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Chronic Idiopathic Constipation in Adults: A Review on Current Guidelines and Emerging Treatment Options

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf01535996openalex-snapshot

Clinical evaluation of methylcellulose as a bulk laxative

inferredcites →https://doi.org/10.1007/bf02087539openalex-snapshot

Misoprostol is effective treatment for patients with severe chronic constipation

inferredcites →https://doi.org/10.1007/s00384-009-0794-zopenalex-snapshot

Colchicine is effective for short-term treatment of slow transit constipation: a double-blind placebo-controlled clinical trial

inferredcites →https://doi.org/10.1007/s00535-017-1383-5openalex-snapshot

Determining an optimal clinical dose of elobixibat, a novel inhibitor of the ileal bile acid transporter, in Japanese patients with chronic constipation: a phase II, multicenter, double-blind, placebo-controlled randomized clinical trial

inferredcites →https://doi.org/10.1007/s10620-015-3876-5openalex-snapshot

Short-Term Effects of Relamorelin on Descending Colon Motility in Chronic Constipation: A Randomized, Controlled Trial

inferredcites →https://doi.org/10.1007/s10620-015-3929-9openalex-snapshot

Relamorelin to Treat Constipation: “Pusher” or Pushover?

inferredcites →https://doi.org/10.1007/s12664-018-0901-6openalex-snapshot

A randomized double-blind placebo-controlled trial showing rifaximin to improve constipation by reducing methane production and accelerating colon transit: A pilot study

inferredcites →https://doi.org/10.1007/s40264-018-0781-9openalex-snapshot

Benefit–Risk Assessment of Plecanatide in the Treatment of Chronic Idiopathic Constipation

inferredcites →https://doi.org/10.1016/j.cgh.2013.12.005openalex-snapshot

Efficacy and Safety of a Magnesium Sulfate–Rich Natural Mineral Water for Patients With Functional Constipation

inferredcites →https://doi.org/10.1016/j.cgh.2015.04.184openalex-snapshot

Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial

inferredcites →https://doi.org/10.1016/j.cgh.2015.05.037openalex-snapshot

Factors Associated With Efficacy of Nurse-led Bowel Training of Patients With Chronic Constipation

inferredcites →https://doi.org/10.1016/j.clinthera.2020.05.012openalex-snapshot

Evaluation of Plecanatide for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation in Patients 65 Years or Older

inferredcites →https://doi.org/10.1016/j.dld.2014.04.005openalex-snapshot

Efficacy of a CO2-releasing suppository in dyschezia: A double-blind, randomized, placebo-controlled clinical trial

inferredcites →https://doi.org/10.1016/j.ejim.2005.06.014openalex-snapshot

Lipoid pneumonia: A preventable form of drug-induced lung injury

inferredcites →https://doi.org/10.1016/j.gastre.2017.03.013openalex-snapshot

Clinical practice guidelines for the management of constipation in adults. Part 2: Diagnosis and treatment

inferredcites →https://doi.org/10.1016/j.gastrohep.2016.02.007openalex-snapshot

Guía de práctica clínica sobre el manejo del estreñimiento crónico en el paciente adulto. Parte 2: Diagnóstico y tratamiento

inferredcites →https://doi.org/10.1016/j.jpainsymman.2008.04.016openalex-snapshot

A Review of the Literature on Gender and Age Differences in the Prevalence and Characteristics of Constipation in North America

inferredcites →https://doi.org/10.1016/s0002-9270(03)00135-7openalex-snapshot

Treatment of Chronic Constipation With Colchicine: Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

inferredcites →https://doi.org/10.1016/s0002-9270(03)00442-8openalex-snapshot

Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women

inferredcites →https://doi.org/10.1016/s0016-5085(10)60590-2openalex-snapshot

905 A Novel Gastrointestinal Prokinetic, ATI-7505, Increased Spontaneous Bowel Movements (Sbms) in a Phase II, Randomized, Placebo-Controlled Study of Patients With Chronic Idiopathic Constipation (CIC)

