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Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer

https://doi.org/10.3390/cells9051287
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miR‐211 and MITF modulation by Bcl‐2 protein in melanoma cells
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Immunohistochemical characterization of undifferentiated carcinomas of the ovary
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Mcl-1 is a potential therapeutic target in multiple types of cancer
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Oblimersen in combination with temozolomide and albumin-bound paclitaxel in patients with advanced melanoma: a phase I trial
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Combined antitumor effect of γ-secretase inhibitor and ABT-737 in Notch-expressing non-small cell lung cancer
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Bcl-2 expression correlates with lymphovascular invasion and long-term prognosis in breast cancer
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Phase I trial of oblimersen (Genasense®) and gemcitabine in refractory and advanced malignancies
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Cell Death Pathways in Lymphoid Malignancies
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The small-molecule compound BM-1197 inhibits the antiapoptotic regulators Bcl-2/Bcl-xL and triggers apoptotic cell death in human colorectal cancer cells
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Bcl-2 Antiapoptotic Family Proteins and Chemoresistance in Cancer
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Co-inhibition of BCL-XL and MCL-1 with selective BCL-2 family inhibitors enhances cytotoxicity of cervical cancer cell lines
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Targeting MCL-1 in hematologic malignancies: Rationale and progress
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A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line
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Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1
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BCL-xL-selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis
inferredcites →https://doi.org/10.1016/j.canlet.2018.02.036openalex-snapshot
Sabutoclax, pan-active BCL-2 protein family antagonist, overcomes drug resistance and eliminates cancer stem cells in breast cancer
inferredcites →https://doi.org/10.1016/j.canlet.2020.02.041openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.cbpa.2017.06.014openalex-snapshot
Progress in targeting the BCL-2 family of proteins
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Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy
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BH3-Mimetic Drugs: Blazing the Trail for New Cancer Medicines
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A Short Nur77-Derived Peptide Converts Bcl-2 from a Protector to a Killer
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An Inducible Lentiviral Guide RNA Platform Enables the Identification of Tumor-Essential Genes and Tumor-Promoting Mutations In Vivo
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BH4 domain of Bcl-2 as a novel target for cancer therapy
inferredcites →https://doi.org/10.1016/j.drudis.2017.05.001openalex-snapshot
G-Quadruplex surveillance in BCL-2 gene: a promising therapeutic intervention in cancer treatment
inferredcites →https://doi.org/10.1016/j.ejmech.2018.01.100openalex-snapshot
Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A
inferredcites →https://doi.org/10.1016/j.gene.2016.04.054openalex-snapshot
MCL-1 is the key target of adjuvant chemotherapy to reverse the cisplatin-resistance in NSCLC
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Prognostic significance of Bcl-2 in invasive mammary carcinomas: a comparative clinicopathologic study between “triple-negative” and non–“triple-negative” tumors
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A ruthenium(II) complex capable of inducing and stabilizing bcl-2 G-quadruplex formation as a potential cancer inhibitor
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Potent and Specific Peptide Inhibitors of Human Pro-Survival Protein Bcl-xL
inferredcites →https://doi.org/10.1016/j.molcel.2016.06.010openalex-snapshot
An Autoinhibited Dimeric Form of BAX Regulates the BAX Activation Pathway
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Apoptosome Structure, Assembly, and Procaspase Activation
inferredcites →https://doi.org/10.1016/j.surg.2003.11.015openalex-snapshot
Prognostic significance of Bcl-xL in human hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.tcb.2020.03.004openalex-snapshot
Noncanonical Cell Fate Regulation by Bcl-2 Proteins
inferredcites →https://doi.org/10.1016/j.ymgme.2014.11.017openalex-snapshot
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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity
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Molecular Determinants for the Activation/Inhibition of Bak Protein by BH3 Peptides
inferredcites →https://doi.org/10.1021/acs.jmedchem.9b00262openalex-snapshot
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives
inferredcites →https://doi.org/10.1021/acs.jmedchem.9b00919openalex-snapshot
Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands
inferredcites →https://doi.org/10.1021/bi100957hopenalex-snapshot
The BCL-2 5′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression
inferredcites →https://doi.org/10.1021/jacs.5b08596openalex-snapshot
A New G-Quadruplex with Hairpin Loop Immediately Upstream of the Human BCL2 P1 Promoter Modulates Transcription
inferredcites →https://doi.org/10.1021/jm1013665openalex-snapshot
N-Cyclic Bay-Substituted Perylene G-Quadruplex Ligands Have Selective Antiproliferative Effects on Cancer Cells and Induce Telomere Damage
inferredcites →https://doi.org/10.1021/jm300608wopenalex-snapshot
Structure-Based Design of Potent Bcl-2/Bcl-xL Inhibitors with Strong in Vivo Antitumor Activity
inferredcites →https://doi.org/10.1021/ml5001867openalex-snapshot
Discovery of a Potent and Selective BCL-X L Inhibitor with in Vivo Activity
inferredcites →https://doi.org/10.1023/a:1014510508664openalex-snapshot
Resistance to apoptosis is increased during metastatic dissemination of colon cancer
inferredcites →https://doi.org/10.1038/bjc.2017.281openalex-snapshot
Targeting apoptosis in acute myeloid leukaemia
inferredcites →https://doi.org/10.1038/cdd.2010.175openalex-snapshot
Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells
inferredcites →https://doi.org/10.1038/cdd.2012.105openalex-snapshot
The secrets of the Bcl-2 family
inferredcites →https://doi.org/10.1038/cdd.2017.161openalex-snapshot
The BCL-2 arbiters of apoptosis and their growing role as cancer targets
inferredcites →https://doi.org/10.1038/cdd.2017.183openalex-snapshot
Why do BCL-2 inhibitors work and where should we use them in the clinic?
