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Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s00125-003-1103-yopenalex-snapshot
Gastric inhibitory polypeptide (GIP) dose-dependently stimulates glucagon secretion in healthy human subjects at euglycaemia
inferredcites →https://doi.org/10.1007/s00125-004-1379-6openalex-snapshot
Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
inferredcites →https://doi.org/10.1007/s00125-005-1933-xopenalex-snapshot
Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia
inferredcites →https://doi.org/10.1007/s00125-010-1809-6openalex-snapshot
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
inferredcites →https://doi.org/10.1007/s00125-011-2118-4openalex-snapshot
Pancreatic alpha cell mass in European subjects with type 2 diabetes
inferredcites →https://doi.org/10.1007/s00125-012-2716-9openalex-snapshot
A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
inferredcites →https://doi.org/10.1016/j.cell.2012.07.029openalex-snapshot
Pancreatic β Cell Dedifferentiation as a Mechanism of Diabetic β Cell Failure
inferredcites →https://doi.org/10.1016/j.cmet.2009.02.007openalex-snapshot
Insulin Signaling in α Cells Modulates Glucagon Secretion In Vivo
inferredcites →https://doi.org/10.1016/j.numecd.2009.03.018openalex-snapshot
Glucose toxicity: The leading actor in the pathogenesis and clinical history of type 2 diabetes – mechanisms and potentials for treatment
inferredcites →https://doi.org/10.1016/s0092-8674(00)80546-2openalex-snapshot
Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes
inferredcites →https://doi.org/10.1016/s0092-8674(00)81896-6openalex-snapshot
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
inferredcites →https://doi.org/10.1016/s0140-6736(11)60614-4openalex-snapshot
Type 2 diabetes across generations: from pathophysiology to prevention and management
inferredcites →https://doi.org/10.1038/ijo.2012.205openalex-snapshot
Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates
inferredcites →https://doi.org/10.1038/ng872openalex-snapshot
β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass
inferredcites →https://doi.org/10.1038/oby.2010.11openalex-snapshot
25‐Hydroxyvitamin D Concentration Correlates With Insulin‐Sensitivity and BMI in Obesity
inferredcites →https://doi.org/10.1055/s-2004-826158openalex-snapshot
On the Physiology of GIP and GLP-1
inferredcites →https://doi.org/10.1073/pnas.0237106100openalex-snapshot
Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice
inferredcites →https://doi.org/10.1073/pnas.1006639107openalex-snapshot
Paracrinology of islets and the paracrinopathy of diabetes
inferredcites →https://doi.org/10.1073/pnas.162352599openalex-snapshot
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects
inferredcites →https://doi.org/10.1073/pnas.85.18.6768openalex-snapshot
Patterns of mRNA expression during early cell growth differ in kidney epithelial cells destined to undergo compensatory hypertrophy versus regenerative hyperplasia.
inferredcites →https://doi.org/10.1097/00000658-198009000-00005openalex-snapshot
Preservation of the Pylorus in Pancreaticoduodenectomy
inferredcites →https://doi.org/10.1097/mot.0b013e3283344932openalex-snapshot
Regenerating pancreatic β-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis
inferredcites →https://doi.org/10.1111/j.1399-5448.2008.00468.xopenalex-snapshot
Growth factor control of pancreatic islet regeneration and function
inferredcites →https://doi.org/10.1152/ajpendo.1979.237.3.e214openalex-snapshot
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
inferredcites →https://doi.org/10.1172/jci113338openalex-snapshot
Quantitative study of insulin secretion and clearance in normal and obese subjects.
