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Cellular Mechanisms Accounting for the Refractoriness of Colorectal Carcinoma to Pharmacological Treatment

https://doi.org/10.3390/cancers12092605
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Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy
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Genomic Profiling of Small-Bowel Adenocarcinoma
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p53 mutations as a possible predictor of response to chemotherapy in metastatic colorectal carcinomas
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Role of metallothionein in cisplatin sensitivity of germ-cell tumours
inferredcites →https://doi.org/10.1002/cam4.1480openalex-snapshot
DNA repair protein XPA is differentially expressed in colorectal cancer and predicts better prognosis
inferredcites →https://doi.org/10.1002/cbin.11262openalex-snapshot
Sensitization of HT29 colorectal cancer cells to vemurafenib in three‐dimensional collagen cultures
inferredcites →https://doi.org/10.1002/cpt.1301openalex-snapshot
Protein Abundance of Clinically Relevant Drug Transporters in the Human Liver and Intestine: A Comparative Analysis in Paired Tissue Specimens
inferredcites →https://doi.org/10.1002/ibd.21814openalex-snapshot
Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients
inferredcites →https://doi.org/10.1002/ijc.24273openalex-snapshot
Increased levels of copper efflux transporter ATP7B are associated with poor outcome in colorectal cancer patients receiving oxaliplatin‐based chemotherapy
inferredcites →https://doi.org/10.1002/ijc.24929openalex-snapshot
Combination of p53 codon 72 polymorphism and inactive p53 mutation predicts chemosensitivity to 5‐fluorouracil in colorectal cancer
inferredcites →https://doi.org/10.1002/ijc.28226openalex-snapshot
Roles of Chk1 in cell biology and cancer therapy
inferredcites →https://doi.org/10.1002/ijc.30026openalex-snapshot
SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients
inferredcites →https://doi.org/10.1002/ijc.30507openalex-snapshot
EGFR gene copy number predicts response to anti‐EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer
inferredcites →https://doi.org/10.1002/ijc.31282openalex-snapshot
The role of the miR‐200 family in epithelial–mesenchymal transition in colorectal cancer: a systematic review
inferredcites →https://doi.org/10.1002/ijc.32417openalex-snapshot
Impact of single‐nucleotide polymorphisms in DNA repair pathway genes on response to chemoradiotherapy in rectal cancer patients: Results from ACCORD‐12/PRODIGE‐2 phase III trial
inferredcites →https://doi.org/10.1002/ijc.32429openalex-snapshot
VPS33B negatively modulated by nicotine functions as a tumor suppressor in colorectal cancer
inferredcites →https://doi.org/10.1002/iub.1361openalex-snapshot
Micro RNA ‐494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD
inferredcites →https://doi.org/10.1002/jcp.27984openalex-snapshot
HER2 + mCRC patients with exon 20 R784G substitution mutation do not respond to the cetuximab therapy
inferredcites →https://doi.org/10.1002/mc.21832openalex-snapshot
miR‐1915 inhibits Bcl‐2 to modulate multidrug resistance by increasing drug‐sensitivity in human colorectal carcinoma cells
inferredcites →https://doi.org/10.1007/s00280-001-0416-0openalex-snapshot
Determinants of the cytotoxicity of irinotecan in two human colorectal tumor cell lines
inferredcites →https://doi.org/10.1007/s00432-001-0310-5openalex-snapshot
Markers of drug resistance in relapsing colon cancer
inferredcites →https://doi.org/10.1007/s00464-003-8253-3openalex-snapshot
Laparoscopic resection of colon Cancer: Consensus of the European Association of Endoscopic Surgery (EAES)
inferredcites →https://doi.org/10.1007/s00535-006-1801-6openalex-snapshot
Colorectal cancer: genetics of development and metastasis
inferredcites →https://doi.org/10.1007/s00535-015-1061-4openalex-snapshot
Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles
inferredcites →https://doi.org/10.1007/s00595-010-4390-1openalex-snapshot
Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer
inferredcites →https://doi.org/10.1007/s00775-017-1467-yopenalex-snapshot
Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells
inferredcites →https://doi.org/10.1007/s11010-018-3365-1openalex-snapshot
Biglycan promotes the chemotherapy resistance of colon cancer by activating NF-κB signal transduction
inferredcites →https://doi.org/10.1007/s11095-005-7595-zopenalex-snapshot
Human Multidrug Resistance Associated Protein 4 Confers Resistance to Camptothecins
inferredcites →https://doi.org/10.1007/s12032-009-9224-xopenalex-snapshot
Overexpression of FADD enhances 5-fluorouracil-induced apoptosis in colorectal adenocarcinoma cells
inferredcites →https://doi.org/10.1007/s12032-013-0802-6openalex-snapshot
Association of single nucleotide polymorphisms in MTHFR and ABCG2 with the different efficacy of first-line chemotherapy in metastatic colorectal cancer
inferredcites →https://doi.org/10.1007/s12041-018-0978-9openalex-snapshot
Genetic variations in influx transporter gene SLC22A1 are associated with clinical responses to imatinib mesylate among Malaysian chronic myeloid leukaemia patients
inferredcites →https://doi.org/10.1007/s12253-013-9695-0openalex-snapshot
Down-Regulation of BAX Gene During Carcinogenesis and Acquisition of Resistance to 5-FU in Colorectal Cancer
inferredcites →https://doi.org/10.1007/s13167-019-00185-yopenalex-snapshot
