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Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

https://doi.org/10.2174/138955711797247707

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SAR studies toward discovery of emvododstat (PTC299), a potent dihydroorotate dehydrogenase (DHODH) inhibitor

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DHODH-mediated mitochondrial redox homeostasis: a novel ferroptosis regulator and promising therapeutic target

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Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production

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N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia

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Optimization of Tetrahydroindazoles as Inhibitors of Human Dihydroorotate Dehydrogenase and Evaluation of Their Activity and In Vitro Metabolic Stability

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Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors

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Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis

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inferred← citeshttps://doi.org/10.1080/1062936x.2013.792871openalex-snapshot

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Identification of novel PfDHODH inhibitors as antimalarial agents via pharmacophore-based virtual screening followed by molecular docking and in vivo antimalarial activity

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Integrative Multi-Omics and Structure-based Analysis of DHODH Reveals its Therapeutic Potential in Colorectal Cancer

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Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma

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A Patent Review of Human Dihydroorotate Dehydrogenase (hDHODH) Inhibitors as Anticancer Agents and their Other Therapeutic Applications (1999-2022)

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Computational Design of Thioxanthone Derivatives as Potential Antimalarial Agents through Plasmodium falciparum Protein Inhibition

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The Role of Ferroptosis in Nervous System Disorders

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Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

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Ferroptosis in diabetic retinopathy: from pathogenic mechanisms to translational prospects

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Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions

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Cloning and Characterization of Yak DHODH Gene and Its Functional Studies in a Bisphenol S-Induced Ferroptosis Model of Fetal Fibroblasts

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A Novel Graph Neural Network Methodology to Investigate Dihydroorotate Dehydrogenase Inhibitors in Small Cell Lung Cancer

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DHODH Inhibition Exerts Synergistic Therapeutic Effect with Cisplatin to Induce Ferroptosis in Cervical Cancer through Regulating mTOR Pathway

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Inhibition of DHODH Enhances Replication-Associated Genomic Instability and Promotes Sensitivity in Endometrial Cancer

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Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target

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The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

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Regioselective Synthesis of 5- and 3-Hydroxy-N-Aryl-1H-Pyrazole-4-Carboxylates and Their Evaluation as Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

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Potential Anti-SARS-CoV-2 Therapeutics That Target the Post-Entry Stages of the Viral Life Cycle: A Comprehensive Review

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Ferroptosis in schizophrenia: Mechanisms and therapeutic potentials (Review)

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DOCKING MOLECULAR E AVALIAÇÃO DA ATIVIDADE ANTILEISHMANIA IN VITRO DE UM COMPLEXO METÁLICO DE RUTÊNIO COM EPIISOPILOTURINA E ÓXIDO NÍTRICO

inferred← citeshttps://doi.org/10.52711/0974-360x.2022.00075openalex-snapshot

Apigenin: Review of Mechanisms of Action as Antimalarial

inferred← citeshttps://doi.org/10.53846/goediss-4298openalex-snapshot

Identifizierung und Charakterisierung der Dihydroorotat Dehydrogenase als Zielstruktur von 1-Hydroxyquinolonen in Toxoplasma gondii

inferred← citeshttps://doi.org/10.56808/3027-7922.3018openalex-snapshot

Molecular docking, molecular dynamics simulation, and in vitro evaluation of hydroxythioxanthone derivatives as antimalarial agents

inferred← citeshttps://doi.org/10.7150/jca.14835openalex-snapshot

Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase

inferred← citeshttps://doi.org/10.7324/japs.2021.110418openalex-snapshot

Exploring the potentials of selected bioactive compounds isolated from Piper guineense Schumach. & Thonn. leaf toward identification of novel pfDHFR and pfDHODH inhibitors as antimalaria agents

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