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Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

https://doi.org/10.3390/molecules25081800
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Three new polyketides from the marine sponge-derived fungus Trichoderma sp. SCSIO41004
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Dectin-1 Mediates the Biological Effects of β-Glucans
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Anti-HIV, antitumor and immunomodulatory activities of paclitaxel from fermentation broth using molecular imprinting technique
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Hepatitis C Virus NS3-NS4A Protease Inhibitors from the Endophytic Penicillium chrysogenum Isolated from the Red Alga Liagora viscida
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Potential Therapeutic Agents for COVID-19 Based on the Analysis of Protease and RNA Polymerase Docking
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Virtual Screening of an FDA Approved Drugs Database on Two COVID-19 Coronavirus Proteins
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Recent status and prospects of the fungal immunomodulatory protein family
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The Author's Response: Case of the Index Patient Who Caused Tertiary Transmission of Coronavirus Disease 2019 in Korea: the Application of Lopinavir/Ritonavir for the Treatment of COVID-19 Pneumonia Monitored by Quantitative RT-PCR
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Antiviral Agents From Fungi: Diversity, Mechanisms and Potential Applications
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Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro
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The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and Its Mechanism: An Investigation Using Network Pharmacology-Based Analysis
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The Alternaria alternata Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation
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Different Culture Metabolites of the Red Sea Fungus Fusarium equiseti Optimize the Inhibition of Hepatitis C Virus NS3/4A Protease (HCV PR)
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Current and Novel Inhibitors of HIV Protease
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Systematic Comparison of Two Animal-to-Human Transmitted Human Coronaviruses: SARS-CoV-2 and SARS-CoV
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Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis
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Immunomodulators in Autoimmunity and Viral Infections
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Paclitaxel Against Cancer: A Short Review
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Triterpenoids from the spores of Ganoderma lucidum
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Introductory Chapter: Terpenes and Terpenoids
inferredcites →https://doi.org/10.5812/archcid.13823openalex-snapshot
Lopinavir; A Potent Drug against Coronavirus Infection: Insight from Molecular Docking Study
inferredcites →https://doi.org/10.7123/01.epj.0000421517.80892.edopenalex-snapshot
In-vitro bioassays on the metabolites of the fungus Emericella nidulans isolated from the Egyptian Red Sea algae
inferredcites →https://doi.org/10.7150/jca.32071openalex-snapshot
Cordycepin Induces Apoptosis and G2/M Phase Arrest through the ERK Pathways in Esophageal Cancer Cells
inferredcites →https://doi.org/10.7164/antibiotics.50.395openalex-snapshot
Semicochliodinol A and B: Inhibitors of HIV-1 Protease and EGF-R Protein Tyrosine Kinase Related to Asterriquinones Produced by the Fungus Chrysosporium merdarium.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3942525openalex-extracted
Effect of Marine and Mushroom Fungal Derived Bioactive Compounds to Mitigate Methane Gas Production: A Docking Studies on Methyl-Coenzyme M Reductase (MCR)
inferred← citeshttps://doi.org/10.1002/9781119818779.ch14openalex-snapshot
Herbs and Plants Used for the Management and Treatment of Hepatitis Infections
inferred← citeshttps://doi.org/10.1002/9781394249190.ch2openalex-snapshot
Bioactive Small Molecules and Drug Discovery
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Biological Properties, Health Benefits and Semisynthetic Derivatives of Edible Astraeus Mushrooms ( Diplocystidiaceae ): A Comprehensive Review
inferred← citeshttps://doi.org/10.1002/fft2.119openalex-snapshot
The direct and indirect effects of bioactive compounds against coronavirus
inferred← citeshttps://doi.org/10.1002/ptr.6794openalex-snapshot
Natural products as home‐based prophylactic and symptom management agents in the setting of COVID ‐19
inferred← citeshttps://doi.org/10.1007/978-3-030-58756-7_7openalex-snapshot
Bioactive Constituents and Pharmacological Activities
inferred← citeshttps://doi.org/10.1007/978-3-032-09291-5_1openalex-snapshot
Fungal-Based Cosmetics: An Introduction
inferred← citeshttps://doi.org/10.1007/978-981-16-6257-7_2openalex-snapshot
Therapeutic Potential of Medicinal Mushrooms: Insights into Its Use Against Covid-19
inferred← citeshttps://doi.org/10.1007/978-981-19-9550-7_6openalex-snapshot
Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health
inferred← citeshttps://doi.org/10.1007/s00284-020-02170-5openalex-snapshot
Enzymatic Modulators from Induratia spp.
