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Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/hup.2259openalex-snapshot
Is Ginkgo biloba a cognitive enhancer in healthy individuals? A meta‐analysis
inferredcites →https://doi.org/10.1016/j.ijpharm.2014.06.032openalex-snapshot
Effect of liquid crystals with cyclodextrin on the bioavailability of a poorly water-soluble compound, diosgenin, after its oral administration to rats
inferredcites →https://doi.org/10.1016/j.jep.2015.02.017openalex-snapshot
UPLC-QTOF-MS identification of metabolites in rat biosamples after oral administration of Dioscorea saponins: A comparative study
inferredcites →https://doi.org/10.1016/j.phymed.2011.06.021openalex-snapshot
Specific memory effects of Ginkgo biloba extract EGb 761 in middle-aged healthy volunteers
inferredcites →https://doi.org/10.1016/s1875-5364(15)30053-4openalex-snapshot
Advances in the pharmacological activities and mechanisms of diosgenin
inferredcites →https://doi.org/10.1038/nature14432openalex-snapshot
Structural and functional features of central nervous system lymphatic vessels
inferredcites →https://doi.org/10.1038/srep00535openalex-snapshot
Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice
inferredcites →https://doi.org/10.1038/srep03395openalex-snapshot
Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS
inferredcites →https://doi.org/10.1074/mcp.m500279-mcp200openalex-snapshot
A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics
inferredcites →https://doi.org/10.1076/jcen.20.3.310.823openalex-snapshot
The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary Clinical Validity
inferredcites →https://doi.org/10.1080/13543784.2017.1323868openalex-snapshot
Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010-2015
inferredcites →https://doi.org/10.1142/s0192415x09007296openalex-snapshot
Yam (Dioscorea pseudojaponicaYamamoto) Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose
inferredcites →https://doi.org/10.1142/s0192415x11009020openalex-snapshot
Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose
inferredcites →https://doi.org/10.3233/jad-132690openalex-snapshot
Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis
inferredcites →https://doi.org/10.3389/fnins.2017.00281openalex-snapshot
Time to Amyloid Positivity and Preclinical Changes in Brain Metabolism, Atrophy, and Cognition: Evidence for Emerging Amyloid Pathology in Alzheimer's Disease
inferredcites →https://doi.org/10.3390/nu8020086openalex-snapshot
DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults
inferredcites →https://doi.org/10.3945/ajcn.112.053371openalex-snapshot
DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4658480openalex-extracted
Oligopeptidase B of Dioscorea Opposita “Nagaimo”: Isolation, Biochemical Characterization, and Primary Structure
inferred← citeshttps://doi.org/10.1002/cns.71194openalex-snapshot
Metabolomics Analysis Revealed That SXZ Ameliorates Cognitive Impairment in Naturally Aged Rats by Promoting Glutathione Metabolism and Inhibiting the Ferroptosis Pathway
inferred← citeshttps://doi.org/10.1002/iid3.698openalex-snapshot
Diosgenin protects retinal pigment epithelial cells from inflammatory damage and oxidative stress induced by high glucose by activating AMPK/Nrf2/HO‐1 pathway
inferred← citeshttps://doi.org/10.1002/mnfr.202400158openalex-snapshot
Alleviation of Menopausal Symptoms by Yam ( Dioscorea japonica Thunb.) and Gromwell ( Lithospermum erythrorhizon Sieb. Et Zucc.) Extracts in Ovariectomized Mice
inferred← citeshttps://doi.org/10.1002/ptr.7212openalex-snapshot
Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, enhances cognitive function via neurite outgrowth and synaptic plasticity
inferred← citeshttps://doi.org/10.1002/tkm2.1311openalex-snapshot
Conference report: Second annual young researcher forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine
inferred← citeshttps://doi.org/10.1007/s00425-020-03458-3openalex-snapshot
An underutilized orphan tuber crop—Chinese yam : a review
inferred← citeshttps://doi.org/10.1007/s11418-020-01451-4openalex-snapshot
Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts
inferred← citeshttps://doi.org/10.1007/s11483-020-09643-xopenalex-snapshot
Structure and Properties of Organogels Developed by Diosgenin in Canola Oil