inferredcites →https://doi.org/10.1038/cdd.2017.186openalex-snapshot
BCL-2 family proteins: changing partners in the dance towards death
inferredcites →https://doi.org/10.1038/cddis.2014.365openalex-snapshot
Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer
inferredcites →https://doi.org/10.1038/cddis.2014.561openalex-snapshot
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
inferredcites →https://doi.org/10.1038/cddis.2015.141openalex-snapshot
Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction
inferredcites →https://doi.org/10.1038/cddis.2015.357openalex-snapshot
Affinity purification-mass spectrometry analysis of bcl-2 interactome identified SLIRP as a novel interacting protein
inferredcites →https://doi.org/10.1038/jid.2015.145openalex-snapshot
Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells
inferredcites →https://doi.org/10.1038/nature03579openalex-snapshot
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
inferredcites →https://doi.org/10.1038/nature08822openalex-snapshot
The landscape of somatic copy-number alteration across human cancers
inferredcites →https://doi.org/10.1038/nature19830openalex-snapshot
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
inferredcites →https://doi.org/10.1038/nchembio.1246openalex-snapshot
Structure-guided design of a selective BCL-XL inhibitor
inferredcites →https://doi.org/10.1038/nchembio.2174openalex-snapshot
Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain
inferredcites →https://doi.org/10.1038/ncomms10384openalex-snapshot
Bcl-xL promotes metastasis independent of its anti-apoptotic activity
inferredcites →https://doi.org/10.1038/ncomms16078openalex-snapshot
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy
inferredcites →https://doi.org/10.1038/nm.3048openalex-snapshot
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
inferredcites →https://doi.org/10.1038/nm.3788openalex-snapshot
Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia
inferredcites →https://doi.org/10.1038/nrc.2015.17openalex-snapshot
Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies
inferredcites →https://doi.org/10.1038/nrm2952openalex-snapshot
Mitochondria and cell death: outer membrane permeabilization and beyond
inferredcites →https://doi.org/10.1038/nsmb.3223openalex-snapshot
Allosteric inhibition of antiapoptotic MCL-1
inferredcites →https://doi.org/10.1038/onc.2014.21openalex-snapshot
Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance
inferredcites →https://doi.org/10.1038/s41388-018-0268-2openalex-snapshot
Dual inhibition of BCL-XL and MCL-1 is required to induce tumour regression in lung squamous cell carcinomas sensitive to FGFR inhibition
inferredcites →https://doi.org/10.1038/s41388-020-1212-9openalex-snapshot
The apoptosis inhibitor Bcl-xL controls breast cancer cell migration through mitochondria-dependent reactive oxygen species production
inferredcites →https://doi.org/10.1038/s41389-020-0203-6openalex-snapshot
microRNA-378a-5p iS a novel positive regulator of melanoma progression
inferredcites →https://doi.org/10.1038/s41419-017-0035-2openalex-snapshot
MCL-1 is a prognostic indicator and drug target in breast cancer
inferredcites →https://doi.org/10.1038/s41419-017-0055-yopenalex-snapshot
BCL-XL overexpression promotes tumor progression-associated properties
inferredcites →https://doi.org/10.1038/s41419-019-1407-6openalex-snapshot
BCL-2 family isoforms in apoptosis and cancer
inferredcites →https://doi.org/10.1038/s41419-019-1568-3openalex-snapshot
BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival
inferredcites →https://doi.org/10.1038/s41467-017-00263-7openalex-snapshot
Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response
inferredcites →https://doi.org/10.1038/s41467-019-10363-1openalex-snapshot
Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations
inferredcites →https://doi.org/10.1038/s41467-019-10460-1openalex-snapshot
Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
inferredcites →https://doi.org/10.1038/s41586-019-1432-8openalex-snapshot
De novo design of bioactive protein switches
inferredcites →https://doi.org/10.1038/s41591-019-0668-zopenalex-snapshot
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
inferredcites →https://doi.org/10.1038/sj.cdd.4401670openalex-snapshot
Involvement of hTERT in apoptosis induced by interference with Bcl-2 expression and function
inferredcites →https://doi.org/10.1038/sj.cdd.4401937openalex-snapshot
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
inferredcites →https://doi.org/10.1038/srep40706openalex-snapshot
Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions
inferredcites →https://doi.org/10.1046/j.0022-202x.2001.01677.xopenalex-snapshot
Bcl-2 and bcl-xL Antisense Oligonucleotides Induce Apoptosis in Melanoma Cells of Different Clinical Stages
inferredcites →https://doi.org/10.1056/nejm199309023291003openalex-snapshot
bcl-2 Protein in Non-Small-Cell Lung Carcinoma
inferredcites →https://doi.org/10.1056/nejmoa1513257openalex-snapshot
Targeting BCL2 with Venetoclax in Relapsed Chronic Lymphocytic Leukemia
inferredcites →https://doi.org/10.1056/nejmoa1713976openalex-snapshot
Venetoclax–Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia
inferredcites →https://doi.org/10.1056/nejmoa1900574openalex-snapshot
Ibrutinib and Venetoclax for First-Line Treatment of CLL
inferredcites →https://doi.org/10.1056/nejmra0901217openalex-snapshot
Cell Death
inferredcites →https://doi.org/10.1073/pnas.0709443104openalex-snapshot
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
inferredcites →https://doi.org/10.1073/pnas.1411848112openalex-snapshot
Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer
inferredcites →https://doi.org/10.1073/pnas.90.8.3516openalex-snapshot
MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.
