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Recent Advances in Oligonucleotide Therapeutics in Oncology

https://doi.org/10.3390/ijms22073295

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Protein Kinase C in Cancer Signaling and Therapy

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Oligonucleotide Therapeutics in Cancer

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DNA Mutations May Not Be the Cause of Cancer

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Oligonucleotide–Polymer Conjugates: From Molecular Basics to Practical Application

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Overview of the Nonclinical Development Strategies and Class-Effects of Oligonucleotide-Based Therapeutics

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Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

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Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

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Designing Chemically Modified Oligonucleotides for Targeted Gene Silencing

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Targeted tumor therapy with the TGF-β2 antisense compound AP 12009

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TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes

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Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics

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Resistance to Checkpoint Inhibition in Cancer Immunotherapy

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Clinical evaluation of CpG oligonucleotides as adjuvants for vaccines targeting infectious diseases and cancer

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Defibrotide: Properties and clinical use of an old/new drug

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RNase H1-Dependent Antisense Oligonucleotides Are Robustly Active in Directing RNA Cleavage in Both the Cytoplasm and the Nucleus

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Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

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A randomized controlled clinical trial of intravitreous fomivirsen for treatment of newly diagnosed peripheral cytomegalovirus retinitis in patients with aids

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Oligonucleotide N3′→P5′ thiophosphoramidates: synthesis and properties

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Antisense therapy directed to protein kinase C-alpha (affinitak, LY900003/ISIS 3521): Potential role in breast cancer

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Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER)

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Locked nucleic acid (LNA): fine-tuning the recognition of DNA and RNA

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Custirsen in combination with docetaxel and prednisone for patients with metastatic castration-resistant prostate cancer (SYNERGY trial): a phase 3, multicentre, open-label, randomised trial

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Custirsen (OGX-011) combined with cabazitaxel and prednisone versus cabazitaxel and prednisone alone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel (AFFINITY): a randomised, open-label, international, phase 3 trial

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Safety and activity of microRNA-loaded minicells in patients with recurrent malignant pleural mesothelioma: a first-in-man, phase 1, open-label, dose-escalation study

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Comparing In Vitro and In Vivo Activity of 2′-O-[2-(Methylamino)-2-oxoethyl]- and 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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CpG motifs in bacterial DNA trigger direct B-cell activation

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Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo

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MicroRNA and drug resistance

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The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia

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Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy

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siRNA Versus miRNA as Therapeutics for Gene Silencing

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Comprehensive molecular portraits of human breast tumours

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The chemical evolution of oligonucleotide therapies of clinical utility

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Cellular uptake and trafficking of antisense oligonucleotides

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Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

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Drugging the 'undruggable' cancer targets

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MicroRNA therapeutics: towards a new era for the management of cancer and other diseases

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Regulation of microRNA biogenesis

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Comprehensive review of targeted therapy for colorectal cancer

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The current state and future directions of RNAi-based therapeutics

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Advances in oligonucleotide drug delivery

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The role of MicroRNAs in human cancer

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The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

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The myb gene family in cell growth, differentiation and apoptosis

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Tumor regression by combination antisense therapy against Plk1 and Bcl-2

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Deoxyribozymes: DNA catalysts for bioorganic chemistry

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In vivo and in vitro studies of antisense oligonucleotides – a review

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Antisense technologies

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Antisense therapy directed to protein kinase C-alpha (affinitak, LY900003/ISIS 3521): Potential role in breast cancer

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Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties

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An oligomer complementary to c-myb-encoded mRNA inhibits proliferation of human myeloid leukemia cell lines.

inferredcites →https://doi.org/10.1080/07357907.2018.1550090openalex-snapshot

c-MYB and DMTF1 in Cancer

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In vitroevolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies

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Transforming growth factor-β: A therapeutic target for cancer

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What does PD-L1 positive or negative mean?

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Phosphorothioate Oligodeoxynucleotides: Antisense or Anti-Protein?

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Preclinical Evaluation of the Toxicological Effects of a Novel Constrained Ethyl Modified Antisense Compound Targeting Signal Transducer and Activator of Transcription 3 in Mice and Cynomolgus Monkeys

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Effect of Chemical Modifications on Aptamer Stability in Serum

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Integrated Assessment of the Clinical Performance of GalNAc 3 -Conjugated 2′- O -Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience

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The 10th Oligonucleotide Therapy Approved: Golodirsen for Duchenne Muscular Dystrophy

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Inhibition of TGF- β 2 with AP 12009 in Recurrent Malignant Gliomas: From Preclinical to Phase I/II Studies

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A phase III randomized study of gemcitabine and cisplatin with or without PF-3512676 (TLR9 agonist) as first-line treatment of advanced non-small-cell lung cancer

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Restoring expression of miR-16: a novel approach to therapy for malignant pleural mesothelioma

