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A Blockchain-Based Dynamic Consent Architecture to Support Clinical Genomic Data Sharing (ConsentChain): Proof-of-Concept Study

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Genomics really gets personal: How exome and whole genome sequencing challenge the ethical framework of human genetics research
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Data Privacy Management, Cryptocurrencies and Blockchain Technology
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Medical Record System Using Blockchain, Big Data and Tokenization
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How Blockchain Could Empower eHealth: An Application for Radiation Oncology
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Cosmic User Story Standard
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Whitepaper
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Step by Step Towards Creating a Safe Smart Contract: Lessons and Insights from a Cryptocurrency Lab
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Principles of Security and Trust
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Theoretizität im Logischen Empirismus und im Strukturalismus – erläutert am Fallbeispiel des Neurobiologischen Konstruktivismus
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Blockchain-Based Medical Records Secure Storage and Medical Service Framework
inferredcites →https://doi.org/10.1007/s12687-017-0331-7openalex-snapshot
The challenges of the expanded availability of genomic information: an agenda-setting paper
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International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases
inferredcites →https://doi.org/10.1016/j.atg.2014.09.013openalex-snapshot
The need to redefine genomic data sharing: A focus on data accessibility
inferredcites →https://doi.org/10.1016/j.csbj.2020.03.027openalex-snapshot
Dynamic-informed consent: A potential solution for ethical dilemmas in population sequencing initiatives
inferredcites →https://doi.org/10.1016/j.ejmg.2017.05.001openalex-snapshot
A 'joint venture' model of recontacting in clinical genomics: challenges for responsible implementation
inferredcites →https://doi.org/10.1016/j.scs.2018.02.014openalex-snapshot
Ancile: Privacy-preserving framework for access control and interoperability of electronic health records using blockchain technology
inferredcites →https://doi.org/10.1017/9781108609708.004openalex-snapshot
Blockchains and the General Data Protection Regulation
inferredcites →https://doi.org/10.1038/ejhg.2014.71openalex-snapshot
Dynamic consent: a patient interface for twenty-first century research networks
inferredcites →https://doi.org/10.1038/ejhg.2016.188openalex-snapshot
Recontacting in clinical practice: an investigation of the views of healthcare professionals and clinical scientists in the United Kingdom
inferredcites →https://doi.org/10.1038/gim.2016.196openalex-snapshot
Laboratory and clinical genomic data sharing is crucial to improving genetic health care: a position statement of the American College of Medical Genetics and Genomics
inferredcites →https://doi.org/10.1038/nm.4089openalex-snapshot
Facilitating a culture of responsible and effective sharing of cancer genome data
inferredcites →https://doi.org/10.1038/nrd.2017.246openalex-snapshot
Addressing challenges in the diagnosis and treatment of rare genetic diseases
inferredcites →https://doi.org/10.1038/nrg.2016.162openalex-snapshot
Evolving health care through personal genomics
inferredcites →https://doi.org/10.1038/nrg2483openalex-snapshot
Genotype–phenotype databases: challenges and solutions for the post-genomic era
inferredcites →https://doi.org/10.1038/s41431-019-0560-9openalex-snapshot
Dwarna: a blockchain solution for dynamic consent in biobanking
inferredcites →https://doi.org/10.1038/s41436-018-0017-5openalex-snapshot
Development of a consent resource for genomic data sharing in the clinical setting
inferredcites →https://doi.org/10.1038/s41525-018-0057-4openalex-snapshot
Responsible sharing of biomedical data and biospecimens via the “Automatable Discovery and Access Matrix” (ADA-M)
inferredcites →https://doi.org/10.1080/09332480.2015.1042736openalex-snapshot
O Privacy, Where Art Thou?: Genomics and Privacy
inferredcites →https://doi.org/10.1080/14740338.2017.1313227openalex-snapshot
A review of existing and emerging digital technologies to combat the global trade in fake medicines
inferredcites →https://doi.org/10.1093/annonc/mdx037openalex-snapshot
Towards a global cancer knowledge network: dissecting the current international cancer genomic sequencing landscape
inferredcites →https://doi.org/10.1093/bib/bbx102openalex-snapshot
Federation in genomics pipelines: techniques and challenges
inferredcites →https://doi.org/10.1093/jamia/ocy149openalex-snapshot
Blockchain-based platforms for genomic data sharing: a de-centralized approach in response to the governance problems?
