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The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and Its Mechanism: An Investigation Using Network Pharmacology-Based Analysis
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Systems Pharmacology-Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes
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Cordycepin: A Cordyceps Metabolite with Promising Therapeutic Potential
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Cordycepin: A Cordyceps Metabolite with Promising Therapeutic Potential
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Antioxidant and anticancer effects of extracts from fermented Haliotis discus hannai with Cordyceps militaris mycelia
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Anti-inflammatory effect of the extract from fermented Asterina pectinifera with Cordyceps militaris mycelia in LPS-induced RAW264.7 macrophages
inferredcites →https://doi.org/10.1007/s10549-008-0217-9openalex-snapshot
MCF-7 breast carcinoma cells do not express caspase-3
inferredcites →https://doi.org/10.1007/s10637-012-9859-xopenalex-snapshot
The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells
inferredcites →https://doi.org/10.1007/s13205-013-0121-9openalex-snapshot
Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin
inferredcites →https://doi.org/10.1016/0959-8049(94)00342-3openalex-snapshot
Apoptosis in breast cancer as related to histopathological characteristics and prognosis
inferredcites →https://doi.org/10.1016/j.aspen.2015.04.015openalex-snapshot
Cordyceps militaris polysaccharide triggers apoptosis and G0/G1 cell arrest in cancer cells
inferredcites →https://doi.org/10.1016/j.biopha.2017.02.065openalex-snapshot
Jatamanvaltrate P induces cell cycle arrest, apoptosis and autophagy in human breast cancer cells in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.carbpol.2016.06.108openalex-snapshot
Polysaccharides purified from Cordyceps cicadae protects PC12 cells against glutamate-induced oxidative damage
inferredcites →https://doi.org/10.1016/j.cell.2018.05.015openalex-snapshot
Next-Generation Machine Learning for Biological Networks
inferredcites →https://doi.org/10.1016/j.etap.2016.02.009openalex-snapshot
Neuroprotective effects of adenosine isolated from Cordyceps cicadae against oxidative and ER stress damages induced by glutamate in PC12 cells
inferredcites →https://doi.org/10.1016/j.fitote.2018.05.010openalex-snapshot
The genus Cordyceps : An extensive review of its traditional uses, phytochemistry and pharmacology
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The potential applications of mushrooms against some facets of atherosclerosis: A review
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Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
inferredcites →https://doi.org/10.1016/j.jep.2017.12.012openalex-snapshot
Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression
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Effect of light-emitting diodes on the production of cordycepin, mannitol and adenosine in solid-state fermented rice by Cordyceps militaris
inferredcites →https://doi.org/10.1016/j.phrs.2016.06.018openalex-snapshot
Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature
inferredcites →https://doi.org/10.1016/j.semcancer.2016.03.001openalex-snapshot
Role of dietary bioactive natural products in estrogen receptor-positive breast cancer
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Anti-tumor and anti-metastatic roles of cordycepin, one bioactive compound of Cordyceps militaris
inferredcites →https://doi.org/10.1016/j.tiv.2017.10.002openalex-snapshot
Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy
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The platinum agents: A role in breast cancer treatment?
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Advances in Toxicological Research of the Anticancer Drug Cisplatin
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Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris
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New apoptosis drugs face critical test
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Network biology concepts in complex disease comorbidities
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TCM-Mesh: The database and analytical system for network pharmacology analysis for TCM preparations
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Soya-cerebroside, an extract of Cordyceps militaris, suppresses monocyte migration and prevents cartilage degradation in inflammatory animal models
inferredcites →https://doi.org/10.1039/c5ib00121hopenalex-snapshot
Phytochemicals potently inhibit migration of metastatic breast cancer cells
inferredcites →https://doi.org/10.1042/bj2860331openalex-snapshot
Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation
inferredcites →https://doi.org/10.1080/14786419.2018.1519824openalex-snapshot