inferredcites →https://doi.org/10.1016/s2468-1253(18)30123-7openalex-snapshot

Safety and efficacy of elobixibat for chronic constipation: results from a randomised, double-blind, placebo-controlled, phase 3 trial and an open-label, single-arm, phase 3 trial

inferredcites →https://doi.org/10.1016/s2468-1253(18)30165-1openalex-snapshot

Safety and efficacy of the sodium-glucose cotransporter 1 inhibitor mizagliflozin for functional constipation: a randomised, placebo-controlled, double-blind phase 2 trial

inferredcites →https://doi.org/10.1016/s2468-1253(19)30246-8openalex-snapshot

Efficacy of drugs in chronic idiopathic constipation: a systematic review and network meta-analysis

inferredcites →https://doi.org/10.1038/ajg.2011.162openalex-snapshot

A Randomized Placebo-Controlled Phase IIb Trial of A3309, A Bile Acid Transporter Inhibitor, for Chronic Idiopathic Constipation

inferredcites →https://doi.org/10.1038/ajg.2011.285openalex-snapshot

Effects of A3309, an Ileal Bile Acid Transporter Inhibitor, on Colonic Transit and Symptoms in Females With Functional Constipation

inferredcites →https://doi.org/10.1038/ajg.2014.187openalex-snapshot

American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation

inferredcites →https://doi.org/10.1038/ajg.2016.611openalex-snapshot

A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation

inferredcites →https://doi.org/10.1046/j.1365-2036.1997.00237.xopenalex-snapshot

Misoprostol in the treatment of chronic refractory constipation: results of a long‐term open label trial

inferredcites →https://doi.org/10.1053/j.gastro.2005.11.014openalex-snapshot

Biofeedback Is Superior to Laxatives for Normal Transit Constipation Due to Pelvic Floor Dyssynergia

inferredcites →https://doi.org/10.1053/j.gastro.2011.12.025openalex-snapshot

Stimulant Laxatives for the Treatment of Chronic Constipation: Is it Time to Change the Paradigm?

inferredcites →https://doi.org/10.1053/j.gastro.2012.10.028openalex-snapshot

American Gastroenterological Association Technical Review on Constipation

inferredcites →https://doi.org/10.1053/j.gastro.2016.02.031openalex-snapshot

Bowel Disorders

inferredcites →https://doi.org/10.1055/a-1491-1784openalex-snapshot

Effects of linaclotide in the treatment of chronic constipation and irritable bowel syndrome with constipation: a meta-analysis

inferredcites →https://doi.org/10.1080/13543784.2016.1195369openalex-snapshot

Velusetrag for the treatment of chronic constipation

inferredcites →https://doi.org/10.1080/14656566.2018.1494728openalex-snapshot

Linaclotide for the treatment of chronic constipation

inferredcites →https://doi.org/10.1080/14740338.2021.1952980openalex-snapshot

Safety of elobixibat and lubiprostone in Japanese patients with chronic constipation: a retrospective cohort study

inferredcites →https://doi.org/10.1080/17474124.2018.1522248openalex-snapshot

Elobixibat for the treatment of constipation

inferredcites →https://doi.org/10.1080/17474124.2019.1568238openalex-snapshot

Prucalopride for the treatment of constipation: a view from 2015 and beyond

inferredcites →https://doi.org/10.1080/17474124.2021.1913054openalex-snapshot

New pharmacologic treatments for idiopathic chronic constipation: a financial strain for strainers

inferredcites →https://doi.org/10.1080/17512433.2019.1670057openalex-snapshot

Plecanatide for the treatment of chronic idiopathic constipation in adult patients

inferredcites →https://doi.org/10.1097/dcr.0000000000000098openalex-snapshot

A Concomitant Treatment by CO2-Releasing Suppositories Improves the Results of Anorectal Biofeedback Training in Patients With Dyschezia

