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Quaternary Ammonium Compound Disinfectants Reduce Lupus-Associated Splenomegaly by Targeting Neutrophil Migration and T-Cell Fate

https://doi.org/10.3389/fimmu.2020.575179
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bdr2.1064openalex-snapshot
Ambient and Dosed Exposure to Quaternary Ammonium Disinfectants Causes Neural Tube Defects in Rodents
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Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
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Disinfection, Sterilization, and Control of Hospital Waste
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An emerging role of neutrophils and NETosis in chronic inflammation and fibrosis in systemic lupus erythematosus (SLE) and ANCA-associated vasculitides (AAV): Implications for the pathogenesis and treatment
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Interleukin-6 expands homeostatic space for peripheral T cells
inferredcites →https://doi.org/10.1016/j.devcel.2012.02.003openalex-snapshot
LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis
inferredcites →https://doi.org/10.1016/j.jaut.2008.04.009openalex-snapshot
The consequences of apoptosis in autoimmunity
inferredcites →https://doi.org/10.1016/j.rdc.2014.05.003openalex-snapshot
Environmental Influences on Systemic Lupus Erythematosus Expression
inferredcites →https://doi.org/10.1016/j.reprotox.2014.07.071openalex-snapshot
Exposure to common quaternary ammonium disinfectants decreases fertility in mice
inferredcites →https://doi.org/10.1016/j.reprotox.2015.10.006openalex-snapshot
Quaternary ammonium disinfectants cause subfertility in mice by targeting both male and female reproductive processes
inferredcites →https://doi.org/10.1016/s0171-2985(98)80052-1openalex-snapshot
Effects of Administration of Monoclonal Antibodies (anti-CD4 or anti-CD8) on the Development of Autoimmune Diseases in (NZW × BXSB)F1 Mice
inferredcites →https://doi.org/10.1016/s1074-7613(03)00263-2openalex-snapshot
Chemokines Acting via CXCR2 and CXCR4 Control the Release of Neutrophils from the Bone Marrow and Their Return following Senescence
inferredcites →https://doi.org/10.1016/s1550-8579(04)80006-8openalex-snapshot
Gender differences in systemic lupus erythematosus
inferredcites →https://doi.org/10.1021/acs.chemrestox.9b00293openalex-snapshot
Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450
inferredcites →https://doi.org/10.1038/356314a0openalex-snapshot
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
inferredcites →https://doi.org/10.1038/75068openalex-snapshot
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: Evidence in Crohn disease and experimental colitis in vivo
inferredcites →https://doi.org/10.1038/nrneph.2016.71openalex-snapshot
The role of neutrophils and NETosis in autoimmune and renal diseases
inferredcites →https://doi.org/10.1038/nrrheum.2010.46openalex-snapshot
The role of defective clearance of apoptotic cells in systemic autoimmunity
inferredcites →https://doi.org/10.1038/nrrheum.2010.60openalex-snapshot
T cells as therapeutic targets in SLE
inferredcites →https://doi.org/10.1038/nrrheum.2011.132openalex-snapshot
Neutrophils in the pathogenesis and manifestations of SLE
inferredcites →https://doi.org/10.1038/nrrheum.2016.186openalex-snapshot
New insights into the immunopathogenesis of systemic lupus erythematosus
inferredcites →https://doi.org/10.1038/srep20651openalex-snapshot
A pathogenic IFNα, BLyS and IL-17 axis in Systemic Lupus Erythematosus patients
inferredcites →https://doi.org/10.1080/14397595.2017.1377146openalex-snapshot
Alpha beta double negative T cells in children with systemic lupus erythematosus: The relation to disease activity and characteristics
inferredcites →https://doi.org/10.1080/1547691x.2017.1397826openalex-snapshot
Divergent hypersensitivity responses following topical application of the quaternary ammonium compound, didecyldimethylammonium bromide
inferredcites →https://doi.org/10.1084/jem.155.6.1690openalex-snapshot
A spontaneous rheumatoid arthritis-like disease in MRL/l mice.
