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Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors

https://doi.org/10.3390/molecules23040719
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbdv.201200144openalex-snapshot
Alkaloids from Zephyranthes robusta Baker and Their Acetylcholinesterase‐ and Butyrylcholinesterase‐Inhibitory Activity
inferredcites →https://doi.org/10.1002/med.20119openalex-snapshot
Preclinical efficacy on GSK‐3 inhibitors: Towards a future generation of powerful drugs
inferredcites →https://doi.org/10.1007/s11064-006-9128-5openalex-snapshot
Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics
inferredcites →https://doi.org/10.1007/s12272-017-1000-4openalex-snapshot
Alkaloids from Narcissus poeticus cv. Pink Parasol of various structural types and their biological activity
inferredcites →https://doi.org/10.1016/j.bmc.2009.01.019openalex-snapshot
Design, synthesis and structure–activity relationships of 1,3,4-oxadiazole derivatives as novel inhibitors of glycogen synthase kinase-3β
inferredcites →https://doi.org/10.1016/j.bmcl.2004.01.050openalex-snapshot
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
inferredcites →https://doi.org/10.1016/j.canlet.2008.05.045openalex-snapshot
Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy
inferredcites →https://doi.org/10.1016/j.ejmech.2015.10.018openalex-snapshot
Pivotal role of glycogen synthase kinase-3: A therapeutic target for Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.ejmech.2017.11.103openalex-snapshot
Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions
inferredcites →https://doi.org/10.1016/j.phytol.2015.08.004openalex-snapshot
Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells
inferredcites →https://doi.org/10.1016/j.phytol.2016.09.007openalex-snapshot
GSK-3β inhibitory activities of novel dichroloresorcinol derivatives from Cosmospora vilior isolated from a mangrove plant
inferredcites →https://doi.org/10.1016/s0040-4039(00)86943-9openalex-snapshot
Isolation and X-ray crystal structure of a novel bromo-compound from two marine sponges
inferredcites →https://doi.org/10.1016/s0960-894x(02)00169-5openalex-snapshot
Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors
inferredcites →https://doi.org/10.1016/s0960-894x(03)00134-3openalex-snapshot
5-Aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
inferredcites →https://doi.org/10.1016/s0960-894x(03)00135-5openalex-snapshot
5-Aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
inferredcites →https://doi.org/10.1016/s1074-5521(00)00025-9openalex-snapshot
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
inferredcites →https://doi.org/10.1016/s1074-5521(00)00063-6openalex-snapshot
Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent
inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00191openalex-snapshot
In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood–Brain Barrier
inferredcites →https://doi.org/10.1021/jm011020uopenalex-snapshot
First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease
inferredcites →https://doi.org/10.1021/np060092ropenalex-snapshot
Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure–Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease
inferredcites →https://doi.org/10.1038/35096075openalex-snapshot
The renaissance of GSK3
inferredcites →https://doi.org/10.1038/nature01640openalex-snapshot
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
inferredcites →https://doi.org/10.1038/nn.2583openalex-snapshot
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
inferredcites →https://doi.org/10.1038/srep42957openalex-snapshot
Cancer Cell Mitochondria Targeting by Pancratistatin Analogs is Dependent on Functional Complex II and III
inferredcites →https://doi.org/10.1039/c6ra20205eopenalex-snapshot
Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson and their biological activities
inferredcites →https://doi.org/10.1046/j.1432-1327.2000.01673.xopenalex-snapshot
Paullones are potent inhibitors of glycogen synthase kinase‐3β and cyclin‐dependent kinase 5/p25
inferredcites →https://doi.org/10.1046/j.1471-4159.2000.0741878.xopenalex-snapshot
