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Apoptosis and Molecular Targeting Therapy in Cancer
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Retraction Watch lists this work as retracted (export 2026-10-28; notice 2020-08-30, 10.1155/2020/2451249). OpenCitations Index CSV, figshare 24356626 v8 (2026-09-08) records 969 citing works; 422 have dates after the notice under the dataset’s date-resolution rule.
1 of the 200 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1038/ncb950 (notice 2007-04-01).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ijc.1637openalex-snapshotP53 overexpression predicts poor chemosensitivity to high‐dose 5‐fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection
inferredcites →https://doi.org/10.1002/jcp.20295openalex-snapshotAntisense clusterin oligodeoxynucleotides increase the response of HER‐2 gene amplified breast cancer cells to Trastuzumab
inferredcites →https://doi.org/10.1006/gyno.1998.5094openalex-snapshotImmunophenotype of Ovarian Cancer as Predictor of Clinical Outcome: Evaluation at Primary Surgery and Second-Look Procedure
inferredcites →https://doi.org/10.1007/s00280-004-0865-3openalex-snapshotPharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2-dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts
inferredcites →https://doi.org/10.1007/s00345-004-0474-0openalex-snapshotUse of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer
inferredcites →https://doi.org/10.1007/s004320000181openalex-snapshotFas receptor counterattack against tumor-infiltrating lymphocytes in vivo as a mechanism of immune escape in gastric carcinoma
inferredcites →https://doi.org/10.1016/0006-2952(96)00035-4openalex-snapshotImmunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells
inferredcites →https://doi.org/10.1016/j.dnarep.2009.11.010openalex-snapshotDefining the DNA mismatch repair-dependent apoptotic pathway in primary cells: Evidence for p53-independence and involvement of centrosomal caspase 2
inferredcites →https://doi.org/10.1016/j.urology.2006.03.017openalex-snapshotExpression of clusterin in prostate cancer correlates with gleason score but not with prognosis in patients undergoing radical prostatectomy without neoadjuvant hormonal therapy
inferredcites →https://doi.org/10.1016/j.ygyno.2007.11.026openalex-snapshotClusterin expression predicts survival of invasive cervical cancer patients treated with radical hysterectomy and systematic lymphadenectomy
inferredcites →https://doi.org/10.1016/s0006-2952(02)00931-0openalex-snapshotBasal levels and patterns of anticancer drug-induced activation of nuclear factor-κB (NF-κB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells
inferredcites →https://doi.org/10.1016/s0026-895x(24)12090-1openalex-snapshotSynergistic Induction of Apoptosis in Human Myeloid Leukemia Cells by Phorbol 12-Myristate 13-Acetate and Flavopiridol Proceeds via Activation of Both the Intrinsic and Tumor Necrosis Factor-Mediated Extrinsic Cell Death Pathways
inferredcites →https://doi.org/10.1021/jm701018hopenalex-snapshot4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
inferredcites →https://doi.org/10.1021/jm900357yopenalex-snapshotCombining Hit Identification Strategies: Fragment-Based and in Silico Approaches to Orally Active 2-Aminothieno[2,3-d]pyrimidine Inhibitors of the Hsp90 Molecular Chaperone
inferredcites →https://doi.org/10.1021/mp900015yopenalex-snapshotThe First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic
inferredcites →https://doi.org/10.1038/sj.bjc.6605683openalex-snapshotNovel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction
inferredcites →https://doi.org/10.1038/sj.cdd.4400629openalex-snapshotDistinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis
inferredcites →https://doi.org/10.1038/sj.cdd.4401384openalex-snapshotHuman αA- and αB-crystallins bind to Bax and Bcl-XS to sequester their translocation during staurosporine-induced apoptosis
inferredcites →https://doi.org/10.1038/sj.onc.1205704openalex-snapshotNovel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil
inferredcites →https://doi.org/10.1073/pnas.88.19.8577openalex-snapshotHuman gliomas and epileptic foci express high levels of a mRNA related to rat testicular sulfated glycoprotein 2, a purported marker of cell death.
