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Apelin Treatment Increases Complete Fatty Acid Oxidation, Mitochondrial Oxidative Capacity, and Biogenesis in Muscle of Insulin-Resistant Mice

https://doi.org/10.2337/db11-0100
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1006/bbrc.1998.9489openalex-snapshot
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
inferredcites →https://doi.org/10.1007/bf03165767openalex-snapshot
Expanding role for the apelin/APJ system in physiopathology
inferredcites →https://doi.org/10.1007/s00018-008-8244-6openalex-snapshot
AMP-activated protein kinase in skeletal muscle: From structure and localization to its role as a master regulator of cellular metabolism
inferredcites →https://doi.org/10.1007/s00125-003-1265-7openalex-snapshot
Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes
inferredcites →https://doi.org/10.1016/j.bbagen.2011.05.004openalex-snapshot
Apelin-transgenic mice exhibit a resistance against diet-induced obesity by increasing vascular mass and mitochondrial biogenesis in skeletal muscle
inferredcites →https://doi.org/10.1016/j.bbrc.2011.04.012openalex-snapshot
Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity
inferredcites →https://doi.org/10.1016/j.cmet.2005.05.004openalex-snapshot
Metabolic control through the PGC-1 family of transcription coactivators
inferredcites →https://doi.org/10.1016/j.cmet.2007.10.013openalex-snapshot
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
inferredcites →https://doi.org/10.1016/j.cmet.2008.10.003openalex-snapshot
Apelin Stimulates Glucose Utilization in Normal and Obese Insulin-Resistant Mice
inferredcites →https://doi.org/10.1016/j.jneumeth.2008.12.023openalex-snapshot
Method for functional study of mitochondria in rat hypothalamus
inferredcites →https://doi.org/10.1016/j.phrs.2005.07.008openalex-snapshot
Methylamine but not mafenide mimics insulin-like activity of the semicarbazide-sensitive amine oxidase-substrate benzylamine on glucose tolerance and on human adipocyte metabolism
inferredcites →https://doi.org/10.1016/j.tem.2008.08.001openalex-snapshot
Is mitochondrial dysfunction a cause of insulin resistance?
inferredcites →https://doi.org/10.1016/s0021-9258(17)34394-6openalex-snapshot
Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay.
inferredcites →https://doi.org/10.1016/s0021-9258(19)78162-9openalex-snapshot
Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases
inferredcites →https://doi.org/10.1038/ng1180openalex-snapshot
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
inferredcites →https://doi.org/10.1038/oby.2009.510openalex-snapshot
Increased Levels of Plasma Acylcarnitines in Obesity and Type 2 Diabetes and Identification of a Marker of Glucolipotoxicity
inferredcites →https://doi.org/10.1073/pnas.1032913100openalex-snapshot
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
inferredcites →https://doi.org/10.1074/jbc.m507621200openalex-snapshot
Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency
inferredcites →https://doi.org/10.1074/jbc.m602992200openalex-snapshot
5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranoside-induced AMP-activated Protein Kinase Phosphorylation Inhibits Basal and Insulin-stimulated Glucose Uptake, Lipid Synthesis, and Fatty Acid Oxidation in Isolated Rat Adipocytes
inferredcites →https://doi.org/10.1093/clinchem/43.11.2106openalex-snapshot
Rapid diagnosis of MCAD deficiency: quantitative analysis of octanoylcarnitine and other acylcarnitines in newborn blood spots by tandem mass spectrometry
inferredcites →https://doi.org/10.1113/jphysiol.2006.109512openalex-snapshot
The role of AMP‐activated protein kinase in mitochondrial biogenesis
inferredcites →https://doi.org/10.1139/h07-083openalex-snapshot
Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1α: implications for metabolic disease
inferredcites →https://doi.org/10.1139/o59-099openalex-snapshot
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
inferredcites →https://doi.org/10.1152/ajpendo.00312.2005openalex-snapshot
Identification of fatty acid translocase on human skeletal muscle mitochondrial membranes: essential role in fatty acid oxidation
inferredcites →https://doi.org/10.1152/ajpendo.00385.2009openalex-snapshot
Apelin is necessary for the maintenance of insulin sensitivity
inferredcites →https://doi.org/10.1152/ajpendo.00598.2009openalex-snapshot
Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans
inferredcites →https://doi.org/10.1152/ajpendo.2000.278.5.e778openalex-snapshot
Endurance training increases FFA oxidation and reduces triacylglycerol utilization in contracting rat soleus
inferredcites →https://doi.org/10.1152/ajpregu.00422.2009openalex-snapshot
The effects of apelin treatment on skeletal muscle mitochondrial content
inferredcites →https://doi.org/10.1161/circresaha.107.158659openalex-snapshot
Impaired Heart Contractility in Apelin Gene–Deficient Mice Associated With Aging and Pressure Overload
inferredcites →https://doi.org/10.1161/circresaha.107.165472openalex-snapshot
Role of Mitochondrial Dysfunction in Insulin Resistance
inferredcites →https://doi.org/10.1172/jci32601openalex-snapshot
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
inferredcites →https://doi.org/10.1210/en.2004-0359openalex-snapshot