inferredcites →https://doi.org/10.1210/edrv-16-4-411openalex-snapshot
Mechanisms of Nonneoplastic Endocrine Hyperplasia—A Changing Concept: A Review Focused on the Thyroid Gland
inferredcites →https://doi.org/10.1210/en.2003-0323openalex-snapshot
Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets
inferredcites →https://doi.org/10.1210/jc.2002-020735openalex-snapshot
Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea
inferredcites →https://doi.org/10.1210/jc.2009-0826openalex-snapshot
Impaired Glucose-Induced Glucagon Suppression after Partial Pancreatectomy
inferredcites →https://doi.org/10.1210/jc.2012-1206openalex-snapshot
Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life
inferredcites →https://doi.org/10.1210/jc.2012-3832openalex-snapshot
Predominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes
inferredcites →https://doi.org/10.1210/jc.85.10.3575openalex-snapshot
Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide
inferredcites →https://doi.org/10.1210/jcem.85.10.6855openalex-snapshot
Degradation of Endogenous and Exogenous Gastric Inhibitory Polypeptide in Healthy and in Type 2 Diabetic Subjects as Revealed Using a New Assay for the Intact Peptide1
inferredcites →https://doi.org/10.1371/journal.pone.0028050openalex-snapshot
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus
inferredcites →https://doi.org/10.2337/db11-1067openalex-snapshot
Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
inferredcites →https://doi.org/10.2337/db12-1747openalex-snapshot
X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function
inferredcites →https://doi.org/10.2337/dc06-0392openalex-snapshot
Hyperinsulinemic Hypoglycemia After Gastric Bypass Surgery Is Not Accompanied by Islet Hyperplasia or Increased β-Cell Turnover
inferredcites →https://doi.org/10.2337/dc11-s062openalex-snapshot
Diagnosis and Classification of Diabetes Mellitus
inferredcites →https://doi.org/10.2337/dc12-0811openalex-snapshot
Removal of Duodenum Elicits GLP-1 Secretion
inferredcites →https://doi.org/10.2337/dc13-0486openalex-snapshot
Response to Comment on: Saisho et al. β-Cell Mass and Turnover in Humans: Effects of Obesity and Aging. Diabetes Care 2013;36:111–117
inferredcites →https://doi.org/10.2337/dc13-s067openalex-snapshot
Diagnosis and Classification of Diabetes Mellitus
inferredcites →https://doi.org/10.2337/diab.38.1.49openalex-snapshot
Compensatory Growth of Pancreatic β-Cells in Adult Rats After Short-Term Glucose Infusion
inferredcites →https://doi.org/10.2337/diabetes.47.3.358openalex-snapshot
Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat.
inferredcites →https://doi.org/10.2337/diabetes.48.12.2270openalex-snapshot
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
inferredcites →https://doi.org/10.2337/diabetes.50.2007.s154openalex-snapshot
Beta-cell adaptation and decompensation during the progression of diabetes.
inferredcites →https://doi.org/10.2337/diabetes.52.1.102openalex-snapshot
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diabetes.54.2.482openalex-snapshot
β-Cell Pdx1 Expression Is Essential for the Glucoregulatory, Proliferative, and Cytoprotective Actions of Glucagon-Like Peptide-1
inferredcites →https://doi.org/10.3727/096368912x659916openalex-snapshot
Birth and Death of Human β-Cells in Pancreases from Cadaver Donors, Autopsies, Surgical Specimens, and Islets Transplanted into Mice
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Unlocking Regenerative Potential: Beta-Cell Neogenesis and Novel Myokines Involved in Adaptation to Insulin Resistance in Mice
inferred← citeshttps://doi.org/10.1002/9781118387658.ch24openalex-snapshot
β‐Cell mass and function in human type 2 diabetes
inferred← citeshttps://doi.org/10.1002/9781119697473.ch16openalex-snapshot
Abnormalities of Insulin Secretion and β‐Cell Defects in Type 2 Diabetes
inferred← citeshttps://doi.org/10.1002/ardp.70110openalex-snapshot
Exploring the Antidiabetic Potential of Heterophylliin A From Elaeocarpus grandis
inferred← citeshttps://doi.org/10.1002/cjp2.140openalex-snapshot
Characterisation of the endocrine pancreas in type 1 diabetes: islet size is maintained but islet number is markedly reduced
inferred← citeshttps://doi.org/10.1002/dmrr.2663openalex-snapshot
Bariatric surgery: beta cells in type 2 diabetes remission
inferred← citeshttps://doi.org/10.1007/978-3-030-11748-1_14openalex-snapshot
Animal Models of Type 2 Diabetes, Obesity and Nonalcoholic Steatohepatitis – Clinical Translatability and Applicability in Preclinical Drug Development
inferred← citeshttps://doi.org/10.1007/978-3-030-53370-0_13openalex-snapshot
Pancreatic Islets of Langerhans: Adapting Cell and Molecular Biology to Changes of Metabolism
inferred← citeshttps://doi.org/10.1007/978-3-031-13177-6_12openalex-snapshot
The Metabolic Syndrome and Vascular Disease
inferred← citeshttps://doi.org/10.1007/978-3-031-40116-9_27openalex-snapshot
Pancreatic Islet Adaptation and Failure in Obesity
inferred← citeshttps://doi.org/10.1007/978-3-031-62232-8_3openalex-snapshot
β-Cell Heterogeneity and Plasticity
inferred← citeshttps://doi.org/10.1007/978-3-319-12125-3_27-3openalex-snapshot
Pancreatic Islet Adaptation and Failure in Obesity
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The Elusive Pancreatic Stem Cell
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The regulation of pre- and post-maturational plasticity of mammalian islet cell mass
inferred← citeshttps://doi.org/10.1007/s00125-015-3699-0openalex-snapshot
New insights into the architecture of the islet of Langerhans: a focused cross-species assessment
inferred← citeshttps://doi.org/10.1007/s00125-015-3859-2openalex-snapshot
Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice
inferred← citeshttps://doi.org/10.1007/s00125-018-4546-xopenalex-snapshot
Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource
inferred← citeshttps://doi.org/10.1007/s00125-019-05038-xopenalex-snapshot
Heterozygous deletion of Seipin in islet beta cells of male mice has an impact on insulin synthesis and secretion through reduced PPARγ expression
inferred← citeshttps://doi.org/10.1007/s00125-021-05467-7openalex-snapshot
Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-025-06524-1openalex-snapshot
Evaluating the role of alpha cell dysregulation in the progression to type 2 diabetes using mathematical simulations
inferred← citeshttps://doi.org/10.1007/s00125-026-06839-7openalex-snapshot
Pancreatic islets: new discoveries for innovative treatments of diabetes?
