371/journal.pone.0095452openalex-snapshot

Chlorogenic Acid Protects against Atherosclerosis in ApoE−/− Mice and Promotes Cholesterol Efflux from RAW264.7 Macrophages

inferredcites →https://doi.org/10.1371/journal.pone.0176432openalex-snapshot

Baicalein protects rat insulinoma INS-1 cells from palmitate-induced lipotoxicity by inducing HO-1

inferredcites →https://doi.org/10.1371/journal.pone.0182467openalex-snapshot

In vivo therapeutic effect of combination treatment with metformin and Scutellaria baicalensis on maintaining bile acid homeostasis

inferredcites →https://doi.org/10.1371/journal.pone.0189310openalex-snapshot

Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite

inferredcites →https://doi.org/10.1586/17474124.2013.811061openalex-snapshot

Role of the gastroenterologist in managing obesity

inferredcites →https://doi.org/10.1621/nrs.07003openalex-snapshot

Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism

inferredcites →https://doi.org/10.18632/oncotarget.12788openalex-snapshot

Baicalein protects against oxLDL-caused oxidative stress and inflammation by modulation of AMPK- alpha

inferredcites →https://doi.org/10.18632/oncotarget.18825openalex-snapshot

Baicalin attenuates monocrotaline-induced pulmonary hypertension through bone morphogenetic protein signaling pathway

inferredcites →https://doi.org/10.22038/ijbms.2016.7906openalex-snapshot

Cinnamon effects on metabolic syndrome: a review based on its mechanisms.

inferredcites →https://doi.org/10.22038/ijbms.2018.25200.6238openalex-snapshot

A review of the effects of Capsicum annuum L. and its constituent, capsaicin, in metabolic syndrome.

inferredcites →https://doi.org/10.22038/ijbms.2019.31964.7678openalex-snapshot

The effects of Crataegus pinnatifida (Chinese hawthorn) on metabolic syndrome: A review.

inferredcites →https://doi.org/10.22038/ijbms.2020.41638.9832openalex-snapshot

An overview of glucagon-like peptide-1 receptor agonists for the treatment of metabolic syndrome: A drug repositioning.

inferredcites →https://doi.org/10.3109/13880209.2011.608076openalex-snapshot

Inhibitory activities of baicalin against renin and angiotensin-converting enzyme

inferredcites →https://doi.org/10.3317/jraas.2003.008openalex-snapshot

Review: Potential of renin inhibition in cardiovascular disease

inferredcites →https://doi.org/10.3346/jkms.2011.26.9.1178openalex-snapshot

A Novel Biomarker of Coronary Atherosclerosis: Serum DKK1 Concentration Correlates with Coronary Artery Calcification and Atherosclerotic Plaques

inferredcites →https://doi.org/10.33549/physiolres.931525openalex-snapshot

The Role of Renin-Angiotensin System in Prothrombotic State in Essential Hypertension

inferredcites →https://doi.org/10.3389/fphar.2019.01271openalex-snapshot

Baicalin Protects Against Hypertension-Associated Intestinal Barrier Impairment in Part Through Enhanced Microbial Production of Short-Chain Fatty Acids

inferredcites →https://doi.org/10.3390/ijms15058153openalex-snapshot

Baicalin Inhibits Hypoxia-Induced Pulmonary Artery Smooth Muscle Cell Proliferation via the AKT/HIF-1α/p27-Associated Pathway

inferredcites →https://doi.org/10.3390/ijms20030727openalex-snapshot

Scutellaria baicalensis Alleviates Insulin Resistance in Diet-Induced Obese Mice by Modulating Inflammation

inferredcites →https://doi.org/10.3831/kpi.2019.22.001openalex-snapshot

A Pharmacological Review on Portulaca oleracea L.: Focusing on Anti-Inflammatory, Anti- Oxidant, Immuno-Modulatory and Antitumor Activities

inferredcites →https://doi.org/10.3892/etm.2016.3884openalex-snapshot

Baicalin promotes cholesterol efflux by regulating the expression of SR-BI in macrophages

inferredcites →https://doi.org/10.3892/ijmm.2018.4009openalex-snapshot

Baicalin inhibits proliferation and promotes apoptosis of vascular smooth muscle cells by regulating the�MEG3/p53 pathway following treatment with ox‑LDL

