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Induction of Apoptosis by Coptisine in Hep3B Hepatocellular Carcinoma Cells through Activation of the ROS-Mediated JNK Signaling Pathway

https://doi.org/10.3390/ijms21155502
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1 of the 50 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1155/2014/150845 (notice 2020-08-30).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbin.11137openalex-snapshot
Cell death: a review of the major forms of apoptosis, necrosis and autophagy
inferredcites →https://doi.org/10.1002/ijc.29210openalex-snapshot
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
inferredcites →https://doi.org/10.1002/jcb.21707openalex-snapshot
Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities
inferredcites →https://doi.org/10.1007/s00204-017-2084-9openalex-snapshot
ROS generation and JNK activation contribute to 4-methoxy-TEMPO-induced cytotoxicity, autophagy, and DNA damage in HepG2 cells
inferredcites →https://doi.org/10.1007/s11745-014-3983-7openalex-snapshot
The Safety and Anti‐Hypercholesterolemic Effect of Coptisine in Syrian Golden Hamsters
inferredcites →https://doi.org/10.1007/s12012-016-9364-0openalex-snapshot
Causation by Diesel Exhaust Particles of Endothelial Dysfunctions in Cytotoxicity, Pro-inflammation, Permeability, and Apoptosis Induced by ROS Generation
inferredcites →https://doi.org/10.1007/s13258-019-00790-1openalex-snapshot
Reversine induces caspase-dependent apoptosis of human osteosarcoma cells through extrinsic and intrinsic apoptotic signaling pathways
inferredcites →https://doi.org/10.1007/s43188-020-00038-1openalex-snapshot
Myristoylated TMEM39AS41, a cell-permeable peptide, causes lung cancer cell death
inferredcites →https://doi.org/10.1016/j.bbamcr.2016.09.012openalex-snapshot
Activation of apoptosis signalling pathways by reactive oxygen species
inferredcites →https://doi.org/10.1016/j.bbrc.2015.01.137openalex-snapshot
Calcium and mitochondria in the regulation of cell death
inferredcites →https://doi.org/10.1016/j.bbrc.2017.06.190openalex-snapshot
BCL-2 proteins and apoptosis: Recent insights and unknowns
inferredcites →https://doi.org/10.1016/j.biopha.2018.04.052openalex-snapshot
Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122
inferredcites →https://doi.org/10.1016/j.biopha.2018.08.104openalex-snapshot
Herbal management of hepatocellular carcinoma through cutting the pathways of the common risk factors
inferredcites →https://doi.org/10.1016/j.biopha.2019.108749openalex-snapshot
Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling
inferredcites →https://doi.org/10.1016/j.febslet.2008.06.051openalex-snapshot
Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway
inferredcites →https://doi.org/10.1016/j.fitote.2011.09.014openalex-snapshot
Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells
inferredcites →https://doi.org/10.1016/j.fitote.2015.06.005openalex-snapshot
Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters
inferredcites →https://doi.org/10.1016/j.phymed.2017.12.027openalex-snapshot
Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway
inferredcites →https://doi.org/10.1016/j.suronc.2016.03.002openalex-snapshot
Hepatocellular carcinoma: From diagnosis to treatment
inferredcites →https://doi.org/10.1016/s0092-8674(00)81683-9openalex-snapshot
The Hallmarks of Cancer
inferredcites →https://doi.org/10.1021/tx050321uopenalex-snapshot
Endogenous Reactive Intermediates as Modulators of Cell Signaling and Cell Death
inferredcites →https://doi.org/10.1038/nrgastro.2010.100openalex-snapshot
Hepatocellular carcinoma: a global view
inferredcites →https://doi.org/10.1038/onc.2008.301openalex-snapshot