An examination of colorectal cancer burden by socioeconomic status: evidence from GLOBOCAN 2018
inferredcites →https://doi.org/10.1007/s13277-015-3348-8openalex-snapshot
Integrin β6 can be translationally regulated by eukaryotic initiation factor 4E: Contributing to colonic tumor malignancy
inferredcites →https://doi.org/10.1007/s13277-015-3723-5openalex-snapshot
Association between mismatch repair gene and irinotecan-based chemotherapy in metastatic colon cancer
inferredcites →https://doi.org/10.1016/0959-8049(93)90123-wopenalex-snapshot
Increased chemosensitivity to doxorubicin of intrinsically multidrug-resistant human colon carcinoma cells by prolonged exposure to verapamil
inferredcites →https://doi.org/10.1016/j.bbadis.2017.06.005openalex-snapshot
Chemoresistance and chemosensitization in cholangiocarcinoma
inferredcites →https://doi.org/10.1016/j.bbrc.2012.01.115openalex-snapshot
Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells
inferredcites →https://doi.org/10.1016/j.bbrc.2015.05.031openalex-snapshot
Chemoresistance of CD133 + colon cancer may be related with increased survivin expression
inferredcites →https://doi.org/10.1016/j.bcp.2006.06.007openalex-snapshot
Expression of transporters potentially involved in the targeting of cytostatic bile acid derivatives to colon cancer and polyps
inferredcites →https://doi.org/10.1016/j.bcp.2007.05.001openalex-snapshot
p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells
inferredcites →https://doi.org/10.1016/j.bcp.2007.09.029openalex-snapshot
Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis
inferredcites →https://doi.org/10.1016/j.bcp.2008.07.020openalex-snapshot
Induction of P-glycoprotein expression and function in human intestinal epithelial cells (T84)
inferredcites →https://doi.org/10.1016/j.bcp.2016.09.024openalex-snapshot
Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression
inferredcites →https://doi.org/10.1016/j.bcp.2017.10.007openalex-snapshot
Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells
inferredcites →https://doi.org/10.1016/j.biochi.2018.11.003openalex-snapshot
Role of adenomatous polyposis coli (APC) gene mutations in the pathogenesis of colorectal cancer; current status and perspectives
inferredcites →https://doi.org/10.1016/j.bulcan.2014.12.010openalex-snapshot
Functional TP53 mutations have no impact on response to cytotoxic agents in metastatic colon cancer
inferredcites →https://doi.org/10.1016/j.cancergencyto.2008.01.023openalex-snapshot
Common germline MDR1/ABCB1 functional polymorphisms and haplotypes modify susceptibility to colorectal cancers with high microsatellite instability
inferredcites →https://doi.org/10.1016/j.canlet.2017.11.040openalex-snapshot
NFYB-induced high expression of E2F1 contributes to oxaliplatin resistance in colorectal cancer via the enhancement of CHK1 signaling
inferredcites →https://doi.org/10.1016/j.cell.2017.07.008openalex-snapshot
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
inferredcites →https://doi.org/10.1016/j.clcc.2016.11.001openalex-snapshot
Response to Chemotherapy and Prognosis in Metastatic Colorectal Cancer With DNA Deficient Mismatch Repair
inferredcites →https://doi.org/10.1016/j.clcc.2018.10.003openalex-snapshot
E-Cadherin in Colorectal Cancer: Relation to Chemosensitivity
inferredcites →https://doi.org/10.1016/j.drup.2016.06.005openalex-snapshot
The impact of Organic Anion-Transporting Polypeptides (OATPs) on disposition and toxicity of antitumor drugs: Insights from knockout and humanized mice
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TP53 Mutational Status and Prediction of Benefit from Adjuvant 5-Fluorouracil in Stage III Colon Cancer Patients
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The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status
inferredcites →https://doi.org/10.1016/j.ejca.2014.04.007openalex-snapshot
ERBB2 gene as a potential therapeutic target in small bowel adenocarcinoma
inferredcites →https://doi.org/10.1016/j.ejps.2006.03.003openalex-snapshot
Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: Comparison between human segments and Caco-2 cells
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Pathophysiology, Clinical Presentation, and Management of Colon Cancer
inferredcites →https://doi.org/10.1016/j.jss.2003.11.023openalex-snapshot
Inhibition of NF-Kappa B augments sensitivity to 5-Fluorouracil/Folinic acid in colon cancer1
inferredcites →https://doi.org/10.1016/j.molonc.2013.09.001openalex-snapshot
Plasma microRNAs predicting clinical outcome in metastatic colorectal cancer patients receiving first‐line oxaliplatin‐based treatment
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Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy
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S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer
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Epithelial–mesenchymal transition in colorectal cancer metastasis: A system review
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Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway
inferredcites →https://doi.org/10.1016/s0006-2952(01)00812-7openalex-snapshot
Enhanced clearance of topoisomerase I inhibitors from human colon cancer cells by glucuronidation
inferredcites →https://doi.org/10.1016/s0026-895x(25)08844-3openalex-snapshot
Overexpression of glutathione S-transferase and elevation of thiol pools in a multidrug-resistant human colon cancer cell line.