inferredcites →https://doi.org/10.1088/1478-3975/10/6/065007openalex-snapshot
Surface code—biophysical signals for apoptotic cell clearance
inferredcites →https://doi.org/10.1089/jir.2011.0047openalex-snapshot
The Role of Cytokines in the Pathogenesis and Treatment of Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1093/ckj/sfx063openalex-snapshot
Causes and predictors of mortality in biopsy-proven lupus nephritis: the Sarawak experience
inferredcites →https://doi.org/10.1093/toxsci/kfz002openalex-snapshot
Topical Application of the Quaternary Ammonium Compound Didecyldimethylammonium Chloride Activates Type 2 Innate Lymphoid Cells and Initiates a Mixed-Type Allergic Response
inferredcites →https://doi.org/10.1097/bor.0000000000000197openalex-snapshot
The role of neutrophils in the pathogenesis of systemic lupus erythematosus
inferredcites →https://doi.org/10.1097/bor.0000000000000412openalex-snapshot
An update on lupus animal models
inferredcites →https://doi.org/10.1097/rhu.0b013e3182a6a924openalex-snapshot
Diffuse Lymphadenopathy as the Presenting Manifestation of Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1111/cea.12215openalex-snapshot
Asthma among workers in healthcare settings: role of disinfection with quaternary ammonium compounds
inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00367.xopenalex-snapshot
A crucial role for TNF‐α in mediating neutrophil influx induced by endogenously generated or exogenous chemokines, KC/CXCL1 and LIX/CXCL5
inferredcites →https://doi.org/10.1111/j.1742-7843.2011.00851.xopenalex-snapshot
Airway Effects of Inhaled Quaternary Ammonium Compounds in Mice
inferredcites →https://doi.org/10.1126/science.285.5425.260openalex-snapshot
BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator
inferredcites →https://doi.org/10.1126/science.7539157openalex-snapshot
Mutations in Fas Associated with Human Lymphoproliferative Syndrome and Autoimmunity
inferredcites →https://doi.org/10.1126/scitranslmed.3001201openalex-snapshot
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1128/aac.02437-12openalex-snapshot
Mitochondrial Dysfunction Is the Focus of Quaternary Ammonium Surfactant Toxicity to Mammalian Epithelial Cells
inferredcites →https://doi.org/10.1128/aem.02633-14openalex-snapshot
Quaternary Ammonium Biocides: Efficacy in Application
inferredcites →https://doi.org/10.1128/cmr.12.1.147openalex-snapshot
Antiseptics and Disinfectants: Activity, Action, and Resistance
inferredcites →https://doi.org/10.1136/gutjnl-2016-313075openalex-snapshot
Tumour-activated neutrophils in gastric cancer foster immune suppression and disease progression through GM-CSF-PD-L1 pathway
inferredcites →https://doi.org/10.1136/lupus-2018-000280openalex-snapshot
SLE: reconciling heterogeneity
inferredcites →https://doi.org/10.1155/2011/432595openalex-snapshot
Inflammatory Cytokines in Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.1172/jci41649openalex-snapshot
CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow
inferredcites →https://doi.org/10.1177/0961203316635286openalex-snapshot
Gender differences in disease activity and clinical features in newly diagnosed systemic lupus erythematosus patients
inferredcites →https://doi.org/10.1177/0961203316638934openalex-snapshot
Gender differences in systemic lupus erythematosus concerning anxiety, depression and quality of life
inferredcites →https://doi.org/10.1182/blood-2003-10-3638openalex-snapshot
Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis
inferredcites →https://doi.org/10.1182/blood-2008-09-177287openalex-snapshot
CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions
inferredcites →https://doi.org/10.1182/blood-2010-01-263145openalex-snapshot
Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome
inferredcites →https://doi.org/10.1182/blood.v92.11.4212openalex-snapshot
Interleukin-6 (IL-6) Prevents Activation-Induced Cell Death: IL-2–Independent Inhibition of Fas/fasL Expression and Cell Death
inferredcites →https://doi.org/10.1186/ar2391openalex-snapshot
TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood
inferredcites →https://doi.org/10.1186/ar3206openalex-snapshot
Disturbances of apoptotic cell clearance in systemic lupus erythematosus