Modification of the Terminal Residue of Apelin-13 Antagonizes Its Hypotensive Action
inferredcites →https://doi.org/10.1210/en.2004-1427openalex-snapshot
Apelin, a Newly Identified Adipokine Up-Regulated by Insulin and Obesity
inferredcites →https://doi.org/10.1210/en.2006-1270openalex-snapshot
Apelin, an APJ Receptor Ligand, Regulates Body Adiposity and Favors the Messenger Ribonucleic Acid Expression of Uncoupling Proteins in Mice
inferredcites →https://doi.org/10.1210/en.2008-0180openalex-snapshot
Brain Glucagon-Like Peptide 1 Signaling Controls the Onset of High-Fat Diet-Induced Insulin Resistance and Reduces Energy Expenditure
inferredcites →https://doi.org/10.1210/en.2010-0576openalex-snapshot
Apelin Decreases Lipolysis via Gq, Gi, and AMPK-Dependent Mechanisms
inferredcites →https://doi.org/10.1210/er.2009-0027openalex-snapshot
The Role of Mitochondria in the Pathogenesis of Type 2 Diabetes
inferredcites →https://doi.org/10.1677/jme-10-0105openalex-snapshot
Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo
inferredcites →https://doi.org/10.2337/db06-s002openalex-snapshot
Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4074496openalex-extracted
The Role of Apelin in Obesity Treatment by Exercise Training
inferred← citeshttps://doi.org/10.1002/2211-5463.12587openalex-snapshot
Hypoxia exposure alleviates impaired muscular metabolism, glucose tolerance, and aerobic capacity in apelin‐knockout mice
inferred← citeshttps://doi.org/10.1002/advs.202507713openalex-snapshot
Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney
inferred← citeshttps://doi.org/10.1002/cbin.11191openalex-snapshot
Apelin and stem cells: the role played in the cardiovascular system and energy metabolism
inferred← citeshttps://doi.org/10.1002/cphy.c170028openalex-snapshot
Apelinergic System Structure and Function
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2018.tb00012.xopenalex-snapshot
Apelinergic System Structure and Function
inferred← citeshttps://doi.org/10.1002/jcsm.12766openalex-snapshot
Is muscle and protein loss relevant in long‐term fasting in healthy men? A prospective trial on physiological adaptations
inferred← citeshttps://doi.org/10.1002/mus.25596openalex-snapshot
Effects of exercise‐induced apelin levels on skeletal muscle and their capillarization in type 2 diabetic rats
inferred← citeshttps://doi.org/10.1002/pdi.2109openalex-snapshot
Novel therapies in type 2 diabetes: insulin resistance
inferred← citeshttps://doi.org/10.1002/pep2.24064openalex-snapshot
Apelins, ELABELA, and their derivatives: Peptidic regulators of the cardiovascular system and beyond
inferred← citeshttps://doi.org/10.1007/978-1-62703-770-9_17openalex-snapshot
Adipokines in Nonalcoholic Fatty Liver Disease
inferred← citeshttps://doi.org/10.1007/978-2-8178-0332-6_14openalex-snapshot
Fonctions métaboliques de l’apeline
inferred← citeshttps://doi.org/10.1007/978-2-8178-0343-2_14openalex-snapshot
Apelin Metabolic Functions
inferred← citeshttps://doi.org/10.1007/978-3-031-40116-9_56openalex-snapshot
Obesity, Myokines, and Metabolic Health
inferred← citeshttps://doi.org/10.1007/978-3-319-12125-3_56-1openalex-snapshot
Obesity, Myokines, and Metabolic Health
inferred← citeshttps://doi.org/10.1007/978-3-319-41677-9_7openalex-snapshot
Apelin and Cancer
inferred← citeshttps://doi.org/10.1007/978-3-319-89506-2_9openalex-snapshot
Adipokines, Inflammation, and Insulin Resistance in Obesity
inferred← citeshttps://doi.org/10.1007/s00109-020-01993-wopenalex-snapshot
A multitarget angiogenesis inhibitor, CTT peptide-endostatin mimic-kringle 5, prevents diet-induced obesity
inferred← citeshttps://doi.org/10.1007/s00125-026-06863-7openalex-snapshot
Unimolecular GLP-1/APJ receptor co-agonism improves metabolism and dyslipidaemia as well as normalising hepatic triglyceride and aminotransferase elevation in high-fat-fed mice
inferred← citeshttps://doi.org/10.1007/s00335-014-9538-7openalex-snapshot
The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis
inferred← citeshttps://doi.org/10.1007/s00394-014-0668-1openalex-snapshot
Combination of low dose of the anti-adipogenic agents resveratrol and phenelzine in drinking water is not sufficient to prevent obesity in very-high-fat diet-fed mice
inferred← citeshttps://doi.org/10.1007/s10557-026-07913-3openalex-snapshot
The Apelin-APJ Axis in Heart Failure: Mechanistic Insights, Clinical Evidence, and Translational Challenges
inferred← citeshttps://doi.org/10.1007/s10989-016-9551-7openalex-snapshot
Betaine Down Regulates Apelin Gene Expression in Cardiac and Adipose Tissues of Insulin Resistant Diabetic Rats Fed by High-Calorie Diet
inferred← citeshttps://doi.org/10.1007/s10989-016-9565-1openalex-snapshot
5-Hydroxydecanoate Abolishes Cardioprotective Effects of a Structural Analogue of Apelin-12 in Ischemia/Reperfusion Injury
inferred← citeshttps://doi.org/10.1007/s10989-017-9638-9openalex-snapshot
Effect of Intracerebroventricular Administration of Apelin-13 on the Hypothalamus–Pituitary–Thyroid Axis and Peripheral Uncoupling Proteins
inferred← citeshttps://doi.org/10.1007/s11357-013-9595-yopenalex-snapshot
AMPK activation—protean potential for boosting healthspan
inferred← citeshttps://doi.org/10.1007/s11690-013-0364-yopenalex-snapshot
Le dialogue intestin, tissu adipeux et hypothalamus influence l’obésité et le diabète de type 2