inferredcites →https://doi.org/10.1074/jbc.ra117.001101openalex-snapshot
B cell lymphoma 2 (Bcl-2) residues essential for Bcl-2's apoptosis-inducing interaction with Nur77/Nor-1 orphan steroid receptors
inferredcites →https://doi.org/10.1080/07391102.2017.1404933openalex-snapshot
Binding modes of Bcl-2 homology 3 (BH3) peptides with anti-apoptotic protein A1 and redesign of peptide inhibitors: a computational study
inferredcites →https://doi.org/10.1080/10428194.2017.1283032openalex-snapshot
Pathways and mechanisms of venetoclax resistance
inferredcites →https://doi.org/10.1080/10428194.2020.1719098openalex-snapshot
Venetoclax in acute myeloid leukemia – current and future directions
inferredcites →https://doi.org/10.1080/17460441.2017.1356286openalex-snapshot
Targeting intrinsic apoptosis and other forms of cell death by BH3-mimetics in glioblastoma
inferredcites →https://doi.org/10.1080/17474086.2018.1420474openalex-snapshot
A concise review of BCL-2 inhibition in acute myeloid leukemia
inferredcites →https://doi.org/10.1091/mbc.e04-12-1087openalex-snapshot
Involvement of PI3K and MAPK Signaling in bcl-2-induced Vascular Endothelial Growth Factor Expression in Melanoma Cells
inferredcites →https://doi.org/10.1093/carcin/bgt242openalex-snapshot
BH4 domain of bcl-2 protein is required for its proangiogenic function under hypoxic condition
inferredcites →https://doi.org/10.1093/carcin/bgx016openalex-snapshot
Non-canonical roles of Bcl-2 and Bcl-xL proteins: relevance of BH4 domain
inferredcites →https://doi.org/10.1097/cmr.0000000000000056openalex-snapshot
Dacarbazine with or without oblimersen (a Bcl-2 antisense oligonucleotide) in chemotherapy-naive patients with advanced melanoma and low–normal serum lactate dehydrogenase
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A Phase I Trial of Oblimersen Sodium in Combination With Cisplatin and 5-Fluorouracil in Patients With Advanced Esophageal, Gastroesophageal Junction, and Gastric Carcinoma
inferredcites →https://doi.org/10.1101/gad.215855.113openalex-snapshot
Deletion of MCL-1 causes lethal cardiac failure and mitochondrial dysfunction
inferredcites →https://doi.org/10.1101/gad.215871.113openalex-snapshot
Loss of MCL-1 leads to impaired autophagy and rapid development of heart failure
inferredcites →https://doi.org/10.1111/bjh.12633openalex-snapshot
AT ‐101 downregulates BCL 2 and MCL 1 and potentiates the cytotoxic effects of lenalidomide and dexamethasone in preclinical models of multiple myeloma and W aldenström macroglobulinaemia
inferredcites →https://doi.org/10.1111/ceo.12397openalex-snapshot
Expression of pro‐apoptotic Bax and anti‐apoptotic Bcl‐2 proteins in human retinoblastoma
inferredcites →https://doi.org/10.1111/febs.13624openalex-snapshot
The deadly landscape of pro‐apoptotic BCL ‐2 proteins in the outer mitochondrial membrane
inferredcites →https://doi.org/10.1111/j.1471-4159.2008.05661.xopenalex-snapshot
Involvement of nuclear factor‐kappa B in bcl‐xL‐induced interleukin 8 expression in glioblastoma
inferredcites →https://doi.org/10.1111/sji.12192openalex-snapshot
Induction of B cl‐x L ‐Specific Cytotoxic T Lymphocytes in Mice
inferredcites →https://doi.org/10.1126/scitranslmed.aaa4642openalex-snapshot
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
inferredcites →https://doi.org/10.1126/scitranslmed.aam7049openalex-snapshot
Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
inferredcites →https://doi.org/10.1136/jitc-2019-000489openalex-snapshot
Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages
inferredcites →https://doi.org/10.1155/2014/953203openalex-snapshot
The Expression of Bcl-2 and BID in Gastric Cancer Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-14-3013openalex-snapshot
Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline
inferredcites →https://doi.org/10.1158/0008-5472.can-16-1901openalex-snapshot
Systematic Drug Screening Identifies Tractable Targeted Combination Therapies in Triple-Negative Breast Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-16-3424openalex-snapshot
Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses
inferredcites →https://doi.org/10.1158/0008-5472.can-19-1784openalex-snapshot
Inhibition of BCL2 Family Members Increases the Efficacy of Copper Chelation in BRAFV600E-Driven Melanoma
inferredcites →https://doi.org/10.1158/1078-0432.ccr-14-0259openalex-snapshot
Cell and Molecular Determinants of In Vivo Efficacy of the BH3 Mimetic ABT-263 against Pediatric Acute Lymphoblastic Leukemia Xenografts
inferredcites →https://doi.org/10.1158/1078-0432.ccr-19-1853openalex-snapshot
AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-19-1872openalex-snapshot
Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor–Positive Breast Cancer
inferredcites →https://doi.org/10.1158/1535-7163.23.4.1openalex-snapshot
(−)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-XL-mediated apoptosis resistance
inferredcites →https://doi.org/10.1158/1535-7163.mct-12-0767openalex-snapshot
A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth In Vitro and In Vivo
inferredcites →https://doi.org/10.1158/1535-7163.mct-14-0928openalex-snapshot
MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor
inferredcites →https://doi.org/10.1158/1541-7786.mcr-07-0088openalex-snapshot
Modulation of bcl-xL in Tumor Cells Regulates Angiogenesis through CXCL8 Expression
inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0315openalex-snapshot
mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0011openalex-snapshot
The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
inferredcites →https://doi.org/10.1158/2159-8290.cd-16-0313openalex-snapshot
Efficacy and Biological Correlates of Response in a Phase II Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia
inferredcites →https://doi.org/10.1158/2159-8290.cd-17-0797openalex-snapshot
Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax
inferredcites →https://doi.org/10.1158/2159-8290.cd-18-0140openalex-snapshot
A Novel MCL1 Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia
inferredcites →https://doi.org/10.1158/2159-8290.cd-18-0277openalex-snapshot
Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS -Mutant Non–Small Cell Lung Cancer
inferredcites →https://doi.org/10.1158/2159-8290.cd-18-1151openalex-snapshot
A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2–Positive Metastatic Breast Cancer
inferredcites →https://doi.org/10.1172/jci28281openalex-snapshot
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737
inferredcites →https://doi.org/10.1177/40.12.1453000openalex-snapshot
Ultrastructural localization of bcl-2 protein.