inferredcites →https://doi.org/10.1186/s13075-016-0942-0openalex-snapshot
PD-L1-expressing neutrophils as a novel indicator to assess disease activity and severity of systemic lupus erythematosus
inferredcites →https://doi.org/10.1186/s40168-017-0300-8openalex-snapshot
Control of lupus nephritis by changes of gut microbiota
inferredcites →https://doi.org/10.1186/s42358-019-0072-xopenalex-snapshot
CD4+CD69+ T cells and CD4+CD25+FoxP3+ Treg cells imbalance in peripheral blood, spleen and peritoneal lavage from pristane-induced systemic lupus erythematosus (SLE) mice
inferredcites →https://doi.org/10.1191/0961203305lu2079oaopenalex-snapshot
MHC class I expression regulates susceptibility to spontaneous autoimmune disease in (NZBxNZW)F1 mice
inferredcites →https://doi.org/10.1196/annals.1397.001openalex-snapshot
Cationic Surfactants Induce Apoptosis in Normal and Cancer Cells
inferredcites →https://doi.org/10.1371/journal.pone.0072249openalex-snapshot
IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1
inferredcites →https://doi.org/10.1371/journal.pone.0118176openalex-snapshot
Paradoxical Effects of All-Trans-Retinoic Acid on Lupus-Like Disease in the MRL/lpr Mouse Model
inferredcites →https://doi.org/10.1371/journal.ppat.1003993openalex-snapshot
Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway
inferredcites →https://doi.org/10.14740/jocmr2717wopenalex-snapshot
Generalized Lymphadenopathy as Presenting Feature of Systemic Lupus Erythematosus: Case Report and Review of the Literature
inferredcites →https://doi.org/10.21769/bioprotoc.1631openalex-snapshot
Immune Cell Isolation from Mouse Femur Bone Marrow
inferredcites →https://doi.org/10.21873/anticanres.12446openalex-snapshot
PD-1 and PD-L1 Up-regulation Promotes T-cell Apoptosis in Gastric Adenocarcinoma
inferredcites →https://doi.org/10.2215/cjn.03400412openalex-snapshot
Lupus Nephritis
inferredcites →https://doi.org/10.3389/fimmu.2014.00164openalex-snapshot
Breaking Immunological Tolerance in Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.3389/fimmu.2018.02285openalex-snapshot
BAFF and BAFF-Receptor in B Cell Selection and Survival
inferredcites →https://doi.org/10.3389/fimmu.2019.00054openalex-snapshot
The PD-1/PD-L1 Pathway Affects the Expansion and Function of Cytotoxic CD8+ T Cells During an Acute Retroviral Infection
inferredcites →https://doi.org/10.3389/fimmu.2019.00105openalex-snapshot
Neutrophils Which Migrate to Lymph Nodes Modulate CD4+ T Cell Response by a PD-L1 Dependent Mechanism
inferredcites →https://doi.org/10.3389/fimmu.2019.00359openalex-snapshot
Super-Low Dose Lipopolysaccharide Dysregulates Neutrophil Migratory Decision-Making
inferredcites →https://doi.org/10.3389/fimmu.2020.00408openalex-snapshot
Retinoic Acid Exerts Disease Stage-Dependent Effects on Pristane-Induced Lupus
inferredcites →https://doi.org/10.3390/ijms150916043openalex-snapshot
Environmental Factors, Toxicants and Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.3390/ijms160818149openalex-snapshot
A Review of Cell Adhesion Studies for Biomedical and Biological Applications
inferredcites →https://doi.org/10.4049/jimmunol.0902199openalex-snapshot
A Distinct Subset of Proinflammatory Neutrophils Isolated from Patients with Systemic Lupus Erythematosus Induces Vascular Damage and Synthesizes Type I IFNs
inferredcites →https://doi.org/10.4049/jimmunol.1101776openalex-snapshot
MHC Class I Family Proteins Retard Systemic Lupus Erythematosus Autoimmunity and B Cell Lymphomagenesis
inferredcites →https://doi.org/10.4049/jimmunol.129.6.2612openalex-snapshot
Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.
inferredcites →https://doi.org/10.4049/jimmunol.1302112openalex-snapshot
Neutrophil-Mediated IFN Activation in the Bone Marrow Alters B Cell Development in Human and Murine Systemic Lupus Erythematosus
inferredcites →https://doi.org/10.4049/jimmunol.148.4.1119openalex-snapshot
Neutrophil chemotactic factors promote leukocytosis. A common mechanism for cellular recruitment from bone marrow
inferredcites →https://doi.org/10.4049/jimmunol.154.10.5411openalex-snapshot
TNF- alpha mediates recruitment of neutrophils and eosinophils during airway inflammation.