inferred← citeshttps://doi.org/10.1007/s11695-016-2509-1openalex-snapshot
Plasma Apelin and Asymmetric Dimethylarginine (ADMA) Levels Shortly After Laparoscopic Greater Curvature Plication
inferred← citeshttps://doi.org/10.1007/s12012-026-10107-wopenalex-snapshot
Targeting the Apelin–APJ Axis: A Promising Strategy to Mitigate Anthracycline-Induced Cardiotoxicity
inferred← citeshttps://doi.org/10.1007/s12020-018-1536-1openalex-snapshot
Chronic apelin treatment improves hepatic lipid metabolism in obese and insulin-resistant mice by an indirect mechanism
inferred← citeshttps://doi.org/10.1007/s12035-025-05519-8openalex-snapshot
Apelin Regulates PVN Dopaminergic Activity and Limits Weight Gain in Mice: An Effect Attenuated by High-Fat Diet
inferred← citeshttps://doi.org/10.1007/s12272-026-01624-xopenalex-snapshot
Exercise-induced myokines in metabolic regulation: mechanisms, mimetics, and translational potential
inferred← citeshttps://doi.org/10.1007/s13105-026-01233-8openalex-snapshot
Myokines and mitochondrial function in cardiometabolic diseases
inferred← citeshttps://doi.org/10.1007/s13679-015-0174-7openalex-snapshot
Novel Mediators of Adipose Tissue and Muscle Crosstalk
inferred← citeshttps://doi.org/10.1016/b978-0-12-811752-1.00003-1openalex-snapshot
Overview of the Cross-Talk Between Hormones and Mitochondria
inferred← citeshttps://doi.org/10.1016/b978-0-12-822146-4.00002-8openalex-snapshot
Molecular mechanisms of exercise providing therapeutic rationale to counter sarcopenia
inferred← citeshttps://doi.org/10.1016/b978-0-443-51072-4.00014-4openalex-snapshot
Molecular and functional characteristics of modified C-terminal fragments of apelin with cardioprotective properties
inferred← citeshttps://doi.org/10.1016/j.advms.2014.11.001openalex-snapshot
The effects of apelin treatment on a rat model of type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.ajpath.2016.12.011openalex-snapshot
High Glucose–Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase
inferred← citeshttps://doi.org/10.1016/j.ando.2016.01.001openalex-snapshot
New adipokines
inferred← citeshttps://doi.org/10.1016/j.animal.2025.101551openalex-snapshot
Early high nutrition enhances grass-fed beef productivity through epigenetically regulated muscle metabolism, altered early adipogenesis, and rumen fermentation dynamics
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2025.120446openalex-snapshot
Pigment epithelium-derived factor prevents endothelial dysfunction in early stage of hyperlipidemia by regulating endothelial fatty acid transport
inferred← citeshttps://doi.org/10.1016/j.bbamem.2024.184289openalex-snapshot
Localized apelin-17 analogue-bicelle interactions as a facilitator of membrane-catalyzed receptor recognition and binding
inferred← citeshttps://doi.org/10.1016/j.bbr.2020.113059openalex-snapshot
Aplnr knockout mice display sex-specific changes in conditioned fear
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117813openalex-snapshot
Sarcopenia: An overview of emerging therapies and pathophysiological insights in age-related skeletal muscle decline
inferred← citeshttps://doi.org/10.1016/j.beem.2026.102115openalex-snapshot
Key hormones for the control of muscle mass: Myokines
inferred← citeshttps://doi.org/10.1016/j.biocel.2018.08.013openalex-snapshot
Dynamic transcriptome profile in db/db skeletal muscle reveal critical roles for long noncoding RNA regulator
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111397openalex-snapshot
The melatonergic pathway and its interactions in modulating respiratory system disorders
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118879openalex-snapshot
Adipocyte-derived apelin protects against radiation-induced enteropathy through Wnt/β-catenin–mediated intestinal regeneration
inferred← citeshttps://doi.org/10.1016/j.cca.2014.03.030openalex-snapshot
Plasma apelin: A novel biomarker for predicting diabetes
inferred← citeshttps://doi.org/10.1016/j.cca.2018.10.011openalex-snapshot
Apelin/APJ system: A novel promising target for anti-aging intervention
inferred← citeshttps://doi.org/10.1016/j.cellsig.2017.08.003openalex-snapshot
Apelin protects against liver X receptor-mediated steatosis through AMPK and PPARα in human and mouse hepatocytes
inferred← citeshttps://doi.org/10.1016/j.celrep.2016.02.076openalex-snapshot
α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108461openalex-snapshot
Maternal Inactivity Programs Skeletal Muscle Dysfunction in Offspring Mice by Attenuating Apelin Signaling and Mitochondrial Biogenesis
inferred← citeshttps://doi.org/10.1016/j.cmet.2012.10.016openalex-snapshot
Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance
inferred← citeshttps://doi.org/10.1016/j.cophys.2019.04.008openalex-snapshot
Current advances in our understanding of exercise as medicine in metabolic disease
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2017.01.001openalex-snapshot
Effects of adipokines and obesity on uterine contractility
inferred← citeshttps://doi.org/10.1016/j.diabet.2019.02.006openalex-snapshot
Role of myokines in the development of skeletal muscle insulin resistance and related metabolic defects in type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.diabres.2018.12.012openalex-snapshot
Elevated blood apelin levels in type 2 diabetes mellitus: A systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1016/j.dsx.2017.07.016openalex-snapshot
