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Design and Synthesis of Small Molecules as Potent Staphylococcus aureus Sortase A Inhibitors

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Synthesis of (2R,3S) 3‐Amino‐4‐mercapto‐2‐butanol, a Threonine Analogue for Covalent Inhibition of Sortases.
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Studies on Synthesis and Pharmacological Activities of 3,6‐Disubstituted‐1,2,4‐triazolo[3,4‐b]‐1,3,4‐thiadiazoles and Their Dihydro Analogues.
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The reaction of 2‐substituted‐4,5‐dichloro‐3(2H)‐pyridazinones with alkoxides and alkylthiolates
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Kinetics of the Decomposition of a Mannich Base
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Spectroscopic studies on olefins—III: NMR of cis‐ and trans‐ disubstituted olefins
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The binding mechanism, multiple binding modes, and allosteric regulation of Staphylococcus aureus Sortase A probed by molecular dynamics simulations
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NMR spectral studies—IV
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13C- and 15N-NMR spectra of phenylazoacetoacetamides and similar compounds
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A review of global initiatives to fight antibiotic resistance and recent antibiotics׳ discovery
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Protein sorting to the cell wall envelope of Gram-positive bacteria
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Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics
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Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors
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Antifungal activity of a series of 1,2-benzisothiazol-3(2H)-one derivatives
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Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors
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Design, synthesis and characterization of novel 1,2-benzisothiazol-3(2H)-one and 1,3,4-oxadiazole hybrid derivatives: Potent inhibitors of Dengue and West Nile virus NS2B/NS3 proteases
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Discovery and structure–activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase
inferredcites →https://doi.org/10.1016/j.bmc.2016.12.030openalex-snapshot
Synthesis, biological evaluation and molecular docking analysis of 2-phenyl-benzofuran-3-carboxamide derivatives as potential inhibitors of Staphylococcus aureus Sortase A
inferredcites →https://doi.org/10.1016/j.bmc.2019.115043openalex-snapshot
Discovery and development of substituted thiadiazoles as inhibitors of Staphylococcus aureus Sortase A
inferredcites →https://doi.org/10.1016/j.bmcl.2005.07.073openalex-snapshot
Synthesis of (2R,3S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases
inferredcites →https://doi.org/10.1016/j.bmcl.2007.05.070openalex-snapshot
Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
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Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase
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Synthesis and bio-evaluation of aryl hydrazono esters for oviposition responses in Aedes albopictus
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Synthesis, biological evaluation and molecular docking of 2-phenyl-benzo[d]oxazole-7-carboxamide derivatives as potential Staphylococcus aureus Sortase A inhibitors
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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
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Synthesis, antibacterial and antitubercular activities of some 7-[4-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-piperazin-1-yl] fluoroquinolonic derivatives
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Studies on synthesis and pharmacological activities of 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and their dihydro analogues
inferredcites →https://doi.org/10.1016/j.ejmech.2010.05.024openalex-snapshot