inferredcites →https://doi.org/10.1074/jbc.270.1.387openalex-snapshotSelf-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects
inferredcites →https://doi.org/10.1074/jbc.m109.091645openalex-snapshotInhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin
inferredcites →https://doi.org/10.1074/jbc.m412569200openalex-snapshotDelayed Activation of Insulin-like Growth Factor-1 Receptor/Src/MAPK/Egr-1 Signaling Regulates Clusterin Expression, a Pro-survival Factor
inferredcites →https://doi.org/10.1080/09553000400029460openalex-snapshotHeat shock protein 90 (Hsp90) chaperone complex inhibitor, Radicicol, potentiated radiation-induced cell killing in a hormone-sensitive prostate cancer cell line through degradation of the androgen receptor
inferredcites →https://doi.org/10.1093/emboj/17.2.609openalex-snapshotKu protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double‐strand breaks
inferredcites →https://doi.org/10.1101/gad.14.8.927openalex-snapshotBASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
inferredcites →https://doi.org/10.1101/gad.897601openalex-snapshotBH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4089878openalex-extractedKi-67 Proliferation Index in Fine Needle Aspiration to Predict the Tumor Biological Aggressiveness in Pancreatic Neuroendocrine Tumors
inferred← citeshttps://doi.org/10.1002/bab.1918openalex-snapshotDi‐2‐picolylamine triggers caspase‐independent apoptosis by inducing oxidative stress in human liver hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1002/biof.1940openalex-snapshotIsolation and characterization of N ‐( 2‐Hydroxyethyl )hexadecanamide from Colletotrichum gloeosporioides with apoptosis‐inducing potential in breast cancer cells
inferred← citeshttps://doi.org/10.1002/biof.2058openalex-snapshotNerolidol rescues hippocampal injury of diabetic rats through inhibiting NLRP3 inflammasome and regulation of MAPK / AKT pathway
inferred← citeshttps://doi.org/10.1002/cam4.2206openalex-snapshotMetformin and 4SC‐202 synergistically promote intrinsic cell apoptosis by accelerating ΔNp63 ubiquitination and degradation in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1002/cam4.2409openalex-snapshotIn Vitro and in Vivo antitumor activity and the mechanism of siphonodictyal B in human colon cancer cells
inferred← citeshttps://doi.org/10.1002/cbdv.201700223openalex-snapshotSynthesis and Biological Evaluation of Novel 1‐(4‐(Hydroxy(1‐oxo‐1,3‐dihydro‐2H‐inden‐2‐ylidene)methyl)phenyl)‐3‐phenylurea Derivatives
inferred← citeshttps://doi.org/10.1002/cbf.3266openalex-snapshotGold nanoparticles–conjugated quercetin induces apoptosis via inhibition of EGFR/PI3K/Akt–mediated pathway in breast cancer cell lines (MCF‐7 and MDA‐MB‐231)
inferred← citeshttps://doi.org/10.1002/cbic.202400373openalex-snapshotDeciphering the Effect of a Cu(II)‐hydrazone Complex on Intracellular Cell Signalling Pathways in a Human Osteosarcoma 2D and 3D Models
inferred← citeshttps://doi.org/10.1002/cmdc.202100520openalex-snapshotAnticancer Activity and Mechanism of Action Evaluation of an Acylhydrazone Cu(II) Complex toward Breast Cancer Cells, Spheroids, and Mammospheres
inferred← citeshttps://doi.org/10.1002/cre2.668openalex-snapshotEvaluation of P53 protein expression in gingival tissues of patients with chronic periodontitis by immunohistochemistry methods
inferred← citeshttps://doi.org/10.1002/ddr.22174openalex-snapshotInvestigation of apoptotic effects of Cucurbitacin D, I, and E mediated by Bax/Bcl‐xL, caspase‐3/9, and oxidative stress modulators in HepG2 cell line
inferred← citeshttps://doi.org/10.1002/hsr2.72406openalex-snapshotCyclooxygenase‐2 (COX‐2) as a Potential Prognostic Marker in Oral Squamous Cell Carcinoma: A Systematic Review and Meta‐Analysis
inferred← citeshttps://doi.org/10.1002/iub.2827openalex-snapshotKaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP ‐1 expression, and the STAT3 pathway