An overview on biological functions and emerging therapeutic roles of apelin in diabetes mellitus
inferred← citeshttps://doi.org/10.1016/j.ejphar.2015.05.017openalex-snapshot
Apelin receptors: From signaling to antidiabetic strategy
inferred← citeshttps://doi.org/10.1016/j.ejphar.2021.174286openalex-snapshot
Apelin/APJ system: A novel therapeutic target for locomotor system diseases
inferred← citeshttps://doi.org/10.1016/j.exger.2020.111022openalex-snapshot
Sarcopenic obesity: Myokines as potential diagnostic biomarkers and therapeutic targets?
inferred← citeshttps://doi.org/10.1016/j.gene.2018.04.003openalex-snapshot
Effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats
inferred← citeshttps://doi.org/10.1016/j.ijcard.2016.11.215openalex-snapshot
Apelin/APJ system: A bifunctional target for cardiac hypertrophy
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.108230openalex-snapshot
Apelin-13-Mediated AMPK ameliorates endothelial barrier dysfunction in acute lung injury mice via improvement of mitochondrial function and autophagy
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104589openalex-snapshot
A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle
inferred← citeshttps://doi.org/10.1016/j.jep.2021.114487openalex-snapshot
Andrographolide, a novel inducer of apelin gene expression
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2015.03.003openalex-snapshot
Grape seed procyanidins administered at physiological doses to rats during pregnancy and lactation promote lipid oxidation and up-regulate AMPK in the muscle of male offspring in adulthood
inferred← citeshttps://doi.org/10.1016/j.mce.2021.111278openalex-snapshot
The therapeutic potentials of apelin in obesity-associated diseases
inferred← citeshttps://doi.org/10.1016/j.metabol.2011.10.008openalex-snapshot
Effects of weight loss and exercise on chemerin serum concentrations and adipose tissue expression in human obesity
inferred← citeshttps://doi.org/10.1016/j.metabol.2023.155597openalex-snapshot
Current and investigational medications for the treatment of sarcopenia
inferred← citeshttps://doi.org/10.1016/j.molmet.2015.07.007openalex-snapshot
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice
inferred← citeshttps://doi.org/10.1016/j.molmet.2018.10.012openalex-snapshot
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
inferred← citeshttps://doi.org/10.1016/j.npep.2018.05.008openalex-snapshot
Apelin, a promising target for Alzheimer disease prevention and treatment
inferred← citeshttps://doi.org/10.1016/j.nut.2022.111629openalex-snapshot
Could “cellular exercise” be the missing ingredient in a healthy life? Diets, caloric restriction, and exercise-induced hormesis
inferred← citeshttps://doi.org/10.1016/j.peptides.2012.08.004openalex-snapshot
In vivo, ex vivo, and in vitro studies on apelin's effect on myocardial glucose uptake
inferred← citeshttps://doi.org/10.1016/j.peptides.2018.04.011openalex-snapshot
Apelin and Elabela/Toddler; double ligands for APJ/Apelin receptor in heart development, physiology, and pathology
inferred← citeshttps://doi.org/10.1016/j.peptides.2018.09.006openalex-snapshot
Elabela, a newly discovered APJ ligand: Similarities and differences with Apelin
inferred← citeshttps://doi.org/10.1016/j.peptides.2019.03.006openalex-snapshot
The effect of apelin-13 on pancreatic islet beta cell mass and myocardial fatty acid and glucose metabolism of experimental type 2 diabetic rats
inferred← citeshttps://doi.org/10.1016/j.peptides.2021.170697openalex-snapshot
Apelin pathway in cardiovascular, kidney, and metabolic diseases: Therapeutic role of apelin analogs and apelin receptor agonists
inferred← citeshttps://doi.org/10.1016/j.pharma.2012.07.008openalex-snapshot
Expansion de la masse grasse, acides gras et adipokines : des marqueurs métaboliques et des facteurs de risque de pathologies cardiovasculaires
inferred← citeshttps://doi.org/10.1016/j.pharmr.2026.100130openalex-snapshot
International Union of Basic and Clinical Pharmacology. CXXI. Apelin receptor pharmacology in the human cardiovascular system and emerging clinical applications
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107207openalex-snapshot
Decreased circulating IPA levels identify subjects with metabolic comorbidities: A multi-omics study
inferred← citeshttps://doi.org/10.1016/j.prostaglandins.2015.07.003openalex-snapshot
Omega-3 fatty acids and adipose tissue function in obesity and metabolic syndrome
inferred← citeshttps://doi.org/10.1016/j.psyneuen.2022.105711openalex-snapshot
Apelin controls emotional behavior in age- and metabolic state-dependent manner
inferred← citeshttps://doi.org/10.1016/j.rvsc.2019.07.012openalex-snapshot
Serum Apelin-36 alteration in late pregnancy and early lactation of dairy cows and its association with negative energy balance markers
inferred← citeshttps://doi.org/10.1016/j.surg.2015.01.011openalex-snapshot
Apelin inhibits the activation of the nucleotide-binding domain and the leucine-rich, repeat-containing family, pyrin-containing 3 (NLRP3) inflammasome and ameliorates insulin resistance in severely burned rats
inferred← citeshttps://doi.org/10.1016/j.tem.2012.02.005openalex-snapshot
Apelin, a promising target for type 2 diabetes treatment?
