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Immunometabolic Markers in a Small Patient Cohort Undergoing Immunotherapy

https://doi.org/10.3390/biom12050716

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Peripheral blood clinical laboratory variables associated with outcomes following combination nivolumab and ipilimumab immunotherapy in melanoma

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Pretreatment Glasgow prognostic score predicts survival among patients with high PD‐L1 expression administered first‐line pembrolizumab monotherapy for non‐small cell lung cancer

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Tumor mutational load, CD8+ T cells, expression of PD-L1 and HLA class I to guide immunotherapy decisions in NSCLC patients

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A high number of PD-L1+ CD14+ monocytes in peripheral blood is correlated with shorter survival in patients receiving immune checkpoint inhibitors

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Sex-specific hormone changes during immunotherapy and its influence on survival in metastatic renal cell carcinoma

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Function of CD147 in Atherosclerosis and Atherothrombosis

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CD147 in regulatory T cells

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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

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Relevance of nutritional assessment and treatment to counteract cardiac cachexia and sarcopenia in chronic heart failure

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Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

inferredcites →https://doi.org/10.1016/j.esmoop.2021.100118openalex-snapshot

Immune-inflammatory biomarkers as prognostic factors for immunotherapy in pretreated advanced urinary tract cancer patients: an analysis of the Italian SAUL cohort

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2018 Nobel Prize in medicine awarded to cancer immunotherapy: Immune checkpoint blockade – A personal account

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Cholesterol delivery to the adrenal glands estimated by adrenal venous sampling: An in vivo model to determine the contribution of circulating lipoproteins to steroidogenesis in humans

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Longitudinal associations between lymphocyte count and LDL cholesterol in a health screening population

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Peripheral Blood Biomarkers Associated with Clinical Outcome in Non–Small Cell Lung Cancer Patients Treated with Nivolumab

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The impact of body mass index on the efficacy of anti-PD-1/PD-L1 antibodies in patients with non-small cell lung cancer

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Ratio of CD147 high /CD147 low in CD4 + CD25 + T cells: A potential biomarker for early diagnosis and prediction of response to therapy for autoimmune diseases

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High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy

inferredcites →https://doi.org/10.1038/s41423-020-00570-yopenalex-snapshot

CD147 regulates antitumor CD8+ T-cell responses to facilitate tumor-immune escape

inferredcites →https://doi.org/10.1038/s41467-020-15397-4openalex-snapshot

Loss of testosterone impairs anti-tumor neutrophil function

inferredcites →https://doi.org/10.1038/s41568-021-00348-yopenalex-snapshot

Sex disparities matter in cancer development and therapy

inferredcites →https://doi.org/10.1038/s41586-022-04522-6openalex-snapshot

Androgen receptor activity in T cells limits checkpoint blockade efficacy

inferredcites →https://doi.org/10.1042/bsr20150256openalex-snapshot

How, with whom and when: an overview of CD147-mediated regulatory networks influencing matrix metalloproteinase activity

inferredcites →https://doi.org/10.1080/21645515.2020.1852872openalex-snapshot

The interplay between cholesterol (and other metabolic conditions) and immune-checkpoint immunotherapy: shifting the concept from the “inflamed tumor” to the “inflamed patient”

inferredcites →https://doi.org/10.1093/gerona/57.7.m460openalex-snapshot

Effects of Transdermal Testosterone on Lipids and Vascular Reactivity in Older Men With Low Bioavailable Testosterone Levels

inferredcites →https://doi.org/10.1097/cji.0000000000000321openalex-snapshot

The Prognostic Role of High Blood Cholesterol in Advanced Cancer Patients Treated With Immune Checkpoint Inhibitors

inferredcites →https://doi.org/10.1097/spc.0000000000000464openalex-snapshot

Endocrinopathies and cancer cachexia

inferredcites →https://doi.org/10.1101/2021.11.30.21267064openalex-snapshot

Machine learning for prediction of immunotherapy efficacy in non-small cell lung cancer from simple clinical and biological data

inferredcites →https://doi.org/10.1111/1759-7714.14256openalex-snapshot

Host immune‐inflammatory markers to unravel the heterogeneous outcome and assessment of patients with PD‐L1 ≥50% metastatic non‐small cell lung cancer and poor performance status receiving first‐line immunotherapy

inferredcites →https://doi.org/10.1111/j.1365-3083.2007.02051.xopenalex-snapshot

Peripheral Blood CD14high CD16+ Monocytes are Main Producers of IL‐10

inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot

Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing

inferredcites →https://doi.org/10.1126/sciimmunol.aay1863openalex-snapshot

Targeted deletion of PD-1 in myeloid cells induces antitumor immunity

inferredcites →https://doi.org/10.1126/sciimmunol.abq2630openalex-snapshot

Androgen conspires with the CD8 + T cell exhaustion program and contributes to sex bias in cancer