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Highly efficient cellular uptake of c-myb antisense oligonucleotides through specifically designed polymeric nanospheres

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Modulation of plasma protein binding and in vivo liver cell uptake of phosphorothioate oligodeoxynucleotides by cholesterol conjugation

inferredcites →https://doi.org/10.1093/nar/gkaa126openalex-snapshot

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model

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Phosphorothioate modified oligonucleotide–protein interactions

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RNA cleaving '10-23' DNAzymes with enhanced stability and activity

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Position-dependent effects of locked nucleic acid (LNA) on DNA sequencing and PCR primers

inferredcites →https://doi.org/10.1093/nar/gkw236openalex-snapshot

The delivery of therapeutic oligonucleotides

inferredcites →https://doi.org/10.1093/nar/gky1260openalex-snapshot

Characterization of the interactions of chemically-modified therapeutic nucleic acids with plasma proteins using a fluorescence polarization assay

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Targeted therapy for high-grade glioma with the TGF- 2 inhibitor trabedersen: results of a randomized and controlled phase IIb study

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Randomized Phase II Study of the X-linked Inhibitor of Apoptosis (XIAP) Antisense AEG35156 in Combination With Sorafenib in Patients With Advanced Hepatocellular Carcinoma (HCC)

inferredcites →https://doi.org/10.1098/rsob.180002openalex-snapshot

Targeting BCL-2 regulated apoptosis in cancer

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Transforming growth factor‐beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer

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Combination Drug Delivery Approaches in Metastatic Breast Cancer

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Role of STAT3 in Cancer Metastasis and Translational Advances

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Efficiency of CAR-T Therapy for Treatment of Solid Tumor in Clinical Trials: A Meta-Analysis

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Deoxyribozymes as Catalytic Nanotherapeutic Agents

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A Phase I/II Study of LY900003, an Antisense Inhibitor of Protein Kinase C-α, in Combination with Cisplatin and Gemcitabine in Patients with Advanced Non–Small Cell Lung Cancer

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Integration of Novel Therapeutics into Combined Modality Therapy of Locally Advanced Non–Small Cell Lung Cancer

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Hsp27 Inhibition with OGX-427 Sensitizes Non–Small Cell Lung Cancer Cells to Erlotinib and Chemotherapy

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First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

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SD-101 in Combination with Pembrolizumab in Advanced Melanoma: Results of a Phase Ib, Multicenter Study

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Protein Kinase C Alpha Expression in Breast and Ovarian Cancer

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Evaluation of Factors Related to Late Recurrence - Later than 10 Years after the Initial Treatment - in Primary Breast Cancer

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PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

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Melanoma immunotherapy using mature DCs expressing the constitutive proteasome

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Antisense Oligonucleotide Therapies

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Clusterin confers resistance to TNF-alpha-induced apoptosis in breast cancer cells through NF-kappaB activation and Bcl-2 overexpression

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Combination immunotherapy with a CpG oligonucleotide (1018 ISS) and rituximab in patients with non-Hodgkin lymphoma: increased interferon-α/β–inducible gene expression, without significant toxicity

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The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization

inferredcites →https://doi.org/10.1182/blood.v99.4.1150openalex-snapshot

Oligodeoxynucleotide-mediated inhibition of c-myb gene expression in autografted bone marrow: a pilot study

inferredcites →https://doi.org/10.1182/blood.v99.9.3461openalex-snapshot

Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia

inferredcites →https://doi.org/10.1182/bloodadvances.2019000937openalex-snapshot

Venetoclax for AML: changing the treatment paradigm

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DCE-MRI assessment of the effect of Epstein-Barr virus-encoded latent membrane protein-1 targeted DNAzyme on tumor vasculature in patients with nasopharyngeal carcinomas

inferredcites →https://doi.org/10.1186/s12885-017-3827-yopenalex-snapshot

Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin

inferredcites →https://doi.org/10.1186/s13046-019-1094-2openalex-snapshot

Clinical development of targeted and immune based anti-cancer therapies

inferredcites →https://doi.org/10.1186/s13048-019-0573-6openalex-snapshot

The Jun N-terminal kinases signaling pathway plays a “seesaw” role in ovarian carcinoma: a molecular aspect

inferredcites →https://doi.org/10.1186/s40425-018-0436-5openalex-snapshot

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

inferredcites →https://doi.org/10.1186/s40425-019-0738-2openalex-snapshot

TLR9 acts as a sensor for tumor-released DNA to modulate anti-tumor immunity after chemotherapy

inferredcites →https://doi.org/10.1186/s40880-017-0206-7openalex-snapshot

Cancer metastasis: issues and challenges

inferredcites →https://doi.org/10.1200/jco.2005.04.3299openalex-snapshot

Phase III Study of Gemcitabine and Cisplatin With or Without Aprinocarsen, a Protein Kinase C-Alpha Antisense Oligonucleotide, in Patients With Advanced-Stage Non–Small-Cell Lung Cancer