inferred← citeshttps://doi.org/10.1016/j.tem.2013.11.001openalex-snapshot
Endothelium as a gatekeeper of fatty acid transport
inferred← citeshttps://doi.org/10.1016/j.tice.2026.103455openalex-snapshot
Obesity impacts the histological features and modifies the apelin levels in different skeletal muscles of aging female wistar rat
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2013.07.002openalex-snapshot
Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction
inferred← citeshttps://doi.org/10.1016/j.ymgme.2016.07.012openalex-snapshot
Apelin/APJ system as a therapeutic target in diabetes and its complications
inferred← citeshttps://doi.org/10.1016/s1957-2557(19)30213-5openalex-snapshot
L'apeline : au-delà de ses fonctions reconnues, un nouveau rôle prometteur dans la prise en charge de la sarcopénie
inferred← citeshttps://doi.org/10.1021/acs.chemrev.8b00807openalex-snapshot
Crystal Structures of Protein-Bound Cyclic Peptides
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01448openalex-snapshot
Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00723openalex-snapshot
Synthetic Modification within the “RPRL” Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation
inferred← citeshttps://doi.org/10.1038/ijo.2014.122openalex-snapshot
Transition from metabolic adaptation to maladaptation of the heart in obesity: role of apelin
inferred← citeshttps://doi.org/10.1038/s12276-019-0273-8openalex-snapshot
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1038/s41467-025-66305-7openalex-snapshot
Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment
inferred← citeshttps://doi.org/10.1038/s41586-025-08811-8openalex-snapshot
Constitutively active glucagon receptor drives high blood glucose in birds
inferred← citeshttps://doi.org/10.1038/s41598-017-08920-zopenalex-snapshot
iNOS promotes hypothalamic insulin resistance associated with deregulation of energy balance and obesity in rodents
inferred← citeshttps://doi.org/10.1038/s41598-018-32354-wopenalex-snapshot
Increasing Acyl CoA thioesterase activity alters phospholipid profile without effect on insulin action in skeletal muscle of rats
inferred← citeshttps://doi.org/10.1038/s41598-026-43238-9openalex-snapshot
Microneedle patch–based delivery of Pyr-Apelin-13 reverses functional and structural deficits in age-related sarcopenia
inferred← citeshttps://doi.org/10.1038/srep16104openalex-snapshot
Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity
inferred← citeshttps://doi.org/10.1038/srep31849openalex-snapshot
Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice
inferred← citeshttps://doi.org/10.1039/d0fo01269fopenalex-snapshot
Impact of diets rich in olive oil, palm oil or lard on myokine expression in rats
inferred← citeshttps://doi.org/10.1042/bcj20200343openalex-snapshot
Loss of APJ mediated β-arrestin signalling improves high-fat diet induced metabolic dysfunction but does not alter cardiac function in mice
inferred← citeshttps://doi.org/10.1051/medsci/20153103013openalex-snapshot
Le récepteur de l’apeline
inferred← citeshttps://doi.org/10.1055/s-0033-1351321openalex-snapshot
Hypothalamic Actions of Apelin on Energy Metabolism: New Insight on Glucose Homeostasis and Metabolic Disorders
inferred← citeshttps://doi.org/10.1074/jbc.m113.526210openalex-snapshot
Apelin Attenuates Oxidative Stress in Human Adipocytes
inferred← citeshttps://doi.org/10.1074/jbc.m115.643817openalex-snapshot
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes
inferred← citeshttps://doi.org/10.1080/13813455.2018.1453521openalex-snapshot
Interactive effects of apelin, renin–angiotensin system and nitric oxide in treatment of obesity-induced type 2 diabetes mellitus in male albino rats
inferred← citeshttps://doi.org/10.1080/15563650.2025.2510528openalex-snapshot
Exogenous [Pyr 1 ]apelin-13 prevents bupivacaine-induced cardiotoxicity via the apelin (APJ) receptor
inferred← citeshttps://doi.org/10.1080/17446651.2018.1416290openalex-snapshot
Exercise-induced myokines: a brief review of controversial issues of this decade
inferred← citeshttps://doi.org/10.1080/20905068.2024.2320039openalex-snapshot
The relation between plasma apelin 36 and insulin resistance in obese type 2 diabetic Egyptian population
inferred← citeshttps://doi.org/10.1093/abbs/gmt040openalex-snapshot
Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis
inferred← citeshttps://doi.org/10.1093/abbs/gmt140openalex-snapshot
ERK1/2 mediates lung adenocarcinoma cell proliferation and autophagy induced by apelin-13