inferredcites →https://doi.org/10.1136/esmoopen-2019-000531openalex-snapshot

Elevated CRP levels indicate poor progression-free and overall survival on cancer patients treated with PD-1 inhibitors

inferredcites →https://doi.org/10.1136/jitc-2019-000472openalex-snapshot

Circulating CD14high CD16low intermediate blood monocytes as a biomarker of ascites immune status and ovarian cancer progression

inferredcites →https://doi.org/10.1136/jitc-2020-000842openalex-snapshot

Serum interleukin-6 and C-reactive protein are associated with survival in melanoma patients receiving immune checkpoint inhibition

inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-0127openalex-snapshot

Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab

inferredcites →https://doi.org/10.1158/2159-8290.cd-19-0541openalex-snapshot

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity

inferredcites →https://doi.org/10.1158/2326-6066.cir-15-0193openalex-snapshot

Phase I/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab

inferredcites →https://doi.org/10.1158/2326-6066.cir-20-0358openalex-snapshot

Oxidized Lipoproteins Promote Resistance to Cancer Immunotherapy Independent of Patient Obesity

inferredcites →https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a138openalex-snapshot

Abstract A138: CD39 increase on cytotoxic T-cell induced by myeloid-derived suppressor cell correlated with poor prognosis in patients with non-small cell lung cancer

inferredcites →https://doi.org/10.1161/circresaha.115.307071openalex-snapshot

Effects of Evolocumab on Vitamin E and Steroid Hormone Levels

inferredcites →https://doi.org/10.1172/jci.insight.133501openalex-snapshot

Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy

inferredcites →https://doi.org/10.1172/jci.insight.98867openalex-snapshot

Classical and intermediate monocytes scavenge non-transferrin-bound iron and damaged erythrocytes

inferredcites →https://doi.org/10.1177/1758835920970049openalex-snapshot

Pretreatment hemoglobin level as a predictor to evaluate the efficacy of immune checkpoint inhibitors in patients with advanced non-small cell lung cancer

inferredcites →https://doi.org/10.1182/blood-2009-08-240580openalex-snapshot

Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis

inferredcites →https://doi.org/10.1182/blood-2011-02-339242openalex-snapshot

CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells

inferredcites →https://doi.org/10.1186/1479-5876-9-90openalex-snapshot

Functional characterization of human Cd33+ And Cd11b+ myeloid-derived suppressor cell subsets induced from peripheral blood mononuclear cells co-cultured with a diverse set of human tumor cell lines

inferredcites →https://doi.org/10.1186/s12944-015-0014-5openalex-snapshot

Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet

inferredcites →https://doi.org/10.1186/s40169-014-0040-3openalex-snapshot

Clinical significance of monocyte heterogeneity

inferredcites →https://doi.org/10.1186/s40364-020-00209-0openalex-snapshot

Predictive biomarkers for cancer immunotherapy with immune checkpoint inhibitors

inferredcites →https://doi.org/10.1186/s40425-019-0527-yopenalex-snapshot

A multicenter study of body mass index in cancer patients treated with anti-PD-1/PD-L1 immune checkpoint inhibitors: when overweight becomes favorable

inferredcites →https://doi.org/10.1200/jco.2016.34.15_suppl.e20623openalex-snapshot

C-reactive protein (CRP) as a predictive marker for immunotherapy in lung cancer.

inferredcites →https://doi.org/10.1200/jco.2019.37.15_suppl.e20691openalex-snapshot

Impact of cholesterolemia and body mass index on outcome of metastatic non small cell lung cancer treated with immunotherapy.

inferredcites →https://doi.org/10.1210/me.2006-0534openalex-snapshot

Hormonal Regulation of Testicular Steroid and Cholesterol Homeostasis

inferredcites →https://doi.org/10.18632/oncotarget.21602openalex-snapshot

Predictive clinical parameters for the response of nivolumab in pretreated advanced non-small-cell lung cancer

inferredcites →https://doi.org/10.18632/oncotarget.8153openalex-snapshot

The altered glucose metabolism in tumor and a tumor acidic microenvironment associated with extracellular matrix metalloproteinase inducer and monocarboxylate transporters

inferredcites →https://doi.org/10.21037/tlcr-19-583openalex-snapshot

Neutrophil-to-lymphocyte ratio in combination with PD-L1 or lactate dehydrogenase as biomarkers for high PD-L1 non-small cell lung cancer treated with first-line pembrolizumab

inferredcites →https://doi.org/10.21037/tlcr-21-460openalex-snapshot

Cancer cachexia syndrome and clinical outcome in patients with metastatic non-small cell lung cancer treated with PD-1/PD-L1 inhibitors: results from a prospective, observational study

inferredcites →https://doi.org/10.2147/cmar.s304022openalex-snapshot

Baseline Serum Cholesterol Levels Predict the Response of Patients with Advanced Non-Small Cell Lung Cancer to Immune Checkpoint Inhibitor-Based Treatment