inferred← citeshttps://doi.org/10.1002/jbt.22403openalex-snapshotA ginger derivative, zingerone—a phenolic compound—induces ROS‐mediated apoptosis in colon cancer cells (HCT‐116)
inferred← citeshttps://doi.org/10.1002/jbt.22574openalex-snapshotRetracted : Syringic acid modulates molecular marker–involved cell proliferation, survival, apoptosis, inflammation, and angiogenesis in DMBA‐induced oral squamous cell carcinoma in Syrian hamsters
inferred← citeshttps://doi.org/10.1002/jbt.22611openalex-snapshotZingerone suppresses cell proliferation via inducing cellular apoptosis and inhibition of the PI3K/AKT/mTOR signaling pathway in human prostate cancer PC‐3 cells
inferred← citeshttps://doi.org/10.1002/jbt.22857openalex-snapshotArbutin exerts anticancer activity against rat C6 glioma cells by inducing apoptosis and inhibiting the inflammatory markers and P13/Akt/mTOR cascade
inferred← citeshttps://doi.org/10.1002/jbt.23005openalex-snapshotNovel boron‐containing compound, halogenated boroxine, induces selective cytotoxicity through apoptosis triggering in UT‐7 leukemia
inferred← citeshttps://doi.org/10.1002/jcb.27887openalex-snapshotPutative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand–mediated triple negative breast cancer cell death
inferred← citeshttps://doi.org/10.1002/jcb.28968openalex-snapshotMagnolol induces apoptosis in osteosarcoma cells via G0/G1 phase arrest and p53‐mediated mitochondrial pathway
inferred← citeshttps://doi.org/10.1002/mc.22718openalex-snapshotMetformin incombination with curcumin inhibits the growth, metastasis, and angiogenesis of hepatocellular carcinoma in vitro and in vivo
inferred← citeshttps://doi.org/10.1002/pros.23843openalex-snapshotTargeting prosurvival BCL2 signaling through Akt blockade sensitizes castration‐resistant prostate cancer cells to enzalutamide
inferred← citeshttps://doi.org/10.1002/ptr.5497openalex-snapshotHarmine Hydrochloride Triggers G2 Phase Arrest and Apoptosis in MGC-803 Cells and SMMC-7721 Cells by Upregulating p21, Activating Caspase-8/Bid, and Downregulating ERK/Bad Pathway
inferred← citeshttps://doi.org/10.1002/rmv.2054openalex-snapshotCharacteristics of herpes simplex virus infection and pathogenesis suggest a strategy for vaccine development
inferred← citeshttps://doi.org/10.1002/slct.202004442openalex-snapshotNew Anticancer Agents: Design, Synthesis, Biological Activity, and Molecular Docking of Bicyclic Phloroglucinol Derivatives
inferred← citeshttps://doi.org/10.1002/slct.202403076openalex-snapshotTherapeutic Potential Of M@B 40 (M = Mg and Ca) Fullerene as a Drug Delivery System for Gemcitabine Anti‐Lung Cancer Drug: A DFT Approach
inferred← citeshttps://doi.org/10.1002/tox.22915openalex-snapshotDNA methylation changes of apoptotic genes in organogenesis stage of mice embryos by maternal chlorpyrifos induction
inferred← citeshttps://doi.org/10.1002/tox.23319openalex-snapshotLuteolin‐7‐O ‐glucoside inhibits cell proliferation and modulates apoptosis through the AKT signaling pathway in human nasopharyngeal carcinoma
inferred← citeshttps://doi.org/10.1007/s00044-017-1932-8openalex-snapshotSynthesis, characterization and biological evaluation of some new indomethacin analogs with a colon tumor cell growth inhibitory activity
inferred← citeshttps://doi.org/10.1007/s00044-022-03004-8openalex-snapshotNovel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as antiproliferative and apoptotic agents
inferred← citeshttps://doi.org/10.1007/s00210-018-1584-3openalex-snapshotCucurbitacin B induces mitochondrial-mediated apoptosis pathway in cholangiocarcinoma cells via suppressing focal adhesion kinase signaling
inferred← citeshttps://doi.org/10.1007/s00289-025-05996-wopenalex-snapshotSynergistic anticancer, inflammatory, and antioxidant effect of piperine and chrysin combination loaded on lipid-polymer hybrid nanoparticles
