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Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers
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2 of the 55 references listed on this page are in the Retraction Watch database as retracted (export 2026-10-28): 10.1016/j.biopha.2018.09.087 (notice 2022-03-25), 10.1177/2058738418814341 (notice 2021-09-02).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/jcb.26391openalex-snapshotRETRACTED: Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes
inferredcites →https://doi.org/10.1002/ptr.2913openalex-snapshotKaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase‐3‐dependent apoptosis in oral cavity cancer cells
inferredcites →https://doi.org/10.1002/tox.22396openalex-snapshotFisetin‐induced apoptosis of human oral cancer SCC‐4 cells through reactive oxygen species production, endoplasmic reticulum stress, caspase‐, and mitochondria‐dependent signaling pathways
inferredcites →https://doi.org/10.1093/ecam/nen011openalex-snapshotInhibition of Cell Proliferation and MAP Kinase and Akt Pathways in Oral Squamous Cell Carcinoma by Genistein and Biochanin A
inferredcites →https://doi.org/10.1177/2058738418814341openalex-snapshotRETRACTED: Kaempferol inhibits proliferation, migration, and invasion of liver cancer HepG2 cells by down-regulation of microRNA-21
inferredcites →https://doi.org/10.1371/journal.pone.0080883openalex-snapshotKaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells
inferredcites →https://doi.org/10.21873/invivo.11176openalex-snapshotFisetin Induces Apoptosis of HSC3 Human Oral Cancer Cells Through Endoplasmic Reticulum Stress and Dysfunction of Mitochondria-mediated Signaling Pathways
inferredcites →https://doi.org/10.3164/jcbn.18-63openalex-snapshotInduction of sestrin 2 is associated with fisetin-mediated apoptosis in human head and neck cancer cell lines
inferredcites →https://doi.org/10.3892/ol.2018.8584openalex-snapshotQuercetin induced apoptosis of human oral cancer SAS cells through mitochondria and endoplasmic reticulum mediated signaling pathways
inferredcites →https://doi.org/10.3892/or.2013.2490openalex-snapshotKaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells
inferredcites →https://doi.org/10.7150/jca.31045openalex-snapshotCombination of quercetin and cisplatin enhances apoptosis in OSCC cells by downregulating xIAP through the NF-κB pathway
inferredcites →https://doi.org/10.7759/cureus.2234openalex-snapshotLaryngeal Squamous Cell Carcinoma Survival in the Context of Human Papillomavirus: A Systematic Review and Meta-analysis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4639515openalex-extractedEvaluation of the Binding Efficacy of Flavonol Derivatives on Estrogen Receptors (ER) with Respect to Ring B Hydroxylation
inferred← citeshttps://doi.org/10.1002/ame2.12476openalex-snapshotA comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
inferred← citeshttps://doi.org/10.1002/cbf.3920openalex-snapshotRole of bio‐flavonols and their derivatives in improving mitochondrial dysfunctions associated with pancreatic tumorigenesis
inferred← citeshttps://doi.org/10.1002/fsn3.70634openalex-snapshotExploration of Bioactive Components, Nutritional Properties, Antioxidant, Antimicrobial and Antihemolytic Potential of Different Parts of Mentha longifolia L.
inferred← citeshttps://doi.org/10.1002/mc.23754openalex-snapshotFisetin induces G2/M phase arrest and caspase‐mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC
inferred← citeshttps://doi.org/10.1002/ptr.70018openalex-snapshotFlavonoids Being Chemo‐Preventive Agents Induce Programmed Cell Death: Mechanisms and Therapeutic Potentials
inferred← citeshttps://doi.org/10.1002/ptr.8376openalex-snapshotPhytochemicals as Novel Therapeutics for Triple‐Negative Breast Cancer: A Comprehensive Review of Current Knowledge
inferred← citeshttps://doi.org/10.1007/978-981-95-8165-8_15openalex-snapshotRegulatory Framework for Flavonoid-Based Cancer Therapies: Food and Drug Administration, European Medicines Agency, and World Health Organization Guidelines
inferred← citeshttps://doi.org/10.1007/s40203-025-00350-4openalex-snapshotInhibition of acyl-homoserine-lactone synthase in Pseudomonas aeruginosa biofilms by 7-O-methyl-aromadendrin by using molecular docking and molecular dynamics simulation
inferred← citeshttps://doi.org/10.1016/j.focha.2022.100126openalex-snapshotFlavonoids from the butanol extract of Carica papaya L. cultivar 'Red Lady' leaf using UPLC-ESI-Q-ToF-MS/MS analysis and evaluation of the antioxidant activities of its fractions