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Glucoregulatory, endocrine and morphological effects of [P5K]hymenochirin-1B in mice with diet-induced glucose intolerance and insulin resistance
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RETRACTED ARTICLE: Individual and combined antagonism of aryl hydrocarbon receptor (AhR) and estrogen receptors (ERs) offers distinct level of protection against Bisphenol A (BPA)-induced pancreatic islet cell toxicity in mice
inferred← citeshttps://doi.org/10.1007/s00592-024-02295-0openalex-snapshot
Extra-islet cells expressing insulin or glucagon in the pancreas of young organ donors
inferred← citeshttps://doi.org/10.1007/s11892-018-1023-3openalex-snapshot
Methods for Measuring Risk for Type 2 Diabetes in Youth: the Oral Glucose Tolerance Test (OGTT)
inferred← citeshttps://doi.org/10.1007/s12020-014-0418-4openalex-snapshot
The Langerhans islet cells of female rabbits are differentially affected by hypothyroidism depending on the islet size
inferred← citeshttps://doi.org/10.1007/s13410-015-0412-2openalex-snapshot
MicroRNAs 103 and 107 link type 2 diabetes and post-menopausal breast cancer
inferred← citeshttps://doi.org/10.1007/s40620-024-02048-wopenalex-snapshot
The influence of insulin and incretin-based therapies on renal tubular transport
inferred← citeshttps://doi.org/10.1016/b978-0-12-800563-7.00008-7openalex-snapshot
Gene Therapy for Diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-12-814831-0.00014-2openalex-snapshot
Strategies to promote beta-cell replication and regeneration
inferred← citeshttps://doi.org/10.1016/b978-0-323-18907-1.00050-0openalex-snapshot
Beta Cell Transplantation and Regeneration
inferred← citeshttps://doi.org/10.1016/b978-0-443-27370-4.00015-9openalex-snapshot
Endoplasmic reticulum as a pharmacological target in metabolic diseases
inferred← citeshttps://doi.org/10.1016/j.aanat.2015.01.007openalex-snapshot
Influence of gender and time diet exposure on endocrine pancreas remodeling in response to high fat diet-induced metabolic disturbances in mice
inferred← citeshttps://doi.org/10.1016/j.acthis.2016.06.002openalex-snapshot
Favorable outcomes of hydroxychloroquine in insulin resistance may be accomplished by adjustment of the endothelial dysfunction as well as the skewed balance of adipokines
inferred← citeshttps://doi.org/10.1016/j.addr.2018.10.010openalex-snapshot
Stem-cell based organ-on-a-chip models for diabetes research
inferred← citeshttps://doi.org/10.1016/j.ajpath.2014.09.009openalex-snapshot
Chronic Continuous Exenatide Infusion Does Not Cause Pancreatic Inflammation and Ductal Hyperplasia in Non-Human Primates
inferred← citeshttps://doi.org/10.1016/j.amjsurg.2014.12.052openalex-snapshot
Metabolic consequences of the occlusion of the main pancreatic duct with acrylic glue after pancreaticoduodenectomy
inferred← citeshttps://doi.org/10.1016/j.amjsurg.2024.115987openalex-snapshot
A single-center prospective analysis of the impact of glucose metabolism on pancreatic fistula onset after pancreaticoduodenectomy for periampullary tumors
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101674openalex-snapshot
The pancreatic β-cell in ageing: Implications in age-related diabetes
inferred← citeshttps://doi.org/10.1016/j.bcp.2022.115398openalex-snapshot
Antidiabetic actions of GPR55 agonist Abn-CBD and sitagliptin in obese-diabetic high fat fed mice
inferred← citeshttps://doi.org/10.1016/j.biocel.2014.12.021openalex-snapshot
KLF10 affects pancreatic function via the SEI-1/p21Cip1 pathway
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Pancreatic β-cell apoptosis caused by apolipoprotein C3-rich low-density lipoprotein is attenuated by kansuinine A through oxidative stress inhibition
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Proinflammatory Cytokines Induce Endocrine Differentiation in Pancreatic Ductal Cells via STAT3-Dependent NGN3 Activation
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The effects of Mediterranean diets with low or high glycemic index on plasma glucose and insulin profiles are different in adult men and women: Data from MEDGI-Carb randomized clinical trial
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Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes
inferred← citeshttps://doi.org/10.1016/j.diabet.2016.01.001openalex-snapshot
Resting beta-cells – A functional reserve?