inferredcites →https://doi.org/10.1016/s0065-2423(08)60198-5openalex-snapshot
Glutathione S-Transferases: Biomedical Applications
inferredcites →https://doi.org/10.1016/s1470-2045(18)30142-6openalex-snapshot
Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF-mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial
inferredcites →https://doi.org/10.1021/mp300178aopenalex-snapshot
Cisplatin-Induced Chemoresistance in Colon Cancer Cells Involves FXR-Dependent and FXR-Independent Up-Regulation of ABC Proteins
inferredcites →https://doi.org/10.1021/mp3005353openalex-snapshot
A Cancer-Specific Variant of the SLCO1B3 Gene Encodes a Novel Human Organic Anion Transporting Polypeptide 1B3 (OATP1B3) Localized Mainly in the Cytoplasm of Colon and Pancreatic Cancer Cells
inferredcites →https://doi.org/10.1023/a:1011112227044openalex-snapshot
Rb, mcl-1 and p53 expression correlate with clinical outcome in patients with liver metastases from colorectal cancer
inferredcites →https://doi.org/10.1038/bjc.2013.83openalex-snapshot
ERCC1, defective mismatch repair status as predictive biomarkers of survival for stage III colon cancer patients receiving oxaliplatin-based adjuvant chemotherapy
inferredcites →https://doi.org/10.1038/bjc.2015.5openalex-snapshot
OATP1B1 and tumour OATP1B3 modulate exposure, toxicity, and survival after irinotecan-based chemotherapy
inferredcites →https://doi.org/10.1038/cdd.2014.170openalex-snapshot
Bcl-2 stabilization by paxillin confers 5-fluorouracil resistance in colorectal cancer
inferredcites →https://doi.org/10.1038/clpt.2011.102openalex-snapshot
Pharmacokinetic Impact of SLCO1A2 Polymorphisms on Imatinib Disposition in Patients With Chronic Myeloid Leukemia
inferredcites →https://doi.org/10.1038/clpt.2011.42openalex-snapshot
Environmental and Genetic Factors Affecting Transport of Imatinib by OATP1A2
inferredcites →https://doi.org/10.1038/leu.2015.170openalex-snapshot
OCT1 and imatinib transport in CML: is it clinically relevant?
inferredcites →https://doi.org/10.1038/modpathol.2016.40openalex-snapshot
Clinicopathologic and prognostic associations of KRAS and BRAF mutations in small intestinal adenocarcinoma
inferredcites →https://doi.org/10.1038/ncomms13084openalex-snapshot
Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor
inferredcites →https://doi.org/10.1038/s12276-018-0128-8openalex-snapshot
Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells
inferredcites →https://doi.org/10.1038/s41416-018-0348-7openalex-snapshot
Pharmacogenetic clinical randomised phase II trial to evaluate the efficacy and safety of FOLFIRI with high-dose irinotecan (HD-FOLFIRI) in metastatic colorectal cancer patients according to their UGT1A 1 genotype
inferredcites →https://doi.org/10.1038/s41416-019-0429-2openalex-snapshot
p53 expression status is associated with cancer-specific survival in stage III and high-risk stage II colorectal cancer patients treated with oxaliplatin-based adjuvant chemotherapy
inferredcites →https://doi.org/10.1038/s41416-020-0783-0openalex-snapshot
Targeting CD133 reverses drug-resistance via the AKT/NF-κB/MDR1 pathway in colorectal cancer
inferredcites →https://doi.org/10.1038/s41419-018-0776-6openalex-snapshot
PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer
inferredcites →https://doi.org/10.1038/s41571-019-0241-1openalex-snapshot
Biomarker-guided therapy for colorectal cancer: strength in complexity
inferredcites →https://doi.org/10.1038/s41598-017-07491-3openalex-snapshot
A polymorphism in ABCC4 is related to efficacy of 5-FU/capecitabine-based chemotherapy in colorectal cancer patients
inferredcites →https://doi.org/10.1038/s41598-018-30525-3openalex-snapshot
Cancer stem cells as targets for DC-based immunotherapy of colorectal cancer
inferredcites →https://doi.org/10.1038/s41598-018-36251-0openalex-snapshot
Sox2 is associated with cancer stem-like properties in colorectal cancer
inferredcites →https://doi.org/10.1038/sj.bjc.6604671openalex-snapshot
Pharmacogenetic prediction of clinical outcome in advanced colorectal cancer patients receiving oxaliplatin/5-fluorouracil as first-line chemotherapy
inferredcites →https://doi.org/10.1038/tpj.2011.61openalex-snapshot
Pharmacogenetic profiling of CD133 is associated with response rate (RR) and progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC), treated with bevacizumab-based chemotherapy
inferredcites →https://doi.org/10.1053/gast.2001.24804openalex-snapshot
LST-2, A human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers
inferredcites →https://doi.org/10.1053/j.gastro.2015.07.011openalex-snapshot
Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
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Correlation Between the Response to Cetuximab Alone or in Combination With Irinotecan and the Activated/Phosphorylated Epidermal Growth Factor Receptor in Metastatic Colorectal Cancer
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Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma
inferredcites →https://doi.org/10.1056/nejmoa1305275openalex-snapshot
Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer
inferredcites →https://doi.org/10.1056/nejmoa1908075openalex-snapshot
Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer
inferredcites →https://doi.org/10.1067/msy.2001.116672openalex-snapshot
Nuclear factor-κB is upregulated in colorectal cancer
inferredcites →https://doi.org/10.1073/pnas.1618297114openalex-snapshot
Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer
inferredcites →https://doi.org/10.1073/pnas.1801348115openalex-snapshot
Hypoxic tumor microenvironment activates GLI2 via HIF-1α and TGF-β2 to promote chemoresistance in colorectal cancer
inferredcites →https://doi.org/10.1073/pnas.84.21.7735openalex-snapshot
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.