Mutant Presenilin 1 Increases the Levels of Alzheimer Amyloid β‐Peptide Aβ42 in Late Compartments of the Constitutive Secretory Pathway
inferredcites →https://doi.org/10.1074/jbc.m111.306472openalex-snapshot
Evidence for Irreversible Inhibition of Glycogen Synthase Kinase-3β by Tideglusib
inferredcites →https://doi.org/10.1074/jbc.m603469200openalex-snapshot
The Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation
inferredcites →https://doi.org/10.1089/adt.2006.029openalex-snapshot
A High Throughput Luminescent Assay for Glycogen Synthase Kinase-3 β Inhibitors
inferredcites →https://doi.org/10.1096/fj.10-162263openalex-snapshot
Targeting of eEF1A with Amaryllidaceae isocarbostyrils as a strategy to combat melanomas
inferredcites →https://doi.org/10.1111/j.1476-5381.2010.00661.xopenalex-snapshot
GSK3β: role in therapeutic landscape and development of modulators
inferredcites →https://doi.org/10.1161/circresaha.116.303613openalex-snapshot
The GSK-3 Family as Therapeutic Target for Myocardial Diseases
inferredcites →https://doi.org/10.1177/1934578x1300801110openalex-snapshot
Alkaloids from Chlidanthus fragrans and their Acetylcholinesterase, Butyrylcholinesterase and Prolyl Oligopeptidase Activities
inferredcites →https://doi.org/10.1177/1934578x1400900614openalex-snapshot
Revised NMR Data for 9- O -Demethylgalanthine: An Alkaloid from Zephyranthes robusta (Amaryllidaceae) and its Biological Activity
inferredcites →https://doi.org/10.1177/1934578x1400900823openalex-snapshot
Chemical Composition of Bioactive Alkaloid Extracts from Some Narcissus Species and Varieties and their Biological Activity
inferredcites →https://doi.org/10.1248/cpb.31.2321openalex-snapshot
Marine natural products. XII. On the chemical constituents of the Okinawan marine sponge Hymeniacidon aldis.
inferredcites →https://doi.org/10.1254/jphs.11r01cropenalex-snapshot
Pharmacological Aspects of the Acetylcholinesterase Inhibitor Galantamine
inferredcites →https://doi.org/10.1269/jrr.11098openalex-snapshot
Acquired Radioresistance of Cancer and the AKT/GSK3β/cyclin D1 Overexpression Cycle
inferredcites →https://doi.org/10.1523/jneurosci.4321-06.2007openalex-snapshot
Neuroprotective Effects of Regulators of the Glycogen Synthase Kinase-3β Signaling Pathway in a Transgenic Model of Alzheimer's Disease Are Associated with Reduced Amyloid Precursor Protein Phosphorylation
inferredcites →https://doi.org/10.18632/oncotarget.2037openalex-snapshot
GSK-3 as potential target for therapeutic intervention in cancer
inferredcites →https://doi.org/10.2174/1389450110607011421openalex-snapshot
Glycogen Synthase Kinase-3 (GSK3) in Psychiatric Diseases and Therapeutic Interventions
inferredcites →https://doi.org/10.2174/1389450110607011435openalex-snapshot
Role of Glycogen Synthase Kinase-3 in Insulin Resistance and Type 2 Diabetes
inferredcites →https://doi.org/10.3233/jad-2012-120805openalex-snapshot
Treatment of Alzheimer's Disease with the GSK-3 Inhibitor Tideglusib: A Pilot Study
inferredcites →https://doi.org/10.3390/molecules200813854openalex-snapshot
Antiproliferative and Structure Activity Relationships of Amaryllidaceae Alkaloids
inferredcites →https://doi.org/10.7150/thno.14334openalex-snapshot
Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2019.112055zenodo-depositor-declared
Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1007/978-981-15-2361-8_5openalex-snapshot
Plant Alkaloids: Structures and Bioactive Properties
inferred← citeshttps://doi.org/10.1007/s00706-020-02718-yopenalex-snapshot
An updated research of glycogen synthase kinase-3β inhibitors: a review
inferred← citeshttps://doi.org/10.1007/s11101-020-09675-8openalex-snapshot
The Amaryllidaceae alkaloids haemanthamine, haemanthidine and their semisynthetic derivatives as potential drugs
inferred← citeshttps://doi.org/10.1007/s11101-021-09790-0openalex-snapshot
The Amaryllidaceae alkaloids: an untapped source of acetylcholinesterase inhibitors
inferred← citeshttps://doi.org/10.1007/s11101-025-10122-9openalex-snapshot
Cytotoxic crinane alkaloids of the Amaryllidaceae: in vitro, in vivo and in silico effects, structure–activity relationships and mechanisms of action