inferredcites →https://doi.org/10.2147/ott.s315998openalex-snapshot

Cholesterol Metabolism as a Potential Therapeutic Target and a Prognostic Biomarker for Cancer Immunotherapy

inferredcites →https://doi.org/10.3389/fcell.2020.00672openalex-snapshot

Resistance Mechanisms of Anti-PD1/PDL1 Therapy in Solid Tumors

inferredcites →https://doi.org/10.3389/fimmu.2018.00794openalex-snapshot

Androgen-Induced Immunosuppression

inferredcites →https://doi.org/10.3389/fimmu.2019.01147openalex-snapshot

The CD14+HLA-DRlo/neg Monocyte: An Immunosuppressive Phenotype That Restrains Responses to Cancer Immunotherapy

inferredcites →https://doi.org/10.3389/fimmu.2020.01590openalex-snapshot

Myeloid Cells as Clinical Biomarkers for Immune Checkpoint Blockade

inferredcites →https://doi.org/10.3389/fmed.2019.00174openalex-snapshot

Biomarkers for Predicting Efficacies of Anti-PD1 Antibodies

inferredcites →https://doi.org/10.3389/fmed.2020.00393openalex-snapshot

A Novel Choice to Correct Inflammation-Induced Anemia in CKD: Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat

inferredcites →https://doi.org/10.3389/fonc.2020.00268openalex-snapshot

Current Understanding of the Mechanisms Underlying Immune Evasion From PD-1/PD-L1 Immune Checkpoint Blockade in Head and Neck Cancer

inferredcites →https://doi.org/10.3389/fonc.2020.584477openalex-snapshot

Iron Supplementation Interferes With Immune Therapy of Murine Mammary Carcinoma by Inhibiting Anti-Tumor T Cell Function

inferredcites →https://doi.org/10.3390/biomedicines8070232openalex-snapshot

Sex and Gender Influences on Cancer Immunotherapy Response

inferredcites →https://doi.org/10.3390/cancers11111803openalex-snapshot

CD147 Is a Promising Target of Tumor Progression and a Prognostic Biomarker

inferredcites →https://doi.org/10.3390/cancers12082319openalex-snapshot

C-Reactive Protein (CRP) Levels in Immune Checkpoint Inhibitor Response and Progression in Advanced Non-Small Cell Lung Cancer: A Bi-Center Study

inferredcites →https://doi.org/10.3390/cancers13246210openalex-snapshot

Machine Learning for Prediction of Immunotherapy Efficacy in Non-Small Cell Lung Cancer from Simple Clinical and Biological Data.

inferredcites →https://doi.org/10.3892/ol.2016.4684openalex-snapshot

CD147 modulates androgen receptor activity through the Akt/Gsk-3β/β-catenin/AR pathway in prostate cancer cells

inferredcites →https://doi.org/10.4103/2230-8210.94248openalex-snapshot

Testosterone and metabolic syndrome: The link

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4775796openalex-extracted

Monocyte-Related Markers as Predictors of Immune Checkpoint Inhibitor Efficacy and Immune-Related Adverse Events: A Systematic Review and Meta-Analysis

inferred← citeshttps://doi.org/10.1002/cam4.7241openalex-snapshot

Effect of body mass index and cholesterol‐rich apolipoprotein‐B ‐containing lipoproteins on clinical outcome in NSCLC patients treated with immune checkpoint inhibitors‐based therapy: A retrospective analysis

inferred← citeshttps://doi.org/10.1007/s10555-025-10246-6openalex-snapshot

Monocyte-related markers as predictors of immune checkpoint inhibitor efficacy and immune-related adverse events: a systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1155/2024/4306797openalex-snapshot

Associations between Waist Circumference and Sex Steroid Hormones in US Adult Men: Cross‐Sectional Findings from the NHANES 2013–2016

inferred← citeshttps://doi.org/10.21203/rs.3.rs-1749981/v1openalex-snapshot

Serum cholesterol-riched apolipoprotein-B (apoB) containing lipoproteins predict the response to immune checkpoints inhibitors (ICIs) in non-small cell lung cancer (NSCLC) : A retrospective analysis

inferred← citeshttps://doi.org/10.21203/rs.3.rs-1749981/v2openalex-snapshot

Serum cholesterol-riched apolipoprotein-B (apoB) containing lipoproteins predict the response to immune checkpoints inhibitors (ICIs) in non-small cell lung cancer (NSCLC) : A retrospective analysis

inferred← citeshttps://doi.org/10.3233/cbm-230159openalex-snapshot

Assessing the prognostic value of IMDC risk score for nivolumab-treated patients with renal cancer and malignant melanoma

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1536710openalex-snapshot

Baseline metabolic signatures predict clinical outcomes in immunotherapy-treated melanoma patients: a pilot study

inferred← citeshttps://doi.org/10.3389/fonc.2023.1107484openalex-snapshot

Low-density lipoprotein balances T cell metabolism and enhances response to anti-PD-1 blockade in a HCT116 spheroid model

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