inferred← citeshttps://doi.org/10.1007/s00343-019-8193-yopenalex-snapshotAntiproliferative and apoptosis-inducing potential of 3β-hydroxy-Δ5-steroidal congeners purified from the soft coral Dendronephthya putteri
inferred← citeshttps://doi.org/10.1007/s00441-021-03484-xopenalex-snapshotRetraction Note to: CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model
inferred← citeshttps://doi.org/10.1007/s00709-017-1137-5openalex-snapshotSelective induction of DNA damage, G2 abrogation, and mitochondrial apoptosis by leaf extract of traditional medicinal plant Wrightia arborea in K562 cells
inferred← citeshttps://doi.org/10.1007/s10120-021-01210-8openalex-snapshotSynergism of rMV-Hu191 with cisplatin to treat gastric cancer by acid sphingomyelinase-mediated apoptosis requiring integrity of lipid raft microdomains
inferred← citeshttps://doi.org/10.1007/s10534-018-0117-3openalex-snapshotVanadium quercetin complex attenuates mammary cancer by regulating the P53, Akt/mTOR pathway and downregulates cellular proliferation correlated with increased apoptotic events
inferred← citeshttps://doi.org/10.1007/s10585-023-10202-0openalex-snapshotRepurposing fluphenazine to suppress melanoma brain, lung and bone metastasis by inducing G0/G1 cell cycle arrest and apoptosis and disrupting autophagic flux
inferred← citeshttps://doi.org/10.1007/s10616-018-0287-4openalex-snapshotExpression of P53, BAX, and BCL-2 in human malignant melanoma and squamous cell carcinoma cells after tea tree oil treatment in vitro
inferred← citeshttps://doi.org/10.1007/s10911-019-09428-0openalex-snapshotRETRACTED ARTICLE: Inhibition of Tumor Progression by NG-Nitro-L-arginine Methyl Ester in 7,12- dimethylbenz(a)anthracene Induced Breast Cancer: Nitric Oxide Synthase Inhibition as an Antitumor Prevention
inferred← citeshttps://doi.org/10.1007/s11030-018-9865-9openalex-snapshotDesign, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents
inferred← citeshttps://doi.org/10.1007/s11033-020-05455-xopenalex-snapshotCisplatin and farnesol co-encapsulated PLGA nano-particles demonstrate enhanced anti-cancer potential against hepatocellular carcinoma cells in vitro
inferred← citeshttps://doi.org/10.1007/s11033-021-06136-zopenalex-snapshotDeciphering the molecular pathways of apoptosis using purified fractions from leaf extract of Basella alba through studying the regulation of apoptosis related genes
inferred← citeshttps://doi.org/10.1007/s11064-018-2551-6openalex-snapshotThe Extract of Leonurus sibiricus Transgenic Roots with AtPAP1 Transcriptional Factor Induces Apoptosis via DNA Damage and Down Regulation of Selected Epigenetic Factors in Human Cancer Cells
inferred← citeshttps://doi.org/10.1007/s12010-023-04450-9openalex-snapshotOctyl Gallate and Gallic Acid Isolated from Terminalia bellirica Circumvent Breast Cancer Progression by Enhancing the Intrinsic Apoptotic Signaling Pathway and Elevating the Levels of Anti-oxidant Enzymes
inferred← citeshttps://doi.org/10.1007/s12012-021-09655-0openalex-snapshotPhloretin Alleviates Arsenic Trioxide-Induced Apoptosis of H9c2 Cardiomyoblasts via Downregulation in Ca2+/Calcineurin/NFATc Pathway and Inflammatory Cytokine Release
inferred← citeshttps://doi.org/10.1007/s12032-014-0444-3openalex-snapshotSHARPIN overexpression induces tumorigenesis in human prostate cancer LNCaP, DU145 and PC-3 cells via NF-κB/ERK/Akt signaling pathway
inferred← citeshttps://doi.org/10.1007/s12253-016-0054-9openalex-snapshotDiindolylmethane and Lupeol Modulates Apoptosis and Cell Proliferation in N-Butyl-N-(4-Hydroxybutyl) Nitrosamine Initiated and Dimethylarsinic Acid Promoted rat Bladder Carcinogenesis
inferred← citeshttps://doi.org/10.1007/s12668-024-01438-5openalex-snapshotPropolis Nanoparticles Combined with Gamma-Irradiation Enhance the Potency of Anticancer Against HepG2 Cell Lines: Invitro Investigation
