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The War against Tuberculosis: A Review of Natural Compounds and Their Derivatives

https://doi.org/10.3390/molecules25133011
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Outgoing claims: the papers this work cites, builds on, or argues with.

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Fellutamide B is a potent inhibitor of the Mycobacterium tuberculosis proteasome
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Tea polyphenols: application in the control of oral microorganism infectious diseases
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Combined effect of epigallocatechin gallate and triclosan on enoyl-ACP reductase of Mycobacterium tuberculosis
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Green tea polyphenol inhibits Mycobacterium tuberculosis survival within human macrophages
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Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis
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Biological properties of propolis extracts: Something new from an ancient product
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Recent advances in modular co-culture engineering for synthesis of natural products
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Recent advances in natural products from plants for treatment of liver diseases
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Isocitrate lyase of Mycobacterium tuberculosis is inhibited by quercetin through binding at N-terminus
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Innovation in the pharmaceutical industry: New estimates of R&D costs
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Curcumin as a wound healing agent
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Multifactorial aspects of antimicrobial activity of propolis
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Recent advances in the diagnosis and treatment of multidrug-resistant tuberculosis
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The formation of the granuloma in tuberculosis infection
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Quercetin 3-O-glucoside recovered from the wild Egyptian Sahara plant, Euphorbia paralias L., inhibits glutamine synthetase and has antimycobacterial activity
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Artemisinin: mechanisms of action, resistance and toxicity
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Treatment of tuberculosis
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Tuberculosis
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Present-day treatment of tuberculosis and latent tuberculosis infection
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Antioxidant activity applying an improved ABTS radical cation decolorization assay
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Tuberculosis: progress and advances in development of new drugs, treatment regimens, and host-directed therapies
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Is the directly observed therapy short course (DOTS) an effective strategy for tuberculosis control in a developing country?
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Total Phenol, Catechin, and Caffeine Contents of Teas Commonly Consumed in the United Kingdom
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Controlling Tuberculosis in the United States: Recommendations from the American Thoracic Society, CDC, and the Infectious Diseases Society of America
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Molecular basis of triclosan activity
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Inhibitors selective for mycobacterial versus human proteasomes
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Diarylquinolines target subunit c of mycobacterial ATP synthase
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The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine
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Tuberculosis
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Lactacystin: first-in-class proteasome inhibitor still excelling and an exemplar for future antibiotic research
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Dissecting the mycobacterial cell envelope and defining the composition of the native mycomembrane
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Disrupting coupling within mycobacterial F-ATP synthases subunit ε causes dysregulated energy production and cell wall biosynthesis
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A plausible mechanism for the antimalarial activity of artemisinin: A computational approach
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Predicting natural product value, an exploration of anti-TB drug space
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Isoniazid affects multiple components of the type II fatty acid synthase system of Mycobacterium tuberculosis
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Latent Mycobacterium tuberculosis Infection
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Treatment of Tuberculosis
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Understanding the mechanism of proteasome 20S core particle gating
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The Mycobacterium tuberculosis Pup-proteasome system regulates nitrate metabolism through an essential protein quality control pathway
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Isoniazid Induces Apoptosis Of Activated CD4+ T Cells
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Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions
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Tannins and Human Health: A Review
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Triclosan exposure, transformation, and human health effects
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Effects of epigallocatechin gallate on the cell-wall structure ofMycobacterial smegmatismc2155
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How do we measure adherence to anti-tuberculosis treatment?
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Translating the Tuberculosis Research Agenda: Much Accomplished, but Much More to Be Done: Figure 1.
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Official American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America Clinical Practice Guidelines: Treatment of Drug-Susceptible Tuberculosis
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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children
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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children
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Cough and the Transmission of Tuberculosis
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Tuberculosis Diagnostics in 2015: Landscape, Priorities, Needs, and Prospects
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What We Know About Tuberculosis Transmission: An Overview
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Advancing Patient-Centered Care in Tuberculosis Management: A Mixed-Methods Appraisal of Video Directly Observed Therapy
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Tuberculosis in the United States: Medical Consultation Services Provided by 5 Tuberculosis Regional Training and Medical Consultation Centers, 2013–2017
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Tuberculosis Treatment and Drug Regimens
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Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis
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The Mycobacterial Cell Wall—Peptidoglycan and Arabinogalactan
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The Tuberculosis Drug Discovery and Development Pipeline and Emerging Drug Targets
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Coronin-1a inhibits autophagosome formation around Mycobacterium tuberculosis-containing phagosomes and assists mycobacterial survival in macrophages
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Green Tea Polyphenols and Cancer: Biologic Mechanisms and Practical Implications
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Curcumin enhances human macrophage control of Mycobacterium tuberculosis infection
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A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
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Global trends in antimicrobial resistance in animals in low- and middle-income countries
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What does research reproducibility mean?