inferredcites →https://doi.org/10.1093/jamia/ocz208openalex-snapshot
“Just tell me what’s going on”: The views of parents of children with genetic conditions regarding the research use of their child’s electronic health record
inferredcites →https://doi.org/10.1101/gr.207464.116openalex-snapshot
Realizing the potential of blockchain technologies in genomics
inferredcites →https://doi.org/10.1108/978-1-83867-299-720191003openalex-snapshot
Blockchain
inferredcites →https://doi.org/10.1108/rmj-12-2015-0042openalex-snapshot
Trusting records: is Blockchain technology the answer?
inferredcites →https://doi.org/10.1109/access.2016.2566339openalex-snapshot
Blockchains and Smart Contracts for the Internet of Things
inferredcites →https://doi.org/10.1109/access.2017.2730843openalex-snapshot
MeDShare: Trust-Less Medical Data Sharing Among Cloud Service Providers via Blockchain
inferredcites →https://doi.org/10.1109/cvcbt.2018.00011openalex-snapshot
Do you Need a Blockchain?
inferredcites →https://doi.org/10.1109/healthcom.2018.8531125openalex-snapshot
Blockchain-based Personal Health Data Sharing System Using Cloud Storage
inferredcites →https://doi.org/10.1109/icdcs.2017.61openalex-snapshot
On the Design of a Blockchain Platform for Clinical Trial and Precision Medicine
inferredcites →https://doi.org/10.1109/icin.2019.8685888openalex-snapshot
Towards a Performance Evaluation of Private Blockchain Frameworks using a Realistic Workload
inferredcites →https://doi.org/10.1109/icuwb.2017.8251003openalex-snapshot
Towards using blockchain technology for IoT data access protection
inferredcites →https://doi.org/10.1109/iicaiet49801.2020.9257811openalex-snapshot
Performance Analysis of Blockchain Platforms: Empirical Evaluation of Hyperledger Fabric and Ethereum
inferredcites →https://doi.org/10.1109/iotdi.2015.39openalex-snapshot
World of Empowered IoT Users
inferredcites →https://doi.org/10.1109/obd.2016.11openalex-snapshot
MedRec: Using Blockchain for Medical Data Access and Permission Management
inferredcites →https://doi.org/10.1109/p2p.2001.990434openalex-snapshot
A definition of peer-to-peer networking for the classification of peer-to-peer architectures and applications
inferredcites →https://doi.org/10.1109/smartcloud.2018.00031openalex-snapshot
Two-Tier Permission-ed and Permission-Less Blockchain for Secure Data Sharing
inferredcites →https://doi.org/10.1109/trustcom/bigdatase.2018.00190openalex-snapshot
On the Design of a Blockchain-Based System to Facilitate Healthcare Data Sharing
inferredcites →https://doi.org/10.1111/cts.12500openalex-snapshot
Future of Rare Diseases Research 2017–2027: An IRDiRC Perspective
inferredcites →https://doi.org/10.1111/nyas.13259openalex-snapshot
Genome privacy: challenges, technical approaches to mitigate risk, and ethical considerations in the United States
inferredcites →https://doi.org/10.1126/science.aaf6162openalex-snapshot
A federated ecosystem for sharing genomic, clinical data
inferredcites →https://doi.org/10.1136/bmj.k2381openalex-snapshot
WannaCry—a year on
inferredcites →https://doi.org/10.1136/medethics-2011-100043openalex-snapshot
Using human tissue: when do we need consent?