inferredcites →https://doi.org/10.1074/jbc.m114.620252openalex-snapshot
MicroRNA-520g Confers Drug Resistance by Regulating p21 Expression in Colorectal Cancer
inferredcites →https://doi.org/10.1080/10520295.2018.1493220openalex-snapshot
Expression of CYP and GST in human normal and colon tumor tissues
inferredcites →https://doi.org/10.1080/14712598.2019.1680636openalex-snapshot
Role of immune checkpoint inhibitors in the treatment of colorectal cancer: focus on nivolumab
inferredcites →https://doi.org/10.1080/15384047.2017.1414754openalex-snapshot
Expression of Topoisomerase 1 and carboxylesterase 2 correlates with irinotecan treatment response in metastatic colorectal cancer
inferredcites →https://doi.org/10.1080/2162402x.2017.1342918openalex-snapshot
Tumor-associated macrophages and response to 5-fluorouracil adjuvant therapy in stage III colorectal cancer
inferredcites →https://doi.org/10.1084/jem.20131195openalex-snapshot
Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
inferredcites →https://doi.org/10.1089/cbr.2018.2746openalex-snapshot
Knockdown of REG Iα Enhances the Sensitivity to 5-Fluorouracil of Colorectal Cancer Cells via Cyclin D1/CDK4 Pathway and BAX/BCL-2 Pathways
inferredcites →https://doi.org/10.1089/dna.2017.3768openalex-snapshot
Elevated Expression of ERCC6 Confers Resistance to 5-Fluorouracil and Is Associated with Poor Patient Survival in Colorectal Cancer
inferredcites →https://doi.org/10.1093/annonc/mdw235openalex-snapshot
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
inferredcites →https://doi.org/10.1093/annonc/mdy100openalex-snapshot
Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer
inferredcites →https://doi.org/10.1093/carcin/bgq031openalex-snapshot
Glutathione transferase omega 1-1 (GSTO1-1) plays an anti-apoptotic role in cell resistance to cisplatin toxicity
inferredcites →https://doi.org/10.1093/jnci/91.19.1647openalex-snapshot
Multidrug Resistance and the Lung Resistance-Related Protein in Human Colon Carcinoma SW-620 Cells
inferredcites →https://doi.org/10.1093/jnci/94.12.936openalex-snapshot
Association Between Glutathione S-Transferase P1, T1, and M1 Genetic Polymorphism and Survival of Patients With Metastatic Colorectal Cancer
inferredcites →https://doi.org/10.1093/mutage/ger075openalex-snapshot
The role of ABC transporters in progression and clinical outcome of colorectal cancer
inferredcites →https://doi.org/10.1093/toxsci/kfg095openalex-snapshot
Metallothionein Is a Potential Negative Regulator of Apoptosis
inferredcites →https://doi.org/10.1097/coc.0b013e318181f959openalex-snapshot
Prognostic Significance of Interaction Between Somatic APC Mutations and 5-Fluorouracil Adjuvant Chemotherapy in Taiwanese Colorectal Cancer Subjects
inferredcites →https://doi.org/10.1111/cas.13097openalex-snapshot
Wnt‐β‐catenin signaling regulates ABCC 3 ( MRP 3) transporter expression in colorectal cancer
inferredcites →https://doi.org/10.1111/cas.13779openalex-snapshot
Bevacizumab‐enhanced antitumor effect of 5‐fluorouracil via upregulation of thymidine phosphorylase through vascular endothelial growth factor A/vascular endothelial growth factor receptor 2‐specificity protein 1 pathway
inferredcites →https://doi.org/10.1111/cas.13807openalex-snapshot
UGT 1A1 polymorphisms in rectal cancer associated with the efficacy and toxicity of preoperative chemoradiotherapy using irinotecan
inferredcites →https://doi.org/10.1111/cas.14193openalex-snapshot
E‐cadherin‐Fc chimera protein matrix enhances cancer stem‐like properties and induces mesenchymal features in colon cancer cells
inferredcites →https://doi.org/10.1111/cpr.12480openalex-snapshot
A novel inhibitor of ADAM 17 sensitizes colorectal cancer cells to 5‐Fluorouracil by reversing Notch and epithelial‐mesenchymal transition in vitro and in vivo
inferredcites →https://doi.org/10.1111/j.1365-2362.2007.01916.xopenalex-snapshot
Expression of the multidrug resistance proteins MRP2 and MRP3 in human cholangiocellular carcinomas
inferredcites →https://doi.org/10.1111/j.1600-0463.2005.apm_201.xopenalex-snapshot
Immunohistochemical expression of thymidylate synthase as predictor of response to capecitabine in patients with advanced colorectal adenocarcinoma
inferredcites →https://doi.org/10.1124/dmd.104.001909openalex-snapshot
ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS
inferredcites →https://doi.org/10.1124/dmd.106.013342openalex-snapshot
Regional Distribution of Solute Carrier mRNA Expression Along the Human Intestinal Tract
inferredcites →https://doi.org/10.1124/jpet.111.181297openalex-snapshot
Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons
inferredcites →https://doi.org/10.1124/mol.106.022624openalex-snapshot
Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin
inferredcites →https://doi.org/10.1124/mol.116.105544openalex-snapshot
Contribution of Organic Anion-Transporting Polypeptides 1A/1B to Doxorubicin Uptake and Clearance
inferredcites →https://doi.org/10.1126/science.1240527openalex-snapshot
Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
inferredcites →https://doi.org/10.1126/science.aah5043openalex-snapshot
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine
inferredcites →https://doi.org/10.1126/scitranslmed.3010473openalex-snapshot
Cancer and the gut microbiota: An unexpected link
inferredcites →https://doi.org/10.1136/gutjnl-2011-300537openalex-snapshot
Cumulative impact of common genetic variants and other risk factors on colorectal cancer risk in 42 103 individuals
inferredcites →https://doi.org/10.1136/jclinpath-2017-204739openalex-snapshot
Cancer stem cells in colorectal cancer: a review
inferredcites →https://doi.org/10.1136/jcp.52.12.876openalex-snapshot
Prognostic evaluation of metallothionein expression in human colorectal neoplasms.
inferredcites →https://doi.org/10.1146/annurev-pharmtox-010510-100556openalex-snapshot
The Expression and Function of Organic Anion Transporting Polypeptides in Normal Tissues and in Cancer
inferredcites →https://doi.org/10.1155/2018/5416923openalex-snapshot
Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment
inferredcites →https://doi.org/10.1158/0008-5472.can-04-2810openalex-snapshot
The Human Multidrug Resistance Protein MRP5 Transports Folates and Can Mediate Cellular Resistance against Antifolates
inferredcites →https://doi.org/10.1158/0008-5472.can-06-0769openalex-snapshot
Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
inferredcites →https://doi.org/10.1158/0008-5472.can-11-1674openalex-snapshot
Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-17-1869openalex-snapshot
Tight Junction Protein Claudin-2 Promotes Self-Renewal of Human Colorectal Cancer Stem-like Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-0094openalex-snapshot
Analysis of Apoptosis Protein Expression in Early-Stage Colorectal Cancer Suggests Opportunities for New Prognostic Biomarkers
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-4913openalex-snapshot
Interaction of Imatinib with Human Organic Ion Carriers
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-5160openalex-snapshot
Proapoptotic Bad and Bid Protein Expression Predict Survival in Stages II and III Colon Cancers
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-2169openalex-snapshot
ERCC1 and ERCC2 Polymorphisms Predict Clinical Outcomes of Oxaliplatin-Based Chemotherapies in Gastric and Colorectal Cancer: A Systemic Review and Meta-analysis
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-3186openalex-snapshot
Tumor Infiltration by T Lymphocytes Expressing Chemokine Receptor 7 (CCR7) Is Predictive of Favorable Outcome in Patients with Advanced Colorectal Carcinoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-12-2535openalex-snapshot
Predictive Impact of Circulating Vascular Endothelial Growth Factor in Four Phase III Trials Evaluating Bevacizumab
inferredcites →https://doi.org/10.1158/1078-0432.ccr-17-1283openalex-snapshot
The Immune-microenvironment Confers Chemoresistance of Colorectal Cancer through Macrophage-Derived IL6
inferredcites →https://doi.org/10.1158/1078-0432.ccr-18-1480openalex-snapshot
DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway
inferredcites →https://doi.org/10.1158/1078-0432.ccr-19-1985openalex-snapshot
Impact of Prior Bevacizumab Treatment on VEGF-A and PlGF Levels and Outcome Following Second-Line Aflibercept Treatment: Biomarker Post Hoc Analysis of the VELOUR Trial
inferredcites →https://doi.org/10.1158/1078-0432.ccr-19-3728openalex-snapshot
Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
inferredcites →https://doi.org/10.1158/1535-7163.1543.3.12openalex-snapshot
Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells
inferredcites →https://doi.org/10.1158/1535-7163.mct-04-0291openalex-snapshot
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites
inferredcites →https://doi.org/10.1158/1535-7163.mct-08-0539openalex-snapshot
Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
inferredcites →https://doi.org/10.1158/1535-7163.mct-09-0663openalex-snapshot
Breast Cancer Resistance Protein and P-glycoprotein Limit Sorafenib Brain Accumulation
inferredcites →https://doi.org/10.1158/1535-7163.mct-11-0980openalex-snapshot
Inhibition of OCTN2-Mediated Transport of Carnitine by Etoposide
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0753openalex-snapshot