Synthesis and structure activity relationship studies of novel Staphylococcus aureus Sortase A inhibitors
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Localization and mutagenesis of the sorting signal binding site on sortase A from Staphylococcus aureus
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Sortase A: An ideal target for anti-virulence drug development
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New strategies for combating multidrug-resistant bacteria
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Confirmation and prevention of halogen exchange: practical and highly efficient one-pot synthesis of dibromo- and dichloropyridazinones
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Spectroscopic studies of tautomeric systems—III
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Synthesis of secorapamycin esters and amides
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Tideglusib and Its Analogues As Inhibitors of Staphylococcus aureus SrtA
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Sortase A Inhibitors: Recent Advances and Future Perspectives
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Mechanism-Based Inactivation of Thioredoxin Reductase from Plasmodium falciparum by Mannich Bases. Implication for Cytotoxicity
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Analysis of the Substrate Specificity of the Staphylococcus aureus Sortase Transpeptidase SrtA
inferredcites →https://doi.org/10.1021/bi050141jopenalex-snapshot
Staphylococcus aureus Sortase Transpeptidase SrtA: Insight into the Kinetic Mechanism and Evidence for a Reverse Protonation Catalytic Mechanism
inferredcites →https://doi.org/10.1021/cr00038a004openalex-snapshot
The Pictet-Spengler condensation: a new direction for an old reaction
inferredcites →https://doi.org/10.1021/ie50336a007openalex-snapshot
Esterification A review of the recent past and a look towards the future
inferredcites →https://doi.org/10.1021/ja100579zopenalex-snapshot
Synthesis, Structural Investigations, Hydrogen−Deuterium Exchange Studies, and Molecular Modeling of Conformationally Stablilized Aromatic Oligoamides
inferredcites →https://doi.org/10.1021/jm00300a014openalex-snapshot
Spasmolytics. III. 3-Tropanyl 2,3-diarylacrylates. Case history of .pi.-.sigma. structure-function correlation
inferredcites →https://doi.org/10.1021/jm010254aopenalex-snapshot
Estrogen Receptor-β Potency-Selective Ligands: Structure−Activity Relationship Studies of Diarylpropionitriles and Their Acetylene and Polar Analogues
inferredcites →https://doi.org/10.1021/jm0498708openalex-snapshot
Discovery of Diarylacrylonitriles as a Novel Series of Small Molecule Sortase A Inhibitors
inferredcites →https://doi.org/10.1021/jm800557dopenalex-snapshot
2-Aminothienopyridazines as Novel Adenosine A1Receptor Allosteric Modulators and Antagonists
inferredcites →https://doi.org/10.1021/jm980101wopenalex-snapshot
Novel Combretastatin Analogues Effective against Murine Solid Tumors: Design and Structure−Activity Relationships
inferredcites →https://doi.org/10.1021/jo00392a031openalex-snapshot
Preparation of arylpropiolate esters from trichlorocyclopropenium cation and elaboration of the esters to unsymmetrical 1,4-pentadiyn-3-ones and unsymmetrical tellurapyranones
inferredcites →https://doi.org/10.1021/jo034762zopenalex-snapshot
Michael Addition of Amines and Thiols to Dehydroalanine Amides: A Remarkable Rate Acceleration in Water
inferredcites →https://doi.org/10.1021/jo501134dopenalex-snapshot
Organoboron-Based Allylation Approach to the Total Synthesis of the Medium-Ring Dilactone (+)-Antimycin A1b
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Synthesis of 2-Pyridinylbenzoxazole: Mechanism for the Intramolecular Photosubstitution of the Haloarene with the Carbonyl Oxygen of the Amide Bond in Basic Medium
inferredcites →https://doi.org/10.1021/ml200263yopenalex-snapshot
Small Molecule Inhibitors of Regulators of G Protein Signaling (RGS) Proteins
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A Multivalent Approach to Drug Discovery for Novel Antibiotics
inferredcites →https://doi.org/10.1038/nrmicro2200openalex-snapshot