inferredcites →https://doi.org/10.3892/mmr.2015.3186openalex-snapshot

Baicalin inhibits the expression of monocyte chemoattractant protein-1 and interleukin-6 in the kidneys of apolipoprotein E-knockout mice fed a high cholesterol diet

inferredcites →https://doi.org/10.3892/mmr.2015.4219openalex-snapshot

Baicalin alleviates diabetes-associated cognitive deficits via modulation of mitogen-activated protein kinase signaling, brain-derived neurotrophic factor and apoptosis

inferredcites →https://doi.org/10.3892/mmr.2016.4941openalex-snapshot

Scutellaria baicalensis Georgi extract protects against alcohol-induced acute liver injury in mice and affects the mechanism of ER stress

inferredcites →https://doi.org/10.4103/0973-7847.79096openalex-snapshot

α-glucosidase inhibitors from plants: A natural approach to treat diabetes

inferredcites →https://doi.org/10.5223/pghn.2020.23.3.189openalex-snapshot

Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4688306openalex-extracted

Rapid and Comprehensive Quality Evaluation of Scutellaria Baicalensis Georgi from Different Origins by Ft-Ir and Nir Spectroscopy Combined with Chemometrics

inferred← citeshttps://doi.org/10.2139/ssrn.4823842openalex-extracted

Efficacy and Safety Of Combined Chinese and Western Medicine in the Treatment of Metabolic Syndrome: A Network Meta-Analysis of Randomized Controlled Trials

inferred← citeshttps://doi.org/10.1002/ar.24770openalex-snapshot

Network pharmacology‐based investigation to explore the effect and mechanism of Erchen decoction against the nonalcoholic fatty liver disease

inferred← citeshttps://doi.org/10.1002/biof.1892openalex-snapshot

Promising influences of gingerols against metabolic syndrome: A mechanistic review

inferred← citeshttps://doi.org/10.1002/jat.4670openalex-snapshot

Ferroptosis: Latest evidence and perspectives on plant‐derived natural active compounds mitigating doxorubicin‐induced cardiotoxicity

inferred← citeshttps://doi.org/10.1002/pca.3402openalex-snapshot

Rapid and comprehensive quality evaluation of Huang‐qin from different origins by FT‐IR and NIR spectroscopy combined with chemometrics

inferred← citeshttps://doi.org/10.1002/ptr.70186openalex-snapshot

Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short‐Chain Fatty Acids

inferred← citeshttps://doi.org/10.1002/ptr.7406openalex-snapshot

Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review

inferred← citeshttps://doi.org/10.1002/ptr.8508openalex-snapshot

Natural Compounds Exert Anti‐Obesity Effects by Regulating Cytokines

inferred← citeshttps://doi.org/10.1007/978-3-030-94753-8_4-1openalex-snapshot

Baicalin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

inferred← citeshttps://doi.org/10.1007/s00210-022-02258-8openalex-snapshot

Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review

inferred← citeshttps://doi.org/10.1007/s00210-024-03706-3openalex-snapshot

New horizons for promising influences of sulforaphane in the management of metabolic syndrome: a mechanistic review

inferred← citeshttps://doi.org/10.1007/s10586-022-03656-6openalex-snapshot

Deep learning application detecting SARS-CoV-2 key enzymes inhibitors

inferred← citeshttps://doi.org/10.1007/s10787-025-01820-zopenalex-snapshot

Baicalin as a potential candidate for treating systemic sclerosis

inferred← citeshttps://doi.org/10.1007/s11684-024-1101-7openalex-snapshot

Preclinical and clinical studies on Qin-Zhu-Liang-Xue decoction: insights from network pharmacology and implications for atopic dermatitis treatment

inferred← citeshttps://doi.org/10.1007/s12010-023-04849-4openalex-snapshot

Treatment of Intracerebral Hemorrhage with Traditional Chinese Medicine Monomer Wogonin by Modifying NLRP3 with METTL14 to Inhibit Neuronal Cell Pyroptosis

inferred← citeshttps://doi.org/10.1007/s12672-025-03190-yopenalex-snapshot

Therapeutic potential of natural compounds in targeting cancer stem cells: a promising approach for cancer treatment

inferred← citeshttps://doi.org/10.1007/s13273-024-00426-wopenalex-snapshot

Cheong-sang-gyeon-tong-tang improves hepatic steatosis by regulating cholesterol metabolism

inferred← citeshttps://doi.org/10.1007/s40199-022-00443-xopenalex-snapshot

Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms

inferred← citeshttps://doi.org/10.1016/j.bbrc.2022.10.061openalex-snapshot

Baicalin regulates TLR4/IκBα/NFκB signaling pathway to alleviate inflammation in Doxorubicin related cardiotoxicity

inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115210openalex-snapshot

Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116276openalex-snapshot

Baicalin-2-ethoxyethyl ester alleviates gentamicin-induced acute kidney injury via NF-κB signaling pathway