inferredcites →https://doi.org/10.1182/blood-2008-08-173450openalex-snapshot
Mcl-1 expression predicts progression-free survival in chronic lymphocytic leukemia patients treated with pentostatin, cyclophosphamide, and rituximab
inferredcites →https://doi.org/10.1182/blood-2011-04-347849openalex-snapshot
Bcl-xL–inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets
inferredcites →https://doi.org/10.1182/blood-2017-06-788323openalex-snapshot
Promising efficacy and acceptable safety of venetoclax plus bortezomib and dexamethasone in relapsed/refractory MM
inferredcites →https://doi.org/10.1182/blood-2017-06-788786openalex-snapshot
Efficacy of venetoclax as targeted therapy for relapsed/refractory t(11;14) multiple myeloma
inferredcites →https://doi.org/10.1182/blood-2019-01-896290openalex-snapshot
Phase 1b study of venetoclax-obinutuzumab in previously untreated and relapsed/refractory chronic lymphocytic leukemia
inferredcites →https://doi.org/10.1186/1476-4598-8-28openalex-snapshot
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells
inferredcites →https://doi.org/10.1186/1756-9966-32-13openalex-snapshot
Decrease of survivin, p53 and Bcl-2 expression in chemorefractory colorectal liver metastases may be predictive of radiosensivity after radioembolization with yttrium-90 resin microspheres
inferredcites →https://doi.org/10.1186/s12885-017-3383-5openalex-snapshot
Potential mechanisms of resistance to venetoclax and strategies to circumvent it
inferredcites →https://doi.org/10.1186/s12885-019-6169-0openalex-snapshot
A Novel Bcl-2 Inhibitor, BM-1197, Induces Apoptosis in Malignant Lymphoma Cells Through the Endogenous Apoptotic Pathway
inferredcites →https://doi.org/10.1186/s13000-019-0884-3openalex-snapshot
Elevated expression of mcl-1 inhibits apoptosis and predicts poor prognosis in patients with surgically resected non-small cell lung cancer
inferredcites →https://doi.org/10.1186/s13046-018-0933-xopenalex-snapshot
Semaphorin 5A drives melanoma progression: role of Bcl-2, miR-204 and c-Myb
inferredcites →https://doi.org/10.1186/s13058-016-0686-4openalex-snapshot
Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications
inferredcites →https://doi.org/10.1186/s13058-016-0781-6openalex-snapshot
MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib
inferredcites →https://doi.org/10.1200/jco.2011.34.7898openalex-snapshot
Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease
inferredcites →https://doi.org/10.1371/journal.pone.0011772openalex-snapshot
Bcl-2 Regulates HIF-1α Protein Stabilization in Hypoxic Melanoma Cells via the Molecular Chaperone HSP90
inferredcites →https://doi.org/10.1371/journal.pone.0080836openalex-snapshot
Targeting Bcl-2/Bcl-XL Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts
inferredcites →https://doi.org/10.1371/journal.pone.0099404openalex-snapshot
BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo
inferredcites →https://doi.org/10.1371/journal.pone.0210608openalex-snapshot
Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors
inferredcites →https://doi.org/10.1586/17474086.2013.827415openalex-snapshot
The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches
inferredcites →https://doi.org/10.1593/neo.121392openalex-snapshot
Removal of the BH4 Domain from Bcl-2 Protein Triggers an Autophagic Process that Impairs Tumor Growth
inferredcites →https://doi.org/10.1593/neo.12640openalex-snapshot
Sabutoclax, a Mcl-1 Antagonist, Inhibits Tumorigenesis in Transgenic Mouse and Human Xenograft Models of Prostate Cancer
inferredcites →https://doi.org/10.18632/oncoscience.231openalex-snapshot
Mcl-1 protects prostate cancer cells from cell death mediated by chemotherapy-induced DNA damage
inferredcites →https://doi.org/10.18632/oncotarget.10277openalex-snapshot
BRAFV600E-dependent Mcl-1 stabilization leads to everolimus resistance in colon cancer cells
inferredcites →https://doi.org/10.18632/oncotarget.24744openalex-snapshot
S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth
inferredcites →https://doi.org/10.18632/oncotarget.25370openalex-snapshot
Bcl-2 inhibition sensitizes triple-negative human breast cancer cells to doxorubicin
inferredcites →https://doi.org/10.18632/oncotarget.2634openalex-snapshot
Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation
inferredcites →https://doi.org/10.18632/oncotarget.27070openalex-snapshot
Therapeutic inhibition of Mcl-1 blocks cell survival in estrogen receptor-positive breast cancers
inferredcites →https://doi.org/10.18632/oncotarget.27262openalex-snapshot
Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide
inferredcites →https://doi.org/10.18632/oncotarget.5333openalex-snapshot
Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin
inferredcites →https://doi.org/10.18632/oncotarget.8513openalex-snapshot
BCL2-BH4 antagonist BDA-366 suppresses human myeloma growth
inferredcites →https://doi.org/10.21037/sci.2016.11.09openalex-snapshot
Peptide vaccination against multiple myeloma using peptides derived from anti-apoptotic proteins: a phase I trial
inferredcites →https://doi.org/10.3389/fgene.2019.00804openalex-snapshot
Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing
inferredcites →https://doi.org/10.3390/biology9020035openalex-snapshot
Combining DNA Damage Induction with BCL-2 Inhibition to Enhance Merkel Cell Carcinoma Cytotoxicity
inferredcites →https://doi.org/10.3390/cancers11050690openalex-snapshot
Future Options of Molecular-Targeted Therapy in Small Cell Lung Cancer
inferredcites →https://doi.org/10.3390/cells9030717openalex-snapshot
Restoring Apoptosis with BH3 Mimetics in Mature B-Cell Malignancies
inferredcites →https://doi.org/10.3390/ma12162567openalex-snapshot
Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release
inferredcites →https://doi.org/10.3748/wjg.14.3069openalex-snapshot
Significance of Bcl-xL in human colon carcinoma
inferredcites →https://doi.org/10.3892/ijo.2015.2890openalex-snapshot
Myeloid cell leukemia-1 regulates the cell growth and predicts prognosis in gastric cancer
inferredcites →https://doi.org/10.3892/ijo.2017.4028openalex-snapshot
APG-1252-12A induces mitochondria-dependent apoptosis through inhibiting the antiapoptotic proteins Bcl-2/Bcl-xl in HL-60 cells
inferredcites →https://doi.org/10.3892/ijo.28.3.661openalex-snapshot
Bcl-xL and bcl-2 proteins in melanoma progression and UVB-induced apoptosis
inferredcites →https://doi.org/10.4049/jimmunol.175.4.2709openalex-snapshot
Spontaneous Immunity against Bcl-xL in Cancer Patients
inferredcites →https://doi.org/10.7554/elife.20352openalex-snapshot
Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The Potential Role of Sanguinarine as an Inhibitor of Leishmania PP2C in the Induction of Apoptosis
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Nanocarriers in Ovarian Cancer: Targeted Drug Delivery, Theranostics, and Immunomodulation
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Disrupting CDK9 activity suppresses triple-negative breast cancer and is enhanced by EGFR Inhibition
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The ER-mitochondria Ca2+ signaling in cancer progression: Fueling the monster
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Oxidative stress–mediated proapoptosis signaling
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Unraveling the meta-hallmarks between senescent and tumor cells: A new perspective for senolytic drug discovery
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Modulation of Ca2+ signaling by antiapoptotic Bcl-2 versus Bcl-xL: From molecular mechanisms to relevance for cancer cell survival
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BCL2L10 Is a non-GCB-associated prognostic biomarker and functional driver in diffuse large B-Cell lymphoma
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NA1—115—7, from Zygogynum pancheri, is a new selective MCL-1 inhibitor inducing the apoptosis of hematological cancer cells but non-toxic to normal blood cells or cardiomyocytes
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BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells
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Mitochondrial signaling pathways and their role in cancer drug resistance
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Revenge unraveling the fortress: Exploring anticancer drug resistance mechanisms in BC for enhanced therapeutic strategies
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Inflammatory cell death and leukemia treatment
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Targeting colorectal cancer with natural compounds: From molecular mechanisms to clinical therapeutic potential
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Senolytics: Opening avenues in drug discovery to find novel therapeutics for Parkinson’s Disease
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Resensitizing drug-resistant cancers by co-targeting apoptosis and mitochondrial stress pathway
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Biological evaluation of novel 5-((1H-indol-3-yl) methyl)-2-(4-chlorobenzyl)-6-phenyl-imidazo[2,1-b][13,4]thiadiazole derivatives as novel BCL-2 specific inhibitors
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Discovery of benzimidazole-based Mcl-1 inhibitors via AlphaShape-enabled virtual screening
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The therapeutic potential and molecular mechanism of Alpha-pinene, Gamma-terpinene, and P-cymene against melanoma cells
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Exosomes-coated bcl-2 siRNA inhibits the growth of digestive system tumors both in vitro and in vivo
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Myeloid cell leukemia 1 (MCL-1): Structural characteristics and application in cancer therapy
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Design, synthesis, and characterization of M(II)-Schiff base complexes containing 3,5-di-tert-butyl salicylaldehyde: DNA binding/cleavage, DPPH radical scavenging activity, cytotoxic activity, and catalytic activity investigation
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Investigation on antineoplastic potential of Barleria lupulina Lindl: From phytochemical profiling to molecular dynamics simulation assessment
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Evolving therapeutic proteins to precisely kill cancer cells
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B-cell lymphoma 2 inhibitor venetoclax treatment of a patient with cutaneous T-cell lymphoma
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Folic acid-conjugated UIO-66-MOF enhances the targeted co-delivery of cisplatin and cyclophosphamide for breast cancer therapy
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Expression Differences in BCL2 Family Members between Uveal and Cutaneous Melanomas Account for Varying Sensitivity to BH3 Mimetics
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Enantiomeric alkynyl-protected Au10 clusters with chirality-dependent radiotherapy enhancing effects
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The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy
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Prostate cancer and microRNAs: New insights into apoptosis