inferred← citeshttps://doi.org/10.1093/cvr/cvad171openalex-snapshot
Targeting the apelin system for the treatment of cardiovascular diseases
inferred← citeshttps://doi.org/10.1093/lifemeta/loae006openalex-snapshot
Myokines: metabolic regulation in obesity and type 2 diabetes
inferred← citeshttps://doi.org/10.1093/ndt/gft261openalex-snapshot
Adipokines protecting CKD
inferred← citeshttps://doi.org/10.1101/cshperspect.a029793openalex-snapshot
Skeletal Muscle as an Endocrine Organ: The Role of Myokines in Exercise Adaptations
inferred← citeshttps://doi.org/10.1111/bph.13485openalex-snapshot
Apelin‐13 administration protects against ischaemia/reperfusion‐mediated apoptosis through the FoxO1 pathway in high‐fat diet‐induced obesity
inferred← citeshttps://doi.org/10.1111/dom.13055openalex-snapshot
Apelin administration improves insulin sensitivity in overweight men during hyperinsulinaemic‐euglycaemic clamp
inferred← citeshttps://doi.org/10.1111/dom.70091openalex-snapshot
Adipocyte‐specific IGF1R knockout activates the β‐catenin/apelin axis to combat diet‐induced obesity in male mice
inferred← citeshttps://doi.org/10.1111/febs.16173openalex-snapshot
Prenatal exercise in fetal development: a placental perspective
inferred← citeshttps://doi.org/10.1124/pr.119.017533openalex-snapshot
International Union of Basic and Clinical Pharmacology. CVII. Structure and Pharmacology of the Apelin Receptor with a Recommendation that Elabela/Toddler Is a Second Endogenous Peptide Ligand
inferred← citeshttps://doi.org/10.1126/scitranslmed.aad4000openalex-snapshot
Endothelial APLNR regulates tissue fatty acid uptake and is essential for apelin’s glucose-lowering effects
inferred← citeshttps://doi.org/10.1139/bcb-2014-0072openalex-snapshot
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR
inferred← citeshttps://doi.org/10.1152/ajpcell.00427.2023openalex-snapshot
Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model
inferred← citeshttps://doi.org/10.1152/ajpendo.00215.2014openalex-snapshot
Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans
inferred← citeshttps://doi.org/10.1152/japplphysiol.00186.2022openalex-snapshot
Muscle strength after resistance training correlates to mediators of muscle mass and mitochondrial respiration in middle-aged adults
inferred← citeshttps://doi.org/10.1152/physiol.00024.2024openalex-snapshot
Charting the Molecular Terrain of Exercise: Energetics, Exerkines, and the Future of Multiomic Mapping
inferred← citeshttps://doi.org/10.1155/2021/8866725openalex-snapshot
Relationship between Apelin/APJ Signaling, Oxidative Stress, and Diseases
inferred← citeshttps://doi.org/10.1158/1541-7786.22526565.v1openalex-snapshot
FigureS1 from Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-20-0991openalex-snapshot
Adipokine Apelin/APJ Pathway Promotes Peritoneal Dissemination of Ovarian Cancer Cells by Regulating Lipid Metabolism
inferred← citeshttps://doi.org/10.1159/000348667openalex-snapshot
Effects of Weight Loss and Exercise on Apelin Serum Concentrations and Adipose Tissue Expression in Human Obesity
inferred← citeshttps://doi.org/10.1159/000492093openalex-snapshot
Serum Elabela/Toddler Levels Are Associated with Albuminuria in Patients with Type 2 Diabetes
inferred← citeshttps://doi.org/10.1161/circresaha.115.301130openalex-snapshot
The Metabolic Theory of Pulmonary Arterial Hypertension
inferred← citeshttps://doi.org/10.1161/circresaha.124.325614openalex-snapshot
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
inferred← citeshttps://doi.org/10.1161/hypertensionaha.116.08916openalex-snapshot
Beneficial Effects of Apelin on Vascular Function in Patients With Central Obesity
inferred← citeshttps://doi.org/10.1161/jaha.120.017247openalex-snapshot
p53‐Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio‐oncology
inferred← citeshttps://doi.org/10.1172/jci.insight.87489openalex-snapshot
Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells
inferred← citeshttps://doi.org/10.1177/10998004231178835openalex-snapshot
Apelin and Visfatin Expression in Placental Tissue in Women With Preeclampsia and Overweight/Obesity
inferred← citeshttps://doi.org/10.1177/11795514221074679openalex-snapshot
Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update
inferred← citeshttps://doi.org/10.1186/s12864-024-10417-9openalex-snapshot
Apelin-13 modulates the endometrial transcriptome of the domestic pig during implantation