inferredcites →https://doi.org/10.1200/jco.2006.07.1191openalex-snapshot

Randomized Phase III Trial of Fludarabine Plus Cyclophosphamide With or Without Oblimersen Sodium (Bcl-2 antisense) in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia

inferredcites →https://doi.org/10.1200/jco.2010.32.8971openalex-snapshot

Randomized Phase III Trial of Paclitaxel/Carboplatin With or Without PF-3512676 (Toll-Like Receptor 9 Agonist) As First-Line Treatment for Advanced Non–Small-Cell Lung Cancer

inferredcites →https://doi.org/10.1200/jco.2014.32.15_suppl.2586openalex-snapshot

Pharmacokinetics of the BCL2-targeted DNA interference (DNAi) nanoparticle PNT2258 in patients with recurrent or refractory non-Hodgkin lymphoma.

inferredcites →https://doi.org/10.1200/jco.2015.33.15_suppl.11006openalex-snapshot

Safety and activity of DCR-MYC, a first-in-class Dicer-substrate small interfering RNA (DsiRNA) targeting MYC, in a phase I study in patients with advanced solid tumors.

inferredcites →https://doi.org/10.1200/jco.2017.35.15_suppl.7564openalex-snapshot

Phase 1 trial evaluating MRG-106, a synthetic inhibitor of microRNA-155, in patients with cutaneous t-cell lymphoma (CTCL).

inferredcites →https://doi.org/10.1200/jco.2020.38.15_suppl.tps4672openalex-snapshot

A phase II study of siG12D-LODER in combination with chemotherapy in patients with locally advanced pancreatic cancer (PROTACT).

inferredcites →https://doi.org/10.1201/9781420008906openalex-snapshot

Chemistry and Pharmacology of Anticancer Drugs

inferredcites →https://doi.org/10.14800/rd.1393openalex-snapshot

Antisense Oligonucleotides: Treatment Strategies and Cellular Internalization

inferredcites →https://doi.org/10.1517/14712598.2015.1025048openalex-snapshot

DNA enzymes as potential therapeutics: towards clinical application of 10-23 DNAzymes

inferredcites →https://doi.org/10.1586/era.09.138openalex-snapshot

Treatment of malignant gliomas with TGF-β2 antisense oligonucleotides

inferredcites →https://doi.org/10.1634/theoncologist.2017-0066openalex-snapshot

A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial

inferredcites →https://doi.org/10.1634/theoncologist.2018-0518openalex-snapshot

A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial

inferredcites →https://doi.org/10.18632/oncotarget.4183openalex-snapshot

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

inferredcites →https://doi.org/10.2147/cmar.s196273openalex-snapshot

The role of Clusterin in cancer metastasis

inferredcites →https://doi.org/10.2147/ijn.s200253openalex-snapshot

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based approach

inferredcites →https://doi.org/10.2165/00126839-200708050-00006openalex-snapshot

Oblimersen

inferredcites →https://doi.org/10.2174/138920210793175895openalex-snapshot

MicroRNA: Biogenesis, Function and Role in Cancer

inferredcites →https://doi.org/10.3109/10428194.2011.608451openalex-snapshot

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inferred← citeshttps://doi.org/10.2174/0115672018306882240618093152openalex-snapshot

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The Potential Impact of New Drug and Therapeutic Modalities on Drug Resistance to Renal Cell Carcinoma

inferred← citeshttps://doi.org/10.21873/cgp.20368openalex-snapshot

Triple-negative Breast Cancer: Identification of circRNAs With Efficacy in PreclinicalIn VivoModels

inferred← citeshttps://doi.org/10.25259/jhas_4_2025openalex-snapshot

RNA-based therapeutics for the treatment of blood disorders: A review and an overview

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RNA binding proteins in cancer chemotherapeutic drug resistance

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Genomic innovations in cancer prevention, diagnosis, prognosis and precision therapeutics

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pH-Responsive Polymer Nanomaterials for Tumor Therapy

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Synthetic short RNA in cancer

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Feedforward Loops: Evolutionary Conserved Network Motifs Redesigned for Synthetic Biology Applications

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The Landscape of Noncoding RNA in Pulmonary Hypertension

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Biological Nanocarriers in Cancer Therapy: Cutting Edge Innovations in Precision Drug Delivery

inferred← citeshttps://doi.org/10.3390/cancers14030566openalex-snapshot

Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts

inferred← citeshttps://doi.org/10.3390/cancers14061480openalex-snapshot

The Fra-1/AP-1 Oncoprotein: From the “Undruggable” Transcription Factor to Therapeutic Targeting

inferred← citeshttps://doi.org/10.3390/cancers14184421openalex-snapshot

MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and Prognosis to Targeted Treatment