inferred← citeshttps://doi.org/10.1007/s12672-026-04399-1openalex-snapshot
Therapeutic potential of diosgenin in hepatocellular carcinoma through molecular mechanisms and nanodelivery strategies
inferred← citeshttps://doi.org/10.1007/s44372-026-00526-yopenalex-snapshot
An integrative review on traditional uses, phytochemical composition, biological activities, nutritional relevance and technological application of Dioscoreaceae species
inferred← citeshttps://doi.org/10.1016/j.abb.2023.109759openalex-snapshot
Diosgenin prevents dexamethasone-induced myotube atrophy in C2C12 cells
inferred← citeshttps://doi.org/10.1016/j.bbii.2024.100069openalex-snapshot
Exploring the therapeutic potential of dioscin and diosgenin in neurological disorders
inferred← citeshttps://doi.org/10.1016/j.bbrep.2025.102071openalex-snapshot
Isolation, biochemical characterization, and primary structure and active site determination of Dioscorea opposita (‘Nagaimo’) oligopeptidase B
inferred← citeshttps://doi.org/10.1016/j.cbi.2022.109885openalex-snapshot
Diosgenin inhibits ER stress-induced inflammation in aorta via iRhom2/TACE mediated signaling in experimental diabetic rats: An in vivo and in silico approach
inferred← citeshttps://doi.org/10.1016/j.cjche.2020.09.009openalex-snapshot
Designing and optimizing a parallel neural network model for predicting the solubility of diosgenin in n-alkanols
inferred← citeshttps://doi.org/10.1016/j.ecofro.2025.02.010openalex-snapshot
An overview of the nutritional composition, bioactivities and applications of Chinese yam (Dioscoreas Oppositae)
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116915openalex-snapshot
Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects
inferred← citeshttps://doi.org/10.1016/j.fct.2023.113798openalex-snapshot
Dietary phytoestrogen diosgenin interrupts metabolism, physiology, and reproduction of Swiss albino mice: Possible mode of action as an emerging environmental contaminant, endocrine disruptor and reproductive toxicant
inferred← citeshttps://doi.org/10.1016/j.fhfh.2023.100134openalex-snapshot
Encapsulated diosgenin powder production using binary carrier: Process optimization and powder characterization
inferred← citeshttps://doi.org/10.1016/j.foodres.2022.111576openalex-snapshot
Heterophyllin B, a cyclopeptide from Pseudostellaria heterophylla, improves memory via immunomodulation and neurite regeneration in i.c.v.Aβ-induced mice
inferred← citeshttps://doi.org/10.1016/j.foohum.2024.100273openalex-snapshot
Critical review on Nutra-pharmaceutical usage of yams
inferred← citeshttps://doi.org/10.1016/j.foohum.2026.101449openalex-snapshot
Nature’s estrogen: Dioscorea and the emerging potential of β-selective estrogen receptor modulation in menopause
inferred← citeshttps://doi.org/10.1016/j.jep.2025.119508openalex-snapshot
Jiajian Shuyu pills effectively ameliorate cognitive impairment via regulating the inflammation of microglia in an Alzheimer's disease mouse model
inferred← citeshttps://doi.org/10.1016/j.jff.2025.106915openalex-snapshot
Detection of anti-AD active ingredients from Huai yam using surface plasmon resonance technology and mechanistic exploration based on ERβ-harmonized inflammation and autophagy
inferred← citeshttps://doi.org/10.1016/j.jsbmb.2019.105575openalex-snapshot
The role of diosgenin in diabetes and diabetic complications
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118182openalex-snapshot
Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases
inferred← citeshttps://doi.org/10.1016/j.neulet.2024.137954openalex-snapshot
Diosgenin upregulates axonal guidance partner molecules, Galectin-1 and Secernin-1
inferred← citeshttps://doi.org/10.1016/j.phrs.2020.105069openalex-snapshot
Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals
inferred← citeshttps://doi.org/10.1016/j.phrs.2022.106621openalex-snapshot
Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation
inferred← citeshttps://doi.org/10.1016/j.phyplu.2024.100613openalex-snapshot
Diosgenin-rich Yam (rhizome of Dioscorea batatas) extract ameliorates cognitive functions and plasma biomarkers for mild cognitive impairment and mild Alzheimer's disease: A randomized controlled trial
inferred← citeshttps://doi.org/10.1016/j.phyplu.2025.100823openalex-snapshot
Oral administration of diosgenin protects optic nerve degeneration in a mouse model of normal-tension glaucoma