inferred← citeshttps://doi.org/10.1186/s12933-025-02863-wopenalex-snapshot
Crosstalk between perivascular adipose tissue and adipocyte-derived peptide in the pathogenesis of diabetic cardiomyopathy
inferred← citeshttps://doi.org/10.1194/jlr.r094060openalex-snapshot
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
inferred← citeshttps://doi.org/10.1210/en.2012-2034openalex-snapshot
Increased Bone Mass in Mice Lacking the Adipokine Apelin
inferred← citeshttps://doi.org/10.1210/endrev/bnaf032openalex-snapshot
Advances in Adipose Tissue Biology
inferred← citeshttps://doi.org/10.1210/jc.2012-3111openalex-snapshot
Enhanced Skeletal Muscle Lipid Oxidative Efficiency in Insulin-Resistant vs Insulin-Sensitive Nondiabetic, Nonobese Humans
inferred← citeshttps://doi.org/10.1213/ane.0000000000005692openalex-snapshot
Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate–Activated Protein Kinase Pathway
inferred← citeshttps://doi.org/10.1254/fpj.153.172openalex-snapshot
The functional role of endogenous APJ agonists; Apelin and Elabela/Toddler in cardiovascular diseases
inferred← citeshttps://doi.org/10.12659/msm.890124openalex-snapshot
Apelin-13 Decreases Lipid Storage in Hypertrophic Adipocytes In Vitro Through the Upregulation of AQP7 Expression by the PI3K Signaling Pathway
inferred← citeshttps://doi.org/10.12677/acm.2024.1492506openalex-snapshot
Advances in the Study of Adipokine Apelin and Pathogenesis of Gestational Diabetes Mellitus
inferred← citeshttps://doi.org/10.12816/0045168openalex-snapshot
EFFECTS OF -3 POLYUNSATURATED FATTY ACIDS SUPPLEMENTATION ON LIVER FUNCTION AND SERUM APELIN-13 IN TYPE II DIABETIC RATS
inferred← citeshttps://doi.org/10.1371/journal.pone.0051236openalex-snapshot
Altered Glucose Homeostasis Is Associated with Increased Serum Apelin Levels in Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1371/journal.pone.0078874openalex-snapshot
Effects of Dietary Eicosapentaenoic Acid (EPA) Supplementation in High-Fat Fed Mice on Lipid Metabolism and Apelin/APJ System in Skeletal Muscle
inferred← citeshttps://doi.org/10.14814/phy2.13450openalex-snapshot
Dietary weight loss‐induced changes in RBP 4, FFA , and ACE predict weight regain in people with overweight and obesity
inferred← citeshttps://doi.org/10.15252/embj.201387038openalex-snapshot
The miR‐379/miR‐410 cluster at the imprinted Dlk1‐Dio3 domain controls neonatal metabolic adaptation
inferred← citeshttps://doi.org/10.1530/joe-12-0498openalex-snapshot
Adipokine inflammation and insulin resistance: the role of glucose, lipids and endotoxin
inferred← citeshttps://doi.org/10.1530/joe-13-0227openalex-snapshot
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis
inferred← citeshttps://doi.org/10.18087/cardio.2026.2.n3008openalex-snapshot
Cardiometabolic and Antioxidant Properties of Modified C-Terminal Fragments of Apelin in Experimental Cardiac Pathology
inferred← citeshttps://doi.org/10.18097/pbmc20247003135openalex-snapshot
The structural analogue of apelin-12 prevents energy disorders in the heart in experimental type 1 diabetes mellitus
inferred← citeshttps://doi.org/10.20452/pamw.3390openalex-snapshot
Effects of antihypertensive treatment on plasma apelin, resistin, and visfatin concentrations
inferred← citeshttps://doi.org/10.21203/rs.3.rs-10118506/v1openalex-snapshot
An orally active apelin receptor agonist improves Alzheimer’s disease pathology and cognitive functions by restoring microglial metabolism
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2749295/v1openalex-snapshot
Exogenous [Pyr 1 ]apelin-13 prevents bupivacaine-induced cardiotoxicity via the receptor APJ
inferred← citeshttps://doi.org/10.21203/rs.3.rs-41868/v1openalex-snapshot
Habitual Dietary Intakes of Fat were Associated with Apelin Gene Expression in Visceral and Subcutaneous Adipose Tissues
inferred← citeshttps://doi.org/10.21203/rs.3.rs-95255/v1openalex-snapshot
Apelin-mediated deamidation modification of HMGA1 promotes tumorigenesis by enhancing SRBEP1 activity and Lipid Synthesis
inferred← citeshttps://doi.org/10.21608/mjcu.2018.61483openalex-snapshot
Serum Apelin Level in Normal and Gestational Diabetic Rats: Effect of Treatment with Vitamin D
inferred← citeshttps://doi.org/10.2174/0929867325666171205162248openalex-snapshot
New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.22074/cellj.2018.5408openalex-snapshot
Effect of L-Carnitine Supplementation on Apelin and Apelin Receptor (Apj) Expression in Cardiac Muscle of Obese Diabetic Rats.