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Splicing-Disrupting Mutations in Inherited Predisposition to Solid Pediatric Cancer

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Aptamer-Based Strategies to Boost Immunotherapy in TNBC

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Circular RNAs—New Kids on the Block in Cancer Pathophysiology and Management

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A New Wave of Targeting ‘Undruggable’ Wnt Signaling for Cancer Therapy: Challenges and Opportunities

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A Comprehensive Review of miRNAs and Their Epigenetic Effects in Glioblastoma

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Clinical Applications of Antisense Oligonucleotides in Cancer: A Focus on Glioblastoma

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Breast Cancer Treatment: The Potential of Organic and Inorganic Nanocarriers in Targeted Drug Delivery

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Therapeutic Targeting of RNA Splicing in Cancer

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Genetic Therapy and Molecular Targeted Therapy in Oncology: Safety, Pharmacovigilance, and Perspectives for Research and Clinical Practice

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Boron Clusters as Enhancers of RNase H Activity in the Smart Strategy of Gene Silencing by Antisense Oligonucleotides

inferred← citeshttps://doi.org/10.3390/ijms24087287openalex-snapshot

Extracellular Vesicles for Therapeutic Nucleic Acid Delivery: Loading Strategies and Challenges

inferred← citeshttps://doi.org/10.3390/ijms241914862openalex-snapshot

RNA-Based Strategies for Cancer Therapy: In Silico Design and Evaluation of ASOs for Targeted Exon Skipping

inferred← citeshttps://doi.org/10.3390/ijms242316933openalex-snapshot

Nucleic Acid-Based Approaches to Tackle KRAS Mutant Cancers

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inferred← citeshttps://doi.org/10.3390/pharmaceutics13081106openalex-snapshot

Nanoparticles-Based Oligonucleotides Delivery in Cancer: Role of Zebrafish as Animal Model

inferred← citeshttps://doi.org/10.3390/pharmaceutics13091442openalex-snapshot

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inferred← citeshttps://doi.org/10.3390/pharmaceutics13101722openalex-snapshot

Future Perspectives of Oral Delivery of Next Generation Therapies for Treatment of Skin Diseases

inferred← citeshttps://doi.org/10.3390/pharmaceutics14020342openalex-snapshot

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inferred← citeshttps://doi.org/10.3390/pharmaceutics14071453openalex-snapshot

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inferred← citeshttps://doi.org/10.3390/pharmaceutics15020600openalex-snapshot

A Review of Protein- and Peptide-Based Chemical Conjugates: Past, Present, and Future

inferred← citeshttps://doi.org/10.3390/pharmaceutics15041112openalex-snapshot

Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny

inferred← citeshttps://doi.org/10.3390/pharmaceutics17070903openalex-snapshot

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inferred← citeshttps://doi.org/10.3762/bjoc.17.125openalex-snapshot

Cationic oligonucleotide derivatives and conjugates: A favorable approach for enhanced DNA and RNA targeting oligonucleotides

inferred← citeshttps://doi.org/10.4014/jmb.2204.04041openalex-snapshot

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inferred← citeshttps://doi.org/10.4062/biomolther.2025.022openalex-snapshot

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inferred← citeshttps://doi.org/10.4155/bio-2022-0160openalex-snapshot

Feasibility of using PALSAR technology as a signal amplifier for antibody bridging assay

inferred← citeshttps://doi.org/10.5204/thesis.eprints.244746openalex-snapshot

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inferred← citeshttps://doi.org/10.5772/intechopen.107136openalex-snapshot

Perspective Chapter: RNA Therapeutics for Cancers

inferred← citeshttps://doi.org/10.6084/m9.figshare.24655814openalex-snapshot

Additional file 1 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.24656080openalex-snapshot

Additional file 2 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.25264205openalex-snapshot

Additional file 1 of The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.25264487openalex-snapshot

Additional file 2 of The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.26646091openalex-snapshot

Additional file 3 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.26646094openalex-snapshot

Additional file 4 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.26646097openalex-snapshot

Additional file 5 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.26646100openalex-snapshot

Additional file 6 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.26646103openalex-snapshot

Additional file 7 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.26646106openalex-snapshot

Additional file 8 of Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer

inferred← citeshttps://doi.org/10.6084/m9.figshare.26684163openalex-snapshot

Additional file 3 of The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma

inferred← citeshttps://doi.org/10.6084/m9.figshare.26684166openalex-snapshot

Additional file 4 of The therapeutically actionable long non-coding RNA ‘T-RECS’ is essential to cancer cells’ survival in NRAS/MAPK-driven melanoma

inferred← citeshttps://doi.org/10.7124/bc.000b33openalex-snapshot

Studying the interaction between pentameric oligonucleotides and recombinant signaling proteins and receptors

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