inferredcites →https://doi.org/10.1145/2600821.2600846openalex-snapshot
On the need to study the impact of model driven engineering on software processes
inferredcites →https://doi.org/10.1145/3190508.3190538openalex-snapshot
Hyperledger fabric
inferredcites →https://doi.org/10.1146/annurev-genom-082410-101454openalex-snapshot
The Tension Between Data Sharing and the Protection of Privacy in Genomics Research
inferredcites →https://doi.org/10.1155/2019/1431578openalex-snapshot
A Blockchain-Based Platform for Consent Management of Personal Data Processing in the IoT Ecosystem
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0821openalex-snapshot
All the World's a Stage: Facilitating Discovery Science and Improved Cancer Care through the Global Alliance for Genomics and Health
inferredcites →https://doi.org/10.1159/000334718openalex-snapshot
Balancing the Risks and Benefits of Genomic Data Sharing: Genome Research Participants’ Perspectives
inferredcites →https://doi.org/10.1161/circoutcomes.117.003800openalex-snapshot
Blockchain Technology
inferredcites →https://doi.org/10.1177/0963662520942132openalex-snapshot
A deliberative study of public attitudes towards sharing genomic data within NHS genomic medicine services in England
inferredcites →https://doi.org/10.1186/gm342openalex-snapshot
Challenges in clinical genomics
inferredcites →https://doi.org/10.1186/s12910-017-0207-8openalex-snapshot
Healthcare professionals’ and patients’ perspectives on consent to clinical genetic testing: moving towards a more relational approach
inferredcites →https://doi.org/10.1186/s12911-017-0437-1openalex-snapshot
Clinical records anonymisation and text extraction (CRATE): an open-source software system
inferredcites →https://doi.org/10.1186/s40504-014-0022-7openalex-snapshot
Challenges of web-based personal genomic data sharing
inferredcites →https://doi.org/10.1197/jamia.m3191openalex-snapshot
The Shared Health Research Information Network (SHRINE): A Prototype Federated Query Tool for Clinical Data Repositories
inferredcites →https://doi.org/10.12688/f1000research.9756.1openalex-snapshot
Improving data transparency in clinical trials using blockchain smart contracts
inferredcites →https://doi.org/10.1309/ajcpxba69lnscvmhopenalex-snapshot
Comprehensive Genomic Studies
inferredcites →https://doi.org/10.1371/journal.pgen.1005772openalex-snapshot
Consent Codes: Upholding Standard Data Use Conditions
inferredcites →https://doi.org/10.1371/journal.pone.0243043openalex-snapshot
Healthchain: A novel framework on privacy preservation of electronic health records using blockchain technology
inferredcites →https://doi.org/10.1377/hlthaff.2017.1579openalex-snapshot
Real-World Evidence In Support Of Precision Medicine: Clinico-Genomic Cancer Data As A Case Study
inferredcites →https://doi.org/10.18420/blockchain2018_03openalex-snapshot
Privacy by BlockChain Design: A BlockChain-enabled GDPR-compliant Approach for Handling Personal Data
inferredcites →https://doi.org/10.21552/edpl/2016/3/21openalex-snapshot
Practitioner's Corner ∙ Blockchain Technology and the GDPR – How to Reconcile Privacy and Distributed Ledgers?
inferredcites →https://doi.org/10.2196/13598openalex-snapshot
ACTION-EHR: Patient-Centric Blockchain-Based Electronic Health Record Data Management for Cancer Care
inferredcites →https://doi.org/10.2196/19029openalex-snapshot
Generalizable Layered Blockchain Architecture for Health Care Applications: Development, Case Studies, and Evaluation
inferredcites →https://doi.org/10.2196/mhealth.7938openalex-snapshot
Tamper-Resistant Mobile Health Using Blockchain Technology
inferredcites →https://doi.org/10.24251/hicss.2019.850openalex-snapshot
Design of a Forgetting Blockchain: A Possible Way to Accomplish GDPR Compatibility
inferredcites →https://doi.org/10.30953/bhty.v1.10openalex-snapshot
Enforcing Human Subject Regulations using Blockchain and Smart Contracts
inferredcites →https://doi.org/10.30953/bhty.v1.13openalex-snapshot
Blockchain as a Foundation for Sharing Healthcare Data
inferredcites →https://doi.org/10.30953/bhty.v1.34openalex-snapshot
Accelerating Genomic Data Generation and Facilitating Genomic Data Access Using Decentralization, Privacy-Preserving Technologies and Equitable Compensation
inferredcites →https://doi.org/10.3390/app9091788openalex-snapshot
Assessing Blockchain Consensus and Security Mechanisms against the 51% Attack
inferredcites →https://doi.org/10.3390/healthcare9020206openalex-snapshot
A Blockchain-Based Secret-Data Sharing Framework for Personal Health Records in Emergency Condition
inferredcites →https://doi.org/10.3390/jpm6010002openalex-snapshot
Building the Partners HealthCare Biobank at Partners Personalized Medicine: Informed Consent, Return of Research Results, Recruitment Lessons and Operational Considerations
inferredcites →https://doi.org/10.3868/s050-004-015-0003-8openalex-snapshot
DOES THE BUSINESS JUDGMENT RULE HELP PROMOTE CORPORATE SOCIAL RESPONSIBILITY