inferred← citeshttps://doi.org/10.1007/s00403-025-04048-7openalex-snapshot
Mushrooms in modern cosmetics: unlocking anti-aging, antioxidant, and therapeutic potential
inferred← citeshttps://doi.org/10.1007/s12550-024-00539-0openalex-snapshot
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis
inferred← citeshttps://doi.org/10.1007/s42250-020-00203-xopenalex-snapshot
Natural and Synthetic Drugs as Potential Treatment for Coronavirus Disease 2019 (COVID-2019)
inferred← citeshttps://doi.org/10.1016/b978-0-12-821734-4.00010-1openalex-snapshot
Fungal endophytes as a potential source of therapeutically important metabolites
inferred← citeshttps://doi.org/10.1016/b978-0-12-824523-1.00019-5openalex-snapshot
Fungal strains as source of bioactive compounds and their potential application
inferred← citeshttps://doi.org/10.1016/b978-0-323-95047-3.00021-6openalex-snapshot
Natural products and SARS-CoV-2
inferred← citeshttps://doi.org/10.1016/j.afres.2025.101322openalex-snapshot
Advancements in extraction and encapsulation of immunomodulatory mushroom biomolecules for enhanced food applications
inferred← citeshttps://doi.org/10.1016/j.bmc.2021.116366openalex-snapshot
Antiviral fungal metabolites and some insights into their contribution to the current COVID-19 pandemic
inferred← citeshttps://doi.org/10.1016/j.bsheal.2023.12.006openalex-snapshot
Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi
inferred← citeshttps://doi.org/10.1016/j.cej.2024.155669openalex-snapshot
Bioactives from biomass: Treasure for future potent antimicrobial applications
inferred← citeshttps://doi.org/10.1016/j.fct.2022.113438openalex-snapshot
Lucidenic acid A inhibits the binding of hACE2 receptor with spike protein to prevent SARS-CoV-2 invasion
inferred← citeshttps://doi.org/10.1016/j.foodchem.2021.130927openalex-snapshot
A new look at edible and medicinal mushrooms as a source of ergosterol and ergosterol peroxide - UHPLC-MS/MS analysis
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2021.06.122openalex-snapshot
Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties
inferred← citeshttps://doi.org/10.1016/j.imu.2021.100753openalex-snapshot
Discovery of mushroom-derived bioactive compound's draggability against nsP3 macro domain, nsP2 protease and envelope glycoprotein of Chikungunya virus: An in silico approach
inferred← citeshttps://doi.org/10.1016/j.imu.2021.100821openalex-snapshot
A computerized pharmaceutical repurposing approach reveals Semicochliodinol B synthesized from Chrysosporium merdarium as a viable therapeutic contender for Marburg virus's VP35 and VP40 proteins
inferred← citeshttps://doi.org/10.1016/j.jaim.2024.100979openalex-snapshot
Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris
inferred← citeshttps://doi.org/10.1016/j.jff.2022.105036openalex-snapshot
Thelephoric acid, p-terphenyl, induces bone-forming activities in pre-osteoblasts
inferred← citeshttps://doi.org/10.1016/j.jgr.2024.12.004openalex-snapshot
Antiviral potential of ginseng: Targeting human pathogenic viruses with compounds derived from ginseng
inferred← citeshttps://doi.org/10.1016/j.jsps.2022.05.003openalex-snapshot
Virtual screening and molecular dynamics simulation analysis of Forsythoside A as a plant-derived inhibitor of SARS-CoV-2 3CLpro
inferred← citeshttps://doi.org/10.1016/j.jtcme.2020.12.002openalex-snapshot
Mushroom-derived bioactive compounds potentially serve as the inhibitors of SARS-CoV-2 main protease: An in silico approach
inferred← citeshttps://doi.org/10.1016/j.napere.2025.100134openalex-snapshot
Biological control of Alternaria alternata MW970059, the causal agent of tomato rot, by Aspergillus nidulans MW732187 isolated from green household waste
inferred← citeshttps://doi.org/10.1016/j.omto.2022.01.005openalex-snapshot
Carboranes as unique pharmacophores in antitumor medicinal chemistry