inferred← citeshttps://doi.org/10.1016/j.jrras.2025.101835openalex-snapshotSuppression of PI3K/AKT/mTOR signaling pathway by ethyl acetate extract from garden balsam seed induces apoptosis and inhibits migration in prostate cancer cells
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.136180openalex-snapshotSynthesis, in vitro and in silico evaluation of new flavonoids-trifluoroacetylated amino acid conjugates as anti-acetylcholinesterase and anti-proliferative agents
inferred← citeshttps://doi.org/10.1111/cbdd.14561openalex-snapshotExploring anticancer properties of the phytoconstituents and comparative analysis of their chemical space parameters with USFDA ‐approved synthetic anticancer agents
inferred← citeshttps://doi.org/10.1186/s12870-024-04949-1openalex-snapshotIntegrated transcriptomic and WGCNA analyses reveal candidate genes regulating mainly flavonoid biosynthesis in Litsea coreana var. sinensis
inferred← citeshttps://doi.org/10.1186/s13765-025-01072-zopenalex-snapshotRETRACTED ARTICLE: Fisetin protects against renal injury and fibrosis evoked by diesel particulate matter via downregulation of IL-23/mTOR/S6K-b1 signaling and caveolin-1 expression in rats
inferred← citeshttps://doi.org/10.26538/tjnpr/v10i1.1openalex-snapshotA Review on Botanicals, Traditional Uses, Phytochemistry, Therapeutic Potentials, Clinical Trials, and Toxicity Profile of A. muricata
inferred← citeshttps://doi.org/10.3389/fnut.2023.1232129openalex-snapshotCryopreservation of bioflavonoid-rich plant sources and bioflavonoid-microcapsules: emerging technologies for preserving bioactivity and enhancing nutraceutical applications
inferred← citeshttps://doi.org/10.3389/fphar.2023.1285243openalex-snapshotCapparis cartilaginea decne (capparaceae): isolation of flavonoids by high-speed countercurrent chromatography and their anti-inflammatory evaluation
inferred← citeshttps://doi.org/10.3390/ani15162415openalex-snapshotTranscriptomic Analysis Reveals the Inhibitory Mechanism of Fisetin Against the Pathogenicity of Aeromonas hydrophila
inferred← citeshttps://doi.org/10.3390/antiox10101615openalex-snapshotRedox-Modulating Capacity and Antineoplastic Activity of Wastewater Obtained from the Distillation of the Essential Oils of Four Bulgarian Oil-Bearing Roses
inferred← citeshttps://doi.org/10.3390/antiox11122421openalex-snapshotAntioxidant and Chemopreventive Activity of Protein Hydrolysates from Raw and Germinated Flour of Legumes with Commercial Interest in Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/antiox13040429openalex-snapshotDietary Polyphenols: Review on Chemistry/Sources, Bioavailability/Metabolism, Antioxidant Effects, and Their Role in Disease Management
inferred← citeshttps://doi.org/10.3390/foods11111665openalex-snapshotA Comparative Study of the Influence of Various Fungal-Based Pretreatments of Grape Pomace on Phenolic Compounds Recovery
inferred← citeshttps://doi.org/10.3390/ijms252312799openalex-snapshotThe Antioxidant, Antimicrobial, and Antitumor Proprieties of Flavonol-Rich Extracts from Allium ursinum (Wild Garlic) Leaves: A Comparison of Conventional Maceration and Ultrasound-Assisted Extraction Techniques
inferred← citeshttps://doi.org/10.3390/nu14132604openalex-snapshotFisetin, a Potent Anticancer Flavonol Exhibiting Cytotoxic Activity against Neoplastic Malignant Cells and Cancerous Conditions: A Scoping, Comprehensive Review
inferred← citeshttps://doi.org/10.3390/nu16081201openalex-snapshotSelected Flavonols Targeting Cell Death Pathways in Cancer Therapy: The Latest Achievements in Research on Apoptosis, Autophagy, Necroptosis, Pyroptosis, Ferroptosis, and Cuproptosis
inferred← citeshttps://doi.org/10.3390/ph16060840openalex-snapshotExploring the Multi-Faceted Potential of Carob (Ceratonia siliqua var. Rahma) Leaves from Morocco: A Comprehensive Analysis of Polyphenols Profile, Antimicrobial Activity, Cytotoxicity against Breast Cancer Cell Lines, and Genotoxicity
inferred← citeshttps://doi.org/10.34172/jhp.53989openalex-snapshotA systematic review of fisetin in oral premalignant and malignant disorders: Molecular mechanisms and therapeutic potential
inferred← citeshttps://doi.org/10.4103/jiaphd.jiaphd_208_25openalex-snapshotTiny Seeds with Mighty Benefits: Evaluation of Bioactive Profiling and Cytotoxicity of Various Extracts of Chia Seeds on Epithelial Carcinoma Cell Line Model
inferred← citeshttps://doi.org/10.6084/m9.figshare.25522649openalex-snapshotAdditional file 1 of Integrated transcriptomic and WGCNA analyses reveal candidate genes regulating mainly flavonoid biosynthesis in Litsea coreana var. sinensis
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