Cuminum cyminum fruits as source of luteolin- 7-O-glucoside, potent cytotoxic flavonoid against breast cancer cell lines
inferredcites →https://doi.org/10.1093/nar/gkv1277openalex-snapshot
STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data
inferredcites →https://doi.org/10.1093/nar/gkw377openalex-snapshot
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
inferredcites →https://doi.org/10.1101/gr.1239303openalex-snapshot
Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks
inferredcites →https://doi.org/10.1152/nips.01519.2004openalex-snapshot
Morphological Features of Cell Death
inferredcites →https://doi.org/10.1371/journal.pone.0093437openalex-snapshot
Dietary Mushroom Intake May Reduce the Risk of Breast Cancer: Evidence from a Meta-Analysis of Observational Studies
inferredcites →https://doi.org/10.1615/intjmedmushrooms.2019031138openalex-snapshot
Radical Scavenging and Antiproliferative Effects of Cordycepin-Rich Ethanol Extract from Brown Rice-Cultivated Cordyceps militaris (Ascomycetes) Mycelium on Breast Cancer Cell Lines
inferredcites →https://doi.org/10.20307/nps.2017.23.1.21openalex-snapshot
Diarylbutane-type Lignans from Myristica fragrans (Nutmeg) show the Cytotoxicity against Breast Cancer Cells through Activation of AMP-activated Protein Kinase
inferredcites →https://doi.org/10.20307/nps.2018.24.4.219openalex-snapshot
The Cytotoxic Constituents ofBetula platyphyllaand their Effects on Human Lung A549 Cancer Cells
inferredcites →https://doi.org/10.2147/ott.s164670openalex-snapshot
Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo
inferredcites →https://doi.org/10.2147/ott.s45322openalex-snapshot
Cordycepin enhances cisplatin apoptotic effect through caspase/MAPK pathways in human head and neck tumor cells
inferredcites →https://doi.org/10.2174/0929867325666181001105749openalex-snapshot
Cordycepin in Anticancer Research: Molecular Mechanism of Therapeutic Effects
inferredcites →https://doi.org/10.2478/fv-2018-0030openalex-snapshot
Antioxidant Activity of the Fungus Cordyceps sinensis Grown on Two Different Media
inferredcites →https://doi.org/10.3390/biom9080362openalex-snapshot
The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology
inferredcites →https://doi.org/10.3390/cancers10110461openalex-snapshot
Network Pharmacology to Unveil the Biological Basis of Health-Strengthening Herbal Medicine in Cancer Treatment
inferredcites →https://doi.org/10.3390/molecules23112841openalex-snapshot
A Systems-Level Analysis of Mechanisms of Platycodon grandiflorum Based on A Network Pharmacological Approach
inferredcites →https://doi.org/10.3390/nu8030156openalex-snapshot
Dietary Natural Products for Prevention and Treatment of Liver Cancer
inferredcites →https://doi.org/10.3390/nu9070728openalex-snapshot
Dietary Natural Products for Prevention and Treatment of Breast Cancer
inferredcites →https://doi.org/10.3892/mmr.2016.5175openalex-snapshot
Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells
inferredcites →https://doi.org/10.3892/ol.2015.3273openalex-snapshot
Apoptosis and inhibition of proliferation of cancer cells induced by cordycepin
inferredcites →https://doi.org/10.3892/or.2016.4785openalex-snapshot
Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis
inferredcites →https://doi.org/10.4048/jbc.2016.19.3.231openalex-snapshot
Cell-in-Cell Death Is Not Restricted by Caspase-3 Deficiency in MCF-7 Cells
inferredcites →https://doi.org/10.4314/tjpr.v15i10.23openalex-snapshot
Determination of cordycepin content of Cordyceps militaris recombinant rice by high performance liquid chromatography
inferredcites →https://doi.org/10.5941/myco.2017.45.1.31openalex-snapshot
Development of High Cordycepin-Producing Cordyceps militaris Strains
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4118479openalex-extracted
Repurposing of Metabolic Drugs and Mitochondrial Modulators as an Emerging Class of Cancer Therapeutics with a Special Focus on Breast Cancer
inferred← citeshttps://doi.org/10.1002/9781394212699.ch12openalex-snapshot
Applications of Mushrooms in the Management of Cancers
inferred← citeshttps://doi.org/10.1002/cbf.70103openalex-snapshot
Cordycepin Inhibits Proliferation, Migration, and Promotes Apoptosis in Fibrosarcoma HT1080 Cells by Targeting Akt1 and Kinase Activity Through Network Pharmacology Analysis
inferred← citeshttps://doi.org/10.1002/pca.2949openalex-snapshot
Discovery and identification of proangiogenic chemical markers from Gastrodiae Rhizoma based on zebrafish model and metabolomics approach
inferred← citeshttps://doi.org/10.1007/978-3-031-44630-6_28openalex-snapshot
Characteristics of Ethanolic Cordyceps Militaris Extract by Ultrasonic-Assisted Extraction Method
inferred← citeshttps://doi.org/10.1007/s00203-024-03833-8openalex-snapshot
Ethanolic extract from fruiting bodies of Cordyceps militaris HL8 exhibits cytotoxic activities against cancer cells, skin pathogenic yeasts, and postharvest pathogen Penicillium digitatum
inferred← citeshttps://doi.org/10.1007/s00253-020-10476-4openalex-snapshot
Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials
inferred← citeshttps://doi.org/10.1007/s11010-026-05575-1openalex-snapshot
Deciphering the anticancer potential of an entomopathogenic fungus, Cordyceps militaris in Dalton’s Lymphoma transplanted murine model: a multidimensional approach involving computational methods and in vivo validation
inferred← citeshttps://doi.org/10.1007/s12032-026-03407-2openalex-snapshot
Overcoming cordycepin limitations with SLNs-based nanoformulation: formulation development and cytotoxicity evaluation against human breast cancer cells
inferred← citeshttps://doi.org/10.1007/s12094-020-02428-1openalex-snapshot
Recent findings on the role of fungal products in the treatment of cancer
inferred← citeshttps://doi.org/10.1016/j.adcanc.2022.100065openalex-snapshot
Repurposing of metabolic drugs and mitochondrial modulators as an emerging class of cancer therapeutics with a special focus on breast cancer
inferred← citeshttps://doi.org/10.1016/j.drudis.2021.02.020openalex-snapshot
Potential and promising anticancer drugs from adenosine and its analogs
inferred← citeshttps://doi.org/10.1016/j.fgb.2020.103431openalex-snapshot
Synthesis of cordycepin: Current scenario and future perspectives
inferred← citeshttps://doi.org/10.1016/j.foodchem.2025.142982openalex-snapshot
Enhancing Cordyceps Sinensis shelf life: The role of liquid nitrogen spray freezing in maintaining hypha structure and reducing metabolic degradation
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2023.02.016openalex-snapshot
Integrative approach to uncover antioxidant properties of Bupleuri Radix and its active compounds: Multiscale interactome-level analysis with experimental validation
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.10.086openalex-snapshot
Synthesis, characterization, and anti-tumor properties of O-benzoylselenoglycolic chitosan
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111268openalex-snapshot
Single-cell RNA sequencing indicates cordycepin remodels the tumor immune microenvironment to enhance TIGIT blockade's anti-tumor effect in colon cancer
inferred← citeshttps://doi.org/10.1016/j.msec.2021.112232openalex-snapshot
Tailoring chemical compositions of biodegradable mesoporous organosilica nanoparticles for controlled slow release of chemotherapeutic drug
inferred← citeshttps://doi.org/10.1016/j.numecd.2018.04.011openalex-snapshot
Obesity, weight change, and mortality in older adults with metabolic abnormalities
inferred← citeshttps://doi.org/10.1016/j.prmcm.2023.100294openalex-snapshot
Cordyceps sinensis (yarsagumba): Pharmacological properties of a mushroom
inferred← citeshttps://doi.org/10.1016/j.prmcm.2025.100742openalex-snapshot
Harnessing cordycepin’s therapeutic potential: A review with special focus on breast cancer
inferred← citeshttps://doi.org/10.1016/j.semcancer.2020.03.004openalex-snapshot
Regulation of cancer cell signaling pathways as key events for therapeutic relevance of edible and medicinal mushrooms
inferred← citeshttps://doi.org/10.1038/s41368-024-00340-wopenalex-snapshot
Adhesive and injectable hydrogel microspheres for NRF2-mediated periodontal bone regeneration
inferred← citeshttps://doi.org/10.1038/s41467-022-33433-3openalex-snapshot
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors
inferred← citeshttps://doi.org/10.1039/c9fo02879jopenalex-snapshot
Natural cordycepin induces apoptosis and suppresses metastasis in breast cancer cells by inhibiting the Hedgehog pathway
inferred← citeshttps://doi.org/10.1039/d1ra00038aopenalex-snapshot
In silico and in vitro design of cordycepin encapsulation in liposomes for colon cancer treatment
inferred← citeshttps://doi.org/10.1080/01635581.2020.1819350openalex-snapshot
Cordycepin-loaded Nanoparticles from Cassava Starch Promote the Proliferation of Submandibular Gland Cells and Inhibit the Growth of Oral Squamous Carcinoma Cells
inferred← citeshttps://doi.org/10.1080/10286020.2025.2497282openalex-snapshot
Anti-cancer effects of cordyceps sinensis, C. militaris and C. cicadae and their mechanisms of action
inferred← citeshttps://doi.org/10.1097/mrm.0000000000000294openalex-snapshot
Multifunctional dynamic toolbox: cordycepin plays a therapeutic role in various disorders
inferred← citeshttps://doi.org/10.1134/s1068162025601144openalex-snapshot
2-Fluorocordycepin: Chemoenzymatic Synthesis and Study of Anticancer Activities In Vitro
inferred← citeshttps://doi.org/10.1155/2020/9053274openalex-snapshot
Cordyceps militaris Induces Immunogenic Cell Death and Enhances Antitumor Immunogenic Response in Breast Cancer
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A Network Pharmacology Study on the Molecular Mechanisms of FDY003 for Breast Cancer Treatment
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Investigating the Biomarkers of the Sasang Constitution via Network Pharmacology Approach
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System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats
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Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer: opportunities and challenges
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Analyzing the multi-target pharmacological mechanism of folium Artemisia argyi acting on breast cancer: a network pharmacology approach
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Analyzing the Multi-target Pharmacological Mechanism of Folium Artemisiae Argyi Acting on Breast Cancer: A Network Pharmacology Approach
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Drug Delivery of Natural Products Through Nanocarriers for Effective Breast Cancer Therapy: A Comprehensive Review of Literature
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Cordycepin and Its Structural Derivatives Effectively Suppress the High Expression of Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase in Breast Carcinomas: A Computational Drug Development Approach
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Mechanisms of Er Chen Tang on Treating Asthma Explored by Network Pharmacology and Experimental Verification
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A Review of Modeling Checkpoint Blockade Therapy and Therapeutic Strategies in Integrative Pharmacological Approach for Metastatic Breast Cancer
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Effects of Lactobacillus fermentum CQPC04 on Lipid Reduction in C57BL/6J Mice
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Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials
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Natural Product-Based Studies for the Management of Castration-Resistant Prostate Cancer: Computational to Clinical Studies
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Unraveling the Antioxidant Capacity of Spatholobi caulis in Nonalcoholic Fatty Liver Disease: A Multiscale Network Approach Integrated with Experimental Validation
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4,6′-Anhydrooxysporidinone from Fusarium lateritium SSF2 Induces Autophagic and Apoptosis Cell Death in MCF-7 Breast Cancer Cells
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Investigating the Multi-Target Pharmacological Mechanism of Hedyotis diffusa Willd Acting on Prostate Cancer: A Network Pharmacology Approach
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Identifying Candidate Polyphenols Beneficial for Oxidative Liver Injury through Multiscale Network Analysis
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Maintaining the Quality and Nutritional Integrity of Chilled Cordyceps sinensis: Comparative Effects and Mechanisms of Modified Atmosphere Packaging and UV-Based Interventions
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Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology
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Cordycepin Inhibits Growth and Metastasis Formation of MDA-MB-231 Xenografts in Nude Mice by Modulating the Hedgehog Pathway
inferred← citeshttps://doi.org/10.3390/ijms241210120openalex-snapshot
Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer
inferred← citeshttps://doi.org/10.3390/jof7050397openalex-snapshot
Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value
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Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses
inferred← citeshttps://doi.org/10.3390/molecules26195886openalex-snapshot
A Systematic Review of the Biological Effects of Cordycepin
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Proteomic Research on the Antitumor Properties of Medicinal Mushrooms
inferred← citeshttps://doi.org/10.3390/molecules27010036openalex-snapshot
Estrogenic Activity of Mycoestrogen (3β,5α,22E)-Ergost-22-en-3-ol via Estrogen Receptor α-Dependent Signaling Pathways in MCF-7 Cells
inferred← citeshttps://doi.org/10.3390/molecules27196576openalex-snapshot
Chinese Cordyceps: Bioactive Components, Antitumor Effects and Underlying Mechanism—A Review
inferred← citeshttps://doi.org/10.3390/pharmaceutics15061771openalex-snapshot
CD44-Targeted Lipid Polymer Hybrid Nanoparticles Enhance Anti-Breast Cancer Effect of Cordyceps militaris Extracts
inferred← citeshttps://doi.org/10.3892/mmr.2024.13285openalex-snapshot
Application and research progress of cordycepin in the treatment of tumours (Review)
inferred← citeshttps://doi.org/10.53945/2320-7094.1131openalex-snapshot
Antioxidant and cytotoxic potential of potentized preparation of Cordyceps sinensis in vitro in cancer cell lines
inferred← citeshttps://doi.org/10.6084/m9.figshare.19759778openalex-snapshot
Additional file 1 of System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats
inferred← citeshttps://doi.org/10.61565/revista-aquila.i33.632openalex-snapshot
Cordyceps e seu potencial terapeutico no tratamento do cancer: uma revisao bibliografica sobre a cordicepina como indutora de apoptose em celulas cancerigenas
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