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Targeted cancer treatment and fertility: effect of immunotherapy and small molecule inhibitors on female reproduction
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Clinicopathological Significance and Expression Pattern of Bcl2 in Breast Cancer: A Comprehensive in silico and in vitro Study
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Piperlongumine mediated apoptosis in cervical cancer cells beyond docking predictions
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The BH3-only protein NOXA serves as an independent predictor of breast cancer patient survival and defines susceptibility to microtubule targeting agents
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Bcl-2 family inhibitors sensitize human cancer models to therapy
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Inhibition of MCL1 induces apoptosis in anaplastic large cell lymphoma and in primary effusion lymphoma
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Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study
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Development of a multi-target anticancer Sn( ii ) pyridine-2-carboxaldehyde thiosemicarbazone complex
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Natural Dibenzo[b,f]oxepines, Pacharin and Bauhiniastatin-1, Isolated from Bauhinia acuruana Induce Apoptosis on Breast Cancer Cells via MCL-1 Protein Reduction
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Therapeutic potential of dietary bioactive compounds against anti-apoptotic Bcl-2 proteins in breast cancer
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Mitigating the BFL1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs
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Combating chemoresistance in breast cancer: exploring tumour microenvironment, combination therapies and drug repurposing strategies
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GE11 peptide modified CSO-SPION micelles for MRI diagnosis of targeted hepatic carcinoma
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Autophagy-associated immune dysregulation and hyperplasia in a patient with compound heterozygous mutations in ATG9A
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Experimental and computational insights into mitochondrial permeability transition and pro-apoptotic signaling induced by the methanol fraction of Daniellia oliveri leaves in male Wistar rats
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Cancer Resistance Is Mediated by the Upregulation of Several Anti-Apoptotic Gene Products via the Inducible Nitric Oxide Synthase/Nitric Oxide Pathway: Therapeutic Implications
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InDeep: 3D fully convolutional neural networks to assist in silico drug design on protein–protein interactions
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From genetic characterization to new potential therapeutic options: targeting Bcl-xL in Merkel carcinoma
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Azacytidine and Venetoclax in Relapsed and Refractory Patients With Angioimmunoblastic T-cell Lymphoma
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Mitigating the Bfl-1-mediated antiapoptotic pathway in diffuse large B cell lymphoma by inhibiting HDACs
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Discovery of high affinity and specificity stapled peptide Bcl-xL inhibitors using bacterial surface display
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Skin Aging: From Molecular Mechanisms to Therapeutic and Technological Innovations
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Strain‐Specific Antiproliferative Activity of Lactobacillus Cell‐Free Supernatants in Gastric Cancer Cells and Modulation of Apoptosis‐Related Gene Expression
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Data from Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer
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Bcl-xL Enforces a Slow-Cycling State Necessary for Survival in the Nutrient-Deprived Microenvironment of Pancreatic Cancer
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Amphotericin-A21 Induces Antineoplastic Effects through the Modulation of Apoptosis in Human Tumoral Cells
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Epigenetic Reactivation of SOCS-3 and Inhibition of ERK1/2 Underlie Thymoquinone-Induced Apoptosis in a Chronic Myeloid Leukemia Xenograft Model
inferred← citeshttps://doi.org/10.1177/09731296251329683openalex-snapshot
Reserpine Ameliorates 1,2-Dimethylhydrazine-induced Colon Cancer through Regulating Xenobiotic Enzymes and Bax/Caspases/Bcl-2-mediated Apoptotic Mechanisms in Rats
inferred← citeshttps://doi.org/10.1186/s12935-021-02400-1openalex-snapshot
NK cell upraise in the dark world of cancer stem cells
inferred← citeshttps://doi.org/10.1186/s12964-024-01647-1openalex-snapshot
Bcl-2 dependent modulation of Hippo pathway in cancer cells
inferred← citeshttps://doi.org/10.1186/s13045-021-01079-1openalex-snapshot
Targeting MCL-1 in cancer: current status and perspectives
inferred← citeshttps://doi.org/10.1186/s13046-023-02735-9openalex-snapshot
Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment
inferred← citeshttps://doi.org/10.1186/s43042-024-00485-7openalex-snapshot
Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context
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Recent Trends in Nanocarrier-Based Drug Delivery System for Prostate Cancer
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[Effects of matrine combined with LY294002 on proliferation, apoptosis and cell cycle of human myeloid leukemia K562 cells].
