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The Flavonoid Quercetin Ameliorates Liver Inflammation and Fibrosis by Regulating Hepatic Macrophages Activation and Polarization in Mice

https://doi.org/10.3389/fphar.2018.00072
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/eji.200636999openalex-snapshot
Notch signaling is activated by TLR stimulation and regulates macrophage functions
inferredcites →https://doi.org/10.1002/hep.26429openalex-snapshot
Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
inferredcites →https://doi.org/10.1002/hep.26607openalex-snapshot
M2 Kupffer cells promote M1 Kupffer cell apoptosis: A protective mechanism against alcoholic and nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1002/hep.26754openalex-snapshot
Macrophage Plasticity and Polarization in Liver Homeostasis and Pathology
inferredcites →https://doi.org/10.1002/hep.27332openalex-snapshot
Hepatic inflammation and fibrosis: Functional links and key pathways
inferredcites →https://doi.org/10.1002/hep.28386openalex-snapshot
Dual Notch signaling in proinflammatory macrophage activation
inferredcites →https://doi.org/10.1002/hep.28389openalex-snapshot
NKp46+ natural killer cells attenuate metabolism‐induced hepatic fibrosis by regulating macrophage activation in mice
inferredcites →https://doi.org/10.1002/hep.28873openalex-snapshot
Expression of scavenger receptor‐AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis
inferredcites →https://doi.org/10.1007/s10753-015-0227-9openalex-snapshot
Quercetin Protects Mice from ConA-Induced Hepatitis by Inhibiting HMGB1-TLR Expression and Down-Regulating the Nuclear Factor Kappa B Pathway
inferredcites →https://doi.org/10.1016/0168-8278(91)90084-oopenalex-snapshot
Classification of chronic viral hepatitis: a need for reassessment
inferredcites →https://doi.org/10.1016/j.bcp.2011.08.010openalex-snapshot
The flavonoid quercetin in disease prevention and therapy: Facts and fancies
inferredcites →https://doi.org/10.1016/j.clinre.2015.05.016openalex-snapshot
Notch signaling and M1 macrophage activation in obesity-alcohol synergism
inferredcites →https://doi.org/10.1016/j.immuni.2016.02.015openalex-snapshot
Macrophages in Tissue Repair, Regeneration, and Fibrosis
inferredcites →https://doi.org/10.1016/j.jhep.2013.12.025openalex-snapshot
Macrophage heterogeneity in liver injury and fibrosis
inferredcites →https://doi.org/10.1016/j.jhep.2017.02.026openalex-snapshot
Targeting hepatic macrophages to treat liver diseases
inferredcites →https://doi.org/10.1016/j.omtm.2016.11.004openalex-snapshot
Antibody-Directed Glucocorticoid Targeting to CD163 in M2-type Macrophages Attenuates Fructose-Induced Liver Inflammatory Changes
inferredcites →https://doi.org/10.1016/j.toxlet.2016.09.002openalex-snapshot
Quercetin attenuates the activation of hepatic stellate cells and liver fibrosis in mice through modulation of HMGB1-TLR2/4-NF-κB signaling pathways
inferredcites →https://doi.org/10.1016/j.yexmp.2014.04.003openalex-snapshot
M1- and M2-macrophage polarization in rat liver cirrhosis induced by thioacetamide (TAA), focusing on Iba1 and galectin-3
inferredcites →https://doi.org/10.1038/ijo.2010.272openalex-snapshot
Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media
inferredcites →https://doi.org/10.1038/nature12034openalex-snapshot
Macrophage biology in development, homeostasis and disease
inferredcites →https://doi.org/10.1038/nrgastro.2017.38openalex-snapshot
Mechanisms of hepatic stellate cell activation
inferredcites →https://doi.org/10.1038/nri3088openalex-snapshot
Transcriptional regulation of macrophage polarization: enabling diversity with identity
inferredcites →https://doi.org/10.1038/nri3623openalex-snapshot
Liver fibrosis and repair: immune regulation of wound healing in a solid organ
inferredcites →https://doi.org/10.1038/s41598-017-09673-5openalex-snapshot
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways
inferredcites →https://doi.org/10.1038/srep18272openalex-snapshot
The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis
inferredcites →https://doi.org/10.1053/j.gastro.2008.03.003openalex-snapshot
Mechanisms of Hepatic Fibrogenesis
inferredcites →https://doi.org/10.1111/j.1440-1746.2012.07262.xopenalex-snapshot
Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance
inferredcites →https://doi.org/10.1111/jcmm.13158openalex-snapshot
Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease
inferredcites →https://doi.org/10.1124/jpet.107.128264openalex-snapshot
Comparative Protection against Liver Inflammation and Fibrosis by a Selective Cyclooxygenase-2 Inhibitor and a Nonredox-Type 5-Lipoxygenase Inhibitor
inferredcites →https://doi.org/10.1128/jvi.02293-15openalex-snapshot