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Mycobacterium tuberculosis Folate Metabolism and the Mechanistic Basis for para -Aminosalicylic Acid Susceptibility and Resistance
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A Flow Cytometry Method for Rapidly Assessing Mycobacterium tuberculosis Responses to Antibiotics with Different Modes of Action
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Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection
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Practical Guidance for Clinical Microbiology Laboratories: Mycobacteria
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Characterization of Activity and Expression of Isocitrate Lyase in Mycobacterium avium and Mycobacterium tuberculosis
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Role of the Health Department in Tuberculosis Prevention and Control—Legal and Public Health Considerations
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Encouraging News for Multidrug-resistant Tuberculosis Treatment
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Tuberculosis Elimination Efforts in the United States in the Era of Insurance Expansion and the Affordable Care Act
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Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Polymerase Discovered from High-Throughput Screening
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Second-line anti-tuberculosis drug concentrations for susceptibility testing in the MODS assay
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Treatment outcomes of patients with multidrug-resistant and extensively drug resistant tuberculosis in Hunan Province, China
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Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypes
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Factors associated with primary transmission of multidrug-resistant tuberculosis compared with healthy controls in Henan Province, China
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Factors influencing adherence to tuberculosis treatment in Asmara, Eritrea: a qualitative study
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Reproducible research practices, transparency, and open access data in the biomedical literature, 2015–2017
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Adherence to Tuberculosis Therapy among Patients Receiving Home-Based Directly Observed Treatment: Evidence from the United Republic of Tanzania
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Prevalence of anemia in pregnant women in Styria, Austria—A retrospective analysis of mother-child examinations 2006–2014
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Synergism Between Ethanolic Extract of Propolis (EEP) and Anti-Tuberculosis Drugs on Growth of Mycobacteria
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Major Infectious Diseases: Key Messages from Disease Control Priorities, Third Edition
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A great honor and a huge challenge for China: You-you TU getting the Nobel Prize in Physiology or Medicine
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Carbohydrate antigen 125 and carcinoembryonic antigen in the differentiation of tuberculous peritonitis and peritonitis carcinomatosa
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Comparative Pharmacokinetics and Pharmacodynamics of the Rifamycin Antibacterials
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Natural Products as Leads for Tuberculosis Drug Development
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Challenges Associated with Current and Future TB Treatment
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Mycobacteriosis and Tuberculosis: Laboratory Diagnosis
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Use of Smartphone-Based Video Directly Observed Therapy (vDOT) in Tuberculosis Care: Single-Arm, Prospective Feasibility Study
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Tmc207: the First Compound of A New class of Potent Anti-Tuberculosis Drugs
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Discovery and Development of SQ109: A New Antitubercular Drug with a Novel Mechanism of Action
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Double-Blind, Placebo-Controlled, 1:1 Randomized Phase III Clinical Trial Of Immunoxel Honey Lozenges as an Adjunct Immunotherapy in 269 Patients with Pulmonary Tuberculosis
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Clinical Validation of Sublingual Formulations of Immunoxel (Dzherelo) as an Adjuvant Immunotherapy in Treatment of TB Patients
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Antimicrobial activity of pomegranate fruit constituents against drug-resistantMycobacterium tuberculosisandβ-lactamase producingKlebsiella pneumoniae
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Modeling the Mycobacterium tuberculosis Granuloma – the Critical Battlefield in Host Immunity and Disease
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Nanoparticle-Formulated Curcumin Prevents Posttherapeutic Disease Reactivation and Reinfection with Mycobacterium tuberculosis following Isoniazid Therapy
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Malnutrition: Modulator of Immune Responses in Tuberculosis
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Mycobacterial Cell Wall Synthesis Inhibitors Cause Lethal ATP Burst
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Action of Dicumarol on Glucosamine-1-Phosphate Acetyltransferase of GlmU and Mycobacterium tuberculosis
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Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis
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Addressing the Challenges of Tuberculosis: A Brief Historical Account
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Chloroplast Glutamine Synthetase, the Key Regulator of Nitrogen Metabolism in Wheat, Performs Its Role by Fine Regulation of Enzyme Activity via Negative Cooperativity of Its Subunits
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Bioactive Compounds and Biological Functions of Garlic (Allium sativum L.)