inferred← citeshttps://doi.org/10.1371/journal.pone.0254929openalex-snapshot
Norcycloartocarpin targets Akt and suppresses Akt-dependent survival and epithelial-mesenchymal transition in lung cancer cells
inferred← citeshttps://doi.org/10.14715/cmb/2022.68.11.4openalex-snapshot
Unveiling Antioxidant and Antiproliferative Effects of Prosopis juliflora Leaves against Human Prostate Cancer LNCaP Cells
inferred← citeshttps://doi.org/10.1515/ntrev-2022-0114openalex-snapshot
Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells
inferred← citeshttps://doi.org/10.1515/ntrev-2023-0152openalex-snapshot
Fabrication and physicochemical characterization of copper oxide–pyrrhotite nanocomposites for the cytotoxic effects on HepG2 cells and the mechanism
inferred← citeshttps://doi.org/10.1515/oncologie-2025-0056openalex-snapshot
Snake venom in conjugation with silica nanoparticles: an emerging cancer therapy
inferred← citeshttps://doi.org/10.1556/112.2021.00028openalex-snapshot
A gyógyszerkutatás új irányzatai: hatékonyság és biztonságosság
inferred← citeshttps://doi.org/10.18502/ijrm.v22i6.16796openalex-snapshot
Positive correlation between Bax and Bcl-2 gene polymorphisms with the risk of endometriosis: A case-control study
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1863059/v1openalex-snapshot
Molecular Docking and In-vitro Evaluation of Apoptotic Effect of Novel Synthetic Organocopper Derivative in Human Breast Cancer Cell line as Anticancer Agent
inferred← citeshttps://doi.org/10.2174/0113895575269644231120104501openalex-snapshot
SMAC Mimetics for the Treatment of Lung Carcinoma: Present Development and Future Prospects
inferred← citeshttps://doi.org/10.2174/0118741045413023251029095309openalex-snapshot
The Role of the BCL2 Family in Targeted Anticancer Response as Apoptotic Mediators
inferred← citeshttps://doi.org/10.2174/1389203724666230418123409openalex-snapshot
Bioactive Pentacyclic Triterpenes Trigger Multiple Signalling Pathways for Selective Apoptosis Leading to Anticancer Efficacy: Recent Updates and Future Perspectives
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BH3 Mimetic Peptides: An Effective Strategy to Complement Anticancer Therapy
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Nano-Based Targeted Drug Delivery for Lung Cancer: Therapeutic Avenues and Challenges
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The Promising Therapeutic Effects of Pomegranate (Punica granatum) on Gastric Ulcers: A Comprehensive Review on Antioxidant, Anti-inflammatory Properties and Molecular Mechanisms
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Type I Topoisomerases As Potential Targets For Therapeutics
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Radioprotectors & mitigators in radiation therapy: Harnessing diverse pathways for optimizing clinical outcomes
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Apoptosis, guardian of the genome: Review
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NUEVAS DIANAS MOLECULARES EN CÁNCER DE GINECOLÓGICO
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Micro RNA-148a Targets Bcl-2 in Patients with Non-Small Cell Lung Cancer
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Chemotherapy Resistance in Cancer: Mechanism and Roadmap to Evade Exploring Apoptosis
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Myeloid Cell Leukemia-1 (MCL-1) and Its Correlation with the Prognostic Scoring System in Chronic Myeloid Leukemia
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Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing
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Neuroglial Senescence, α-Synucleinopathy, and the Therapeutic Potential of Senolytics in Parkinson’s Disease
inferred← citeshttps://doi.org/10.3389/fonc.2021.598319openalex-snapshot
In Vitro Sensitivity to Venetoclax and Microenvironment Protection in Hairy Cell Leukemia
inferred← citeshttps://doi.org/10.3389/fonc.2021.795548openalex-snapshot
Recent Progress in Understanding the Action of Natural Compounds at Novel Therapeutic Drug Targets for the Treatment of Liver Cancer
inferred← citeshttps://doi.org/10.3389/fonc.2022.1071171openalex-snapshot
Harnessing the immune system in the treatment of cutaneous T cell lymphomas
inferred← citeshttps://doi.org/10.3390/antibiotics14101029openalex-snapshot
Environmental Amoxicillin Exposure Induces Cardiotoxicity in Zebrafish Embryos: A Comprehensive Assessment of Heart Function and Molecular Responses
inferred← citeshttps://doi.org/10.3390/biomedicines10092233openalex-snapshot
The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target
inferred← citeshttps://doi.org/10.3390/biomedicines11061666openalex-snapshot
Simultaneous Inhibition of Mcl-1 and Bcl-2 Induces Synergistic Cell Death in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3390/biomedicines12040794openalex-snapshot
Natural Products as Regulators against Matrix Metalloproteinases for the Treatment of Cancer
inferred← citeshttps://doi.org/10.3390/biomedicines13061298openalex-snapshot
Molecular Biomarkers of Glioma
inferred← citeshttps://doi.org/10.3390/cancers13010078openalex-snapshot
BCL2L10 Is Overexpressed in Melanoma Downstream of STAT3 and Promotes Cisplatin and ABT-737 Resistance
inferred← citeshttps://doi.org/10.3390/cancers13102310openalex-snapshot
Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA
inferred← citeshttps://doi.org/10.3390/cancers13205164openalex-snapshot