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Relationship of betatrophin with youth onset type 2 diabetes among Asian Indians
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Altered BAG3-insulin colocalization is associated with impaired first phase insulin secretion in humans
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The RB gene family controls the maturation state of the EndoC-βH2 human pancreatic β-cells
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Association of temporal distribution of fine particulate matter with glucose homeostasis during pregnancy in women of Chiayi City, Taiwan
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The underlying mechanism of transcription factor IRF1, PRDM1, and ZNF263 involved in the regulation of NPPB rs3753581 on pulse pressure hypertension
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One week of continuous corticosterone exposure impairs hepatic metabolic flexibility, promotes islet β-cell proliferation, and reduces physical activity in male C57BL/6 J mice
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A dissociated glucocorticoid receptor modulator mitigates glucolipotoxicity in the endocrine pancreas and peripheral tissues: Preclinical data from a mouse model of diet-induced type 2 diabetes
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Progenitor cells may aid successful islet compensation in metabolically healthy obese individuals
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β-Cell function in type 2 diabetes
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Human subjects with impaired beta-cell function and glucose tolerance have higher levels of intra-islet intact GLP-1
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Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis
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Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation
inferred← citeshttps://doi.org/10.1016/j.molmet.2019.06.003openalex-snapshot
“Omics” and “epi-omics” underlying the β-cell adaptation to insulin resistance
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Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance
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An update on pancreatic regeneration mechanisms: Searching for paths to a cure for type 2 diabetes
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GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice
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Peptides from frog skin with potential for development into agents for Type 2 diabetes therapy
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Mitochondrial-derived peptides (Humanin, MOTS-c, and SHLP2) protect pancreatic islet cells and delay the onset and progression of type 2 diabetes mellitus in mice
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Nano-based drug delivery systems used as vehicles to enhance polyphenols therapeutic effect for diabetes mellitus treatment
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Maternal exposure to Δ9-tetrahydrocannabinol impairs female offspring glucose homeostasis and endocrine pancreatic development in the rat
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Association of ambient particle pollution with gestational diabetes mellitus and fasting blood glucose levels in pregnant women from two Chinese birth cohorts
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Heterogeneity of SOX9 and HNF1β in Pancreatic Ducts Is Dynamic
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First-phase insulin secretion: can its evaluation direct therapeutic approaches?
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10.1016/s1155-1941(23)43263-5
inferred← citeshttps://doi.org/10.1016/s2213-8587(20)30022-xopenalex-snapshot
Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes
inferred← citeshttps://doi.org/10.1021/acs.jafc.6b03424openalex-snapshot
Oral Administration of Apple Procyanidins Ameliorates Insulin Resistance via Suppression of Pro-Inflammatory Cytokine Expression in Liver of Diabetic ob/ob Mice
inferred← citeshttps://doi.org/10.1038/nrendo.2015.142openalex-snapshot
The past 10 years—new hormones, new functions, new endocrine organs
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Human pancreatic α-cell heterogeneity and trajectory inference analyses reveal SMOC1 as a β-cell dedifferentiation gene
inferred← citeshttps://doi.org/10.1038/s41591-019-0610-4openalex-snapshot
Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans
inferred← citeshttps://doi.org/10.1038/s41598-024-60022-9openalex-snapshot
The proteomic profile is altered but not repaired after bariatric surgery in type 2 diabetes pigs
inferred← citeshttps://doi.org/10.1038/s42003-021-02433-2openalex-snapshot
Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation
inferred← citeshttps://doi.org/10.1038/srep34049openalex-snapshot
Stereological analyses of the whole human pancreas
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Hyphaene thebaica (doum)-derived extract alleviates hyperglycemia in diabetic rats: a comprehensive in silico , in vitro and in vivo study
inferred← citeshttps://doi.org/10.1039/d5fo01469gopenalex-snapshot
Flavonoids of Rosa sterilis S. D. Shi improve high-fat diet-induced obesity in mice by inhibiting lipid accumulation and regulating the gut microbiota
inferred← citeshttps://doi.org/10.1073/pnas.1423849112openalex-snapshot
Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
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Transcription factor-7–like 2 (TCF7L2) gene acts downstream of the Lkb1/Stk11 kinase to control mTOR signaling, β cell growth, and insulin secretion
inferred← citeshttps://doi.org/10.1080/15384101.2015.1064677openalex-snapshot
The pancreatic β-cell in deadly encounter with apolipoprotein CIII
inferred← citeshttps://doi.org/10.1096/fasebj.2022.36.s1.r1914openalex-snapshot
A Novel Animal Model in Diabetes: Regeneration of β cells in the Axolotl Salamander?