Waves of resistance: Staphylococcus aureus in the antibiotic era
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Molecular mechanisms of antibiotic resistance
inferredcites →https://doi.org/10.1039/c5ra07568hopenalex-snapshot
Recent progress in the development of sortase A inhibitors as novel anti-bacterial virulence agents
inferredcites →https://doi.org/10.1039/j39670002307openalex-snapshot
Reactivity of Mannich bases. Part X. The mechanism of the reaction between β-amino-ketones and thiophenols
inferredcites →https://doi.org/10.1046/j.1365-2958.2001.02411.xopenalex-snapshot
Sortase‐catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1073/pnas.101064198openalex-snapshot
Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1073/pnas.1408601111openalex-snapshot
Antiinfective therapy with a small molecule inhibitor of Staphylococcus aureus sortase
inferredcites →https://doi.org/10.1073/pnas.96.22.12424openalex-snapshot
Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif
inferredcites →https://doi.org/10.1074/jbc.275.13.9876openalex-snapshot
Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1074/jbc.m109.022624openalex-snapshot
The Structure of the Staphylococcus aureus Sortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized
inferredcites →https://doi.org/10.1074/jbc.m109194200openalex-snapshot
Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1074/jbc.m305245200openalex-snapshot
Sortase from Staphylococcus aureus Does Not Contain a Thiolate-Imidazolium Ion Pair in Its Active Site
inferredcites →https://doi.org/10.1074/jbc.m401374200openalex-snapshot
Crystal Structures of Staphylococcus aureus Sortase A and Its Substrate Complex
inferredcites →https://doi.org/10.1074/jbc.m405282200openalex-snapshot
Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1074/jbc.m506123200openalex-snapshot
Staphylococcus aureus Sortase A Transpeptidase
inferredcites →https://doi.org/10.1074/jbc.m701857200openalex-snapshot
Activation of Inhibitors by Sortase Triggers Irreversible Modification of the Active Site
inferredcites →https://doi.org/10.1093/jac/39.suppl_1.1openalex-snapshot
Gram-positive resistance: challenge for the development of new antibiotics
inferredcites →https://doi.org/10.1107/s1600536811002200openalex-snapshot
Ethyl 3-oxo-2-(2-phenylhydrazinylidene)butanoate: a re-determination
inferredcites →https://doi.org/10.1111/cbdd.12167openalex-snapshot
Discovery of S taphylococcus aureus Sortase A Inhibitors Using Virtual Screening and the Relaxed Complex Scheme
inferredcites →https://doi.org/10.1111/cbdd.12962openalex-snapshot
NMR structure‐based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors
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MRSA – global threat and personal disaster: patients' experiences
inferredcites →https://doi.org/10.1124/pr.107.07110openalex-snapshot
Sortase as a Target of Anti-Infective Therapy
inferredcites →https://doi.org/10.1126/science.257.5073.1064openalex-snapshot
The Crisis in Antibiotic Resistance
inferredcites →https://doi.org/10.1126/science.285.5428.760openalex-snapshot
Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
inferredcites →https://doi.org/10.1134/s1070428009060013openalex-snapshot
Steric structure of alkyl 2-aryl(hetaryl)hydrazono-3-fluoroalkyl-3-oxopropionates
inferredcites →https://doi.org/10.1172/jci38226openalex-snapshot
Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era
inferredcites →https://doi.org/10.1246/nikkashi1948.87.6_594openalex-snapshot
The Rates of the Reaction of Heterocyclic (Thiophene and Thiazole) Bromoketones with Thioamides
inferredcites →https://doi.org/10.1248/cpb.43.783openalex-snapshot
Synthesis and Pharmacological Evaluation of 1,2,3,4-Tetrahydro-.BETA.-carboline Derivatives.
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The Preparation and Evaluation of 1-Substituted 1,2,3,4-Tetrahydro- and 3,4-Dihydro-.BETA.-carboline Derivatives as Potential Antitumor Agents
inferredcites →https://doi.org/10.14737/journal.aavs/2015/3.2.79.98openalex-snapshot
Methicillin Resistant Staphylococcus aureus (MRSA): A Review
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Advances in MRSA drug discovery: where are we and where do we need to be?