inferred← citeshttps://doi.org/10.1016/j.pupt.2022.102170openalex-snapshot
Treatment of respiratory viral infections through inhalation therapeutics: Challenges and opportunities
inferred← citeshttps://doi.org/10.1021/acs.jpcb.0c06747openalex-snapshot
Revealing the Inhibition Mechanism of RNA-Dependent RNA Polymerase (RdRp) of SARS-CoV-2 by Remdesivir and Nucleotide Analogues: A Molecular Dynamics Simulation Study
inferred← citeshttps://doi.org/10.1021/acsomega.1c05998openalex-snapshot
Potent Inhibitory Activities of the Adenosine Analogue Cordycepin on SARS-CoV-2 Replication
inferred← citeshttps://doi.org/10.1021/acsomega.3c01031openalex-snapshot
Semi-quantification and Potency Verification of the HIV Protease Inhibitor Based on the Matrix-Capsid Protein Immobilized Nickel (II)/NTA-Tol/Graphene Oxide/SPCE Electrochemical Biosensor
inferred← citeshttps://doi.org/10.1038/s41598-022-05349-xopenalex-snapshot
Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approach
inferred← citeshttps://doi.org/10.1039/bk9781837672097-00242openalex-snapshot
Lentinula edodes (Berk.) Pegler
inferred← citeshttps://doi.org/10.1039/d4np00076eopenalex-snapshot
The cytochalasans: potent fungal natural products with application from bench to bedside
inferred← citeshttps://doi.org/10.1080/00275514.2024.2324620openalex-snapshot
Purification of andibenin and a chromanone analogue from rhizospheric Aspergillus flavus and soil-borne Penicillium notatum exhibiting cytotoxic and antibacterial properties
inferred← citeshttps://doi.org/10.1080/0028825x.2024.2384453openalex-snapshot
Unlocking the therapeutic potential of edible mushrooms: Ganoderma and their secondary metabolites as novel antiviral agents for combating COVID-19
inferred← citeshttps://doi.org/10.1080/07391102.2020.1850352openalex-snapshot
Cordycepin: a bioactive metabolite of C ordyceps militaris and polyadenylation inhibitor with therapeutic potential against COVID-19
inferred← citeshttps://doi.org/10.1080/07391102.2024.2333986openalex-snapshot
Bioactive fungal compounds as potential anti-HIV agents against HIV-1 protease: a multi-faceted molecular modelling approach for drug discovery
inferred← citeshttps://doi.org/10.1093/jambio/lxae031openalex-snapshot
Efficacy of ergosterol peroxide obtained from the endophytic fungus Acrophialophora jodhpurensis against Rhizoctonia solani
inferred← citeshttps://doi.org/10.1111/cbdd.13761openalex-snapshot
The recent challenges of highly contagious COVID‐19, causing respiratory infections: Symptoms, diagnosis, transmission, possible vaccines, animal models, and immunotherapy
inferred← citeshttps://doi.org/10.1142/s2737416521500113openalex-snapshot
Exploration of Some Naturally Occurring Fungal-Derived Bioactive Molecules as Potential SARS-CoV-2 Main Protease (MPro) Inhibitors ThroughIn-silicoApproach
inferred← citeshttps://doi.org/10.1186/s42269-021-00561-7openalex-snapshot
Endophytic microbes from Nigerian ethnomedicinal plants: a potential source for bioactive secondary metabolites—a review
inferred← citeshttps://doi.org/10.15574/sp.2021.117.12openalex-snapshot
Досвід у лікуванні та профілактиці рецидивних респіраторних захворювань у дітей із застосуванням фітотерапевтичного комплексу «Альпікол»: feedback лікарів України
inferred← citeshttps://doi.org/10.1615/intjmedmushrooms.2023048109openalex-snapshot
The Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Can Combat Cytokine Storm and Other COVID-19 Related Pathologies: A Review
inferred← citeshttps://doi.org/10.1615/intjmedmushrooms.2023051031openalex-snapshot
Antiviral Activity of Some Compounds of Gasteroid Mushrooms from Western Siberia
inferred← citeshttps://doi.org/10.20944/preprints202407.0119.v1openalex-snapshot
Evaluating the Anti-cancer Potential of Ganoderma lucidum: A Critical Analysis of Clinical Evidence and Methodological Advances.