inferredcites →https://doi.org/10.3390/molecules161210592openalex-snapshot
Global Chemical Composition and Antioxidant and Anti-Tuberculosis Activities of Various Extracts of Globularia alypum L. (Globulariaceae) Leaves
inferredcites →https://doi.org/10.3390/molecules22010183openalex-snapshot
Phloretin Exerts Anti-Tuberculosis Activity and Suppresses Lung Inflammation
inferredcites →https://doi.org/10.3390/nu6126020openalex-snapshot
Resources and Biological Activities of Natural Polyphenols
inferredcites →https://doi.org/10.3390/nu9060544openalex-snapshot
Tea Drinking and Its Association with Active Tuberculosis Incidence among Middle-Aged and Elderly Adults: The Singapore Chinese Health Study
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Inflammation responses in patients with pulmonary tuberculosis in an intensive care unit
inferredcites →https://doi.org/10.3892/ijo.2011.930openalex-snapshot
Ethanolic extract of Brazilian green propolis sensitizes prostate cancer cells to TRAIL-induced apoptosis
inferredcites →https://doi.org/10.4081/mr.2017.6877openalex-snapshot
Antibacterial properties of quercetin
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THE BIOLOGY OF MYCOBACTERIUM TUBERCULOSIS INFECTION.
inferredcites →https://doi.org/10.4155/fmc.11.79openalex-snapshot
Diarylquinolines, Synthesis Pathways and Quantitative Structure–Activity Relationship Studies Leading to the Discovery of TMC207
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Free tuberculosis diagnosis and treatment are not enough: patient cost evidence from three continents
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Antimycobacterial Effect of Extract and Its Components from Rheum rhaponticum
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First– and Second–Line Drugs and Drug Resistance

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Marine microbial resources: Under explored resource for anti-TB drug discovery
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The correlation between serum 25-hydroxyvitamin D3 and oxidative balance score in patients with tuberculosis infection
inferred← citeshttps://doi.org/10.1016/j.eimce.2024.09.016openalex-snapshot
The correlation between serum 25-hydroxyvitamin D3 and oxidative balance score in patients with tuberculosis infection
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114173openalex-snapshot
Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116268openalex-snapshot
Novel strategies based on natural products and synthetic derivatives to overcome resistance in Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.foodchem.2025.146964openalex-snapshot
11,12-dihydrolactaroviolin from edible mushroom Lactarius hatsudake Tanaka as a selective inhibitor of Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.1016/j.fshw.2022.10.017openalex-snapshot
A narrative review on inhibitory effects of edible mushrooms against malaria and tuberculosis-the world’s deadliest diseases
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e13324openalex-snapshot
Explicit molecular dynamics simulation studies to discover novel natural compound analogues as Mycobacterium tuberculosis inhibitors
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e35648openalex-snapshot
Exploring Indonesian actinomycete extracts for anti-tubercular compounds: Integrating inhibition assessment, genomic analysis, and prediction of its target by molecular docking
inferred← citeshttps://doi.org/10.1016/j.ijregi.2025.100665openalex-snapshot
RETRACTED: Anti-tuberculosis drug–induced hepatotoxicity and associated risk factors among patients with pulmonary tuberculosis at a tertiary care hospital in Thailand
inferred← citeshttps://doi.org/10.1016/j.ijtb.2021.09.016openalex-snapshot
In-vitro anti-Mycobacterium tuberculosis effect of Eugenol
inferred← citeshttps://doi.org/10.1016/j.jctube.2023.100399openalex-snapshot
Lymph node dissection effectively shortens the course of anti-tuberculosis treatment
inferred← citeshttps://doi.org/10.1016/j.jep.2022.115501openalex-snapshot
Safety evaluation and bioassay-guided isolation of antimycobacterial compounds from Morella salicifolia root ethanolic extract
inferred← citeshttps://doi.org/10.1016/j.jpha.2023.09.009openalex-snapshot
Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical management
inferred← citeshttps://doi.org/10.1016/j.molliq.2025.127360openalex-snapshot
Identification of novel natural inhibitors of Mycobacterium tuberculosis DNA-directed RNA polymerase via extensive computational screening and MMGBSA
inferred← citeshttps://doi.org/10.1016/j.prmcm.2025.100695openalex-snapshot
Multitarget insights into traditional Chinese phytoconstituents against tuberculosis via network pharmacology, molecular docking, and MD simulation
inferred← citeshttps://doi.org/10.1016/j.sajb.2023.11.025openalex-snapshot
Cytotoxicity and gene expression studies in understanding the mechanism on antimycobacterial properties of methanolic leaf extract of Acalypha indica Linn.