Differential Antitumor Activity of Aflibercept and Bevacizumab in Patient-Derived Xenograft Models of Colorectal Cancer
inferredcites →https://doi.org/10.1158/1535-7163.mct-16-0591openalex-snapshot
MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2
inferredcites →https://doi.org/10.1158/1535-7163.mct-19-0600openalex-snapshot
Targeting Histone Chaperone FACT Complex Overcomes 5-Fluorouracil Resistance in Colon Cancer
inferredcites →https://doi.org/10.1158/1535-7163.mct-20-1028openalex-snapshot
Correction: MALAT1 is Associated with Poor Response to Oxaliplatin-based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2
inferredcites →https://doi.org/10.1159/000055368openalex-snapshot
Expression of Metallothionein in Colorectal Cancers and Synchronous Liver Metastases
inferredcites →https://doi.org/10.1159/000489156openalex-snapshot
Ubiquitin-Specific Peptidase 22 Contributes to Colorectal Cancer Stemness and Chemoresistance via Wnt/β-Catenin Pathway
inferredcites →https://doi.org/10.1159/000496027openalex-snapshot
Concurrent Expression of CD47 and CD44 in Colorectal Cancer Promotes Malignancy
inferredcites →https://doi.org/10.1177/1758834015614530openalex-snapshot
Pharmacologic resistance in colorectal cancer: a review
inferredcites →https://doi.org/10.1177/1758834016648276openalex-snapshot
Exosome-mediated drug resistance in cancer: the near future is here
inferredcites →https://doi.org/10.1182/blood-2005-11-4687openalex-snapshot
OCT-1–mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib
inferredcites →https://doi.org/10.1186/gb-2007-8-7-r131openalex-snapshot
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
inferredcites →https://doi.org/10.1186/s12885-015-1811-yopenalex-snapshot
Clinical detection and categorization of uncommon and concomitant mutations involving BRAF
inferredcites →https://doi.org/10.1186/s12885-019-5763-5openalex-snapshot
Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report
inferredcites →https://doi.org/10.1186/s12935-015-0250-9openalex-snapshot
Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition
inferredcites →https://doi.org/10.1186/s12935-018-0660-6openalex-snapshot
Predictive role of UCA1-containing exosomes in cetuximab-resistant colorectal cancer
inferredcites →https://doi.org/10.1186/s12943-019-0981-7openalex-snapshot
RETRACTED ARTICLE: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
inferredcites →https://doi.org/10.1186/s12943-019-1019-xopenalex-snapshot
CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer
inferredcites →https://doi.org/10.1186/s12943-019-1089-9openalex-snapshot
Role of hypoxia in cancer therapy by regulating the tumor microenvironment
inferredcites →https://doi.org/10.1186/s12943-020-01156-yopenalex-snapshot
Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance
inferredcites →https://doi.org/10.1186/s13046-019-1505-4openalex-snapshot
A pre-existing population of ZEB2+ quiescent cells with stemness and mesenchymal features dictate chemoresistance in colorectal cancer
inferredcites →https://doi.org/10.1200/jco.1999.17.8.2439openalex-snapshot
Eniluracil Treatment Completely Inactivates Dihydropyrimidine Dehydrogenase in Colorectal Tumors
inferredcites →https://doi.org/10.1200/jco.2003.07.039openalex-snapshot
Thymidylate Synthase Protein Expression in Primary Colorectal Cancer: Lack of Correlation With Outcome and Response to Fluorouracil in Metastatic Disease Sites
inferredcites →https://doi.org/10.1200/jco.2008.21.1771openalex-snapshot
Efficacy, Safety, and Biomarkers of Neoadjuvant Bevacizumab, Radiation Therapy, and Fluorouracil in Rectal Cancer: A Multidisciplinary Phase II Study
inferredcites →https://doi.org/10.1200/jco.2009.27.1825openalex-snapshot
Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer
inferredcites →https://doi.org/10.1200/jco.2014.59.4812openalex-snapshot
Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer
inferredcites →https://doi.org/10.1208/s12248-015-9740-xopenalex-snapshot
Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy
inferredcites →https://doi.org/10.1245/s10434-014-3659-9openalex-snapshot
Nuclear Notch3 Expression is Associated with Tumor Recurrence in Patients with Stage II and III Colorectal Cancer
inferredcites →https://doi.org/10.1369/jhc.2009.954446openalex-snapshot
Significance of Increased Apoptosis and Bax Expression in Human Small Intestinal Adenocarcinoma
inferredcites →https://doi.org/10.1371/journal.pone.0025785openalex-snapshot
Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice
inferredcites →https://doi.org/10.1371/journal.pone.0057045openalex-snapshot
Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0077117openalex-snapshot