inferred← citeshttps://doi.org/10.1016/j.sajb.2024.04.013openalex-snapshot
Comparison of nutritional values for dioscorea esculenta grown in a cultivated sub-tropical region and a plastic greenhouse in a cold region
inferred← citeshttps://doi.org/10.1016/j.steroids.2022.108980openalex-snapshot
Anti-apoptotic effects of diosgenin on ovariectomized hearts
inferred← citeshttps://doi.org/10.1038/s41380-023-02052-9openalex-snapshot
Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer’s disease model mice
inferred← citeshttps://doi.org/10.1039/d2fo02877hopenalex-snapshot
Diosgenin relieves oxaliplatin-induced pain by affecting TLR4/NF-κB inflammatory signaling and the gut microbiota
inferred← citeshttps://doi.org/10.1039/d6fo01836jopenalex-snapshot
Prophylactic oral diosgenin attenuates acute sleep deprivation-induced liver injury in mice via modulation of the gut microbiota and vascular barrier
inferred← citeshttps://doi.org/10.1080/00986445.2019.1663181openalex-snapshot
Circuit-based neural network models for estimating the solubility of diosgenin
inferred← citeshttps://doi.org/10.1080/1028415x.2020.1743916openalex-snapshot
DA-9801, a standardized Dioscorea extract, improves memory function via the activation of nerve growth factor-mediated signaling
inferred← citeshttps://doi.org/10.1080/23311932.2020.1870306openalex-snapshot
From poison to food: On the molecular identity and indigenous peoples’ utilisation of poisonous “Lab-o” (Wild Yam, Dioscoreaceae) in Bukidnon, Philippines
inferred← citeshttps://doi.org/10.1109/incit66780.2025.11276003openalex-snapshot
Machine Learning-Based Screening for the Therapeutic Potential of Thai Herbs in Dementia Treatment
inferred← citeshttps://doi.org/10.1155/2019/3949824openalex-snapshot
Bu Shen Zhu Yun Decoction Improves Endometrial Receptivity via VEGFR-2-Mediated Angiogenesis
inferred← citeshttps://doi.org/10.1155/2020/3153082openalex-snapshot
Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances
inferred← citeshttps://doi.org/10.1155/2022/1035441openalex-snapshot
Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
inferred← citeshttps://doi.org/10.1177/1934578x241301228openalex-snapshot
Diosgenin: A Potential Therapeutic Phytocompound for the Management of Atherosclerosis and Other Physiological Disorders
inferred← citeshttps://doi.org/10.1186/s13643-023-02301-6openalex-snapshot
A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with and without subjective cognitive impairment
inferred← citeshttps://doi.org/10.12688/f1000research.160416.1openalex-snapshot
Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024
inferred← citeshttps://doi.org/10.12688/f1000research.160416.2openalex-snapshot
Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024
inferred← citeshttps://doi.org/10.12688/f1000research.160416.3openalex-snapshot
Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024
inferred← citeshttps://doi.org/10.12688/verixiv.2953.1openalex-snapshot
Varietal performance of different certified seed sizes for ware yam (Dioscorea rotundata) production
inferred← citeshttps://doi.org/10.1515/ijfe-2023-0203openalex-snapshot
Quantitative review and machine learning application of refractance window drying of tuber slices
inferred← citeshttps://doi.org/10.1590/fst.119121openalex-snapshot
Cyanogenic compounds removal and characteristics of non- and pregelatinized traditional detoxified wild yam (Dioscorea hispida) tuber flour
inferred← citeshttps://doi.org/10.18053/jctres.07.202104.014openalex-snapshot
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review
inferred← citeshttps://doi.org/10.18311/jnr/2023/30378openalex-snapshot
Diosgenin as a Novel Therapeutic Natural Product for Various Diseases: An Overview
inferred← citeshttps://doi.org/10.2147/dddt.s368836openalex-snapshot
Diosgenin and Its Analogs: Potential Protective Agents Against Atherosclerosis
inferred← citeshttps://doi.org/10.22159/ijap.2022v14i6.45734openalex-snapshot
BIOAVAILABILITY PROBLEMS OF PHYTOSTEROLS: A SYSTEMATIC REVIEW
inferred← citeshttps://doi.org/10.31083/j.jin.2020.02.69openalex-snapshot
Effects of Dioscorea polystachya 'yam gruel' on the cognitive function of diabetic rats with focal cerebral ischemia-reperfusion injury via the gut-brain axis
inferred← citeshttps://doi.org/10.3164/jcbn.21-17openalex-snapshot