inferred← citeshttps://doi.org/10.1016/j.sjbs.2021.06.029openalex-snapshot
Association of IFN-gamma and IL-10 gene variants with the risk of extrapulmonary tuberculosis
inferred← citeshttps://doi.org/10.1016/j.snb.2026.139781openalex-snapshot
Chemiluminescence imaging platform utilizing bimetallic Prussian Blue analogues-assisted luminol-H2O2 system for Rifampicin detection
inferred← citeshttps://doi.org/10.1016/j.tice.2025.102933openalex-snapshot
Enhancing TB diagnosis: Improving specificity with scFv antibodies targeting the PPE17 epitope
inferred← citeshttps://doi.org/10.1016/j.tube.2026.102736openalex-snapshot
Targeting the antigen 85 complex of Mycobacterium tuberculosis: A three-fold validation of antimycobacterial activity of Centella asiatica
inferred← citeshttps://doi.org/10.1021/acs.biomac.1c00355openalex-snapshot
Safe Polycationic Dendrimers as Potent Oral In Vivo Inhibitors of Mycobacterium tuberculosis : A New Therapy to Take Down Tuberculosis
inferred← citeshttps://doi.org/10.1021/acsanm.5c02266openalex-snapshot
Phosphorene-Based Nanocomposite Nanozyme for Sensitive Colorimetric and Fluorescence Sensing Detection of Tuberculosis Drugs Rifampicin and Isoniazid
inferred← citeshttps://doi.org/10.1021/jacs.5c22672openalex-snapshot
Total Synthesis of iso -Gladiolin Methyl Ester (Lagriene Methyl Ester) via Catalytic Asymmetric C–C Coupling of Alcohols
inferred← citeshttps://doi.org/10.1039/d2nj04263kopenalex-snapshot
A highly sensitive and ecofriendly assay platform for the simultaneous electrochemical determination of rifampicin and isoniazid in human serum and pharmaceutical formulations
inferred← citeshttps://doi.org/10.1186/s43094-025-00906-3openalex-snapshot
Investigation of novel hybrid analogues for their antitubercular pharmacological potential
inferred← citeshttps://doi.org/10.12998/wjcc.v8.i19.4320openalex-snapshot
Impact of mTOR gene polymorphisms and gene-tea interaction on susceptibility to tuberculosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0304587openalex-snapshot
Identification of echinoderm metabolites as potential inhibitors targeting wild-type and mutant forms of Escherichia coli RNA polymerase (RpoB) for tuberculosis treatment
inferred← citeshttps://doi.org/10.18311/jnr/2022/30194openalex-snapshot
Computational Investigation of Plant-based Bioactive Compounds as Inhibitors against Tuberculosis
inferred← citeshttps://doi.org/10.18517/ijaseit.12.4.16210openalex-snapshot
Antituberculosis Activity and Iron Chelation Ability of Brazilin Isolated from Caesalpinia Sappan L.