JNK signaling in apoptosis
inferredcites →https://doi.org/10.1038/s41571-020-0341-yopenalex-snapshot
Targeting apoptosis in cancer therapy
inferredcites →https://doi.org/10.1038/sj.cdd.4400938openalex-snapshot
DNA damage and apoptosis
inferredcites →https://doi.org/10.1038/sj.onc.1207532openalex-snapshot
DNA damage-induced apoptosis
inferredcites →https://doi.org/10.1039/c8ra05806gopenalex-snapshot
Coptisine suppresses tumor growth and progression by down-regulating MFG-E8 in colorectal cancer
inferredcites →https://doi.org/10.1080/10286020.2019.1585820openalex-snapshot
Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells
inferredcites →https://doi.org/10.1080/13880209.2019.1577466openalex-snapshot
Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
inferredcites →https://doi.org/10.1080/15569527.2019.1613425openalex-snapshot
Protective effect of diphlorethohydroxycarmalol against oxidative stress-induced DNA damage and apoptosis in retinal pigment epithelial cells
inferredcites →https://doi.org/10.1080/19768354.2019.1706634openalex-snapshot
Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway
inferredcites →https://doi.org/10.1093/nar/gkp100openalex-snapshot
Oxidative stress induces degradation of mitochondrial DNA
inferredcites →https://doi.org/10.1111/j.1365-2672.2009.04292.xopenalex-snapshot
Investigation of the anti-fungal activity of coptisine on Candida albicans growth by microcalorimetry combined with principal component analysis
inferredcites →https://doi.org/10.1155/2010/370835openalex-snapshot
Evasion of Apoptosis as a Cellular Stress Response in Cancer
inferredcites →https://doi.org/10.1155/2013/268963openalex-snapshot
Traditional Herbal Medicine: A Review of Potential of Inhibitory Hepatocellular Carcinoma in Basic Research and Clinical Trial
inferredcites →https://doi.org/10.1155/2014/150845openalex-snapshot
Apoptosis and Molecular Targeting Therapy in Cancer
inferredcites →https://doi.org/10.1155/2019/5080843openalex-snapshot
Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
inferredcites →https://doi.org/10.1177/1010428317694565openalex-snapshot
Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species–dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells
inferredcites →https://doi.org/10.1186/s42826-019-0030-0openalex-snapshot
Inhibition of STAT3 signaling induces apoptosis and suppresses growth of lung cancer: good and bad
inferredcites →https://doi.org/10.2147/jhc.s61146openalex-snapshot
Hepatocellular carcinoma: a review
inferredcites →https://doi.org/10.2174/1871520618666180604085612openalex-snapshot
An Overview of Natural Plant Products in the Treatment of Hepatocellular Carcinoma
inferredcites →https://doi.org/10.2174/2213988501812010009openalex-snapshot
Hepatocellular Carcinoma: Causes, Mechanism of Progression and Biomarkers
inferredcites →https://doi.org/10.22034/apjcp.2017.18.4.863openalex-snapshot
Hepatocellular Carcinoma: a Comprehensive Review of Biomarkers, Clinical Aspects, and Therapy
inferredcites →https://doi.org/10.3109/10715761003667554openalex-snapshot
Reactive oxygen species in cancer
inferredcites →https://doi.org/10.3389/fphar.2018.00517openalex-snapshot
Coptisine Induces Apoptosis in Human Hepatoma Cells Through Activating 67-kDa Laminin Receptor/cGMP Signaling
inferredcites →https://doi.org/10.3390/cancers11070916openalex-snapshot
Exploiting Mitochondrial Vulnerabilities to Trigger Apoptosis Selectively in Cancer Cells
inferredcites →https://doi.org/10.3390/ijms161226126openalex-snapshot
Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects
inferredcites →https://doi.org/10.5493/wjem.v6.i1.21openalex-snapshot
Hepatocellular carcinoma: Where are we?
