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Syk-Targeted, a New 3-Arylbenzofuran Derivative EAPP-2 Blocks Airway Inflammation of Asthma–COPD Overlap in vivo and in vitro

https://doi.org/10.2147/jir.s310875
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.amjmed.2012.06.024openalex-snapshot
Inflammation in COPD: Implications for Management
inferredcites →https://doi.org/10.1016/j.bcp.2020.113949openalex-snapshot
Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-kB pathway
inferredcites →https://doi.org/10.1016/j.bmcl.2014.03.087openalex-snapshot
Design, synthesis, docking and anti-inflammatory evaluation of novel series of benzofuran based prodrugs
inferredcites →https://doi.org/10.1016/j.ejmech.2010.03.045openalex-snapshot
Synthesis and biological evaluation of a novel series of 2,2-bisaminomethylated aurone analogues as anti-inflammatory and antimicrobial agents
inferredcites →https://doi.org/10.1016/j.ejmech.2014.02.033openalex-snapshot
Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: Design, synthesis and evaluation as potential anti-inflammatory agents
inferredcites →https://doi.org/10.1016/j.febslet.2012.02.045openalex-snapshot
TLR‐induced NF‐κB activation regulates NLRP3 expression in murine macrophages
inferredcites →https://doi.org/10.1016/j.imbio.2015.09.009openalex-snapshot
Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A
inferredcites →https://doi.org/10.1016/j.tetlet.2014.02.116openalex-snapshot
Microwave-assisted parallel synthesis of benzofuran-2-carboxamide derivatives bearing anti-inflammatory, analgesic and antipyretic agents
inferredcites →https://doi.org/10.1016/s0091-6749(99)70367-2openalex-snapshot
Syk deficiency in nonreleaser basophils☆☆☆★
inferredcites →https://doi.org/10.1038/nature07965openalex-snapshot
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
inferredcites →https://doi.org/10.1038/nri3452openalex-snapshot
Activation and regulation of the inflammasomes
inferredcites →https://doi.org/10.1038/s41598-017-08689-1openalex-snapshot
NLRP3 inflammasome activation results in liver inflammation and fibrosis in mice infected with Schistosoma japonicum in a Syk-dependent manner
inferredcites →https://doi.org/10.1038/sigtrans.2017.23openalex-snapshot
NF-κB signaling in inflammation
inferredcites →https://doi.org/10.1093/neuonc/noy036openalex-snapshot
Linking inflammation and cancer: the unexpected SYK world
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a022610openalex-snapshot
Purification of a 72-kDa Protein-Tyrosine Kinase from Rat Liver and Its Identification as Syk: Involvement of Syk in Signaling Events of Hepatocytes
inferredcites →https://doi.org/10.1097/md.0000000000000755openalex-snapshot
Comparison of Acute Respiratory Events Between Asthma–COPD Overlap Syndrome and COPD Patients
inferredcites →https://doi.org/10.1159/000365249openalex-snapshot
Src Family Kinases and Syk Are Required for Neutrophil Extracellular Trap Formation in Response to β-Glucan Particles
inferredcites →https://doi.org/10.1183/09031936.00024313openalex-snapshot
Differences in plasma and sputum biomarkers between COPD and COPD–asthma overlap
inferredcites →https://doi.org/10.1186/s12890-017-0571-7openalex-snapshot
Burden of asthma and COPD overlap (ACO) in Taiwan: a nationwide population-based study
inferredcites →https://doi.org/10.1186/s12964-018-0235-0openalex-snapshot
Neutrophil extracellular traps induce aggregation of washed human platelets independently of extracellular DNA and histones
inferredcites →https://doi.org/10.1186/s13045-017-0512-1openalex-snapshot
Syk inhibitors in clinical development for hematological malignancies
inferredcites →https://doi.org/10.1189/jlb.3hi0814-371rropenalex-snapshot
Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization
inferredcites →https://doi.org/10.1371/journal.pone.0010008openalex-snapshot
Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase
inferredcites →https://doi.org/10.1371/journal.pone.0062985openalex-snapshot