inferredcites →https://doi.org/10.1097/mcg.0b013e31820fb914openalex-snapshot

World Gastroenterology Organisation Global Guideline

inferredcites →https://doi.org/10.1097/meg.0000000000001080openalex-snapshot

Clinical practice guidelines from the French National Society of Coloproctology in treating chronic constipation

inferredcites →https://doi.org/10.1111/apt.12571openalex-snapshot

Systematic review with meta‐analysis: highly selective 5‐HT4 agonists (prucalopride, velusetrag or naronapride) in chronic constipation

inferredcites →https://doi.org/10.1111/apt.15950openalex-snapshot

The benefit of elobixibat in chronic constipation is associated with faecal deoxycholic acid but not effects of altered microbiota

inferredcites →https://doi.org/10.1111/apt.16369openalex-snapshot

Review article: diagnosis, management and patient perspectives of the spectrum of constipation disorders

inferredcites →https://doi.org/10.1111/j.1365-2036.2006.02903.xopenalex-snapshot

Efficacy and safety of bisacodyl in the acute treatment of constipation: a double‐blind, randomized, placebo‐controlled study

inferredcites →https://doi.org/10.1111/j.1365-2036.2010.04456.xopenalex-snapshot

Clinical trial: the efficacy and tolerability of velusetrag, a selective 5‐HT4 agonist with high intrinsic activity, in chronic idiopathic constipation – a 4‐week, randomized, double‐blind, placebo‐controlled, dose–response study

inferredcites →https://doi.org/10.1111/j.1365-2036.2011.04594.xopenalex-snapshot

Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation

inferredcites →https://doi.org/10.1111/j.1365-2982.2009.01345.xopenalex-snapshot

Biofeedback therapy in fecal incontinence and constipation

inferredcites →https://doi.org/10.1111/j.1365-2982.2011.01709.xopenalex-snapshot

Diagnosis and treatment of chronic constipation - a European perspective

inferredcites →https://doi.org/10.1111/j.1471-6712.2004.00308.xopenalex-snapshot

Fruit and fibre (Pajala porridge) in the prevention of constipation

inferredcites →https://doi.org/10.1111/nmo.12758openalex-snapshot

Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation‐predominant irritable bowel syndrome and functional constipation

inferredcites →https://doi.org/10.1111/nmo.13571openalex-snapshot

Efficacy, long‐term safety, and impact on quality of life of elobixibat in more severe constipation: Post hoc analyses of two phase 3 trials in Japan

inferredcites →https://doi.org/10.1111/nmo.13762openalex-snapshot

European society of neurogastroenterology and motility guidelines on functional constipation in adults

inferredcites →https://doi.org/10.1111/nmo.14070openalex-snapshot

Chronic constipation in adults: Contemporary perspectives and clinical challenges. 2: Conservative, behavioural, medical and surgical treatment

inferredcites →https://doi.org/10.1136/bmj.328.7436.393openalex-snapshot

Biofeedback for pelvic floor dysfunction in constipation

inferredcites →https://doi.org/10.1136/flgastro-2015-100660openalex-snapshot

A National Biofeedback Practitioners Service Evaluation: Focus on Chronic Idiopathic Constipation

inferredcites →https://doi.org/10.1152/ajpgi.00205.2019openalex-snapshot

What’s in the pipeline for lower functional gastrointestinal disorders in the next 5 years?

inferredcites →https://doi.org/10.1159/000007591openalex-snapshot

Endoluminal Instillation of Bisacodyl inPatients with Severe (Slow Transit Type)Constipation Is Useful to Test Residual ColonicPropulsive Activity

inferredcites →https://doi.org/10.1159/000512745openalex-snapshot

Real-World Comparison of Elobixibat and Lubiprostone Treatment in Patients with Chronic Constipation: A Propensity Score-Matched Analysis

inferredcites →https://doi.org/10.1177/1756283x17734697openalex-snapshot

Randomized clinical trial: efficacy and safety of plecanatide in the treatment of chronic idiopathic constipation