inferred← citeshttps://doi.org/10.1007/s12672-025-02409-2openalex-snapshotMagnolol and its semi-synthetic derivatives: a comprehensive review of anti-cancer mechanisms, pharmacokinetics, and future therapeutic potential
inferred← citeshttps://doi.org/10.1007/s13205-026-04759-2openalex-snapshotTumor-suppressing efficacy of essential oil of Boswellia serrata gum resin and its synergistic effect on doxorubicin-induced growth inhibition of breast cancer cells
inferred← citeshttps://doi.org/10.1007/s13205-026-04943-4openalex-snapshotZeylenone-mediated inhibition of TIMP-1-induced Bax/Bcl-2/Cle-caspase-3 expression and apoptosis via FAK-PI3K/AKT pathway regulation in thyroid cancer cells: in vitro and in silico study
inferred← citeshttps://doi.org/10.1007/s13258-020-00987-9openalex-snapshotTrans-cinnamaldehyde protects C2C12 myoblasts from DNA damage, mitochondrial dysfunction and apoptosis caused by oxidative stress through inhibiting ROS production
inferred← citeshttps://doi.org/10.1007/s13273-020-00102-9openalex-snapshotIndole-6-carboxaldehyde prevents oxidative stress-induced mitochondrial dysfunction, DNA damage and apoptosis in C2C12 skeletal myoblasts by regulating the ROS-AMPK signaling pathway
inferred← citeshttps://doi.org/10.1007/s13277-015-3575-zopenalex-snapshotMST-312 induces G2/M cell cycle arrest and apoptosis in APL cells through inhibition of telomerase activity and suppression of NF-κB pathway
inferred← citeshttps://doi.org/10.1007/s13277-015-4176-6openalex-snapshotHesperetin induces apoptosis of esophageal cancer cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species
inferred← citeshttps://doi.org/10.1007/s13402-018-0398-0openalex-snapshotMetformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)
inferred← citeshttps://doi.org/10.1007/s13402-019-00473-9openalex-snapshotAnti-tumor activity of cediranib, a pan-vascular endothelial growth factor receptor inhibitor, in pancreatic ductal adenocarcinoma cells
inferred← citeshttps://doi.org/10.1007/s43994-023-00058-1openalex-snapshotEfficacy of Prunus armenica, Bee venom, and their combinations on p53 and Bcl-2 gene expression in human pancreatic and lung cancer cells
inferred← citeshttps://doi.org/10.1007/s44279-025-00161-3openalex-snapshotAssessing genetic diversity and population structure of f4:f5 wheat genotypes using morphological and microsatellite markers under heat stress
inferred← citeshttps://doi.org/10.1016/j.abb.2020.108512openalex-snapshotHemistepsin A protects human keratinocytes against hydrogen peroxide-induced oxidative stress through activation of the Nrf2/HO-1 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.amsu.2021.02.010openalex-snapshotThe relationship between NFKB, HER2, ER expression and anthracycline -based neoadjuvan chemotherapy response in local advanced stadium breast cancer: A cohort study in Eastern Indonesia
inferred← citeshttps://doi.org/10.1016/j.anndiagpath.2023.152149openalex-snapshotImproving fine needle aspiration to predict the tumor biological aggressiveness in pancreatic neuroendocrine tumors using Ki-67 proliferation index, phosphorylated histone H3 (PHH3), and BCL-2
inferred← citeshttps://doi.org/10.1016/j.arabjc.2022.103844openalex-snapshotChitosan-sodium alginate-polyethylene glycol-crocin nanocomposite treatment inhibits esophageal cancer KYSE-150 cell growth via inducing apoptotic cell death
inferred← citeshttps://doi.org/10.1016/j.arabjc.2022.104307openalex-snapshotThe effect of magnetic nanoparticles containing hyaluronic acid and methotrexate on the expression of genes involved in apoptosis and metastasis in A549 lung cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.02.063openalex-snapshotAntibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress
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