inferred← citeshttps://doi.org/10.2217/clp.13.19openalex-snapshot
Antiobesity effects of a–lipoic acid supplementation
inferred← citeshttps://doi.org/10.23893/1307-2080.aps.05523openalex-snapshot
On the relationship between serum apelin levels and some parameters related to oxidative stress and energy metabolism in obese and non-obese
inferred← citeshttps://doi.org/10.2478/rrlm-2018-0019openalex-snapshot
Involvement of inflammatory cytokines in obesity and its complications
inferred← citeshttps://doi.org/10.26686/wgtn.17134046openalex-snapshot
Investigating the role of the apelinergic system in glioblastoma
inferred← citeshttps://doi.org/10.26686/wgtn.17134046.v1openalex-snapshot
Investigating the role of the apelinergic system in glioblastoma
inferred← citeshttps://doi.org/10.31362/patd.1247216openalex-snapshot
Investigation of the Possible Relation of Apelin, Kynurenine and IL-4/IL-10/IL-12/Tnf-alfa Levels with Clinical and Metabolic Parameters in Obesity
inferred← citeshttps://doi.org/10.3389/fendo.2022.820002openalex-snapshot
The Role of Apelin–APJ System in Diabetes and Obesity
inferred← citeshttps://doi.org/10.3389/fendo.2022.965167openalex-snapshot
Possible roles of exercise and apelin against pregnancy complications
inferred← citeshttps://doi.org/10.3389/fendo.2023.1193150openalex-snapshot
The role of apelinergic system in metabolism and reproductive system in normal and pathological conditions: an overview
inferred← citeshttps://doi.org/10.3389/fendo.2025.1554617openalex-snapshot
Myokines as potential mediators of changes in glucose homeostasis and muscle mass after bariatric surgery
inferred← citeshttps://doi.org/10.3389/fphys.2015.00115openalex-snapshot
Apelin and energy metabolism
inferred← citeshttps://doi.org/10.3389/fphys.2017.01063openalex-snapshot
Exercise-Induced Hypertrophic and Oxidative Signaling Pathways and Myokine Expression in Fast Muscle of Adult Zebrafish
inferred← citeshttps://doi.org/10.3389/fphys.2021.709807openalex-snapshot
The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations
inferred← citeshttps://doi.org/10.3390/biom16040613openalex-snapshot
Emerging Insights into the Liver–Pancreas Axis: A Central Hub in the Pathogenesis of Diabetes and Metabolic Diseases
inferred← citeshttps://doi.org/10.3390/biomedicines12040873openalex-snapshot
Influence of Adipokines on Metabolic Dysfunction and Aging
inferred← citeshttps://doi.org/10.3390/cells11213361openalex-snapshot
The Role of Crosstalk between Adipose Cells and Myocytes in the Pathogenesis of Sarcopenic Obesity in the Elderly
inferred← citeshttps://doi.org/10.3390/cells11244008openalex-snapshot
Reactive Oxygen and Nitrogen Species (RONS) and Cytokines—Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle
inferred← citeshttps://doi.org/10.3390/diagnostics15192461openalex-snapshot
Relationship Between Serum Apelin-13 and Apelin Receptor Levels and the Severity of Disease in Patients Diagnosed with Obstructive Sleep Apnea Syndrome
inferred← citeshttps://doi.org/10.3390/ijms20225638openalex-snapshot
The Novel Perspectives of Adipokines on Brain Health
inferred← citeshttps://doi.org/10.3390/ijms21218372openalex-snapshot
Adipokines, Myokines, and Cardiokines: The Role of Nutritional Interventions
inferred← citeshttps://doi.org/10.3390/ijms23168962openalex-snapshot
(-)-Epicatechin Is a Biased Ligand of Apelin Receptor
inferred← citeshttps://doi.org/10.3390/ijms24054745openalex-snapshot
The Yin and Yang Effect of the Apelinergic System in Oxidative Stress
inferred← citeshttps://doi.org/10.3390/ijms24086874openalex-snapshot
Serum Levels of Myonectin Are Lower in Adults with Metabolic Syndrome and Are Negatively Correlated with Android Fat Mass
inferred← citeshttps://doi.org/10.3390/ijms25094659openalex-snapshot
New Mediators in the Crosstalk between Different Adipose Tissues
inferred← citeshttps://doi.org/10.3390/life14091198openalex-snapshot
How Can Promoting Skeletal Muscle Health and Exercise in Children and Adolescents Prevent Insulin Resistance and Type 2 Diabetes?
inferred← citeshttps://doi.org/10.3390/metabo14050287openalex-snapshot
The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat
inferred← citeshttps://doi.org/10.3390/nu14030598openalex-snapshot
Bifidobacterium animalis subsp. lactis A6 Enhances Fatty Acid β-Oxidation of Adipose Tissue to Ameliorate the Development of Obesity in Mice
inferred← citeshttps://doi.org/10.3390/nu17152408openalex-snapshot
The Oral–Gut Microbiota Axis as a Mediator of Frailty and Sarcopenia
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