M2 Macrophages Play Critical Roles in Progression of Inflammatory Liver Disease in Hepatitis C Virus Transgenic Mice
inferredcites →https://doi.org/10.1136/gutjnl-2014-308325openalex-snapshot
CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism
inferredcites →https://doi.org/10.1152/ajpcell.1999.277.3.c403openalex-snapshot
Quercetin inhibits inducible ICAM-1 expression in human endothelial cells through the JNK pathway
inferredcites →https://doi.org/10.1152/ajpgi.00365.2011openalex-snapshot
Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2
inferredcites →https://doi.org/10.1172/jci.insight.88689openalex-snapshot
IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans
inferredcites →https://doi.org/10.1172/jci200522675openalex-snapshot
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
inferredcites →https://doi.org/10.1172/jci59643openalex-snapshot
Macrophage plasticity and polarization: in vivo veritas
inferredcites →https://doi.org/10.1172/jci76468openalex-snapshot
NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation
inferredcites →https://doi.org/10.1194/jlr.m038786openalex-snapshot
Quercetin reduces obesity-associated ATM infiltration and inflammation in mice: a mechanism including AMPKα1/SIRT1
inferredcites →https://doi.org/10.3389/fimmu.2014.00430openalex-snapshot
Hepatic Localization of Macrophage Phenotypes during Fibrogenesis and Resolution of Fibrosis in Mice and Humans
inferredcites →https://doi.org/10.3389/fimmu.2017.00635openalex-snapshot
Notch Regulates Macrophage-Mediated Inflammation in Diabetic Wound Healing
inferredcites →https://doi.org/10.3389/fimmu.2017.00801openalex-snapshot
Placental Growth Factor Contributes to Liver Inflammation, Angiogenesis, Fibrosis in Mice by Promoting Hepatic Macrophage Recruitment and Activation
inferredcites →https://doi.org/10.3390/molecules21040450openalex-snapshot
Anti‐Inflammatory Effect of Quercetin on RAW 264.7 Mouse Macrophages Induced with Polyinosinic‐Polycytidylic Acid
inferredcites →https://doi.org/10.3945/jn.112.165274openalex-snapshot
Quercetin Treatment Ameliorates Inflammation and Fibrosis in Mice with Nonalcoholic Steatohepatitis3

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Wuling Capsule Modulates Macrophage Polarization by Inhibiting the TLR4-NF-κB Signaling Pathway to Relieve Liver Fibrosis
inferred← citeshttps://doi.org/10.1002/adhm.202402056openalex-snapshot
Legumain‐Guided Ferulate‐Peptide Self‐Assembly Enhances Macrophage‐Endotheliocyte Partnership to Promote Therapeutic Angiogenesis After Myocardial Infarction
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A Genetically Engineered Biomimetic Nanodecoy for the Treatment of Liver Fibrosis
inferred← citeshttps://doi.org/10.1002/biof.1694openalex-snapshot
The role of phytochemicals in sepsis: A mechanistic and therapeutic perspective
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The Preventive and Therapeutic Potential of the Flavonoids in Liver Cirrhosis: Current and Future Perspectives
inferred← citeshttps://doi.org/10.1002/chem.201905272openalex-snapshot
Mechanistic Insights into the Regio‐ and Stereoselectivities of Testosterone and Dihydrotestosterone Hydroxylation Catalyzed by CYP3A4 and CYP19A1
inferred← citeshttps://doi.org/10.1002/mnfr.70144openalex-snapshot
Flavonoid Polyphenols as Therapeutic Agents for Fatty Liver Disease: Mechanisms, Microbiome Interactions, and Metabolic Insights
inferred← citeshttps://doi.org/10.1002/ptr.7104openalex-snapshot
Quercetin as a protective agent for liver diseases: A comprehensive descriptive review of the molecular mechanism
inferred← citeshttps://doi.org/10.1002/ptr.8043openalex-snapshot
Human diet‐derived polyphenolic compounds and hepatic diseases: From therapeutic mechanisms to clinical utilization
inferred← citeshttps://doi.org/10.1002/ptr.8193openalex-snapshot
Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosis
inferred← citeshttps://doi.org/10.1002/smll.202101505openalex-snapshot
Quercetin‐Loaded Ceria Nanocomposite Potentiate Dual‐Directional Immunoregulation via Macrophage Polarization against Periodontal Inflammation
inferred← citeshttps://doi.org/10.1007/978-981-96-2960-2_10openalex-snapshot
Nutri-Ayur as Immunity Modulator
inferred← citeshttps://doi.org/10.1007/s10735-024-10303-4openalex-snapshot
Possible protective effect of quercetin on lung injury induced by skeletal muscle ischemia reperfusion (IR) injury of adult male albino rats: Histological and biochemical study
inferred← citeshttps://doi.org/10.1007/s10753-023-01826-1openalex-snapshot
Phillygenin Ameliorates Carbon Tetrachloride-Induced Liver Fibrosis: Suppression of Inflammation and Wnt/β-Catenin Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s10787-023-01212-1openalex-snapshot