inferredcites →https://doi.org/10.4258/hir.2020.26.4.265openalex-snapshot
Patient Consent Management by a Purpose-Based Consent Model for Electronic Health Record Based on Blockchain Technology
inferredcites →https://doi.org/10.4337/ielr.2019.01.03openalex-snapshot
GDPR challenges for blockchain technology
inferredcites →https://doi.org/10.48550/arxiv.1709.06528openalex-snapshot
Secure and Trustable Electronic Medical Records Sharing using Blockchain
inferredcites →https://doi.org/10.5210/fm.v2i9.548openalex-snapshot
Formalizing and Securing Relationships on Public Networks
inferredcites →https://doi.org/10.5235/175799610794046186openalex-snapshot
Using NHS Patient Data for Research Without Consent
inferredcites →https://doi.org/10.54648/erpl2018054openalex-snapshot
Interpretation of Contracts and Smart Contracts: Smart Interpretation or Interpretation of Smart Contracts?
inferredcites →https://doi.org/10.5663/aps.v1i1.10138openalex-snapshot
White Paper
inferredcites →https://doi.org/10.5937/vojtehg68-26206openalex-snapshot
Hyperledger frameworks with a special focus on Hyperledger Fabric

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Blockchains and Dynamic Consent in Biobanking
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Integration of Artificial Intelligence and Blockchain
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Exploring Blockchain‐Based Patient‐Centric Healthcare: A Comprehensive Review
inferred← citeshttps://doi.org/10.1007/978-3-031-42944-6_7openalex-snapshot
Blockchain and Dynamic Consent
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Blockchain-Based Dynamic Consent for Healthcare and Research
inferred← citeshttps://doi.org/10.1007/978-3-031-70285-3_41openalex-snapshot
Challenges and Opportunities of Distributed Ledger Technologies for Consent Management – A Review
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Internet of Disease (IOD): A Web Block Chain Framework for Genetic Disease Tracking Using Family Chain
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Artificial Intelligence and Cloud Computing in Healthcare
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Empowering Patients for Disease Diagnosis and Clinical Treatment: A Smart Contract-Enabled Informed Consent Strategy
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DiabeticChain: a novel blockchain approach for patient-centric diabetic data management
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A systematic study on blockchain technology for genomic data management in healthcare: approaches, challenges, and research opportunities
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Smart contract empowered dynamic consent: decentralized storage and access control for healthcare applications
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Design and Architectural Implementation of Consortium Blockchain Based Framework for Open Banking Customer Consent and Data Handling
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2025.110861openalex-snapshot
Healthcare and cutting-edge technology: Advancements, challenges, and future prospects
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Integrating population-based biobanks: Catalyst for advances in precision health
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A blockchain-enabled sharing platform for personal health records
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A framework for sharing of clinical and genetic data for precision medicine applications
inferred← citeshttps://doi.org/10.1093/gigascience/giae021openalex-snapshot
Future-proofing genomic data and consent management: a comprehensive review of technology innovations
inferred← citeshttps://doi.org/10.1093/jamia/ocac165openalex-snapshot
The evolving privacy and security concerns for genomic data analysis and sharing as observed from the iDASH competition
inferred← citeshttps://doi.org/10.1109/access.2022.3194159openalex-snapshot
Development of Blockchain-Based Health Information Exchange Platform Using HL7 FHIR Standards: Usability Test
inferred← citeshttps://doi.org/10.1109/access.2025.3544643openalex-snapshot
Blockchain and NFT-Based Solution for Genomic Data Management, Sharing, and Monetization
inferred← citeshttps://doi.org/10.1109/bcca66705.2025.11229686openalex-snapshot
Towards a Cross-Chain Genomic Data Interoperability Framework: Secure and Compliant Federated Data Exchange Using Private Blockchains
inferred← citeshttps://doi.org/10.1109/compsac69091.2026.00125openalex-snapshot
Scalable Blockchain-Based Healthcare Consent Management with Automated Compliance Verification
inferred← citeshttps://doi.org/10.1109/icbc67748.2026.11575534openalex-snapshot
Demo: EdgeConsent: On-Chain Attribute-Based Access Control for Data Consent Management
inferred← citeshttps://doi.org/10.1109/iccci56745.2023.10223473openalex-snapshot
