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Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

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Purification, characterization and localization of mitochondrial dihydroorotate dehydrogenase in Plasmodium falciparum, human malaria parasite

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Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats

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Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells

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Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH

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A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH

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Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening

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Synthesis, antitumour and antimicrobial activities of new peptidyl derivatives containing the 1,3-benzodioxole system

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Evaluation of 7-arylaminopyrazolo[1,5-a]pyrimidines as anti-Plasmodium falciparum, antimalarial, and Pf-dihydroorotate dehydrogenase inhibitors

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Dietary flavonoids fisetin and myricetin: Dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II

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4,7-Dimethoxy-5-methyl-1,3-benzodioxole from Antrodia camphorata inhibits LPS-induced inflammation via suppression of NF-κB and induction HO-1 in RAW264.7 cells

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Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in

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The kynurenine pathway and neurodegenerative disease

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Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents

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DSM265 for Plasmodium falciparum chemoprophylaxis: a randomised, double blinded, phase 1 trial with controlled human malaria infection

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Optimum population-level use of artemisinin combination therapies: a modelling study

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Identification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening

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Multiple Inhibitor Analysis of the Brequinar and Leflunomide Binding Sites on Human Dihydroorotate Dehydrogenase

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Analysis of Flavin Oxidation and Electron-Transfer Inhibition in Plasmodium falciparum Dihydroorotate Dehydrogenase

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Discovery of Diverse Human Dihydroorotate Dehydrogenase Inhibitors as Immunosuppressive Agents by Structure-Based Virtual Screening

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Leishmanicidal, Antiplasmodial, and Cytotoxic Activity of Novel Diterpenoid 1,2-Quinones from Perovskia abrotanoides : New Source of Tanshinones

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TCM: Made in China

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Genome sequence of the human malaria parasite Plasmodium falciparum

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Peptidomimetic inhibitors of APC–Asef interaction block colorectal cancer migration

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

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Artemisinin, a miracle of traditional Chinese medicine

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Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

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High-throughput Screening for Potent and Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase

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CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

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ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks

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Structure ofPlasmodium falciparumdihydroorotate dehydrogenase with a bound inhibitor

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The X-ray structure ofPlasmodium falciparumdihydroorotate dehydrogenase bound to a potent and selectiveN-phenylbenzamide inhibitor reveals novel binding-site interactions

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Ethnopharmacological Significance of Eclipta alba (L.) Hassk. (Asteraceae)

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Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

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Differential Scanning Calorimetry in Life Science: Thermodynamics, Stability, Molecular Recognition and Application in Drug Design

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Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

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Plasmodium Dihydroorotate Dehydrogenase: A Promising Target for Novel Anti-Malarial Chemotherapy

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The IDO Inhibitor Coptisine Ameliorates Cognitive Impairment in a Mouse Model of Alzheimer's Disease

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Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives

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Suppression of Human Breast Cancer Cell Metastasis by Coptisine in Vitro

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Coptisine Improves Anxiety-Like Behaviors by Regulating the Warburg Effect in Microglia Via Pkm2

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Unveiling the Potential of Natural Resources‐Derived Therapeutics for Improved Malaria Management: Computational to Experimental Studies

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An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins

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Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis

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Shang-Ke-Huang-Shui and Coptisine Alleviate Osteoarthritis in the Knee of Monosodium Iodoacetate-Induced Rats Through Inhibiting CXCR4 Signaling

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A novel quality evaluation method for magnolia bark using electronic nose and colorimeter data with multiple statistical algorithms

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Coptisine activates aryl hydrocarbon receptor to regulate colonic epithelial homeostasis in DSS induced ulcerative colitis and TNF-α challenged intestinal organoids

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Coptisine fromCoptis chinensisexerts diverse beneficial properties: A concise review

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Research Progress in Ulcerative Colitis: The Role of Traditional Chinese Medicine on Gut Microbiota and Signaling Pathways

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Alkaloids from Plants with Antimalarial Activity: A Review of Recent Studies

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Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents

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Alkaloids as Antimalarial Compounds: A Review of Recent Studies

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In Vitro Study: Antimalarial Activity of Rivet Sea Cucumber Extract (Holothuria atra) With Ethyl Acetate Solvent Against Plasmodium falciparum

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Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979

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Synthesis of Mesoionic 1-aryl-4-(phenyl/p-chlorophenyl)imidazo[2,1-b]thiazol-4-ones and Study of their Monoamine Oxidase, Succinate Dehydrogenase Inhibitory, Anti-convulsant, and Antibacterial Activity

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Gut Microbiota-Mediated Transformation of Coptisine Into a Novel Metabolite 8-Oxocoptisine: Insight Into Its Superior Anti-Colitis Effect

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Studies on Activities and Chemical Characterization of Medicinal Plants in Search for New Antimalarials: A Ten Year Review on Ethnopharmacology

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Identification of Photocatalytic Alkaloids from Coptidis Rhizome by an Offline HPLC/CC/SCD Approach

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Application of Molecular Modeling Techniques to Investigate Phytochemicals as Prospective Anti-Malarial Agents

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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7, its clinical isolate Pf140/SS, and Plasmodium berghei ANKA

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Additional file 1 of Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents

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