Polyphenol-based targeted therapy for oral submucous fibrosis
inferred← citeshttps://doi.org/10.1007/s10787-025-01678-1openalex-snapshot
Use quercetin for pulmonary fibrosis: a preclinical systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1007/s11033-019-05148-0openalex-snapshot
The protective effect of quercetin in the alcohol-induced liver and lymphoid tissue injuries in newborns
inferred← citeshttps://doi.org/10.1007/s13346-026-02100-1openalex-snapshot
Bioactive co-assembly of PSA/diT-VES nanomicelles orchestrates macrophage reprogramming for acute lung injury therapy
inferred← citeshttps://doi.org/10.1016/b978-0-12-817890-4.00012-3openalex-snapshot
Lead compounds with the potentials for the treatment of chronic liver diseases
inferred← citeshttps://doi.org/10.1016/b978-0-12-819096-8.00049-5openalex-snapshot
Antioxidants and liver diseases
inferred← citeshttps://doi.org/10.1016/b978-0-323-99111-7.00015-5openalex-snapshot
Natural products in conditions associated with inflammatory bowel diseases: Extraintestinal manifestations
inferred← citeshttps://doi.org/10.1016/j.actatropica.2025.107913openalex-snapshot
Immunomodulatory and anti-fibrotic effects of Toxocara canis infection in a murine model of thioacetamide-induced chronic hepatic fibrosis
inferred← citeshttps://doi.org/10.1016/j.bbi.2023.06.003openalex-snapshot
The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis
inferred← citeshttps://doi.org/10.1016/j.bbrc.2021.07.059openalex-snapshot
ASCs -derived exosomes loaded with vitamin A and quercetin inhibit rapid senescence-like response after acute liver injury
inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.152682openalex-snapshot
Immune cell subsets as therapeutic targets in liver fibrosis: from mechanisms to translational applications
inferred← citeshttps://doi.org/10.1016/j.bbrep.2026.102540openalex-snapshot
Quercetin alleviates CCl4-induced liver fibrosis via regulating gut microbiota and the AGE-RAGE/PI3K/Akt signaling axis
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116823openalex-snapshot
Ziziphus spina-christi L. extract attenuates bleomycin-induced lung fibrosis in mice via regulating TGF-β1/SMAD pathway: LC-MS/MS Metabolic profiling, chemical composition, and histology studies
inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112754openalex-snapshot
Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors
inferred← citeshttps://doi.org/10.1016/j.fbio.2023.102366openalex-snapshot
Luteolin: A flavone with myriads of bioactivities and food applications
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.09.024openalex-snapshot
Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages
inferred← citeshttps://doi.org/10.1016/j.gene.2026.150143openalex-snapshot
Quercetin-driven M2 polarization of macrophages via ALOX5 inhibition in kupffer cells: A strategy for mouse liver fibrosis treatment
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e13722openalex-snapshot
Zinc-glutathione in Chinese Baijiu prevents alcohol-associated liver injury
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e29977openalex-snapshot
Network pharmacology-based analysis on the key mechanisms of Yiguanjian acting on chronic hepatitis
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.129670openalex-snapshot
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107557openalex-snapshot
Inhibitory Effect of Quercetin on Propionibacterium acnes-induced Skin Inflammation
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.109876openalex-snapshot
Oxyberberine suppressed the carbon tetrachloride-induced liver fibrosis by inhibiting liver inflammation in a sirtuin 3-dependent manner in mice
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.111598openalex-snapshot
Wuling capsule modulates macrophage polarization by inhibiting the TLR4-NF-κB signaling pathway to relieve liver fibrosis
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113444openalex-snapshot
Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARγ/PGC-1α/NF-κB axis to improve acute liver failure
inferred← citeshttps://doi.org/10.1016/j.jare.2021.01.007openalex-snapshot
Pathological and immunological characterization of bluetongue virus serotype 1 infection in type I interferons blocked immunocompetent adult mice
inferred← citeshttps://doi.org/10.1016/j.jcm.2021.12.005openalex-snapshot
An Exploratory Review of Potential Adjunct Therapies for the Treatment of Coronavirus Infections
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2024.101406openalex-snapshot
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization
inferred← citeshttps://doi.org/10.1016/j.jep.2018.08.015openalex-snapshot
Evaluation of the toxicity and anti-inflammatory activities of the infusion of leaves of Campomanesia guazumifolia (Cambess.) O. Berg