inferred← citeshttps://doi.org/10.21203/rs.3.rs-8852481/v1openalex-snapshot
Decoding Host Immune Modulation by Mimusops elengi Using Integrated Computational Approaches
inferred← citeshttps://doi.org/10.2174/9789815079098122010008openalex-snapshot
Natural Flavonoid and Chalcone Scaffolds as Leads for Synthetic Antitubercular Agents
inferred← citeshttps://doi.org/10.2174/9789815136203124010005openalex-snapshot
Aromatherapy Evolution and Blending Basics of Essential Oils
inferred← citeshttps://doi.org/10.22270/jddt.v14i3.6475openalex-snapshot
Niosomal Drug Delivery System used in Tuberculosis
inferred← citeshttps://doi.org/10.29261/pakvetj/2023.107openalex-snapshot
Botanical Compounds: A Promising Approach to Control Mycobacterium Species of Veterinary and Zoonotic Importance
inferred← citeshttps://doi.org/10.31782/ijmps.2021.11401openalex-snapshot
Natural Extracts and Compounds for Treating Various Respiratory Disease Conditions
inferred← citeshttps://doi.org/10.32604/biocell.2021.016682openalex-snapshot
Identification of potential inhibitors for Sterol C-24 reductase of Leishmania donovani through virtual screening of natural compounds
inferred← citeshttps://doi.org/10.3389/fbinf.2026.1777858openalex-snapshot
Targeting KasA: isosakuranetin derivatives as promising scaffolds for novel anti-tuberculosis agents against drug-resistant Mycobacterium tuberculosis
inferred← citeshttps://doi.org/10.3389/fcimb.2024.1405627openalex-snapshot
The mechanism of Gejie Zhilao Pill in treating tuberculosis based on network pharmacology and molecular docking verification
inferred← citeshttps://doi.org/10.3389/fnut.2022.999752openalex-snapshot
Promising bioactive properties of quercetin for potential food applications and health benefits: A review
inferred← citeshttps://doi.org/10.3389/fphar.2025.1630134openalex-snapshot
In vitro assessment of Brazilian red propolis against mycobacteria: antibacterial potency, synergy, inhibition of biofilm formation, and intramacrophage effects
inferred← citeshttps://doi.org/10.3389/fphar.2025.1697986openalex-snapshot
Design and synthesis of natural antibacterial derivatives for ocular tuberculosis: a comprehensive review
inferred← citeshttps://doi.org/10.3390/antibiotics12040763openalex-snapshot
Synthesis, Molecular Docking Study, and Biological Evaluation of New 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N’-(2-(substituted)acetyl)benzohydrazides as Dual Enoyl ACP Reductase and DHFR Enzyme Inhibitors
inferred← citeshttps://doi.org/10.3390/antibiotics15030313openalex-snapshot
Antimicrobial Resistance in Rhodococcus equi and the Promise of Synergistic Therapies
inferred← citeshttps://doi.org/10.3390/ijms27198808openalex-snapshot
Maleylated-BSA-Coated Gold Nanopopcorns for Pulmonary Delivery of Quercetin
inferred← citeshttps://doi.org/10.3390/microorganisms11081988openalex-snapshot
The Use of Particulate Systems for Tuberculosis Prophylaxis and Treatment: Opportunities and Challenges
inferred← citeshttps://doi.org/10.3390/nano13020269openalex-snapshot
Nano-Delivery System of Ethanolic Extract of Propolis Targeting Mycobacterium tuberculosis via Aptamer-Modified-Niosomes
inferred← citeshttps://doi.org/10.3390/pr11092793openalex-snapshot
New Alternatives in the Fight against Tuberculosis: Possible Targets for Resistant Mycobacteria
inferred← citeshttps://doi.org/10.52756/bhietm.2023.e02openalex-snapshot
The Basic Handbook of Indian Ethnobotany and Traditional Medicine [Volume: 2]
inferred← citeshttps://doi.org/10.52756/bhietm.2023.e02.010openalex-snapshot
Quercetin: A Promising Bioflavonoid for Health and Healing
inferred← citeshttps://doi.org/10.52756/boesd.2023.e2openalex-snapshot
The Basic Handbook of Indian Ethnobotany and Traditional Medicine
inferred← citeshttps://doi.org/10.53555/jaz.v45i2.3817openalex-snapshot
Computational Approach To Evaluate The Potential Of Some Phytocompounds Of Flacourtia Jangomas Against Udp-Glf Enzyme Of Mycobacterium Tuberculosis (Mtb)
inferred← citeshttps://doi.org/10.5530/pres.15.2.025openalex-snapshot
Novel Approaches for the Treatment of Drug-Resistant Tuberculosis
inferred← citeshttps://doi.org/10.5772/intechopen.92916openalex-snapshot
Molecular Epidemiology Study of Mycobacterium Tuberculosis Complex
inferred← citeshttps://doi.org/10.5772/intechopen.96280openalex-snapshot
Genealogy of Resistant Tuberculosis in Latin America and the Caribbean until 2020
inferred← citeshttps://doi.org/10.59590/upsjb/fcs.med.hum/tesis/4462openalex-snapshot
Factores asociados a la adherencia al tratamiento farmacológico en pacientes con tuberculosis de 5 establecimientos de salud de DIRIS Lima Este, 2022
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