inferredcites →https://doi.org/10.1177/2050640614528175openalex-snapshot

Constipation severity is associated with productivity losses and healthcare utilization in patients with chronic constipation

inferredcites →https://doi.org/10.1186/1471-230x-8-5openalex-snapshot

Epidemiology of constipation in Europe and Oceania: a systematic review

inferredcites →https://doi.org/10.1186/s12876-015-0354-7openalex-snapshot

Trans-anal irrigation therapy to treat adult chronic functional constipation: systematic review and meta-analysis

inferredcites →https://doi.org/10.1186/s12876-016-0556-7openalex-snapshot

Chronic constipation diagnosis and treatment evaluation: the “CHRO.CO.DI.T.E.” study

inferredcites →https://doi.org/10.14309/ajg.0000000000001222openalex-snapshot

Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review

inferredcites →https://doi.org/10.18553/jmcp.2013.19.9.755openalex-snapshot

A Systematic Review of the Economic and Humanistic Burden of Illness in Irritable Bowel Syndrome and Chronic Constipation

inferredcites →https://doi.org/10.2147/tcrm.s269330openalex-snapshot

Current Opinion on Prucalopride in Gastroparesis and Chronic Constipation Treatment: A Focus on Patient Selection and Safety

inferredcites →https://doi.org/10.2174/1871523018666190911121306openalex-snapshot

Tegaserod for the Treatment of Irritable Bowel Syndrome

inferredcites →https://doi.org/10.23922/jarc.2020-006openalex-snapshot

Efficacy and Safety of Elobixibat in Elderly Patients with Chronic Constipation: A Single-center, Observational Study

inferredcites →https://doi.org/10.3748/wjg.v18.i14.1555openalex-snapshot

Consensus statement AIGO/SICCR: Diagnosis and treatment of chronic constipation and obstructed defecation (part I: Diagnosis)

inferredcites →https://doi.org/10.3748/wjg.v18.i36.4994openalex-snapshot

Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation (Part II: Treatment)

inferredcites →https://doi.org/10.3748/wjg.v21.i40.11362openalex-snapshot

Irritable bowel syndrome and chronic constipation: Fact and fiction

inferredcites →https://doi.org/10.3904/kjm.2016.91.2.114openalex-snapshot

Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

inferredcites →https://doi.org/10.5056/jnm15185openalex-snapshot

Guidelines for the Diagnosis and Treatment of Chronic Functional Constipation in Korea, 2015 Revised Edition

inferredcites →https://doi.org/10.5056/jnm20001openalex-snapshot

CSP01, a Novel Superabsorbent Hydrogel, Reduces Colonic Transit Time in Patients With Chronic Idiopathic Constipation in a Randomized, Double-blind, Controlled Pilot Clinical Trial

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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MiR-203 is an Anti-Obese miRNA by Targeting ASBT

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Daikenchuto significantly improves stool consistency and lower gastrointestinal symptoms in patients with chronic constipation

inferred← citeshttps://doi.org/10.1002/jpn3.70428openalex-snapshot

Radiopaque markers in children with functional constipation: Potential role in diagnosis, therapy, and outcomes

inferred← citeshttps://doi.org/10.1002/ueg2.70065openalex-snapshot

Transcutaneous Auricular Vagal Nerve Stimulation to Treat Chronic Constipation: Another Therapeutic Failure?

inferred← citeshttps://doi.org/10.1007/s00384-024-04795-5openalex-snapshot

Outlet type constipation in adult patients treated with type A botulinum toxin: a cohort study

inferred← citeshttps://doi.org/10.1016/j.clnesp.2022.08.025openalex-snapshot

May polydextrose potentially improve gut health in patients with chronic kidney disease?

inferred← citeshttps://doi.org/10.1016/j.dld.2024.02.006openalex-snapshot

Position paper on transanal irrigation in chronic non-organic constipation

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117425openalex-snapshot

Novel gut-restricted bivalent agonists targeting mucosal 5-HT4R: Design, synthesis, and biological evaluation