inferred← citeshttps://doi.org/10.1016/j.jep.2025.119511openalex-snapshot
Mechanism of Qingjie Fuzheng Granules in inhibiting colitis associated colorectal cancer by regulating TLR4 and IL-4R mediated macrophage polarization
inferred← citeshttps://doi.org/10.1016/j.jff.2019.03.001openalex-snapshot
Quercetin confers protection of murine sepsis by inducing macrophage M2 polarization via the TRPM2 dependent calcium influx and AMPK/ATF3 activation
inferred← citeshttps://doi.org/10.1016/j.jfutfo.2026.06.023openalex-snapshot
Natural Flavonoids as Potential Modulators of Liver Fibrosis: A Review of Mechanisms and Therapeutic Targets
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2021.108802openalex-snapshot
Selective suppression of M1 macrophages is involved in zinc inhibition of liver fibrosis in mice
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.117560openalex-snapshot
Dietary calcium regulates the insulin sensitivity by altering the adipokine secretion in high fat diet induced obese rats
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118173openalex-snapshot
Flavonoids-mediated SIRT1 signaling activation in hepatic disorders
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.122143openalex-snapshot
Evaluation of the flavonol-rich fraction of Rosa damascena in an animal model of liver fibrosis by targeting the expression of fibrotic cytokines, antioxidant/oxidant ratio and collagen cross-linking
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.122349openalex-snapshot
Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways
inferred← citeshttps://doi.org/10.1016/j.mex.2023.102537openalex-snapshot
Exploring the effectiveness of flavone derivatives for treating liver diseases: Utilizing DFT, molecular docking, and molecular dynamics techniques
inferred← citeshttps://doi.org/10.1016/j.pharep.2019.01.008openalex-snapshot
Antifibrotic effects of Fraxetin on carbon tetrachloride-induced liver fibrosis by targeting NF-κB/IκBα, MAPKs and Bcl-2/Bax pathways
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2021.108031openalex-snapshot
Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155016openalex-snapshot
Corilagin alleviates liver fibrosis in zebrafish and mice by repressing IDO1-mediated M2 macrophage repolarization
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155932openalex-snapshot
The potential of flavonoids in hepatic fibrosis: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.phyplu.2022.100220openalex-snapshot
Focus on the high therapeutic potentials of quercetin and its derivatives
inferred← citeshttps://doi.org/10.1016/j.toxrep.2021.08.001openalex-snapshot
Quercetin attenuated the Benzene-induced hemato- and hepatotoxicity in mice
inferred← citeshttps://doi.org/10.1021/acs.jproteome.5c01019openalex-snapshot
Mitochondrial Proteomics Uncovers that Myeloid S100A9 Deficiency Promotes Liver Injury and Fibrosis Regression via Mitochondrial Metabolic Reprogramming of Macrophages
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.2c00009openalex-snapshot
Development of Poly(lipoic acid) Nanoparticles with Improved Oral Bioavailability and Hepatoprotective Effects of Quercetin
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5c01439openalex-snapshot
Targeting the Hepatic Stellate Cell Microenvironment: Nanomedicine Strategies for Liver Fibrosis Therapy
inferred← citeshttps://doi.org/10.1021/acsami.4c15494openalex-snapshot
Quercetin-Loaded Melanin Nanoparticles Decorated with Collagenase Mediates Synergistic Immunomodulation and Restores Extracellular Matrix Homeostasis in Liver Fibrosis
inferred← citeshttps://doi.org/10.1038/s41577-022-00785-2openalex-snapshot
COVID-19 and cellular senescence
inferred← citeshttps://doi.org/10.1038/s41586-021-03995-1openalex-snapshot
Virus-induced senescence is a driver and therapeutic target in COVID-19
inferred← citeshttps://doi.org/10.1038/s41598-025-27911-zopenalex-snapshot
Vitamin D3 attenuates hepatic inflammation in primary biliary cholangitis by inhibiting TLR4/NF-κB mediated M1 macrophage polarization
inferred← citeshttps://doi.org/10.1038/s41598-026-62378-6openalex-snapshot
The potential therapeutic effect of quercetin on mitochondrial dysfunction in hepatorenal toxicity induced by aluminum chloride in an experimental rat model
inferred← citeshttps://doi.org/10.1039/c9fo00336copenalex-snapshot
Turmeronol A and turmeronol B from Curcuma longa prevent inflammatory mediator production by lipopolysaccharide-stimulated RAW264.7 macrophages, partially via reduced NF-κB signaling
inferred← citeshttps://doi.org/10.1039/c9fo01134jopenalex-snapshot
Maternal quercetin intake during lactation attenuates renal inflammation and modulates autophagy flux in high-fructose-diet-fed female rat offspring exposed to maternal malnutrition