Blockchain Applications in Healthcare- Recent Advancements
inferred← citeshttps://doi.org/10.1109/iciip68302.2025.11346415openalex-snapshot
Healthcare Big Data Management: A Taxonomy of Data Management Systems and the Emerging Role of Blockchain
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Identity-Centric Architectural Approach for Decentralized Personal Data Exchange
inferred← citeshttps://doi.org/10.1109/isc257844.2023.10293545openalex-snapshot
Blockchain Based Dynamic Consent Management Systems for Enhancing Quality of Life for People with Disabilities
inferred← citeshttps://doi.org/10.1109/scse70081.2026.11499774openalex-snapshot
A Blockchain-Based Patient-Centric Access Control Framework for Electronic Health Record Management with Revocation Mechanism
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SecureConsent: A Blockchain-Based Dynamic and Secure Consent Management for Genomic Data Sharing
inferred← citeshttps://doi.org/10.1145/3563044openalex-snapshot
Blockchain for Genomics: A Systematic Literature Review
inferred← citeshttps://doi.org/10.1155/2022/4389729openalex-snapshot
Authenticated Wireless Links between a Drone and Sensors Using a Blockchain: Case of Smart Farming
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Identifying facilitators of and barriers to the adoption of dynamic consent in digital health ecosystems: a scoping review
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DeSci-Decentralized Science
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Facilitating Patient Consent and Data Sharing with Blockchain Smart Contracts
inferred← citeshttps://doi.org/10.2196/50339openalex-snapshot
Blockchain-Based Dynamic Consent and its Applications for Patient-Centric Research and Health Information Sharing: Protocol for an Integrative Review
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Assessing the Evolution and Influence of Medical Open Databases on Biomedical Research and Health Care Innovation: A 25-Year Perspective With a Focus on Privacy and Privacy-Enhancing Technologies
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Decentralized Biobanking Pathway to Precision Medicine: Futures Study
inferred← citeshttps://doi.org/10.2196/88536openalex-snapshot
Blockchain-Based Dynamic and Revocable Consent for Secondary Health Data Use: Systematic Review
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Double Chain System for Online and Offline Medical Data Sharing via Private and Consortium Blockchain: A System Design Study (Preprint)
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Assessing the Evolution and Influence of Medical Open Databases on Biomedical Research and Healthcare Innovation: A 25-Year Perspective with a Focus on Privacy and Privacy-Enhancing Technologies (Preprint)
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Decentralized Biobanking for the Future of Precision Medicine (Preprint)
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Blockchain-Based Frameworks for Dynamic and Revocable Consent in the Secondary Use of Health Data: A systematic review (Preprint)
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Non-Fungible Tokens for Organoids: Decentralized Biobanking to Empower Patients in Biospecimen Research
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METORY: Development of a Demand-Driven Blockchain-Based Dynamic Consent Platform Tailored for Clinical Trials
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Double chain system for online and offline medical data sharing viaprivate and consortium blockchain: A system design study
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Data Stewardship Barriers to Building Digital Twin Technology for Precision Medicine
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Blockchain-Enabled Privacy-Preserving Ecosystem for DNA Sequence Sharing
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Privacy-First Paradigm for Dynamic Consent Management Systems: Empowering Data Subjects through Decentralized Data Controllers and Privacy-Preserving Techniques
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Blockchain for patients: perspectives of application in digital healthcare
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Blockchain in Critical Care
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Untangling the Intangible
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Cloud computing in population-scale genomics: Strategies, challenges, and future directions
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Additional file 1 of Identifying facilitators of and barriers to the adoption of dynamic consent in digital health ecosystems: a scoping review
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Additional file 2 of Identifying facilitators of and barriers to the adoption of dynamic consent in digital health ecosystems: a scoping review
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.