inferred← citeshttps://doi.org/10.1097/mpa.0000000000001552openalex-snapshot
Dynamic Change of β to α Ratio in Islets of Chinese People With Prediabetes and Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1097/shk.0000000000000607openalex-snapshot
Pancreatic Islet Responses to Metabolic Trauma
inferred← citeshttps://doi.org/10.1097/sla.0000000000006053openalex-snapshot
Quality of Life and Gastrointestinal Symptoms in Long-term Survivors of Pancreatic Cancer Following Pancreatoduodenectomy
inferred← citeshttps://doi.org/10.1101/2023.01.09.523222openalex-snapshot
Insulin resistance-driven beta-cell adaptation in mice: Mechanistic characterization and 3D analysis
inferred← citeshttps://doi.org/10.1101/2024.05.13.593941openalex-snapshot
Loss-of-function of ALDH3B2 transdifferentiates human pancreatic duct cells into beta-like cells
inferred← citeshttps://doi.org/10.1101/212548openalex-snapshot
Perturbed Mitochondrial Metabolism in Islets from Donors with Type-2 Diabetes
inferred← citeshttps://doi.org/10.1111/ajt.15154openalex-snapshot
Variability in endocrine cell identity in patients with chronic pancreatitis undergoing islet autotransplantation
inferred← citeshttps://doi.org/10.1111/dom.12726openalex-snapshot
Stress‐induced adaptive islet cell identity changes
inferred← citeshttps://doi.org/10.1111/dom.12728openalex-snapshot
Mass production of functional human pancreatic β‐cells: why and how?
inferred← citeshttps://doi.org/10.1111/dom.12731openalex-snapshot
Novel factors modulating human β‐cell proliferation
inferred← citeshttps://doi.org/10.1111/dom.13144openalex-snapshot
Aetiology of type 1 diabetes: Physiological growth in children affects disease progression
inferred← citeshttps://doi.org/10.1111/dom.15300openalex-snapshot
Pancreatic islet cell plasticity: Pathogenic or therapeutically exploitable?
inferred← citeshttps://doi.org/10.1111/jdi.12287openalex-snapshot
Quo vadis: Where have the β‐cells gone?
inferred← citeshttps://doi.org/10.1111/jdi.12424openalex-snapshot
Dynamic pathology of islet endocrine cells in type 2 diabetes: β‐Cell growth, death, regeneration and their clinical implications
inferred← citeshttps://doi.org/10.1111/jdi.13232openalex-snapshot
Association of glucose tolerance status with pancreatic β‐ and α‐cell mass in community‐based autopsy samples of Japanese individuals: The Hisayama Study
inferred← citeshttps://doi.org/10.1113/jp278833openalex-snapshot
Early weaning induces short‐ and long‐term effects on pancreatic islets in Wistar rats of both sexes
inferred← citeshttps://doi.org/10.1126/scitranslmed.3010577openalex-snapshot
Cellular stress drives pancreatic plasticity
inferred← citeshttps://doi.org/10.1126/scitranslmed.ady2234openalex-snapshot
Loss of function of ALDH3B2 transdifferentiates human pancreatic duct cells into β-like cells
inferred← citeshttps://doi.org/10.1139/apnm-2019-0144openalex-snapshot
β-Cell compensation concomitant with adaptive endoplasmic reticulum stress and β-cell neogenesis in a diet-induced type 2 diabetes model
inferred← citeshttps://doi.org/10.1155/2021/5015797openalex-snapshot
Relationship between Insulin Secretion and Arterial Stiffness in Essential Hypertension
inferred← citeshttps://doi.org/10.1172/jci.insight.143791openalex-snapshot
Islet cell dedifferentiation is a pathologic mechanism of long-standing progression of type 2 diabetes
inferred← citeshttps://doi.org/10.1172/jci.insight.153877openalex-snapshot
Single-nucleus RNA-Seq reveals singular gene signatures of human ductal cells during adaptation to insulin resistance
inferred← citeshttps://doi.org/10.1172/jci.insight.162255openalex-snapshot
Time-dependent effects of endogenous hyperglucagonemia on glucose homeostasis and hepatic glucagon action
inferred← citeshttps://doi.org/10.1172/jci.insight.99576openalex-snapshot
Human duct cells contribute to β cell compensation in insulin resistance
inferred← citeshttps://doi.org/10.1172/jci129188openalex-snapshot
β Cell dysfunction during progression of metabolic syndrome to type 2 diabetes
inferred← citeshttps://doi.org/10.1172/jci129484openalex-snapshot
The supply chain of human pancreatic β cell lines
inferred← citeshttps://doi.org/10.1172/jci146788openalex-snapshot
Pancreaticoduodenectomy model demonstrates a fundamental role of dysfunctional β cells in predicting diabetes
inferred← citeshttps://doi.org/10.1172/jci83657openalex-snapshot
Stress-impaired transcription factor expression and insulin secretion in transplanted human islets
inferred← citeshttps://doi.org/10.1172/jci87439openalex-snapshot
Advances in β cell replacement and regeneration strategies for treating diabetes