inferred← citeshttps://doi.org/10.1039/d2fo03509jopenalex-snapshot
Analysis of the mechanism of action of quercetin in the treatment of hyperlipidemia based on metabolomics and intestinal flora
inferred← citeshttps://doi.org/10.1080/01480545.2020.1849270openalex-snapshot
Effects of prolonged subchronic benzo(α)pyrene exposure on rat liver morphology and CYP1A expression during treatment with menadione, quercetin, or tocopherol
inferred← citeshttps://doi.org/10.1080/01480545.2021.2012905openalex-snapshot
Protective effects of a chemically characterized extract from solanum torvum leaves on acetaminophen-induced liver injury
inferred← citeshttps://doi.org/10.1080/08923973.2020.1725039openalex-snapshot
Alantolactone mitigates renal injury induced by diabetes via inhibition of high glucose-mediated inflammatory response and macrophage infiltration
inferred← citeshttps://doi.org/10.1080/09553002.2022.2087926openalex-snapshot
Protective effect of acrocarpus fraxinifolius extract against hepatic fibrosis induced by Gamma irradiation and carbon tetrachloride in albino rats
inferred← citeshttps://doi.org/10.1080/10408398.2021.1947772openalex-snapshot
Enhancement of bioavailability and bioactivity of diet-derived flavonoids by application of nanotechnology: a review
inferred← citeshttps://doi.org/10.1080/13813455.2022.2134423openalex-snapshot
Thymoquinone and quercetin protect against hepatic steatosis in association with SIRT1/AMPK stimulation and regulation of autophagy, perilipin-2, and cytosolic lipases
inferred← citeshttps://doi.org/10.1093/bib/bbaa115openalex-snapshot
Dr AFC : drug repositioning through anti-fibrosis characteristic
inferred← citeshttps://doi.org/10.1097/md.0000000000034353openalex-snapshot
Mechanisms of main components in Curcuma longa L. on hepatic fibrosis based on network pharmacology and molecular docking: A review
inferred← citeshttps://doi.org/10.1097/meg.0000000000001485openalex-snapshot
Herbal medicines for the liver: from bench to bedside
inferred← citeshttps://doi.org/10.1097/meg.0000000000002483openalex-snapshot
A review of edible plant-derived natural compounds for the therapy of liver fibrosis
inferred← citeshttps://doi.org/10.1111/acel.13528openalex-snapshot
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
inferred← citeshttps://doi.org/10.1111/jcmm.14805openalex-snapshot
Celastrol exerts anti‐inflammatory effect in liver fibrosis via activation of AMPK‐SIRT3 signalling
inferred← citeshttps://doi.org/10.1111/jcmm.15398openalex-snapshot
RETRACTED: Melatonin modulates mitophagy, innate immunity and circadian clocks in a model of viral‐induced fulminant hepatic failure
inferred← citeshttps://doi.org/10.1111/jcmm.18196openalex-snapshot
Hepatoprotective activity of Lactéol® forte and quercetin dihydrate against thioacetamide‐induced hepatic cirrhosis in male albino rats
inferred← citeshttps://doi.org/10.1111/liv.14940openalex-snapshot
Hepatic macrophages: Key players in the development and progression of liver fibrosis
inferred← citeshttps://doi.org/10.1124/molpharm.123.000675openalex-snapshot
Gossypetin Prevents the Progression of Nonalcoholic Steatohepatitis by Regulating Oxidative Stress and AMP-Activated Protein Kinase
inferred← citeshttps://doi.org/10.1142/s0192415x24500666openalex-snapshot
Research Progress of Chinese Medicine in the Regulation of Liver Fibrosis-Related Signaling Pathways
inferred← citeshttps://doi.org/10.1142/s0192415x25500545openalex-snapshot
Advances and Perspectives on the Anti-Fibrotic Mechanisms of the Quercetin
inferred← citeshttps://doi.org/10.1155/2020/4875764openalex-snapshot
An Overview of the Mechanism of Penthorum chinense Pursh on Alcoholic Fatty Liver
inferred← citeshttps://doi.org/10.1155/2020/7171498openalex-snapshot
A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids
inferred← citeshttps://doi.org/10.1155/2021/6614039openalex-snapshot
A Network Pharmacology Approach to Explore the Mechanisms of Artemisiae scopariae Herba for the Treatment of Chronic Hepatitis B
inferred← citeshttps://doi.org/10.1155/2021/6671129openalex-snapshot
Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
inferred← citeshttps://doi.org/10.1155/2022/7291434openalex-snapshot
Investigating the Molecular Mechanism of Quercetin Protecting against Podocyte Injury to Attenuate Diabetic Nephropathy through Network Pharmacology, MicroarrayData Analysis, and Molecular Docking
inferred← citeshttps://doi.org/10.1155/2022/8925637openalex-snapshot
Mechanisms of Xiaochaihu Decoction on Treating Hepatic Fibrosis Explored by Network Pharmacology
inferred← citeshttps://doi.org/10.1155/jfbc/8094502openalex-snapshot