The Coexistence of Asthma and Chronic Obstructive Pulmonary Disease (COPD): Prevalence and Risk Factors in Young, Middle-aged and Elderly People from the General Population
inferredcites →https://doi.org/10.2147/jir.s281393openalex-snapshot
Multiple Components Rapidly Screened from Perilla Leaves Attenuate Asthma Airway Inflammation by Synergistic Targeting on Syk
inferredcites →https://doi.org/10.3109/02770903.2011.555576openalex-snapshot
Overlap Syndrome of Asthma and COPD Predicts Low Quality of Life
inferredcites →https://doi.org/10.3389/fcell.2021.628957openalex-snapshot
Comparative RNA-Seq Transcriptome Analysis on Pulmonary Inflammation in a Mouse Model of Asthma–COPD Overlap Syndrome
inferredcites →https://doi.org/10.3389/fphar.2019.01157openalex-snapshot
Amurensin H, a Derivative From Resveratrol, Ameliorates Lipopolysaccharide/Cigarette Smoke–Induced Airway Inflammation by Blocking the Syk/NF-κB Pathway
inferredcites →https://doi.org/10.4049/jimmunol.166.1.538openalex-snapshot
Protein-Tyrosine Kinase Syk Expressed in Human Nasal Fibroblasts and Its Effect on RANTES Production
inferredcites →https://doi.org/10.4062/biomolther.2014.038openalex-snapshot
Britanin Suppresses IgE/Ag-Induced Mast Cell Activation by Inhibiting the Syk Pathway
inferredcites →https://doi.org/10.7150/ijbs.4874openalex-snapshot
Role of IL-6 in Asthma and Other Inflammatory Pulmonary Diseases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3948433openalex-extracted
HSP60 Regulates the Cigarette Smoke-Induced Activation of TLR4-NF-κB-MyD88 Signaling Pathway and NLRP3 Inflammasome
inferred← citeshttps://doi.org/10.1002/iid3.934openalex-snapshot
Immunomodulatory role of spleen tyrosine kinase in chronic inflammatory and autoimmune diseases
inferred← citeshttps://doi.org/10.1007/s00210-025-03889-3openalex-snapshot
Wogonin attenuates inflammation and oxidative stress in acute lung injury via regulating PPARα, AKT, and NRF2
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.149701openalex-snapshot
Construction of a three-dimensional inflammation model of human bronchial epithelial cells BEAS-2B by using the self-assembling D-form peptide Sciobio-Ⅲ
inferred← citeshttps://doi.org/10.1016/j.fitote.2025.106655openalex-snapshot
Components, isolated from perilla leaves, synergistically alleviate the inflammation of acute lung injury via Syk/β2-integrin pathway
inferred← citeshttps://doi.org/10.1016/j.iac.2022.04.005openalex-snapshot
Novel Therapeutic Strategies in Asthma-Chronic Obstructive Pulmonary Disease Overlap
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108445openalex-snapshot
HSP60 regulates the cigarette smoke-induced activation of TLR4-NF-κB-MyD88 signalling pathway and NLRP3 inflammasome
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.117211openalex-snapshot
Apigenin-7-O-β-D-glucuronide prophylaxis ameliorates allergic airway inflammation by suppressing the TCF4-mediated Syk pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2025.119513openalex-snapshot
A systematic pharmacological strategy-based to decode the synergistic mechanism of 7,4′-dihydroxyflavone in combination with vitamin D3 against asthma
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106280openalex-snapshot
Molecular and immunomodulatory actions of new antiasthmatic agents: Exploring the diversity of biologics in Th2 endotype asthma
inferred← citeshttps://doi.org/10.1080/10286020.2024.2403617openalex-snapshot
Rosmarinic acid suppresses the progression of COPD via Syk by modulating airway inflammation and epithelial apoptosis in vivo and in vitro
inferred← citeshttps://doi.org/10.2147/copd.s395492openalex-snapshot
Analysis of Communal Molecular Mechanism Between Chronic Obstructive Pulmonary Disease and Osteoporosis
inferred← citeshttps://doi.org/10.3390/cells11111728openalex-snapshot
Unraveling the Pathogenesis of Asthma and Chronic Obstructive Pulmonary Disease Overlap: Focusing on Epigenetic Mechanisms
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