inferred← citeshttps://doi.org/10.2139/ssrn.4947007openalex-snapshot
Biological Control of Alternaria Alternata Mw970059, Responsible to Tomato Rot, by a New Strain Aspergillus Nidulans Mw732187 Isolated from Green Household Waste
inferred← citeshttps://doi.org/10.2174/0113892037297181240605112831openalex-snapshot
Recovery of Proteases and Protease Inhibitors from Ganoderma spp. Cultivated in Amazonian Lignocellulose Wastes
inferred← citeshttps://doi.org/10.2174/0115701638243222230920051050openalex-snapshot
In Silico Screening of Some Active Phytochemicals to Identify Promising Inhibitors Against SARS-CoV-2 Targets
inferred← citeshttps://doi.org/10.2174/1573401318666220308155721openalex-snapshot
Bioactive Compounds from Plants and their Immune Potential against Corona Virus
inferred← citeshttps://doi.org/10.2174/1573406419666230413112802openalex-snapshot
An In silico Investigation to Identify Promising Inhibitors for SARS-CoV-2 Mpro Target
inferred← citeshttps://doi.org/10.2174/1573409919666221117145404openalex-snapshot
Computational Search for Potential COVID-19 Drugs from Ayurvedic Medicinal Plants to Identify Potential Inhibitors against SARS-CoV-2 Targets
inferred← citeshttps://doi.org/10.2174/1874467214666210319145816openalex-snapshot
Harnessing the Natural Pool of Polyketide and Non-ribosomal Peptide Family: A Route Map towards Novel Drug Development
inferred← citeshttps://doi.org/10.2174/2215083810666230602152743openalex-snapshot
Anti-viral Application of Ganoderma lucidum in COVID-19
inferred← citeshttps://doi.org/10.2174/9789815123258123010008openalex-snapshot
Immunomodulators: Chemistry and Analytical Techniques
inferred← citeshttps://doi.org/10.22376/ijpbs/lpr.2021.11.5.l145-150openalex-snapshot
In Silico Prediction, Computational Physico Chemical Analysis in Gymnemic Acids
inferred← citeshttps://doi.org/10.23880/vij-16000254openalex-snapshot
Possible Use of Ganoderma Mushroom Extracts for the Treatment of Some Chronic Risk Factors Associated with Severe Covid-19
inferred← citeshttps://doi.org/10.2478/prilozi-2023-0002openalex-snapshot
Effect of Supplemental Antioxidant-Based Therapy on the Oxidative Stress Level in COVID-19 Patients
inferred← citeshttps://doi.org/10.26434/chemrxiv.12523136openalex-snapshot
Discovery of Fungal Metabolites Bergenin, Quercitrin and Dihydroartemisinin as Potential Inhibitors Against Main Protease of SARS-CoV-2
inferred← citeshttps://doi.org/10.26434/chemrxiv.13369454openalex-snapshot
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines Against COVID-19
inferred← citeshttps://doi.org/10.26599/fshw.2022.9250051openalex-snapshot
Ganoderma lucidum : a comprehensive review of phytochemistry, efficacy, safety and clinical study
inferred← citeshttps://doi.org/10.29086/10413/22998openalex-snapshot
Anti-HIV and Immunomodulatory properties of the fractionated crude extracts isolated from Alternaria alternate.