Health Benefits and Therapeutic Potential of Quercetin
inferred← citeshttps://doi.org/10.1186/s12891-020-03618-2openalex-snapshot
Quercetin reduces tendon adhesion in rat through suppression of oxidative stress
inferred← citeshttps://doi.org/10.1186/s12906-022-03785-wopenalex-snapshot
Quercetin ameliorates acute lung injury in a rat model of hepatopulmonary syndrome
inferred← citeshttps://doi.org/10.1186/s12906-026-05338-xopenalex-snapshot
Hepatosplenic protective role of quercetin in gamma-irradiated rats: modulation of oxidative stress, inflammatory and TGF-β signaling pathways
inferred← citeshttps://doi.org/10.1186/s13071-021-04663-zopenalex-snapshot
The NF-κB signalling pathway and TM7SF3 contribute to liver fibrosis caused by secreted phospholipase A2 of Clonorchis sinensis
inferred← citeshttps://doi.org/10.1186/s40360-020-0388-5openalex-snapshot
Protective and therapeutic effects of nanoliposomal quercetin on acute liver injury in rats
inferred← citeshttps://doi.org/10.12677/hjbm.2025.151007openalex-snapshot
To Explore the Mechanism of Action and Material Basis of Sophora tonkinensis Gagnep in the Treatment of Liver Cirrhosis Based on Bioinformatics
inferred← citeshttps://doi.org/10.1590/s2175-97902020000117707openalex-snapshot
Extract of Solidago chilensis Meyen inflorescences: cytotoxicity and inhibitory activity on nitric oxide synthesis in activated macrophage cell line J774A.1
inferred← citeshttps://doi.org/10.17582/journal.aavs/2020/8.s1.18.25openalex-snapshot
Immunomodulatory and Anti-angiogenic Properties of Linum usitatissium (flaxseed) Seeds Ethanolic Extract in Atherogenic Diet Treated Rats
inferred← citeshttps://doi.org/10.18388/abp.2020_6772openalex-snapshot
Characterization and gastroprotective effects of Rosa brunonii Lindl. fruit on gastric mucosal injury in experimental rats – A preliminary study
inferred← citeshttps://doi.org/10.18632/aging.203752openalex-snapshot
Tartary buckwheat flavonoids relieve the tendency of mammary fibrosis induced by HFD during pregnancy and lactation
inferred← citeshttps://doi.org/10.21037/atm-21-4602openalex-snapshot
Schisandrin B regulates macrophage polarization and alleviates liver fibrosis via activation of PPARγ
inferred← citeshttps://doi.org/10.2139/ssrn.5082461openalex-snapshot
Proteomic Analysis of the Ameliorative Effect of Total Flavonoids from Astragali Complanati Semen on Ccl(4)-Induced Liver Fibrosis in Rats Via the Fak/Akt1 Pathway
inferred← citeshttps://doi.org/10.2147/dmso.s548513openalex-snapshot
Research Progress on the Role and Mechanism of Flavonoids in Improving Metabolic Associated Fatty Liver Disease
inferred← citeshttps://doi.org/10.2147/ijn.s526731openalex-snapshot
Recent Progress in Nano-TCM Active Ingredient Co-Delivery Systems for Inflammation-Mediated Diseases
inferred← citeshttps://doi.org/10.2147/ijn.s542641openalex-snapshot
The Application of Exosomes From Different Sources Loaded with Natural Small-Molecule Compounds in Disease
inferred← citeshttps://doi.org/10.2147/jep.s548399openalex-snapshot
Livogrit Ameliorates Thioacetamide-Induced Liver Fibrosis and Dyslipidemia in Rat Model by Regulating Oxidative Stress and Hepatic Collagen Levels, in a Non-Mutagenic Manner
inferred← citeshttps://doi.org/10.21472/bjbs.051104openalex-snapshot
Role of quercetin in the prevention and treatment of diseases: Mini review
inferred← citeshttps://doi.org/10.21608/besps.2019.14512.1026openalex-snapshot
Quercetin mitigates liver injury in a rat model of liver cholestasis
inferred← citeshttps://doi.org/10.21608/ejh.2019.12675.1117openalex-snapshot
The possible protective effect of quercetin on methotrexate induced hepatotoxicity in albino rats: biochemical , histological and immunohistochemical study
inferred← citeshttps://doi.org/10.2174/0115734013282941240103065848openalex-snapshot
Herbal Components for the Treatment of Liver Disorders: Advances and Prospective
inferred← citeshttps://doi.org/10.2174/1381612825666190829154934openalex-snapshot
Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects
inferred← citeshttps://doi.org/10.22141/2224-0721.20.8.2024.1471openalex-snapshot
The impact of prolonged blockade of the releasing hormone on alterations in cardiac macrophage polarisation subsequent to quercetin administration in rats
inferred← citeshttps://doi.org/10.22146/inajbcs.v56i2.13416openalex-snapshot
The curative effect of ethanolic extract of Moringa oleifera leaf in an animal model of liver fibrosis
inferred← citeshttps://doi.org/10.2217/nnm-2022-0032openalex-snapshot
Quercetin Nanocrystals Prepared by A Novel Technique Improve The Dissolution Rate and Antifibrotic Activity of Quercetin
inferred← citeshttps://doi.org/10.33029/0016-9900-2020-99-1-85-89openalex-snapshot