The Association of Alternate VEGF Ligands with Resistance to Anti-VEGF Therapy in Metastatic Colorectal Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0077223openalex-snapshot
SLCO1B1 and SLC19A1 Gene Variants and Irinotecan-Induced Rapid Response and Survival: A Prospective Multicenter Pharmacogenetics Study of Metastatic Colorectal Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0098882openalex-snapshot
HIF-1α Inhibition Reverses Multidrug Resistance in Colon Cancer Cells via Downregulation of MDR1/P-Glycoprotein
inferredcites →https://doi.org/10.1371/journal.pone.0125625openalex-snapshot
Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer
inferredcites →https://doi.org/10.1371/journal.pone.0136080openalex-snapshot
Multidrug Resistance-Associated Protein 2 Expression Is Upregulated by Adenosine 5’-Triphosphate in Colorectal Cancer Cells and Enhances Their Survival to Chemotherapeutic Drugs
inferredcites →https://doi.org/10.1371/journal.pone.0148739openalex-snapshot
Assessment of the Relation between the Expression of Oxaliplatin Transporters in Colorectal Cancer and Response to FOLFOX-4 Adjuvant Chemotherapy: A Case Control Study
inferredcites →https://doi.org/10.1371/journal.pone.0156871openalex-snapshot
MiR-205 and MiR-373 Are Associated with Aggressive Human Mucinous Colorectal Cancer
inferredcites →https://doi.org/10.1517/14728220903277256openalex-snapshot
cIAP2 as a therapeutic target in colorectal cancer and other malignancies
inferredcites →https://doi.org/10.1593/neo.12486openalex-snapshot
Inhibition of COX-2 in Colon Cancer Modulates Tumor Growth and MDR-1 Expression to Enhance Tumor Regression in Therapy-Refractory Cancers In Vivo
inferredcites →https://doi.org/10.18632/oncotarget.11553openalex-snapshot
Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy
inferredcites →https://doi.org/10.18632/oncotarget.14909openalex-snapshot
Base excision repair imbalance in colorectal cancer has prognostic value and modulates response to chemotherapy
inferredcites →https://doi.org/10.18632/oncotarget.15559openalex-snapshot
miR-503-5p confers drug resistance by targeting PUMA in colorectal carcinoma
inferredcites →https://doi.org/10.18632/oncotarget.19048openalex-snapshot
The molecular mechanisms of chemoresistance in cancers
inferredcites →https://doi.org/10.18632/oncotarget.23142openalex-snapshot
Organic cation transporter 3 mediates cisplatin and copper cross-resistance in hepatoma cells
inferredcites →https://doi.org/10.18632/oncotarget.23372openalex-snapshot
Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis
showing the first 200 of 236

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.3957834openalex-extracted
HSPB8 Induces 5-Fluorouracil Resistance in Colorectal Cancer by Promoting Tumor Autophagy
inferred← citeshttps://doi.org/10.1002/cbin.12270openalex-snapshot
Wnt/β‐catenin pathway as a link between therapy resistance‐driven epithelial‐mesenchymal transition and stemness in colorectal cancer
inferred← citeshttps://doi.org/10.1002/sstr.70559openalex-snapshot
Large Amino Acid‐Mimetic Peptide Redirects Exosomes to L‐Type Amino Acid Transporter 1 for Efficient miRNA Delivery and Cancer Suppression
inferred← citeshttps://doi.org/10.1007/s11010-026-05630-xopenalex-snapshot
METTL3–YTHDF1–driven m6A enhancement of MYC signaling orchestrates DNA repair and metabolic reprogramming to promote chemoresistance in colorectal cancer
inferred← citeshttps://doi.org/10.1007/s12035-021-02431-9openalex-snapshot
Mesenchymal Stem Cell-derived Extracellular Vesicles Transmitting MicroRNA-34a-5p Suppress Tumorigenesis of Colorectal Cancer Through c-MYC/DNMT3a/PTEN Axis
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111285openalex-snapshot
5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition
inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e09033openalex-snapshot
Identification of autophagy related genes in predicting the prognosis and aiding 5- fluorouracil therapy of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.heliyon.2022.e09519openalex-snapshot
Synergistic effects of natural compounds and conventional chemotherapeutic agents: recent insights for the development of cancer treatment strategies
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2023.02.014openalex-snapshot
Mimicking Tumor Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-Fibroblast Model
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154231openalex-snapshot
Synergistic antitumor effects of compound-composed optimal formula from Aidi injection on hepatocellular carcinoma and colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155684openalex-snapshot