inferred← citeshttps://doi.org/10.1172/jci90004openalex-snapshot
Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion
inferred← citeshttps://doi.org/10.1177/03946320251365089openalex-snapshot
Role of β and α1-adrenoceptors in pancreatic regulation of glucose homeostasis, apoptosis, and fibrosis in dexamethasone-treated rats: A new insight into β-arrestin2 crosstalk with cAMP, PKA-ERK1/2-CREB, and PKB-FOXO1 signaling pathways
inferred← citeshttps://doi.org/10.1179/2046023615y.0000000013openalex-snapshot
Evaluation of immunohistochemical staining for glucagon in human pancreatic tissue
inferred← citeshttps://doi.org/10.1186/s12933-018-0747-3openalex-snapshot
β Cell-specific deletion of guanylyl cyclase A, the receptor for atrial natriuretic peptide, accelerates obesity-induced glucose intolerance in mice
inferred← citeshttps://doi.org/10.1186/s12933-019-0828-yopenalex-snapshot
Sotagliflozin, the first dual SGLT inhibitor: current outlook and perspectives
inferred← citeshttps://doi.org/10.1186/s13073-021-00941-8openalex-snapshot
Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
inferred← citeshttps://doi.org/10.1210/clinem/dgac444openalex-snapshot
Circulating 1,5-Anhydroglucitol as a Biomarker of ß-cell Mass Independent of a Diabetes Phenotype in Human Subjects
inferred← citeshttps://doi.org/10.1210/clinem/dgae227openalex-snapshot
Association Between Hypotension During Pancreatectomy and Development of Postoperative Diabetes
inferred← citeshttps://doi.org/10.1210/endocr/bqab019openalex-snapshot
FSTL3-Neutralizing Antibodies Enhance Glucose-Responsive Insulin Secretion in Dysfunctional Male Mouse and Human Islets
inferred← citeshttps://doi.org/10.1210/endocr/bqab119openalex-snapshot
Hyperinsulinemic Compensation for Insulin Resistance Occurs Independent of Elevated Glycemia in Male Dogs
inferred← citeshttps://doi.org/10.1210/endocr/bqab150openalex-snapshot
Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion
inferred← citeshttps://doi.org/10.1210/endrev/bnab010openalex-snapshot
The Human Islet: Mini-Organ With Mega-Impact
inferred← citeshttps://doi.org/10.1210/jc.2015-2802openalex-snapshot
β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans
inferred← citeshttps://doi.org/10.1210/jc.2015-2860openalex-snapshot
Evidence of β-Cell Dedifferentiation in Human Type 2 Diabetes
inferred← citeshttps://doi.org/10.1210/jc.2016-1374openalex-snapshot
Effects of Obesity and Diabetes on α- and β-Cell Mass in Surgically Resected Human Pancreas
inferred← citeshttps://doi.org/10.1210/jendso/bvab128openalex-snapshot
Revisiting Regulators of Human β-cell Mass to Achieve β-cell–centric Approach Toward Type 2 Diabetes
inferred← citeshttps://doi.org/10.1371/journal.pone.0098932openalex-snapshot
Automated Assessment of β-Cell Area and Density per Islet and Patient Using TMEM27 and BACE2 Immunofluorescence Staining in Human Pancreatic β-Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0108202openalex-snapshot
Human Fucci Pancreatic Beta Cell Lines: New Tools to Study Beta Cell Cycle and Terminal Differentiation
inferred← citeshttps://doi.org/10.1371/journal.pone.0179398openalex-snapshot
Co-localization of acinar markers and insulin in pancreatic cells of subjects with type 2 diabetes
inferred← citeshttps://doi.org/10.14341/dm12872openalex-snapshot
Regeneration of β-cells of the islet apparatus of the pancreas. Literature review
inferred← citeshttps://doi.org/10.14814/phy2.14573openalex-snapshot
Spontaneous restoration of functional β‐cell mass in obese SM/J mice
inferred← citeshttps://doi.org/10.15252/embj.201592903openalex-snapshot
IGFBP1 increases β‐cell regeneration by promoting α‐ to β‐cell transdifferentiation
inferred← citeshttps://doi.org/10.1530/joe-23-0317openalex-snapshot
In vivo models of gestational and type 2 diabetes mellitus characterized by endocrine pancreas cell impairments
inferred← citeshttps://doi.org/10.17219/acem/74452openalex-snapshot
Increasing beta cell mass to treat diabetes mellitus
inferred← citeshttps://doi.org/10.17504/protocols.io.bwebpbanopenalex-snapshot
A Systematic Comparison of Protocols for Recovery of High-Quality RNA from Human Islets Extracted by Laser Capture Microdissection v1
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2222452/v1openalex-snapshot
Loss-of-function of ALDH3B2 transdifferentiates human pancreatic duct cells into beta-like cells
inferred← citeshttps://doi.org/10.21926/obm.transplant.1901055openalex-snapshot
Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function
inferred← citeshttps://doi.org/10.2337/db13-1843openalex-snapshot
Insulin Resistance Compensation: Not Just a Matter of β-Cells?