AN EXPERIMENTAL TRIAL OF BIOPROPHYLACTIC FORMULA DESIGNED TO MINIMIZE COMBINED TOXICITY OF BOTH LEAD AND CADMIUM
inferred← citeshttps://doi.org/10.33263/briac114.1234812363openalex-snapshot
Quercetin Extracted from Broccoli Attenuates the Renewal of Hepatic Cells via Downregulation of TGFβ-1 and Arresting of HSCs Activation in Mice
inferred← citeshttps://doi.org/10.33612/diss.128130988openalex-snapshot
Novel molecular targets in hepatic stellate cells for the treatment of liver fibrosis
inferred← citeshttps://doi.org/10.3389/fimmu.2021.803037openalex-snapshot
Macrophage Polarization and Its Role in Liver Disease
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1680878openalex-snapshot
Macrophage-tregs crosstalk: the “hub” of the immune network in MASLD
inferred← citeshttps://doi.org/10.3389/fmed.2020.00071openalex-snapshot
Myricetin Modulates Macrophage Polarization and Mitigates Liver Inflammation and Fibrosis in a Murine Model of Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.3389/fmed.2024.1442071openalex-snapshot
Mechanism of action of quercetin in regulating cellular autophagy in multiple organs of Goto-Kakizaki rats through the PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.3389/fnut.2024.1430768openalex-snapshot
Research progress on antitumor effects of sea buckthorn, a traditional Chinese medicine homologous to food and medicine
inferred← citeshttps://doi.org/10.3389/fphar.2019.01089openalex-snapshot
Morin Hydrate Inhibits TREM-1/TLR4-Mediated Inflammatory Response in Macrophages and Protects Against Carbon Tetrachloride-Induced Acute Liver Injury in Mice
inferred← citeshttps://doi.org/10.3389/fphar.2020.00608openalex-snapshot
Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis via Inhibition of HMGB1
inferred← citeshttps://doi.org/10.3389/fphar.2020.00813openalex-snapshot
The Potentiality of Herbal Remedies in Primary Sclerosing Cholangitis: From In Vitro to Clinical Studies
inferred← citeshttps://doi.org/10.3389/fphar.2021.771459openalex-snapshot
The Potential Application of Chinese Medicine in Liver Diseases: A New Opportunity
inferred← citeshttps://doi.org/10.3389/fphar.2022.887263openalex-snapshot
Dihydromyricetin-Encapsulated Liposomes Inhibit Exhaustive Exercise-Induced Liver Inflammation by Orchestrating M1/M2 Macrophage Polarization
inferred← citeshttps://doi.org/10.3389/fphar.2022.984611openalex-snapshot
The combination of Lonicerae Japonicae Flos and Forsythiae Fructus herb-pair alleviated inflammation in liver fibrosis
inferred← citeshttps://doi.org/10.3389/fphar.2023.1253013openalex-snapshot
Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulation of liver metabolism
inferred← citeshttps://doi.org/10.3389/fphar.2024.1443667openalex-snapshot
A review of Phyllanthus urinaria L. in the treatment of liver disease: viral hepatitis, liver fibrosis/cirrhosis and hepatocellular carcinoma
inferred← citeshttps://doi.org/10.3389/fphar.2025.1517832openalex-snapshot
Extraction, content determination, component analysis, and pharmacological action of Hedysari flavonoids: a review of research progress
inferred← citeshttps://doi.org/10.3389/fphar.2025.1657751openalex-snapshot
Flavonoids as modulators of gut-liver axis: emerging therapeutic strategies for MAFLD
inferred← citeshttps://doi.org/10.3389/fphar.2026.1958426openalex-snapshot
Pharmacological mechanisms of quercetin in liver and intestinal diseases: a gut-liver axis perspective
inferred← citeshttps://doi.org/10.3390/ani14131918openalex-snapshot
Effects of Micellar Quercetin Supplementation on Growth Performance, Nutrient Digestibility, Fecal Microbiota, Meat Quality, and Physiological Status in Broiler Chickens
inferred← citeshttps://doi.org/10.3390/biology15080625openalex-snapshot
Redox Reprogramming of the Diseased Liver by Dietary Flavonoids: From Molecular Signalling to Gut–Liver Crosstalk
inferred← citeshttps://doi.org/10.3390/cells15131206openalex-snapshot
Transplantation of Mesenchymal Stem Cell-Derived Hepatocytes Primed with Quercetin Alone or in Combination with Rutin and LiCl Enhances Liver Regeneration
inferred← citeshttps://doi.org/10.3390/cells9122626openalex-snapshot
Function of TREM1 and TREM2 in Liver-Related Diseases
inferred← citeshttps://doi.org/10.3390/cosmetics12020036openalex-snapshot
Phytochemical Profile, Cytotoxicity, Anti-Inflammatory, Antioxidant, and Antiglycation Activity of Annona crassiflora Extract: An In Vitro Study
inferred← citeshttps://doi.org/10.3390/foods15091509openalex-snapshot
Identification of Potential Bioactive Compounds in Strong-Flavor-Type Baijiu via Integration of Widely Targeted Metabolomics and Network Pharmacology
inferred← citeshttps://doi.org/10.3390/gels9050381openalex-snapshot
Multifunctional Extracellular Matrix Hydrogel with Self-Healing Properties and Promoting Angiogenesis as an Immunoregulation Platform for Diabetic Wound Healing