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116862openalex-snapshot

The most recent progress of baicalein in its anti-neoplastic effects and mechanisms

inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118589openalex-snapshot

Current status and future perspectives of drug delivery systems loaded with baicalein and baicalin in cancer therapy

inferred← citeshttps://doi.org/10.1016/j.cclet.2024.110450openalex-snapshot

Anti-inflammatory drug-assisted microRNA gene therapy for effectively improving pulmonary hemodynamics

inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2025.108831openalex-snapshot

Multi-component synergy of safflower (Carthamus tinctorius L.) against hypertension-dyslipidemia: Network pharmacology and molecular docking study

inferred← citeshttps://doi.org/10.1016/j.crphar.2024.100184openalex-snapshot

Endoplasmic reticulum stress in pancreatic β-cell dysfunction: The potential therapeutic role of dietary flavonoids

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114733openalex-snapshot

Review of bioactivity and structure-activity relationship on baicalein (5,6,7-trihydroxyflavone) and wogonin (5,7-dihydroxy-8-methoxyflavone) derivatives: Structural modifications inspired from flavonoids in Scutellaria baicalensis

inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.174996openalex-snapshot

Baicalin attenuate diet-induced metabolic syndrome by improving abnormal metabolism and gut microbiota

inferred← citeshttps://doi.org/10.1016/j.fbio.2024.104482openalex-snapshot

Baicalein ameliorates lipid accumulation in HepG2 cells via the pregnane X receptor signaling pathway

inferred← citeshttps://doi.org/10.1016/j.fbio.2026.108905openalex-snapshot

Fresh Portulaca oleracea L. exhibits stronger anti-gastric cancer activity than dried purslane: Insights from integrated metabolomics and machine learning

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e38633openalex-snapshot

Pharmacological and toxicological characteristics of baicalin in preventing spontaneous abortion and recurrent pregnancy loss: A multi-level critical review

inferred← citeshttps://doi.org/10.1016/j.indcrop.2024.118555openalex-snapshot

Optimization of extraction, separation and purification of baicalin in Scutellaria baicalensis using response surface methodology

inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.121690openalex-snapshot

Mechanistic insights into the delivery and pharmacodynamic enhancement of baicalin nanoparticles in traditional chinese plant medicine-based antiviral therapies

inferred← citeshttps://doi.org/10.1016/j.jep.2022.115335openalex-snapshot

Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy

inferred← citeshttps://doi.org/10.1016/j.jep.2022.116060openalex-snapshot

Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation

inferred← citeshttps://doi.org/10.1016/j.jep.2023.116856openalex-snapshot

Qinlian hongqu decoction ameliorates hyperlipidemia via the IRE1-α/IKKB-β/NF-κb signaling pathway: Network pharmacology and experimental validation

inferred← citeshttps://doi.org/10.1016/j.jep.2023.117318openalex-snapshot

UPLC-Q-Exactive/MS based analysis explore the correlation between components variations and anti-influenza virus effect of four quantified extracts of Chaihu Guizhi decoction

inferred← citeshttps://doi.org/10.1016/j.jep.2024.117748openalex-snapshot

Metabolomics and lipidomics combined with serum pharmacochemistry uncover the potential mechanism of Huang-Lian-Jie-Du decoction alleviates atherosclerosis in ApoE−/− mice

inferred← citeshttps://doi.org/10.1016/j.jep.2025.120963openalex-snapshot

Unraveling the potential mechanisms of Bupleuri Radix-Scutellariae Radix herb pair on non-alcoholic fatty liver disease by integrated transcriptomics, metabolomics and network pharmacology

inferred← citeshttps://doi.org/10.1016/j.jff.2022.105253openalex-snapshot

Baicalein targets CD36 to prevent foam cell formation by suppressing the excessive uptake of oxLDL and accelerating ABCA1-mediated cholesterol efflux in oxLDL-induced THP-1 macrophages