inferredcites →https://doi.org/10.5740/jaoacint.18-0303openalex-snapshot
Advances in Processing and Quality Control of Traditional Chinese Medicine Coptidis rhizoma (Huanglian): A Review
inferredcites →https://doi.org/10.7314/apjcp.2014.15.14.5747openalex-snapshot
Suppression of Human Breast Cancer Cell Metastasis by Coptisine in Vitro

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4181905openalex-extracted
inferred← citeshttps://doi.org/10.1002/cbdv.202501905openalex-snapshot
Discovery and Evaluation of Oxazole‐Pyrimidine‐Isoquinoline Amides as Anticancer Leads
inferred← citeshttps://doi.org/10.1002/ddr.70071openalex-snapshot
Anticancer and Anti‐Inflammatory Potential of Coptisine as a Planar Quaternary Benzo[C]Phenanthridine Alkaloid With G‐Quadruplex DNA Telomeric Induction Activity
inferred← citeshttps://doi.org/10.1002/fsn3.3817openalex-snapshot
Resveratrol prevents age‐related heart impairment through inhibiting the Notch/ NF‐κB pathway
inferred← citeshttps://doi.org/10.1007/s00210-024-03765-6openalex-snapshot
Coptisine inhibits esophageal carcinoma growth by modulating pyroptosis via inhibition of HGF/c-Met signaling
inferred← citeshttps://doi.org/10.1007/s12668-024-01658-9openalex-snapshot
Study of Characterization, Antimicrobial, and Anticancer Potential of Albumin-Baicalin Nanoparticles in Hep3B Liver Cancer Cell Lines
inferred← citeshttps://doi.org/10.1016/j.abb.2020.108688openalex-snapshot
Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells
inferred← citeshttps://doi.org/10.1016/j.indcrop.2023.117029openalex-snapshot
Integrated extraction-purification and anti-inflammatory activity of berberine-rich extracts from Coptis chinensis Franch
inferred← citeshttps://doi.org/10.1016/j.jbior.2024.101032openalex-snapshot
The potential of the nutraceutical berberine in the treatment of hepatocellular carcinoma and other liver diseases such as NAFLD and NASH
inferred← citeshttps://doi.org/10.1016/j.jep.2023.117008openalex-snapshot
Integrating network analysis and pharmacokinetics to investigate the mechanisms of Danzhi Tiaozhi Decoction in metabolic-associated fatty liver disease (MAFLD)
inferred← citeshttps://doi.org/10.1016/j.jff.2023.105949openalex-snapshot
Methodical selected coptisine attenuates the malignancy of cholangiocarcinoma through the blockade of EGFR signalling
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108593openalex-snapshot
Berberine prevents NAFLD and HCC by modulating metabolic disorders
inferred← citeshttps://doi.org/10.1016/s1875-5364(25)60848-xopenalex-snapshot
The role of 8-OxoG and its repair systems in liver diseases progression: responsible mechanisms and promising natural products
inferred← citeshttps://doi.org/10.1080/17568919.2024.2350878openalex-snapshot
Design, semi-synthesis and bioevaluation of koumine-like derivatives as potential antitumor agents in vitro and in vivo
inferred← citeshttps://doi.org/10.1080/19490976.2022.2163838openalex-snapshot
An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors
inferred← citeshttps://doi.org/10.1142/s0192415x2350091xopenalex-snapshot
Coptisine, the Characteristic Constituent from Coptis chinensis , Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases
inferred← citeshttps://doi.org/10.1159/000542578openalex-snapshot
Immunometabolic Targets in CD8+ T Cells within the Tumor Microenvironment of Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1186/s12935-021-02085-6openalex-snapshot
Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment
inferred← citeshttps://doi.org/10.1186/s12967-026-08441-2openalex-snapshot
Gamabufotalin suppresses pancreatic cancer through redox-homeostasis disruption by G6PD downregulation
inferred← citeshttps://doi.org/10.1186/s13018-020-02043-4openalex-snapshot
MicroRNA-497-5p stimulates osteoblast differentiation through HMGA2-mediated JNK signaling pathway
inferred← citeshttps://doi.org/10.1186/s41182-023-00502-2openalex-snapshot
Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents
inferred← citeshttps://doi.org/10.26524/krj.2022.13openalex-snapshot
Evaluation of antimicrobial and antioxidant activity of cleome gynandra l. and assess its anticancer activity against in vitro cancer model
inferred← citeshttps://doi.org/10.3389/fphar.2022.806175openalex-snapshot
Induction of Apoptosis by Metabolites of Rhei Radix et Rhizoma (Da Huang): A Review of the Potential Mechanism in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3390/applbiosci5020023openalex-snapshot
Harnessing the Anticancer Potential of Plant Alkaloids Through Green Extraction Technologies
inferred← citeshttps://doi.org/10.3390/ijms22041653openalex-snapshot
The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
inferred← citeshttps://doi.org/10.3390/ijms22094797openalex-snapshot
ROS-Mediated Anti-Tumor Effect of Coptidis Rhizoma against Human Hepatocellular Carcinoma Hep3B Cells and Xenografts
inferred← citeshttps://doi.org/10.3390/ijms231810330openalex-snapshot
Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells
inferred← citeshttps://doi.org/10.3390/pr14071099openalex-snapshot
Integrated In Silico Profiling of Chelidonium majus Alkaloids Identifies Potential Anti-Melanoma Candidates
inferred← citeshttps://doi.org/10.6084/m9.figshare.22605398openalex-snapshot
Additional file 1 of Anti-Trypanosoma cruzi activity of Coptis rhizome extract and its constituents
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