inferred← citeshttps://doi.org/10.2337/db14-1675openalex-snapshot
Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-Cells
inferred← citeshttps://doi.org/10.2337/db14-1752openalex-snapshot
Loss of β-Cell Identity Occurs in Type 2 Diabetes and Is Associated With Islet Amyloid Deposits
inferred← citeshttps://doi.org/10.2337/db15-0039openalex-snapshot
Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets
inferred← citeshttps://doi.org/10.2337/db15-0106openalex-snapshot
Adaptation of β-Cell and Endothelial Function to Carbohydrate Loading: Influence of Insulin Resistance
inferred← citeshttps://doi.org/10.2337/db15-1718openalex-snapshot
Alterations in β-Cell Calcium Dynamics and Efficacy Outweigh Islet Mass Adaptation in Compensation of Insulin Resistance and Prediabetes Onset
inferred← citeshttps://doi.org/10.2337/db16-1449openalex-snapshot
[11C]5-hydroxy-tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes
inferred← citeshttps://doi.org/10.2337/db17-1314openalex-snapshot
Adaptive β-Cell Neogenesis in the Adult Mouse in Response to Glucocorticoid-Induced Insulin Resistance
inferred← citeshttps://doi.org/10.2337/db18-0279openalex-snapshot
Increased β-Cell Workload Modulates Proinsulin-to-Insulin Ratio in Humans
inferred← citeshttps://doi.org/10.2337/db18-0856openalex-snapshot
β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity
inferred← citeshttps://doi.org/10.2337/db20-0440openalex-snapshot
Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia
inferred← citeshttps://doi.org/10.2337/db21-0736openalex-snapshot
HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity
inferred← citeshttps://doi.org/10.2337/db25-0572openalex-snapshot
β-Cell Mass in Individuals With and Without Postbariatric Hypoglycemia After Roux-en-Y Gastric Bypass
inferred← citeshttps://doi.org/10.2337/dc20-0864openalex-snapshot
Importance of Intestinal Environment and Cellular Plasticity of Islets in the Development of Postpancreatectomy Diabetes
inferred← citeshttps://doi.org/10.23880/oajpr-16000270openalex-snapshot
In-silico Study for African Plants with Possible Beta-Cell Regeneration Effect through Inhibition of DYRK1A
inferred← citeshttps://doi.org/10.2478/jvetres-2024-0042openalex-snapshot
Immunodetection of selected pancreatic hormones under intragastric administration of apelin-13, a novel endogenous ligand for an angiotensin-like orphan G-protein coupled receptor, in unweaned rats
inferred← citeshttps://doi.org/10.30682/ildia2201copenalex-snapshot
100 anni dopo l’insulina: cosa ancora non sappiamo della sua secrezione nel diabete di tipo 2
inferred← citeshttps://doi.org/10.3389/fgene.2017.00002openalex-snapshot
Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes
inferred← citeshttps://doi.org/10.3390/biom11020320openalex-snapshot
Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis
inferred← citeshttps://doi.org/10.3390/biom11050625openalex-snapshot
A Systematic Comparison of Protocols for Recovery of High-Quality RNA from Human Islets Extracted by Laser Capture Microdissection
inferred← citeshttps://doi.org/10.3390/books978-3-0365-0927-3openalex-snapshot
Islet Inflammation and Metabolic Homeostasis
inferred← citeshttps://doi.org/10.3390/cimb45080392openalex-snapshot
Regeneration of Pancreatic Beta Cells by Modulation of Molecular Targets Using Plant-Derived Compounds: Pharmacological Mechanisms and Clinical Potential
inferred← citeshttps://doi.org/10.3390/ijms19103136openalex-snapshot
The Role of the TGFβ Receptor Signaling Pathway in Adult Beta Cell Proliferation
inferred← citeshttps://doi.org/10.3390/ijms22084239openalex-snapshot
Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes?