inferred← citeshttps://doi.org/10.1016/j.jnutbio.2026.110381openalex-snapshot

Baicalein alleviates Western diet-induced obesity via metabolically activated adipose tissue macrophages by inducing Nrf2

inferred← citeshttps://doi.org/10.1016/j.joim.2022.09.005openalex-snapshot

Effectiveness of Scutellaria baicalensis Georgi root in pregnancy-related diseases: A review

inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116061openalex-snapshot

Deciphering the molecular mechanism of Bu Yang Huan Wu Decoction in interference with diabetic pulmonary fibrosis via regulating oxidative stress and lipid metabolism disorder

inferred← citeshttps://doi.org/10.1016/j.lwt.2026.119712openalex-snapshot

Monosodium glutamate-induced sesame germination enriches phenolics and enhances antioxidant capacity: activation mechanism of phenylpropanoid enzymes

inferred← citeshttps://doi.org/10.1016/j.matdes.2026.116286openalex-snapshot

Metal-phenolic networks: a favorable combination for disease treatment

inferred← citeshttps://doi.org/10.1016/j.microc.2024.111362openalex-snapshot

A high-performance light-driven photoelectrochemical sensor based on CdIn2S4/b-TiO2/GO type-II 2D/3D heterojunction for the detection of baicalein in natural plant samples

inferred← citeshttps://doi.org/10.1016/j.microc.2025.115630openalex-snapshot

Photoinduced charge separation boosted by CdS/f-MWCNTs/MX-TiO₂ heterojunction for sensitive photoelectrochemical detection of baicalein

inferred← citeshttps://doi.org/10.1016/j.phymed.2023.154747openalex-snapshot

Baicalin inhibits pressure overload-induced cardiac hypertrophy by regulating the SIRT3-dependent signaling pathway

inferred← citeshttps://doi.org/10.1016/j.phymed.2025.157197openalex-snapshot

Baicalin ameliorates high-fat diet induced MAFLD by inhibiting ERK/PPARγ/CD36 pathway

inferred← citeshttps://doi.org/10.1016/j.phyplu.2025.100815openalex-snapshot

Early intervention of baicalin suppresses obesity-induced adipose tissue fibrotic remodeling through Interfering NF-κB/HIF-1ɑ/GRK2 Signaling Pathway

inferred← citeshttps://doi.org/10.1016/j.seppur.2025.133154openalex-snapshot

Adsorption and detection of baicalin by ZrO2 carbon microspheres modifying with boronic acid carbon dots

inferred← citeshttps://doi.org/10.1016/j.talanta.2024.126521openalex-snapshot

Zwitterionic polymers grafting of metal organic framework encapsulated boronic acid carbon dots as antibiofouling fluorescent probe for baicalin monitoring

inferred← citeshttps://doi.org/10.1021/acs.jafc.5c16420openalex-snapshot

OVA Inhalation and Baicalin Intervention: Unraveling Their Impact on Hepatic Function and the Involvement of Bitter Taste Signaling

inferred← citeshttps://doi.org/10.1021/acsomega.5c00243openalex-snapshot

Baicalein Ameliorates Experimental Ulcerative Colitis Recurrency by Downregulating Neonatal Fc Receptor via the NF-κB Signaling Pathway

inferred← citeshttps://doi.org/10.1038/s41538-026-00775-xopenalex-snapshot

Long-term sucralose exposure accelerates ovarian aging via gut microbiota dysbiosis

inferred← citeshttps://doi.org/10.1080/09205063.2025.2527254openalex-snapshot

Synergistic evaluation of anti-diabetic and hypolipidemic effects of Alangium salvifolium and Ocimum sanctum extracts

inferred← citeshttps://doi.org/10.1080/10408398.2022.2095349openalex-snapshot

Exploration of natural flavones’ bioactivity and bioavailability in chronic inflammation induced-type-2 diabetes mellitus

inferred← citeshttps://doi.org/10.1080/15384101.2025.2539656openalex-snapshot

THBS1 knockdown and baicalin induce pyroptosis via the NF-κB-NLRP3-Caspase-1 axis in gastric cancer cells

inferred← citeshttps://doi.org/10.1111/cpr.70012openalex-snapshot

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

inferred← citeshttps://doi.org/10.1111/jcmm.18321openalex-snapshot

Baicalin alleviates angiotensin II‐induced cardiomyocyte apoptosis and autophagy and modulates the AMPK/mTOR pathway