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Antibiotic resistance: a rundown of a global crisis
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Microwave Reaction of Diazonium Salts with Nitriles
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Discovery of a New Class of Sortase A Transpeptidase Inhibitors to Tackle Gram-Positive Pathogens: 2-(2-Phenylhydrazinylidene)alkanoic Acids and Related Derivatives
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New 2-Phenylthiazoles as Potential Sortase A Inhibitors: Synthesis, Biological Evaluation and Molecular Docking

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Anti-Biofilm Potential and Mechanistic Insight into Sortasea Inhibition by Secondary Metabolites of C. Longa Against Staphylococcus Aureus and Streptococcus Mutans
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The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment
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Structure‐Based Development of a Covalent Inhibitor Targeting Streptococcus Pyogenes over Staphylococcus Aureus Sortase A
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Inhibitors of Sortases of Gram-Positive Bacteria and their Role in the Treatment of Infectious Diseases (Review)
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Isoflavone glucoside genistin, an inhibitor targeting Sortase A and Listeriolysin O, attenuates the virulence of Listeria monocytogenes in vivo and in vitro
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New polyphenolic glycosides from the stems of Caesalpinia cucullata and their inhibitory effect on methicillin-resistant Staphylococcus aureus with different ways
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Optimized protocols for assessing libraries of poorly soluble sortase A inhibitors for antibacterial activity against medically-relevant bacteria, toxicity and enzyme inhibition
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Ligand-Based Design of Novel Thiazole-Quinazolinone Hybrids with Dual Antimicrobial and Anti-Virulence Activity Targeting Staphylococcal Sortase A
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Structural and functional insights of sortases and their interactions with antivirulence compounds
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SortPred: The first machine learning based predictor to identify bacterial sortases and their classes using sequence-derived information
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Sortase A (SrtA) inhibitors as an alternative treatment for superbug infections
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The inhibition effect and mechanism of litsea cubeba essential oil on the hemolytic activity of listeriolysin O
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A comprehensive insight into plant-derived extracts/bioactives: Exploring their antimicrobial mechanisms and potential for high-performance food applications
inferred← citeshttps://doi.org/10.1016/j.nexres.2026.101725openalex-snapshot
Sortase A inhibition: Updated review of non-peptide ligands for targeting Staphylococcus aureus virulence
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00386openalex-snapshot
Chemical Biology of Sortase A Inhibition: A Gateway to Anti-infective Therapeutic Agents
inferred← citeshttps://doi.org/10.1038/s41429-022-00524-8openalex-snapshot
Identification of novel small-molecular inhibitors of Staphylococcus aureus sortase A using hybrid virtual screening
inferred← citeshttps://doi.org/10.1039/d1md00316jopenalex-snapshot
Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella
inferred← citeshttps://doi.org/10.1080/00397911.2023.2269582openalex-snapshot
Recent insights into synthesis, biological activities, structure activity relationship and molecular interactions of thiazolidinone hybrids: A systematic review
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A staphylococcal capsule-producing enzyme that unfolds via multiple intermediates predominantly exists as the trimers at low concentrations
inferred← citeshttps://doi.org/10.1111/1751-7915.70119openalex-snapshot
Disarming the Pathogenicity of Methicillin‐Resistant Staphylococcus aureus via Osmundacetone‐Mediated Inhibition of Sortase A
inferred← citeshttps://doi.org/10.3390/antibiotics10020164openalex-snapshot
Sorting out the Superbugs: Potential of Sortase A Inhibitors among Other Antimicrobial Strategies to Tackle the Problem of Antibiotic Resistance
inferred← citeshttps://doi.org/10.3390/antibiotics11121836openalex-snapshot
Oligopeptide Sortase Inhibitor Modulates Staphylococcus aureus Cell Adhesion and Biofilm Formation
inferred← citeshttps://doi.org/10.3390/coatings11111354openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/ijms252011279openalex-snapshot
Ensemble Docking as a Tool for the Rational Design of Peptidomimetic Staphylococcus aureus Sortase A Inhibitors
inferred← citeshttps://doi.org/10.3390/ijms252211926openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/md21080431openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/molecules26237095openalex-snapshot
Identification of Novel Antistaphylococcal Hit Compounds Targeting Sortase A
inferred← citeshttps://doi.org/10.3390/molecules26247677openalex-snapshot
Selection of Promising Novel Fragment Sized S. aureus SrtA Noncovalent Inhibitors Based on QSAR and Docking Modeling Studies
inferred← citeshttps://doi.org/10.3390/molecules28052114openalex-snapshot
Sortase A Inhibitor Protein Nanoparticle Formulations Demonstrate Antibacterial Synergy When Combined with Antimicrobial Peptides
inferred← citeshttps://doi.org/10.3390/ph17010058openalex-snapshot
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inferred← citeshttps://doi.org/10.3390/pharmaceutics14050986openalex-snapshot
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