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Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives
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Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/anie.201601967openalex-snapshot
Artemisinin—A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)
inferredcites →https://doi.org/10.1002/bmc.3019openalex-snapshot
Chemical fingerprint analysis and quantitative determination of steroidal compounds from Dioscorea villosa, Dioscorea species and dietary supplements using UHPLC‐ELSD
inferredcites →https://doi.org/10.1002/glia.22333openalex-snapshot
Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor‐mediated ERK1/2 activation to accelerate remyelination
inferredcites →https://doi.org/10.1002/ijc.24419openalex-snapshot
Diosgenin targets Akt‐mediated prosurvival signaling in human breast cancer cells
inferredcites →https://doi.org/10.1002/jat.2715openalex-snapshot
Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways
inferredcites →https://doi.org/10.1002/jbt.22422openalex-snapshot
Expression of chemokines in macrophage polarization and downregulation of NFκB in aorta allow macrophage polarization by diosgenin in atherosclerosis
inferredcites →https://doi.org/10.1002/pmic.201300101openalex-snapshot
i TRAQ ‐based proteomic analysis of dioscin on human HCT ‐116 colon cancer cells
inferredcites →https://doi.org/10.1002/ptr.6884openalex-snapshot
Ficusplants: State of the art from a phytochemical, pharmacological, and toxicological perspective
inferredcites →https://doi.org/10.1002/tox.22876openalex-snapshot
Exploring the impact of a naturally occurring sapogenin diosgenin on underlying mechanisms of Ca2+ movement and cytotoxicity in human prostate cancer cells
inferredcites →https://doi.org/10.1007/s00018-020-03536-5openalex-snapshot
The multifaceted role of reactive oxygen species in tumorigenesis
inferredcites →https://doi.org/10.1007/s10495-014-0994-zopenalex-snapshot
Dioscin induces caspase-independent apoptosis through activation of apoptosis-inducing factor in breast cancer cells
inferredcites →https://doi.org/10.1007/s10787-017-0341-4openalex-snapshot
Inhibitory effects of Dioscin on atherosclerosis and foam cell formation in hyperlipidemia rats
inferredcites →https://doi.org/10.1007/s11274-013-1429-7openalex-snapshot
Investigation on the mechanisms for biotransformation of saponins to diosgenin
inferredcites →https://doi.org/10.1007/s12035-016-0245-0openalex-snapshot
Role of Microglia in Neurological Disorders and Their Potentials as a Therapeutic Target
inferredcites →https://doi.org/10.1007/s12035-019-1496-3openalex-snapshot
Water-Soluble Arginyl–Diosgenin Analog Attenuates Hippocampal Neurogenesis Impairment Through Blocking Microglial Activation Underlying NF-κB and JNK MAPK Signaling in Adult Mice Challenged by LPS
inferredcites →https://doi.org/10.1007/s12272-013-0279-zopenalex-snapshot
The induction of apoptosis by a newly synthesized diosgenyl saponin through the suppression of estrogen receptor-α in MCF-7 human breast cancer cells
inferredcites →https://doi.org/10.1007/s12298-013-0205-3openalex-snapshot
Isolation and characterization of diosgenin from in vitro cultured tissues of Helicteres isora L
inferredcites →https://doi.org/10.1016/j.abb.2015.12.001openalex-snapshot
The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2015.02.044openalex-snapshot
Diosgenin inhibits atherosclerosis via suppressing the MiR-19b-induced downregulation of ATP-binding cassette transporter A1
inferredcites →https://doi.org/10.1016/j.bbrc.2018.07.022openalex-snapshot
Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/j.bcp.2019.03.025openalex-snapshot
Targeting NFE2L2, a transcription factor upstream of MMP-2: A potential therapeutic strategy for temozolomide resistant glioblastoma
inferredcites →https://doi.org/10.1016/j.bej.2009.07.006openalex-snapshot
Modification of cellulase and its application to extraction of diosgenin from Dioscorea zingiberensis C.H. Wright
inferredcites →https://doi.org/10.1016/j.biopha.2016.08.017openalex-snapshot
Exploration in the cascade working mechanisms of liver injury induced by total saponins extracted from Rhizoma Dioscorea bulbifera
inferredcites →https://doi.org/10.1016/j.biopha.2016.10.049openalex-snapshot
Diosgenin ameliorates gestational diabetes through inhibition of sterol regulatory element-binding protein-1
inferredcites →https://doi.org/10.1016/j.biopha.2016.12.068openalex-snapshot
Diosgenin ameliorates development of neuropathic pain in diabetic rats: Involvement of oxidative stress and inflammation
inferredcites →https://doi.org/10.1016/j.biopha.2017.12.046openalex-snapshot
Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway
inferredcites →https://doi.org/10.1016/j.bmc.2009.09.046openalex-snapshot
