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Myricetin Modulates Macrophage Polarization and Mitigates Liver Inflammation and Fibrosis in a Murine Model of Nonalcoholic Steatohepatitis

https://doi.org/10.3389/fmed.2020.00071

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Macrophage Plasticity and Polarization in Liver Homeostasis and Pathology

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NKp46+ natural killer cells attenuate metabolism‐induced hepatic fibrosis by regulating macrophage activation in mice

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Molecular magnetic resonance imaging accurately measures the antifibrotic effect of EDP‐305, a novel farnesoid X receptor agonist

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inferredcites →https://doi.org/10.1002/mnfr.201600392openalex-snapshot

The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice

inferredcites →https://doi.org/10.1002/mnfr.201801393openalex-snapshot

Myricetin Ameliorates Ethanol‐Induced Lipid Accumulation in Liver Cells by Reducing Fatty Acid Biosynthesis

inferredcites →https://doi.org/10.1007/s00394-017-1433-zopenalex-snapshot

Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice

inferredcites →https://doi.org/10.1016/j.cbi.2015.01.030openalex-snapshot

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

inferredcites →https://doi.org/10.1016/j.celrep.2017.06.017openalex-snapshot

RORα Induces KLF4-Mediated M2 Polarization in the Liver Macrophages that Protect against Nonalcoholic Steatohepatitis

inferredcites →https://doi.org/10.1016/j.jhep.2017.02.026openalex-snapshot

Targeting hepatic macrophages to treat liver diseases

inferredcites →https://doi.org/10.1016/j.jhep.2019.03.014openalex-snapshot

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization

inferredcites →https://doi.org/10.1016/j.jnutbio.2015.10.015openalex-snapshot

The dietary flavonoid myricetin regulates iron homeostasis by suppressing hepcidin expression

inferredcites →https://doi.org/10.1016/j.lfs.2007.08.045openalex-snapshot

Myricetin, a naturally occurring flavonol, ameliorates insulin resistance induced by a high-fructose diet in rats

inferredcites →https://doi.org/10.1016/j.omtm.2016.11.004openalex-snapshot

Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes

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Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways

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The TREM receptor family and signal integration

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TLR4 enhances TGF-β signaling and hepatic fibrosis

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Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

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Pirfenidone prevents and reverses hepatic insulin resistance and steatohepatitis by polarizing M2 macrophages

inferredcites →https://doi.org/10.1038/s41423-018-0003-5openalex-snapshot

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Triggering and resolution of inflammation in NASH

inferredcites →https://doi.org/10.1038/s41575-018-0082-xopenalex-snapshot

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

inferredcites →https://doi.org/10.1038/s41598-017-05303-2openalex-snapshot

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α

inferredcites →https://doi.org/10.1038/srep39520openalex-snapshot

Chronic hepatitis C infection–induced liver fibrogenesis is associated with M2 macrophage activation

inferredcites →https://doi.org/10.1038/srep44612openalex-snapshot

Effect of modulation of PPAR-γ activity on Kupffer cells M1/M2 polarization in the development of non-alcoholic fatty liver disease

inferredcites →https://doi.org/10.1039/c4fo01073fopenalex-snapshot

Myricetin derived from Hovenia dulcis Thunb. ameliorates vascular endothelial dysfunction and liver injury in high choline-fed mice

inferredcites →https://doi.org/10.1111/iep.12008openalex-snapshot

An improved mouse model that rapidly develops fibrosis in non‐alcoholic steatohepatitis

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Ficolin‐A/2, acting as a new regulator of macrophage polarization, mediates the inflammatory response in experimental mouse colitis

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Human Fatty Liver Disease: Old Questions and New Insights

inferredcites →https://doi.org/10.1136/gut.2008.156307openalex-snapshot

Toll-like receptors as targets in chronic liver diseases

inferredcites →https://doi.org/10.1152/ajpgi.00027.2018openalex-snapshot

Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages

inferredcites →https://doi.org/10.1152/ajplung.00140.2007openalex-snapshot

Functional genomics of silencing TREM-1 on TLR4 signaling in macrophages

inferredcites →https://doi.org/10.1155/2012/787152openalex-snapshot

Myricetin Increases Hepatic Peroxisome Proliferator-Activated Receptor α Protein Expression and Decreases Plasma Lipids and Adiposity in Rats

inferredcites →https://doi.org/10.1172/jci.insight.88689openalex-snapshot

IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans

inferredcites →https://doi.org/10.1172/jci122258openalex-snapshot

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223

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NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation

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Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat–cholesterol–sugar diet model in mice

inferredcites →https://doi.org/10.1186/s12967-017-1187-7openalex-snapshot

RETRACTED ARTICLE: TREM-1 associated macrophage polarization plays a significant role in inducing insulin resistance in obese population

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inferredcites →https://doi.org/10.3389/fimmu.2014.00430openalex-snapshot

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Regulation of Human Macrophage M1–M2 Polarization Balance by Hypoxia and the Triggering Receptor Expressed on Myeloid Cells-1

inferredcites →https://doi.org/10.3389/fphar.2018.00072openalex-snapshot

The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

inferredcites →https://doi.org/10.3389/fphar.2019.00647openalex-snapshot

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inferredcites →https://doi.org/10.3389/fphar.2019.01089openalex-snapshot

Morin Hydrate Inhibits TREM-1/TLR4-Mediated Inflammatory Response in Macrophages and Protects Against Carbon Tetrachloride-Induced Acute Liver Injury in Mice

inferredcites →https://doi.org/10.3390/nu8020090openalex-snapshot

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inferredcites →https://doi.org/10.3390/nu8120799openalex-snapshot

Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet

inferredcites →https://doi.org/10.3892/ijmm.2019.4402openalex-snapshot

HMGB1 participates in LPS‑induced acute lung injury by�activating the AIM2 inflammasome in macrophages�and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF‑κB signaling pathways

inferredcites →https://doi.org/10.3892/ijmm.2020.4530openalex-snapshot

[Corrigendum] HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF‑κB signaling pathways

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Modular bioinformatics analysis demonstrates that a Toll‑like receptor signaling pathway is involved in the regulation of macrophage polarization

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