inferredcites →https://doi.org/10.4049/jimmunol.158.12.5791openalex-snapshot
IL-6 rescues resting mouse T cells from apoptosis
inferredcites →https://doi.org/10.4049/jimmunol.1700354openalex-snapshot
Neutrophils Slow Disease Progression in Murine Lupus via Modulation of Autoreactive Germinal Centers
inferredcites →https://doi.org/10.4049/jimmunol.181.12.8761openalex-snapshot
Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys
inferredcites →https://doi.org/10.4172/2155-9899.1000239openalex-snapshot
Pro- and Anti-inflammatory Neutrophils in Lupus

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1002/bdr2.2539openalex-snapshot
Maternal and Placental Inflammation Influence Formation of Neural Tube Defects in Quaternary Ammonium Compound Exposed Mice
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Benzalkonium chloride induces hematopoietic stem cell reduction and immunotoxicity in zebrafish larvae
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Identification and characterization of quaternary ammonium compounds in Flemish indoor dust by ion-mobility high-resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.envint.2024.108446openalex-snapshot
An exposure assessment of 27 quaternary ammonium compounds in pet dogs and cats from New York State, USA
inferred← citeshttps://doi.org/10.1016/j.jchromb.2022.123562openalex-snapshot
LC-MS/MS methods for the determination of 30 quaternary ammonium compounds including benzalkonium and paraquat in human serum and urine
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2025.138442openalex-snapshot
Melamine derivatives in indoor dust from China: Temporal trends and human exposure before and during COVID-19 pandemic
inferred← citeshttps://doi.org/10.1016/j.jtcms.2024.05.007openalex-snapshot
Astragalus membranaceus (Fisch.) Bge. administered by dissolving microneedles achieves systemic therapeutic effects at low doses
inferred← citeshttps://doi.org/10.1016/j.toxrep.2021.03.006openalex-snapshot
Altered toxicological endpoints in humans from common quaternary ammonium compound disinfectant exposure
inferred← citeshttps://doi.org/10.1016/j.watres.2025.124935openalex-snapshot
Removal of a quaternary ammonium compound by electrocoagulation: Mechanistic analysis and multi-response optimization using response surface methodology and machine learning
inferred← citeshttps://doi.org/10.1021/acs.est.2c08244openalex-snapshot
Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern
inferred← citeshttps://doi.org/10.1021/acs.est.5c05821openalex-snapshot
Exposure to Quaternary Ammonium Compounds (QACs) in Assisted Living Facilities: Implications for Older Adults
inferred← citeshttps://doi.org/10.1021/acs.est.5c18112openalex-snapshot
Quaternary Ammonium Compound Induced Electrocardiogram Abnormalities with Body Fat as a Potential Effect Modifier: A Longitudinal Multiomics Panel Study in Elderly Adults
inferred← citeshttps://doi.org/10.1021/acs.est.6c08408openalex-snapshot
More than Quaternary Ammonium Compounds: First Evidence of Tertiary Amine Compounds as Novel Contaminants Ubiquitously Present in Indoor Dust
inferred← citeshttps://doi.org/10.1021/acs.estlett.4c00372openalex-snapshot
Quaternary Ammonium Compounds in Paired Human Urine and Feces: Relative Significance of Biliary Elimination
inferred← citeshttps://doi.org/10.1021/acsanm.3c02219openalex-snapshot
Carbon Nanotubes for Optical Detection of Quaternary Ammonium Compounds in Complex Media
inferred← citeshttps://doi.org/10.1089/genbio.2022.0014openalex-snapshot
Single-Cell Technologies: Advances in Single-Cell Migration and Multi-Omics
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Haematological and serum biochemical derangements induced by acute exposure to didecyl dimethyl ammonium bromide in Gallus gallus domesticus
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Electrotaxis-on-Chip to Quantify Neutrophil Migration Towards Electrochemical Gradients
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Nlrp12 deficiency alters gut microbiota and ameliorates Faslpr-mediated systemic autoimmunity in male mice
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1359534openalex-snapshot
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