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Vasculoprotection as a Convergent, Multi-Targeted Mechanism of Anti-AD Therapeutics and Interventions

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

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Impairment of paravascular clearance pathways in the aging brain

inferredcites →https://doi.org/10.1007/s00401-008-0366-2openalex-snapshot

Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

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Lymphatic drainage of the brain and the pathophysiology of neurological disease

inferredcites →https://doi.org/10.1007/s00401-011-0834-yopenalex-snapshot

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

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Cardiovascular Actions of GLP-1 and Incretin-Based Pharmacotherapy

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(Pre)diabetes, brain aging, and cognition

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Cholesterol-related genes in Alzheimer's disease

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Brain metabolic dysfunction at the core of Alzheimer's disease

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The complexities of the pathology–pathogenesis relationship in Alzheimer disease

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Protective effect of rhGLP-1 (7–36) on brain ischemia/reperfusion damage in diabetic rats

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High-Density Lipoproteins and Cerebrovascular Integrity in Alzheimer’s Disease

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The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

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First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

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IC‐P‐067: ADVANCED DIFFUSION WEIGHTING IMAGING (DWI) TRACTOGRAPHY OF THE LIMBIC SYSTEM: NOVEL BIOMARKERS OF NEURODEGENERATIVE CHANGES DURING PROGRESSION/CONVERSION FROM COGNITIVE NORMALITY TO AD DEMENTIA

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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease

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Oral apolipoprotein A-I mimetic peptide improves cognitive function and reduces amyloid burden in a mouse model of Alzheimer's disease

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The capillary dysfunction hypothesis of Alzheimer's disease

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Selective benefits of simvastatin in bitransgenic APPSwe,Ind/TGF-β1 mice

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Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

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The Pathobiology of Vascular Dementia

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Blood-Brain Barrier: A Dual Life of MFSD2A?

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Blood-Brain Barrier Breakdown in the Aging Human Hippocampus

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Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.neuroscience.2009.01.023openalex-snapshot

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

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Insulin in the brain: There and back again

inferredcites →https://doi.org/10.1016/j.pharmthera.2013.01.016openalex-snapshot

Structure and dynamics of molecular networks: A novel paradigm of drug discovery

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Circulating insulin-like growth factor I and cognitive function: Neuromodulation throughout the lifespan

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Pericyte-endothelial crosstalk: implications and opportunities for advanced cellular therapies

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Chapter 3 Cerebrovascular and Cardiovascular Pathology in Alzheimer's Disease

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Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer’s disease☆

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Diabetes drugs and neurological disorders: new views and therapeutic possibilities

inferredcites →https://doi.org/10.1038/jcbfm.2011.43openalex-snapshot

Neurovascular function in Alzheimer's disease patients and experimental models

inferredcites →https://doi.org/10.1038/jcbfm.2013.82openalex-snapshot

Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease

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Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid

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Mfsd2a is critical for the formation and function of the blood–brain barrier

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RETRACTED ARTICLE: Pericyte loss influences Alzheimer-like neurodegeneration in mice

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GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

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Apolipoprotein A-I Deficiency Increases Cerebral Amyloid Angiopathy and Cognitive Deficits in APP/PS1ΔE9 Mice

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Overexpression of Human Apolipoprotein A-I Preserves Cognitive Function and Attenuates Neuroinflammation and Cerebral Amyloid Angiopathy in a Mouse Model of Alzheimer Disease

inferredcites →https://doi.org/10.1074/jbc.m508780200openalex-snapshot

Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease

inferredcites →https://doi.org/10.1093/aje/kwm027openalex-snapshot

The Relation between Apolipoprotein A-I and Dementia: The Honolulu-Asia Aging Study

inferredcites →https://doi.org/10.1093/gerona/57.11.m712openalex-snapshot

Plasma HDL Levels Highly Correlate With Cognitive Function in Exceptional Longevity

inferredcites →https://doi.org/10.1097/crd.0b013e3181c4b508openalex-snapshot

Apolipoprotein A-I Mimetic Peptides

inferredcites →https://doi.org/10.1097/fjc.0000000000000176openalex-snapshot

Protective Effects of Glucagon-like Peptide 1 on Endothelial Function in Hypertension

inferredcites →https://doi.org/10.1097/med.0b013e3283373cb5openalex-snapshot

The promise of apolipoprotein A-I mimetics

inferredcites →https://doi.org/10.1097/mol.0b013e3283518614openalex-snapshot

The role of HDL and its modulators in the development of diabetes

inferredcites →https://doi.org/10.1101/cshperspect.a020412openalex-snapshot

The Blood–Brain Barrier

inferredcites →https://doi.org/10.1111/apha.12250openalex-snapshot

The neurovascular unit - concept review

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Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in A lzheimer's Disease

inferredcites →https://doi.org/10.1111/bpa.12152openalex-snapshot

The Pericyte: A Forgotten Cell Type with Important Implications for A lzheimer's Disease?