inferred← citeshttps://doi.org/10.1111/jcmm.70388openalex-snapshot

Baicalin Prevents Chronic β‐ AR Agonist‐Induced Heart Failure via Preventing Oxidative Stress and Overactivation of the NADPH Oxidase NOX2

inferred← citeshttps://doi.org/10.1155/2021/8402517openalex-snapshot

Noscapine, an Emerging Medication for Different Diseases: A Mechanistic Review

inferred← citeshttps://doi.org/10.1155/2022/2457706openalex-snapshot

Study on the Mechanism of Huanglian Jiedu Decoction in Treating Dyslipidemia Based on Network Pharmacology

inferred← citeshttps://doi.org/10.1177/20420188241252309openalex-snapshot

Chronic kidney disease combined with metabolic syndrome is a non-negligible risk factor

inferred← citeshttps://doi.org/10.1186/s12906-022-03738-3openalex-snapshot

Exploring the protective mechanism of baicalin in treatment of atherosclerosis using endothelial cells deregulation model and network pharmacology

inferred← citeshttps://doi.org/10.1186/s12906-023-04252-wopenalex-snapshot

Ameliorative effects of Scutellaria Pinnatifida subsp. pichleri (Stapf) Rech.f. Extract in streptozotocin-induced diabetic rats: chemical composition, biochemical and histopathological evaluation

inferred← citeshttps://doi.org/10.1186/s12906-025-04760-xopenalex-snapshot

Mechanisms of wogonoside in the treatment of atherosclerosis based on network pharmacology, molecular docking, and experimental validation

inferred← citeshttps://doi.org/10.1186/s12917-025-04753-5openalex-snapshot

Maternal supplementation of Lonicera flos and Scutellaria Baicalensis mixed extracts improve reproduction performance and metabolic health through modulating gut microbiota during pregnancy

inferred← citeshttps://doi.org/10.1186/s13020-025-01222-xopenalex-snapshot

Therapeutic potential of traditional Chinese medicine and mechanisms for the treatment of type 2 diabetes mellitus

inferred← citeshttps://doi.org/10.1186/s43094-026-00943-6openalex-snapshot

Role of plants and phytochemicals in promoting proliferation and osteogenic differentiation of dental mesenchymal stem cells: a comprehensive review

inferred← citeshttps://doi.org/10.12677/acm.2023.134936openalex-snapshot

Effect of Baicalin and Geniposide Combination on Polarization and Inflammation of THP-1-Derived Macrophages

inferred← citeshttps://doi.org/10.2139/ssrn.5378837openalex-snapshot

Unraveling the Potential Mechanisms of Bupleuri Radix-Scutellariae Radix Herb Pair on Non-Alcoholic Fatty Liver Disease by Integrated Transcriptomics, Metabolomics, and Network Pharmacology

inferred← citeshttps://doi.org/10.2174/011570162x345178250316123743openalex-snapshot

Molecular Docking Studies of Scutellaria baicalensis Targeting HIV Co-Receptor CXCR4

inferred← citeshttps://doi.org/10.2174/0118715303257018230927182802openalex-snapshot

Huangqin-Huanglian Decoction Protects Liver against Non-alcoholic Fatty Liver Disease in High Fat-diet Mice

inferred← citeshttps://doi.org/10.2174/0118715303269893231207071440openalex-snapshot

Promising Influences of Moringa oleifera in Functional Foods against Metabolic Syndrome: A Comprehensive and Mechanistic Review

inferred← citeshttps://doi.org/10.22038/ajp.2023.22307openalex-snapshot

Potential therapeutic effects of baicalin and baicalein.

inferred← citeshttps://doi.org/10.22038/ijbms.2022.58734.13047openalex-snapshot

Effect of alpha-mangostin on olanzapine-induced metabolic disorders in rats.