inferred← citeshttps://doi.org/10.3390/ijms22168939openalex-snapshot
Resveratrol and Quercetin as Regulators of Inflammatory and Purinergic Receptors to Attenuate Liver Damage Associated to Metabolic Syndrome
inferred← citeshttps://doi.org/10.3390/ijms231810479openalex-snapshot
Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer
inferred← citeshttps://doi.org/10.3390/ijms25179346openalex-snapshot
Advancements in Plant-Based Therapeutics for Hepatic Fibrosis: Molecular Mechanisms and Nanoparticulate Drug Delivery Systems
inferred← citeshttps://doi.org/10.3390/ijms26052193openalex-snapshot
Enhancing the Therapeutic Efficacy of Berberine and Quercetin Through Salt Formulation for Liver Fibrosis Treatment
inferred← citeshttps://doi.org/10.3390/metabo16040284openalex-snapshot
Quercetin Attenuates Non-Alcoholic Fatty Liver Disease in Association with the Inhibition of Hepatic IL-1β/iNOS and IL-1β/CD45 Axes of Inflammation and Fibrosis Accompanied by Reduced Endogenous Metabolites and Apoptosis
inferred← citeshttps://doi.org/10.3390/molecules27228082openalex-snapshot
Effects of Sorafenib and Quercetin Alone or in Combination in Treating Hepatocellular Carcinoma: In Vitro and In Vivo Approaches
inferred← citeshttps://doi.org/10.3390/molecules28031476openalex-snapshot
Effect of Isoquercitrin on Free Fatty Acid-Induced Lipid Accumulation in HepG2 Cells
inferred← citeshttps://doi.org/10.3390/molecules29235658openalex-snapshot
Elucidation of the Active Agents in a West African Ground Herbal Medicine Formulation That Elicit Antimalarial Activities in In Vitro and In Vivo Models
inferred← citeshttps://doi.org/10.3390/molecules30071407openalex-snapshot
A Targeted Mass Spectrometric Approach to Evaluate the Anti-Inflammatory Activity of the Major Metabolites of Foeniculum vulgare Mill. Waste in Human Bronchial Epithelium
inferred← citeshttps://doi.org/10.3390/nu11122875openalex-snapshot
Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review
inferred← citeshttps://doi.org/10.3390/nu14204225openalex-snapshot
Moringa oleifera Improves MAFLD by Inducing Epigenetic Modifications
inferred← citeshttps://doi.org/10.3390/nu16244282openalex-snapshot
The Effect of Quercetin on Non-Alcoholic Fatty Liver Disease (NAFLD) and the Role of Beclin1, P62, and LC3: An Experimental Study
inferred← citeshttps://doi.org/10.3390/ph15081012openalex-snapshot
Neuroprotective Effect of Morin Hydrate against Attention-Deficit/Hyperactivity Disorder (ADHD) Induced by MSG and/or Protein Malnutrition in Rat Pups: Effect on Oxidative/Monoamines/Inflammatory Balance and Apoptosis
inferred← citeshttps://doi.org/10.35627/2219-5238/2020-332-11-62-66openalex-snapshot
Increasing the Resistance of the Body to Adverse Cytotoxic Effects of Amorphous Silicon Dioxide Nanoparticles
inferred← citeshttps://doi.org/10.35627/2219-5238/2022-30-9-43-48openalex-snapshot
Prevention of the Combined Cytotoxic Effect of Selenium and Copper Oxide Nanoparticles in the Animal Experiment
inferred← citeshttps://doi.org/10.3785/j.issn.1008-9292.2020.12.06openalex-snapshot
[Study on the mechanism of Flos Puerariae and Semen Hoveniae in treatment of alcoholic liver injury based on network pharmacology and molecular docking].
inferred← citeshttps://doi.org/10.4062/biomolther.2019.034openalex-snapshot
Flavonoids: Broad Spectrum Agents on Chronic Inflammation
inferred← citeshttps://doi.org/10.4236/jct.2021.128040openalex-snapshot
Regenerative Medicine to Reduce the Side Effects from Radiotherapy Causing Skin Cancer, Fibrosis, Neuropathic Pain and Hair Loss
inferred← citeshttps://doi.org/10.5530/ijper.58.1s.4openalex-snapshot
Insight into the Regulation of Nrf2/Keap 1 Pathway by Flavonoids as an Approach for Treatment of Liver Diseases: A Review
inferred← citeshttps://doi.org/10.56499/jppres20.976_9.4.397openalex-snapshot
Molecular target mechanisms of celecoxib induced liver damage in rats and the potential prophylactic roles of melatonin and/or quercetin
inferred← citeshttps://doi.org/10.56499/jppres21.9.4openalex-snapshot
inferred← citeshttps://doi.org/10.5772/intechopen.1003072openalex-snapshot
Leveraging a hypothesis-generating transcriptomics approach to elucidate molecular pathways that contribute to the biologic effects of quercetin in the liver
inferred← citeshttps://doi.org/10.5812/jjnpp.113484openalex-snapshot
Quercetin Reduces Hepatic Fibrogenesis by Inhibiting TGF-β/Smad3 Signaling Pathway in LX-2 Cell Line
inferred← citeshttps://doi.org/10.7324/japs.2019.90412openalex-snapshot
Protective effect of quercetin on weight drop injury model-induced neuroinflammation alterations in brain of mice
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