inferredcites →https://doi.org/10.1111/ejn.12181openalex-snapshot

Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models

inferredcites →https://doi.org/10.1111/j.1365-2990.2010.01139.xopenalex-snapshot

Review: Cerebral microvascular pathology in ageing and neurodegeneration

inferredcites →https://doi.org/10.1111/j.1471-4159.2010.06978.xopenalex-snapshot

Linking cardiometabolic disorders to sporadic Alzheimer’s disease: a perspective on potential mechanisms and mediators

inferredcites →https://doi.org/10.1111/j.1601-183x.2007.00380.xopenalex-snapshot

Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques

inferredcites →https://doi.org/10.1111/micc.12186openalex-snapshot

Restoration of Cerebral and Systemic Microvascular Architecture in APP / PS 1 Transgenic Mice Following Treatment with Liraglutide™

inferredcites →https://doi.org/10.1126/science.1217697openalex-snapshot

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

inferredcites →https://doi.org/10.1126/science.1251141openalex-snapshot

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

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A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

inferredcites →https://doi.org/10.1152/ajpcell.00249.2014openalex-snapshot

Exendin-4 promotes endothelial barrier enhancement via PKA- and Epac1-dependent Rac1 activation

inferredcites →https://doi.org/10.1159/000285520openalex-snapshot

The Vascular Hypothesis of Alzheimer’s Disease: Bench to Bedside and Beyond

inferredcites →https://doi.org/10.1161/str.0b013e3182299496openalex-snapshot

Vascular Contributions to Cognitive Impairment and Dementia

inferredcites →https://doi.org/10.1161/strokeaha.108.534388openalex-snapshot

Dysfunctional Cell-Cell Signaling in the Neurovascular Unit as a Paradigm for Central Nervous System Disease

inferredcites →https://doi.org/10.1172/jci33622openalex-snapshot

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

inferredcites →https://doi.org/10.1172/jci58642openalex-snapshot

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

inferredcites →https://doi.org/10.1186/alzrt218openalex-snapshot

When the dust settles: what did we learn from the bexarotene discussion?

inferredcites →https://doi.org/10.1186/s12916-014-0206-2openalex-snapshot

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

inferredcites →https://doi.org/10.1194/jlr.m600214-jlr200openalex-snapshot

D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet

inferredcites →https://doi.org/10.1371/journal.pone.0013741openalex-snapshot

The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells

inferredcites →https://doi.org/10.1371/journal.pone.0022142openalex-snapshot

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inferredcites →https://doi.org/10.1371/journal.pone.0036893openalex-snapshot

Morphological and Pathological Evolution of the Brain Microcirculation in Aging and Alzheimer’s Disease

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Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

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Pioglitazone Improves Reversal Learning and Exerts Mixed Cerebrovascular Effects in a Mouse Model of Alzheimer’s Disease with Combined Amyloid-β and Cerebrovascular Pathology

inferredcites →https://doi.org/10.14573/altex.1310071openalex-snapshot

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inferredcites →https://doi.org/10.1523/jneurosci.0169-12.2012openalex-snapshot

Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits

inferredcites →https://doi.org/10.1523/jneurosci.1592-13.2013openalex-snapshot

Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain

inferredcites →https://doi.org/10.1523/jneurosci.3348-08.2008openalex-snapshot

Complete Rescue of Cerebrovascular Function in Aged Alzheimer's Disease Transgenic Mice by Antioxidants and Pioglitazone, a Peroxisome Proliferator-Activated Receptor γ Agonist

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The Vascular Component of Alzheimer’s Disease

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Vascular Risk Factors and Neurodegeneration in Ageing Related Dementias: Alzheimer’s Disease and Vascular Dementia

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The Role of Vascular Factors in Late-Onset Sporadic Alzheimers Disease. Genetic and Molecular Aspects

inferredcites →https://doi.org/10.2174/1871527311312050008openalex-snapshot

Innate Immunity in Alzheimer’s Disease: A Complex Affair

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Anti-inflammatory and Antioxidant Properties of HDLs Are Impaired in Type 2 Diabetes

inferredcites →https://doi.org/10.3233/jad-2012-120793openalex-snapshot

Cerebral Hemodynamics and Vascular Risk Factors: Setting the Stage for Alzheimer's Disease

inferredcites →https://doi.org/10.3233/jad-2012-129027openalex-snapshot

The NeuroImmune System in Alzheimer's Disease: The Glass is Half Full

inferredcites →https://doi.org/10.3233/jad-2012-129037openalex-snapshot

Neurovascular Defects and Faulty Amyloid-β Vascular Clearance in Alzheimer's Disease

inferredcites →https://doi.org/10.3233/jad-2012-129043openalex-snapshot

Endothelin-Converting Enzymes and Related Metalloproteases in Alzheimer's Disease

inferredcites →https://doi.org/10.3389/fendo.2014.00110openalex-snapshot

Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia

inferredcites →https://doi.org/10.3389/fnagi.2014.00176openalex-snapshot

Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

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The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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