inferred← citeshttps://doi.org/10.1016/bs.alkal.2019.10.002openalex-snapshot
Chemodiversity, chemotaxonomy and chemoecology of Amaryllidaceae alkaloids
inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114675openalex-snapshot
Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3β signaling pathway
inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108619openalex-snapshot
Cytotoxic lycorine alkaloids of the plant family Amaryllidaceae
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.07.147openalex-snapshot
Lycorine: A prospective natural lead for anticancer drug discovery
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.12.013openalex-snapshot
Neuroprotection and improvement of the histopathological and behavioral impairments in a murine Alzheimer’s model treated with Zephyranthes carinata alkaloids
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.116065openalex-snapshot
Targeting glycogen synthase kinase-3β for Alzheimer's disease: Recent advances and future Prospects
inferred← citeshttps://doi.org/10.1016/j.ejphar.2024.176816openalex-snapshot
Evolving significance of kinase inhibitors in the management of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.fct.2019.110665openalex-snapshot
Neuroprotective activity of isoquinoline alkaloids from of Chilean Amaryllidaceae plants against oxidative stress-induced cytotoxicity on human neuroblastoma SH-SY5Y cells and mouse hippocampal slice culture
inferred← citeshttps://doi.org/10.1016/j.heliyon.2025.e42580openalex-snapshot
Antiviral alkaloids from Crinum jagus: Extraction, synergistic effects, and activity against dengue virus and human coronavirus OC43
inferred← citeshttps://doi.org/10.1016/j.imu.2024.101509openalex-snapshot
Phytoconstituents of Terminalia catappa linn fruits extract exhibit promising antidiabetic activities against α-amylase and α-glucosidase in vitro and in silico
inferred← citeshttps://doi.org/10.1016/j.intimp.2019.106114openalex-snapshot
Antitumor effect of baicalin from the Scutellaria baicalensis radix extract in B-acute lymphoblastic leukemia with different chromosomal rearrangements
inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.113017openalex-snapshot
Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.sajb.2020.07.002openalex-snapshot
Cytotoxic tazettine alkaloids of the plant family Amaryllidaceae
inferred← citeshttps://doi.org/10.1016/j.sajb.2020.07.013openalex-snapshot
The plant family Amaryllidaceae as a source of cytotoxic homolycorine alkaloid principles
inferred← citeshttps://doi.org/10.1021/acs.orglett.1c00974openalex-snapshot
Pd-Catalyzed Enantioselective Dicarbofunctionalization of Alkene to Access Disubstituted Dihydroisoquinolinone
inferred← citeshttps://doi.org/10.1021/acs.orglett.6c02414openalex-snapshot
Chiral Monodentate Phosphine Ligand for Palladium-Catalyzed Enantioselective Cascade Arylvinylation of Alkenes with N -Tosylhydrazones
inferred← citeshttps://doi.org/10.1021/acschemneuro.5c00739openalex-snapshot
Exploring the Protective Effects of Two Alkaloids 1 and 2 from Aspergillus terreus C23–3 on Neuronal Cells by Combining Bioinformatics Prediction and Experimental Verification
inferred← citeshttps://doi.org/10.1039/c9sc03406dopenalex-snapshot
Enantioselective synthesis of quaternary 3,4-dihydroisoquinolinones via Heck carbonylation reactions: development and application to the synthesis of Minalrestat analogues
inferred← citeshttps://doi.org/10.1055/a-1380-1888openalex-snapshot
Cytotoxic Agents in the Minor Alkaloid Groups of the Amaryllidaceae
inferred← citeshttps://doi.org/10.2174/1568026620666200224100219openalex-snapshot
Plant Extracts and their Secondary Metabolites as Modulators of Kinases
inferred← citeshttps://doi.org/10.3390/molecules24071307openalex-snapshot
Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/molecules26133990openalex-snapshot
Neuroprotective Activities of Crossyne flava Bulbs and Amaryllidaceae Alkaloids: Implications for Parkinson’s Disease
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Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease
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