Structural analogues of diosgenyl saponins: Synthesis and anticancer activity
inferredcites →https://doi.org/10.1016/j.bmc.2015.10.032openalex-snapshot
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.bmcl.2012.10.086openalex-snapshot
Synthesis, characterization and biological studies of diosgenyl analogues
inferredcites →https://doi.org/10.1016/j.bmcl.2016.05.032openalex-snapshot
Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo
inferredcites →https://doi.org/10.1016/j.canlet.2005.10.050openalex-snapshot
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells
inferredcites →https://doi.org/10.1016/j.cjche.2020.09.009openalex-snapshot
Designing and optimizing a parallel neural network model for predicting the solubility of diosgenin in n-alkanols
inferredcites →https://doi.org/10.1016/j.ejmech.2019.111913openalex-snapshot
Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer’s disease agents
inferredcites →https://doi.org/10.1016/j.ejmech.2021.113361openalex-snapshot
Design and synthesis of diosgenin derivatives as apoptosis inducers through mitochondria-related pathways
inferredcites →https://doi.org/10.1016/j.ejmech.2022.114217openalex-snapshot
Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs
inferredcites →https://doi.org/10.1016/j.ejphar.2020.172942openalex-snapshot
Apoptotic, necrotic, and antiproliferative activity of diosgenin and diosgenin glycosides on cervical cancer cells
inferredcites →https://doi.org/10.1016/j.fbio.2021.100969openalex-snapshot
Dioscorea deltoidea wall. Ex Griseb: A review of traditional uses, bioactive compounds and biological activities
inferredcites →https://doi.org/10.1016/j.fct.2013.07.012openalex-snapshot
Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: A potential new drug for treatment of glioblastoma multiforme
inferredcites →https://doi.org/10.1016/j.fct.2019.110655openalex-snapshot
Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction
inferredcites →https://doi.org/10.1016/j.fitote.2010.06.004openalex-snapshot
Chemical study and medical application of saponins as anti-cancer agents
inferredcites →https://doi.org/10.1016/j.foodchem.2020.128672openalex-snapshot
Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets
inferredcites →https://doi.org/10.1016/j.heliyon.2020.e03296openalex-snapshot
Protective role of diosgenin against hyperglycaemia-mediated cerebral ischemic brain injury in zebrafish model of type II diabetes mellitus
inferredcites →https://doi.org/10.1016/j.hermed.2022.100550openalex-snapshot
Resveratrol’ biotechnological applications: Enlightening its antimicrobial and antioxidant properties
inferredcites →https://doi.org/10.1016/j.intimp.2012.11.019openalex-snapshot
Diosgenin down-regulates NF-κB p65/p50 and p38MAPK pathways and attenuates acute lung injury induced by lipopolysaccharide in mice
inferredcites →https://doi.org/10.1016/j.intimp.2017.06.008openalex-snapshot
Diosgenin glucoside provides neuroprotection by regulating microglial M1 polarization
inferredcites →https://doi.org/10.1016/j.intimp.2019.01.047openalex-snapshot
Diosgenin ameliorates testicular damage in streptozotocin-diabetic rats through attenuation of apoptosis, oxidative stress, and inflammation
inferredcites →https://doi.org/10.1016/j.jcjd.2014.02.004openalex-snapshot
Modulatory Effects of Diosgenin on Attenuating the Key Enzymes Activities of Carbohydrate Metabolism and Glycogen Content in Streptozotocin-Induced Diabetic Rats
inferredcites →https://doi.org/10.1016/j.jclepro.2016.05.030openalex-snapshot
A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis
inferredcites →https://doi.org/10.1016/j.jep.2009.08.047openalex-snapshot
Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents
inferredcites →https://doi.org/10.1016/j.jep.2019.112230openalex-snapshot
Best practice in research – Overcoming common challenges in phytopharmacological research
inferredcites →https://doi.org/10.1016/j.jep.2021.113842openalex-snapshot
Evaluation of antioxidant, anti-inflammatory and anticancer activities of diosgenin enriched Paris polyphylla rhizome extract of Indian Himalayan landraces
inferredcites →https://doi.org/10.1016/j.jep.2021.114018openalex-snapshot
Dioscin and diosgenin: Insights into their potential protective effects in cardiac diseases
inferredcites →https://doi.org/10.1016/j.jfda.2018.02.004openalex-snapshot
Effects of processing adjuvants on traditional Chinese herbs
inferredcites →https://doi.org/10.1016/j.jneuroim.2017.10.018openalex-snapshot
Therapeutic effects of diosgenin in experimental autoimmune encephalomyelitis
inferredcites →https://doi.org/10.1016/j.jsbmb.2014.02.020openalex-snapshot
Acute administration of diosgenin or dioscorea improves hyperglycemia with increases muscular steroidogenesis in STZ-induced type 1 diabetic rats