inferred← citeshttps://doi.org/10.3390/ijms22105303openalex-snapshot
Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies
inferred← citeshttps://doi.org/10.3390/ijms23094843openalex-snapshot
Endoplasmic Reticulum (ER) Stress and Its Role in Pancreatic β-Cell Dysfunction and Senescence in Type 2 Diabetes
inferred← citeshttps://doi.org/10.3390/ijms23105522openalex-snapshot
Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes
inferred← citeshttps://doi.org/10.3390/ijms25074070openalex-snapshot
The Importance of Intra-Islet Communication in the Function and Plasticity of the Islets of Langerhans during Health and Diabetes
inferred← citeshttps://doi.org/10.3390/jcm7030054openalex-snapshot
The Cells of the Islets of Langerhans
inferred← citeshttps://doi.org/10.3390/metabo10110452openalex-snapshot
Beta Cell Physiological Dynamics and Dysfunctional Transitions in Response to Islet Inflammation in Obesity and Diabetes
inferred← citeshttps://doi.org/10.3390/nu12123846openalex-snapshot
Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review
inferred← citeshttps://doi.org/10.3390/nu15010018openalex-snapshot
Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features
inferred← citeshttps://doi.org/10.3390/nu17203225openalex-snapshot
Protein Source Determines the Effectiveness of High-Protein Diets in Improving Adipose Tissue Function and Insulin Resistance in fa/fa Zucker Rats
inferred← citeshttps://doi.org/10.3410/f.736877195.793567201openalex-snapshot
Faculty Opinions recommendation of Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans.
inferred← citeshttps://doi.org/10.3727/096368915x688498openalex-snapshot
Islet Volume and Indexes of β-Cell Function in Humans
inferred← citeshttps://doi.org/10.4093/dmj.2022.0205openalex-snapshot
Glucose Regulation after Partial Pancreatectomy: A Comparison of Pancreaticoduodenectomy and Distal Pancreatectomy in the Short and Long Term
inferred← citeshttps://doi.org/10.4103/njca.njca_44_25openalex-snapshot
Volumetric Analysis of the Pancreas in Autopsy versus Contrast-enhanced Computed Tomography: An Observational Study with Insight Into Type 2 Diabetes Mellitus Related Changes
inferred← citeshttps://doi.org/10.4239/wjd.v6.i1.109openalex-snapshot
β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes
inferred← citeshttps://doi.org/10.4252/wjsc.v13.i1.64openalex-snapshot
Pancreatic β cell regeneration induced by clinical and preclinical agents
inferred← citeshttps://doi.org/10.4314/sa.v22i3.1openalex-snapshot
Aspartame and diet soda impact on blood sugar and insulin in Wistar rat
inferred← citeshttps://doi.org/10.47749/t/unicamp.2018.1102624openalex-snapshot
Papel da via de sinalização Wnt canônica na proliferação e função secretora da célula beta pancreática em condições in vitro e na pré-diabetes
inferred← citeshttps://doi.org/10.47957/ijciar.v7i2.178openalex-snapshot
Role of Sotagliflozin in Managing Heart Failure in Diabetes`
inferred← citeshttps://doi.org/10.5821/dissertation-2117-95576openalex-snapshot
Valoración de la respuesta tisular tras a pancreatotomía media realizada con un dispositivo asistido por radiofrecuencia
inferred← citeshttps://doi.org/10.58920/sciphy01010013openalex-snapshot
In-silico study for African plants with possible beta-cell regeneration effect through inhibition of DYRK1A
inferred← citeshttps://doi.org/10.6035/14104.2024.252852openalex-snapshot
Síndrome metabólico y abuso de alcohol: efectos de la acción combinada de ambas patologías en el balance oxidativo del sistema nervioso central
inferred← citeshttps://doi.org/10.6084/m9.figshare.15145901openalex-snapshot
Additional file 1 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
inferred← citeshttps://doi.org/10.6084/m9.figshare.15145904openalex-snapshot
Additional file 2 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
inferred← citeshttps://doi.org/10.6084/m9.figshare.15145907openalex-snapshot
Additional file 3 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
inferred← citeshttps://doi.org/10.6084/m9.figshare.15145910openalex-snapshot
Additional file 4 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
inferred← citeshttps://doi.org/10.6084/m9.figshare.15145913openalex-snapshot
Additional file 5 of Using single-nucleus RNA-sequencing to interrogate transcriptomic profiles of archived human pancreatic islets
inferred← citeshttps://doi.org/10.64898/2026.01.29.701913openalex-snapshot
A spatial-temporal atlas of human islet pathophysiology identifies a size-dependent trajectory from compensation to decompensation
inferred← citeshttps://doi.org/10.70675/9c2e56d4za035z4fa3zafa6z7786e388a812openalex-snapshot
Dédifférenciation de la cellule bêta pancréatique humaine
inferred← citeshttps://doi.org/10.70675/b2b42aebz2dd5z4743z8c66z2702c45a7634openalex-snapshot
Bioproduction de vésicules extracellulaires à partir de cultures de sphéroïdes de cellules humaines en bioréacteurs à cuves agitées
inferred← citeshttps://doi.org/10.70675/d91f4f63zc995z48d0z8c05z8d9bcd3bb8e4openalex-snapshot
Rôles de SOX9 dans la cellule ß pancréatique humaine
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