inferred← citeshttps://doi.org/10.22270/jddt.v15i7.7284openalex-snapshot

Receptor Tyrosine Kinase (RTKs) Mediated Potent Bioactive Ligand Targeted to Autoimmune Arthritis

inferred← citeshttps://doi.org/10.3389/fcell.2025.1707392openalex-snapshot

Anti-diabetic effects of Dachaihu decoction combined with Sanghuangporus vaninii: insights from network pharmacology, intestinal flora, and liver metabolomics

inferred← citeshttps://doi.org/10.3389/fcvm.2024.1372055openalex-snapshot

Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation

inferred← citeshttps://doi.org/10.3389/fimmu.2024.1377470openalex-snapshot

Immuno-modulatory role of baicalin in atherosclerosis prevention and treatment: current scenario and future directions

inferred← citeshttps://doi.org/10.3389/fmars.2026.1895903openalex-snapshot

Rheum, Scutellaria, and Houttuynia effervescent tablets: a green strategy for controlling Vibrio parahaemolyticus outbreaks in aquaculture

inferred← citeshttps://doi.org/10.3389/fphar.2021.761763openalex-snapshot

Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption

inferred← citeshttps://doi.org/10.3389/fphar.2023.1105405openalex-snapshot

The interplay between herbal medicines and gut microbiota in metabolic diseases

inferred← citeshttps://doi.org/10.3389/fphar.2024.1399460openalex-snapshot

Several major herb pairs containing Coptidis rhizoma: a review of key traditional uses, constituents and compatibility effects

inferred← citeshttps://doi.org/10.3389/fphar.2025.1660294openalex-snapshot

Baicalin protects retinal ganglion cells by regulating microglial polarization and ferroptosis via the JAK2/STAT3 pathway

inferred← citeshttps://doi.org/10.3389/freae.2025.1691949openalex-snapshot

Epigenetic repurposing of carbohydrate metabolic inhibitors for insulin resistance: targeting DNMT1 and HDAC3 for β-cell restoration

inferred← citeshttps://doi.org/10.3390/biology14060637openalex-snapshot

Recent Advances in the Therapeutic Effects and Molecular Mechanisms of Baicalin

inferred← citeshttps://doi.org/10.3390/cancers15072128openalex-snapshot

Baicalein as Promising Anticancer Agent: A Comprehensive Analysis on Molecular Mechanisms and Therapeutic Perspectives

inferred← citeshttps://doi.org/10.3390/cimb47060450openalex-snapshot

Lipid-Lowering Potential of Almond Hulls (Quercetin, Baicalein, and Kaempferol): Insights from Network Pharmacology and Molecular Dynamics

inferred← citeshttps://doi.org/10.3390/ijerph192013076openalex-snapshot

Gut Microbiome: The Interplay of an “Invisible Organ” with Herbal Medicine and Its Derived Compounds in Chronic Metabolic Disorders

inferred← citeshttps://doi.org/10.3390/ijms22126428openalex-snapshot

Skullcapflavone II Suppresses TNF-α/IFN-γ-Induced TARC, MDC, and CTSS Production in HaCaT Cells

inferred← citeshttps://doi.org/10.3390/ijms25042127openalex-snapshot

Network Pharmacology and Experimental Verifications to Discover Scutellaria baicalensis Georgi’s Effects on Joint Inflammation, Destruction, and Pain in Osteoarthritis

inferred← citeshttps://doi.org/10.3390/ijms26083703openalex-snapshot

Flavonoids from Scutellaria baicalensis: Promising Alternatives for Enhancing Swine Production and Health

inferred← citeshttps://doi.org/10.3390/molecules27207110openalex-snapshot

Selected Plant-Derived Polyphenols as Potential Therapeutic Agents for Peripheral Artery Disease: Molecular Mechanisms, Efficacy and Safety

inferred← citeshttps://doi.org/10.3390/molecules28031486openalex-snapshot

Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/nu14193920openalex-snapshot

Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4–FGF21 Signaling in Mouse Hepatocyte AML12 Cells

inferred← citeshttps://doi.org/10.3390/nu15081989openalex-snapshot

Interplay between Phytochemicals and the Colonic Microbiota

inferred← citeshttps://doi.org/10.3390/ph16040570openalex-snapshot

Baicalin—Current Trends in Detection Methods and Health-Promoting Properties

inferred← citeshttps://doi.org/10.3390/pharmaceutics14102141openalex-snapshot

Comparative Evaluation of the Antiglycation and Anti-α-Glucosidase Activities of Baicalein, Baicalin (Baicalein 7-O-Glucuronide) and the Antidiabetic Drug Metformin

inferred← citeshttps://doi.org/10.4251/wjgo.v16.i3.716openalex-snapshot

Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management

inferred← citeshttps://doi.org/10.5376/mpr.2024.14.0001openalex-snapshot

Analysis of the Response and Benefits of Medicinal Plant Chinese Skullcap (Scutellaria baicalensis) to Ecological Environment under Different Planting Modes

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