The effect of 24-week continuous intake of quercetin-rich onion on age-related cognitive decline in healthy elderly people: a randomized, double-blind, placebo-controlled, parallel-group comparative clinical trial
inferred← citeshttps://doi.org/10.3177/jnsv.65.421openalex-snapshot
Diosgenin Supplementation Prevents Lipid Accumulation and Induces Skeletal Muscle-Fiber Hypertrophy in Rats
inferred← citeshttps://doi.org/10.3389/fddsv.2026.1922953openalex-snapshot
Virtual screening of phytochemicals against multiple protein targets of Alzheimer’s disease
inferred← citeshttps://doi.org/10.3389/fnut.2025.1585640openalex-snapshot
Coconut oil derived medium-chain triglycerides ameliorated memory deficits via promoting neurite outgrowth and maintaining gut homeostasis in 5×FAD mice
inferred← citeshttps://doi.org/10.3389/fphar.2025.1573034openalex-snapshot
Effects of natural extracts in cognitive function of healthy adults: a systematic review and network meta-analysis
inferred← citeshttps://doi.org/10.3389/fphar.2025.1601712openalex-snapshot
Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies
inferred← citeshttps://doi.org/10.3390/books978-3-03897-863-3openalex-snapshot
Transitioning to Zero Hunger
inferred← citeshttps://doi.org/10.3390/books978-3-03897-863-3-6openalex-snapshot
Improving the Diversity of Native Edible Plants and Traditional Food and Agriculture Practices for Sustainable Food Security in the Future
inferred← citeshttps://doi.org/10.3390/foods14142537openalex-snapshot
Bioactive Metabolites of Dioscorea Species and Their Potential Applications in Functional Food Development
inferred← citeshttps://doi.org/10.3390/foods9091304openalex-snapshot
The Dioscorea Genus (Yam)—An Appraisal of Nutritional and Therapeutic Potentials
inferred← citeshttps://doi.org/10.3390/ijms21134665openalex-snapshot
Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms221910361openalex-snapshot
Diosgenin Prevents Microglial Activation and Protects Dopaminergic Neurons from Lipopolysaccharide-Induced Neural Damage In Vitro and In Vivo
inferred← citeshttps://doi.org/10.3390/ijms26073166openalex-snapshot
Identification of Novel Therapeutic Targets for MAFLD Based on Bioinformatics Analysis Combined with Mendelian Randomization
inferred← citeshttps://doi.org/10.3390/ijms27198624openalex-snapshot
Diosgenin Alleviates Neuropathic Pain Associated with Alterations in Spinal Mitochondrial and ER Stress-Related Factors in CCI Mice
inferred← citeshttps://doi.org/10.3390/life11070687openalex-snapshot
Metabolome Profiling of Eight Chinese Yam (Dioscorea polystachya Turcz.) Varieties Reveals Metabolite Diversity and Variety Specific Uses
inferred← citeshttps://doi.org/10.3390/molecules23010073openalex-snapshot
In Silico and In Vitro Study of the Bromelain-Phytochemical Complex Inhibition of Phospholipase A2 (Pla2)
inferred← citeshttps://doi.org/10.3390/nu12020303openalex-snapshot
Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults
inferred← citeshttps://doi.org/10.3390/nu14102111openalex-snapshot
Medicinal Plants and Their Impact on the Gut Microbiome in Mental Health: A Systematic Review
inferred← citeshttps://doi.org/10.3390/nu16183156openalex-snapshot
Whole Plant Extracts for Neurocognitive Disorders: A Narrative Review of Neuropsychological and Preclinical Studies
inferred← citeshttps://doi.org/10.3390/nu18111796openalex-snapshot
Herbal Neurotherapeutics for Cognitive Disorders: Integrative Mechanisms Linking Neurotransmitter Systems, Neurodegeneration, and the Gut-Brain Axis
inferred← citeshttps://doi.org/10.3390/pharmaceutics13010124openalex-snapshot
Potential Herb–Drug Interactions in the Management of Age-Related Cognitive Dysfunction
inferred← citeshttps://doi.org/10.4103/ijpvm.ijpvm_143_19openalex-snapshot
Possible Preventive Effect of Donepezil and Hyoscyamoside by Reduction of Plaque Formation and Neuroinflammation in Alzheimer's Disease
inferred← citeshttps://doi.org/10.61186/umj.35.7.604openalex-snapshot
THE EFFECT OF DIOSGENIN ON COGNITIVE DEFICITS AND OXIDATIVE STRESS INDUCED BY LIPOPOLYSACCHARIDE IN RATS
inferred← citeshttps://doi.org/10.7324/japs.2023.134926openalex-snapshot
Preliminary screening of Pioglitazone and Diosgenin novel combination for Alzheimer's disease
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