inferred← citeshttps://doi.org/10.29267/mxjb.2021.6.1.165openalex-snapshot
Bioactive compounds from fungi with antiviral activities: Mechanism of action and biosynthetic pathways
inferred← citeshttps://doi.org/10.33084/bjop.v3i4.1634openalex-snapshot
Activity Prediction of Bioactive Compounds Contained in Etlingera elatior Against the SARS-CoV-2 Main Protease: An In Silico Approach
inferred← citeshttps://doi.org/10.33448/rsd-v10i8.17178openalex-snapshot
Compostos bioativos derivados de matrizes alimentares com potencial terapêutico para a infecção por Sars-Cov-2: Uma revisão de estudos in silico
inferred← citeshttps://doi.org/10.33483/jfpau.1512113openalex-snapshot
MUSHROOM DERIVED COMPOUNDS UNVEILED NARINGIN AS A POTENTIAL MULTI-TARGETED ANTI-BREAST CANCER COMPOUND - AN IN-SILICO APPROACH
inferred← citeshttps://doi.org/10.3389/fmed.2021.752095openalex-snapshot
Investigating Fungi-Derived Bioactive Molecules as Inhibitor of the SARS Coronavirus Papain Like Protease: Computational Based Study
inferred← citeshttps://doi.org/10.3389/fphar.2019.00115openalex-snapshot
Identification of Biologically Active Ganoderma lucidum Compounds and Synthesis of Improved Derivatives That Confer Anti-cancer Activities in vitro
inferred← citeshttps://doi.org/10.3389/fphar.2021.575877openalex-snapshot
Naturally Occurring Bioactives as Antivirals: Emphasis on Coronavirus Infection
inferred← citeshttps://doi.org/10.3390/antiox10121899openalex-snapshot
Antioxidant Activity of Mushroom Extracts/Polysaccharides—Their Antiviral Properties and Plausible AntiCOVID-19 Properties
inferred← citeshttps://doi.org/10.3390/antiox9070595openalex-snapshot
Could Ergothioneine Aid in the Treatment of Coronavirus Patients?
inferred← citeshttps://doi.org/10.3390/app11094221openalex-snapshot
Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa
inferred← citeshttps://doi.org/10.3390/biom11020216openalex-snapshot
In Silico Screening of Natural Products Isolated from Mexican Herbal Medicines against COVID-19
inferred← citeshttps://doi.org/10.3390/books978-3-0365-2640-9openalex-snapshot
New Insights in Oral Health and Diets
inferred← citeshttps://doi.org/10.3390/microorganisms12061150openalex-snapshot
Anti-HIV Activity and Immunomodulatory Properties of Fractionated Crude Extracts of Alternaria alternata
inferred← citeshttps://doi.org/10.3390/molecules26133900openalex-snapshot
Flavonoids as Promising Antiviral Agents against SARS-CoV-2 Infection: A Mechanistic Review
inferred← citeshttps://doi.org/10.3390/molecules27175620openalex-snapshot
Deciphering the Potential of Pre and Pro-Vitamin D of Mushrooms against Mpro and PLpro Proteases of COVID-19: An In Silico Approach
inferred← citeshttps://doi.org/10.3390/pharmaceutics13111759openalex-snapshot
A Comprehensive Review about the Molecular Structure of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): Insights into Natural Products against COVID-19
inferred← citeshttps://doi.org/10.3390/plants10010041openalex-snapshot
Sterols and Triterpenes: Antiviral Potential Supported by In-Silico Analysis
inferred← citeshttps://doi.org/10.3390/vetsci12070634openalex-snapshot
In Vitro Antiviral Activity of the Fungal Metabolite 6-Pentyl-α-Pyrone Against Bovine Coronavirus: A Translational Study to SARS-CoV-2
inferred← citeshttps://doi.org/10.34172/apb.2022.030openalex-snapshot
Lectins Are the Sparkle of Hope for Combating Coronaviruses and the Global COVID 19
inferred← citeshttps://doi.org/10.34297/ajbsr.2021.12.001819openalex-snapshot
Novel Edible Mushroom BDM-X as an Immune Modulator: Possible Role in Dietary Self-Protection Against COVID-19 Pandemic
inferred← citeshttps://doi.org/10.36948/ijfmr.2024.v06i03.21115openalex-snapshot
Recent Advances on Bioactive Molecules Acting on RNA and RNA Binding Proteins
inferred← citeshttps://doi.org/10.3892/ijfn.2020.6openalex-snapshot
Nutraceuticals and herbal extracts: A ray of hope for COVID‑19 and related infections (Review)
inferred← citeshttps://doi.org/10.3934/microbiol.2020028openalex-snapshot
Biologically active compounds from marine organisms in the strategies for combating coronaviruses
inferred← citeshttps://doi.org/10.5493/wjem.v14.i3.95512openalex-snapshot
Phytochemical analysis of Tinospora cordifolia and Withania somnifera and their therapeutic activities with special reference to COVID-19
inferred← citeshttps://doi.org/10.5943/funbiotec/1/1/1openalex-snapshot
Bacteriostatic and Virostatic Activities of Mushrooms: A Mini-review
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.