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MiR-203 is an anti-obese microRNA by targeting apical sodium-dependent bile acid transporter

inferred← citeshttps://doi.org/10.1055/a-2908-5581openalex-snapshot

A Novel Synthesis of 5-HT4 Receptor Intestinal-Restrictive Bivalent Agonist: SIPI11588

inferred← citeshttps://doi.org/10.1080/14656566.2022.2150076openalex-snapshot

Pharmacotherapeutic advances for chronic idiopathic constipation in adults

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Managing gastrointestinal manifestations in systemic sclerosis, a mechanistic approach

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Recommendations for the management of opioid-induced constipation - how to improve usability in clinical practice

inferred← citeshttps://doi.org/10.1080/17474124.2023.2267968openalex-snapshot

Relief from behind: enemas, the back door enforcement to help treating chronic constipation in adults

inferred← citeshttps://doi.org/10.1093/nutrit/nuae119openalex-snapshot

Efficacy of Probiotics Compared With Pharmacological Treatments for Maintenance Therapy for Functional Constipation in Children: A Systematic Review and Network Meta-analysis

inferred← citeshttps://doi.org/10.1126/sciadv.adw3934openalex-snapshot

Lubiprostone in chronic kidney disease: Insights into mitochondrial function and polyamines from a randomized phase 2 clinical trial

inferred← citeshttps://doi.org/10.1136/flgastro-2025-103547openalex-snapshot

Dispelling myths and misconceptions of constipation with a focus on stimulant laxatives

inferred← citeshttps://doi.org/10.1163/18762891-bja00038openalex-snapshot

Bifidobacterium animalis subsp. lactis BLa80 regulates the intestinal habit in adults with chronic constipation: a multicentre, randomised, double-blind, placebo-controlled study

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Impact of Heyndrickxia (Bacillus) coagulans GBI-30, 6086 (BC30) probiotic on gastrointestinal function in healthy adults: a randomised controlled trial

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Biofeedback pelvic floor muscle training versus posterior tibial nerve electrostimulation in treatment of functional obstructed defecation: a prospective randomized clinical trial

inferred← citeshttps://doi.org/10.12968/bjon.2022.31.19.984openalex-snapshot

A nurse-led educational intervention for relieving idiopathic constipation: a retrospective study

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The study to understand management of constipation and prescription pattern of laxative therapy

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An Emulsified Liquid Paraffin Formulation for Functional Constipation: Pharmacokinetics of Vitamins K1, D3, A, and E in a Rat Model

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Efficacy and safety of vibrating capsule in treatment of chronic idiopathic constipation: a systematic review and meta-analysis of randomized controlled trials

inferred← citeshttps://doi.org/10.23736/s0393-3660.23.05038-6openalex-snapshot

Management strategies for chronic idiopathic constipation: an Italian real-life survey

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The practical management of chronic constipation as detected by a survey conducted on Italian gastroenterologists

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Abdominal massage as an adjunctive therapy for pediatric functional constipation: a randomized controlled trial

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Laxative effect of prebiotics in chronic constipation: Mechanisms of action

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Constipation Caused by Anti-calcitonin Gene-Related Peptide Migraine Therapeutics Explained by Antagonism of Calcitonin Gene-Related Peptide’s Motor-Stimulating and Prosecretory Function in the Intestine

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Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway

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Usefulness of Transanal Irrigation and Colon Hydrotherapy in the Treatment of Chronic Constipation and Beyond: A Review with New Perspectives for Bio-Integrated Medicine

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Exploring Pharmacological Treatments for Chronic Idiopathic Constipation in Adults: A Look Back to the Future

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The Diagnosis and Management of Chronic Constipation in Italy: Results from a Survey Conducted among Italian Gastroenterologists

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The Sweet Side of Constipation: Colonic Motor Dysfunction in Diabetes Mellitus

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Moving forward: may some of “functional” gut disorders be reclassified as enteric neuro-gliopathies?

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How to administer an enema in adults

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Chronic Constipation Ameliorated by Thoracic Spinal Cord Stimulation

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