Safety and Efficacy Evaluation In Vivo of a Cationic Nucleolipid Nanosystem for the Nanodelivery of a Ruthenium(III) Complex with Superior Anticancer Bioactivity
inferred← citeshttps://doi.org/10.3390/cancers14194562openalex-snapshot
Current Landscape of Therapeutic Resistance in Lung Cancer and Promising Strategies to Overcome Resistance
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Role of YY1 in the Regulation of Anti-Apoptotic Gene Products in Drug-Resistant Cancer Cells
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Lipocalin-2: A Nurturer of Tumor Progression and a Novel Candidate for Targeted Cancer Therapy
inferred← citeshttps://doi.org/10.3390/cancers16162831openalex-snapshot
MERTK Is a Potential Therapeutic Target in Ewing Sarcoma
inferred← citeshttps://doi.org/10.3390/cells12141893openalex-snapshot
Differentiation Induction of Mesenchymal Stem Cells by a Au Delivery Platform
inferred← citeshttps://doi.org/10.3390/cells13141186openalex-snapshot
Advancements in Utilizing Natural Compounds for Modulating Autophagy in Liver Cancer: Molecular Mechanisms and Therapeutic Targets
inferred← citeshttps://doi.org/10.3390/cells9092121openalex-snapshot
Regulation of Apoptosis by the Bcl-2 Family of Proteins: Field on a Brink
inferred← citeshttps://doi.org/10.3390/cryst11030261openalex-snapshot
Crystal Structure and Solid-State Conformational Analysis of Active Pharmaceutical Ingredient Venetoclax
inferred← citeshttps://doi.org/10.3390/cryst13030382openalex-snapshot
Unconventional Dual Donor-Acceptor Topologies of Aromatic Rings in Amine-Based Polymeric Tetrahedral Zn(II) Compounds Involving Unusual Non-Covalent Contacts: Antiproliferative Evaluation and Theoretical Studies
inferred← citeshttps://doi.org/10.3390/ijms22052777openalex-snapshot
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Recent Advances in Oligonucleotide Therapeutics in Oncology
inferred← citeshttps://doi.org/10.3390/ijms221910442openalex-snapshot
B Cell Lymphoma 2: A Potential Therapeutic Target for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/ijms24054708openalex-snapshot
The Role of BCL-2 and PD-1/PD-L1 Pathway in Pathogenesis of Myelodysplastic Syndromes
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inferred← citeshttps://doi.org/10.3390/ijms26062530openalex-snapshot
Metabolomic Characterization and Bioinformatic Studies of Bioactive Compounds in Two Varieties of Psidium guajava L. Leaf by GC–MS Analysis
inferred← citeshttps://doi.org/10.3390/molecules25235778openalex-snapshot
2-Deoxy-d-glucose Promotes Buforin IIb-Induced Cytotoxicity in Prostate Cancer DU145 Cells and Xenograft Tumors
inferred← citeshttps://doi.org/10.3390/molecules28031393openalex-snapshot
Folic Acid Functionalized Diallyl Trisulfide–Solid Lipid Nanoparticles for Targeting Triple Negative Breast Cancer
inferred← citeshttps://doi.org/10.3390/molecules28062601openalex-snapshot
Cytotoxic Activity of Amaryllidaceae Plants against Cancer Cells: Biotechnological, In Vitro, and In Silico Approaches
inferred← citeshttps://doi.org/10.3390/molecules28073061openalex-snapshot
Assessment of the Anticancer Effect of Chlorojanerin Isolated from Centaurothamnus maximus on A549 Lung Cancer Cells
inferred← citeshttps://doi.org/10.3390/pharmaceutics13091353openalex-snapshot
Combination Therapy of Navitoclax with Chemotherapeutic Agents in Solid Tumors and Blood Cancer: A Review of Current Evidence
inferred← citeshttps://doi.org/10.3390/pharmaceutics15102442openalex-snapshot
TACkling Cancer by Targeting Selective Protein Degradation
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Bcl-2-like protein-10 increases aggressive features of melanoma cells
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Cellular senescence in metastatic prostate cancer: A therapeutic opportunity or challenge (Review)
inferred← citeshttps://doi.org/10.3892/mmr.2025.13537openalex-snapshot
The role of Bcl‑2 in controlling the transition between autophagy and apoptosis (Review)
inferred← citeshttps://doi.org/10.3892/ol.2024.14584openalex-snapshot
Newer combination treatments for breast cancer coexisting with acute myeloid leukemia in the novel regimens era: A case report and literature review
inferred← citeshttps://doi.org/10.4103/ejcrp.ejcrp-d-23-00026openalex-snapshot
Left Kidney Undifferentiated Spindle Cell Sarcoma with Myeloid Cell Leukemia-1 Amplification: Therapeutic Response to Bortezomib, Venetoclax, and Dexamethasone Therapy
inferred← citeshttps://doi.org/10.4103/jasmr.jasmr_19_23openalex-snapshot
Bcl-2 expression and image analysis of premalignant and malignant colonic lesions
inferred← citeshttps://doi.org/10.5772/intechopen.97844openalex-snapshot
The Role of Apoptosis as a Double-Edge Sword in Cancer
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Effect of jorunnamycin a on cancer stem cells of human lung cancer h460 cells
inferred← citeshttps://doi.org/10.70675/165daf1fzf29cz41c9zb8e1z3061f4a40f54openalex-snapshot
Développement d’un outil pronostic et prédictif basé sur la détection des signatures électromagnétiques associées à des caractéristiques des cellules de cancer bronchique
inferred← citeshttps://doi.org/10.70675/bfeb5608zf944z4b23zbb2bzd3f959a16cd3openalex-snapshot
Etude de la structure et la dynamique de Mcl-1 : application en cancérologie
inferred← citeshttps://doi.org/10.7150/thno.51725openalex-snapshot
Molecular stratification by BCL2A1 and AIM2 provides additional prognostic value in penile squamous cell carcinoma
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