Immune-inflammatory modulation by natural products derived from edible and medicinal herbs used in Chinese classical prescriptions
inferred← citeshttps://doi.org/10.1016/j.prp.2024.155520openalex-snapshot
6-Shogaol improves sorafenib efficacy in colorectal cancer cells by modulating its cellular accumulation and metabolism
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.2c00196openalex-snapshot
ATP Mimetic Attack on the Nucleotide-Binding Domain to Overcome ABC Transporter Mediated Chemoresistance
inferred← citeshttps://doi.org/10.1038/s41388-025-03598-4openalex-snapshot
TBKBP1 induces capecitabine resistance through negative regulation of type I interferon pathway in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1038/s41591-025-03843-zopenalex-snapshot
Precemtabart tocentecan, an anti-CEACAM5 antibody–drug conjugate, in metastatic colorectal cancer: a phase 1 trial
inferred← citeshttps://doi.org/10.1038/s41598-022-16669-3openalex-snapshot
Mechanical signatures of human colon cancers
inferred← citeshttps://doi.org/10.1039/d3ra01741aopenalex-snapshot
The link between relative stability constant of DNA- and BSA-chromenopyrimidine complexes and cytotoxicity towards human breast cancer cells (MCF-7)
inferred← citeshttps://doi.org/10.1101/2021.02.04.429849openalex-snapshot
Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer
inferred← citeshttps://doi.org/10.1177/10732748241274196openalex-snapshot
The Role of Tumor Stem Cells in Colorectal Cancer Drug Resistance
inferred← citeshttps://doi.org/10.1186/s12964-025-02364-zopenalex-snapshot
Wnt5a suppresses colorectal cancer progression via TGF-β/NOTUM/OLFM4 axis in patient-derived organoids
inferred← citeshttps://doi.org/10.20517/cdr.2021.82openalex-snapshot
Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review
inferred← citeshttps://doi.org/10.20517/cdr.2021.96openalex-snapshot
Emerging actionable targets to treat therapy-resistant colorectal cancers
inferred← citeshttps://doi.org/10.20944/preprints202403.1777.v1openalex-snapshot
Augmented Therapeutic Potential of Anti-Oxidative Herbal Formula, SR033 in Integration with Chemo-Drugs: In-Vitro and In-Vivo Study
inferred← citeshttps://doi.org/10.21203/rs.3.rs-639983/v1openalex-snapshot
Development And Validation of A Novel Hypoxia- And Immune-Related Prognostic Signature For Bone And Soft Tissue Sarcoma Patients
inferred← citeshttps://doi.org/10.2174/0113862073375723250505095935openalex-snapshot
Synergistic Interactions of Anthraquinones with Conventional Cancer Therapies
inferred← citeshttps://doi.org/10.3389/fonc.2023.1132141openalex-snapshot
Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer
inferred← citeshttps://doi.org/10.3390/biomedicines9050579openalex-snapshot
Identifying Novel Actionable Targets in Colon Cancer
inferred← citeshttps://doi.org/10.3390/cancers14143524openalex-snapshot
Expression of Chemoresistance-Associated ABC Proteins in Hepatobiliary, Pancreatic and Gastrointestinal Cancers
inferred← citeshttps://doi.org/10.3390/cancers15051471openalex-snapshot
Hedgehog-GLI and Notch Pathways Sustain Chemoresistance and Invasiveness in Colorectal Cancer and Their Inhibition Restores Chemotherapy Efficacy
inferred← citeshttps://doi.org/10.3390/cancers17040663openalex-snapshot
Real-World Evidence of Bevacizumab and Panitumumab Drug Resistance and Drug Ineffectiveness from EudraVigilance Database
inferred← citeshttps://doi.org/10.3390/ijms232214058openalex-snapshot
Curcumin: A Novel Way to Improve Quality of Life for Colorectal Cancer Patients?
inferred← citeshttps://doi.org/10.3390/molecules31040710openalex-snapshot
Erica spiculifolia Extract Potentiates Cisplatin Cytotoxicity by Reactivating p53 and Caspase-3-Dependent Apoptosis in Colorectal Carcinoma
inferred← citeshttps://doi.org/10.3892/br.2024.1863openalex-snapshot
STAT3 and the STAT3‑regulated inhibitor of apoptosis protein survivin as potential therapeutic targets in colorectal cancer (Review)
inferred← citeshttps://doi.org/10.3892/ijo.2022.5365openalex-snapshot
Visfatin inhibits colon cancer cell apoptosis and decreases chemosensitivity to 5‑FU by promoting the SDF‑1/CXCR4/Akt axis
inferred← citeshttps://doi.org/10.3892/or.2023.8612openalex-snapshot
5‑Fluorouracil and capecitabine therapies for the treatment of colorectal cancer (Review)
inferred← citeshttps://doi.org/10.47836/mjmhs.21.3.57openalex-snapshot
Mucinous Ovarian Cancer: A Review of Diagnosis and Treatment
inferred← citeshttps://doi.org/10.54133/ajms.v8i2.2019openalex-snapshot
Genetic Predictors of Resistance and Survival in Oxaliplatin-Treated Iraqi Patients with Colorectal Cancer
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