inferredcites →https://doi.org/10.1016/j.jsbmb.2019.105575openalex-snapshot
The role of diosgenin in diabetes and diabetic complications
inferredcites →https://doi.org/10.1016/j.lfs.2018.01.012openalex-snapshot
Atherogenic diet induced lipid accumulation induced NFκB level in heart, liver and brain of Wistar rat and diosgenin as an anti-inflammatory agent
inferredcites →https://doi.org/10.1016/j.lfs.2020.118182openalex-snapshot
Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases
inferredcites →https://doi.org/10.1016/j.nbd.2006.02.005openalex-snapshot
Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: Protection by diosgenin and l-deprenyl
inferredcites →https://doi.org/10.1016/j.pharep.2015.10.011openalex-snapshot
Renoprotective effect of diosgenin in streptozotocin induced diabetic rats
inferredcites →https://doi.org/10.1016/j.phrs.2019.104414openalex-snapshot
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis
inferredcites →https://doi.org/10.1016/j.phymed.2014.02.002openalex-snapshot
Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity
inferredcites →https://doi.org/10.1016/j.phymed.2014.04.005openalex-snapshot
Efficacy of natural diosgenin on cardiovascular risk, insulin secretion, and beta cells in streptozotocin (STZ)-induced diabetic rats
inferredcites →https://doi.org/10.1016/j.phymed.2016.01.010openalex-snapshot
Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells
inferredcites →https://doi.org/10.1016/j.phymed.2016.01.012openalex-snapshot
Potent effects of dioscin against gastric cancer in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.phymed.2016.07.003openalex-snapshot
Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3
inferredcites →https://doi.org/10.1016/j.sajb.2020.12.027openalex-snapshot
HPTLC quantification of diosgenin in Dioscorea deltoidea: Evaluation of extraction efficacy, organ selection, drying method and seasonal variation
inferredcites →https://doi.org/10.1016/j.steroids.2016.07.006openalex-snapshot
Diosgenin attenuates the brain injury induced by transient focal cerebral ischemia-reperfusion in rats
inferredcites →https://doi.org/10.1016/j.steroids.2020.108777openalex-snapshot
Azasteroids from diosgenin: Synthesis and evaluation of their antiproliferative activity
inferredcites →https://doi.org/10.1016/j.ultsonch.2021.105572openalex-snapshot
Comparison of ultrasound and microwave assisted extraction of diosgenin from Trigonella foenum graceum seed
inferredcites →https://doi.org/10.1016/j.xplc.2020.100079openalex-snapshot
The origin and evolution of the diosgenin biosynthetic pathway in yam
inferredcites →https://doi.org/10.1016/j.ymben.2011.06.006openalex-snapshot
A stable yeast strain efficiently producing cholesterol instead of ergosterol is functional for tryptophan uptake, but not weak organic acid resistance
inferredcites →https://doi.org/10.1016/j.ymben.2018.10.001openalex-snapshot
Identification of a novel cytochrome P450 enzyme that catalyzes the C-2α hydroxylation of pentacyclic triterpenoids and its application in yeast cell factories
inferredcites →https://doi.org/10.1016/s1875-5364(15)30053-4openalex-snapshot
Advances in the pharmacological activities and mechanisms of diosgenin
inferredcites →https://doi.org/10.1016/s2468-1253(22)00044-9openalex-snapshot
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
inferredcites →https://doi.org/10.1021/acs.jnatprod.0c00698openalex-snapshot
Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action
inferredcites →https://doi.org/10.1021/acs.jnatprod.9b01285openalex-snapshot
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
inferredcites →https://doi.org/10.1021/ja01246a051openalex-snapshot
Sterols. CLVII. Sapogenins. LXIX.1 Isolation and Structures of Thirteen New Steroidal Sapogenins. New Sources for Known Sapogenins
inferredcites →https://doi.org/10.1021/jf200598wopenalex-snapshot
Diosgenin Suppresses Hepatocyte Growth Factor (HGF)-Induced Epithelial–Mesenchymal Transition by Down-regulation of Mdm2 and Vimentin
inferredcites →https://doi.org/10.1021/jf201640jopenalex-snapshot
Osteoprotective Effect of Monascus-fermented Dioscorea in Ovariectomized Rat Model of Postmenopausal Osteoporosis
inferredcites →https://doi.org/10.1038/aps.2013.133openalex-snapshot
Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' disease
inferredcites →https://doi.org/10.1038/srep00535openalex-snapshot
Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice
inferredcites →https://doi.org/10.1038/srep03395openalex-snapshot
Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D3-MARRS
inferredcites →https://doi.org/10.1038/srep18038openalex-snapshot
Dioscin alleviates alcoholic liver fibrosis by attenuating hepatic stellate cell activation via the TLR4/MyD88/NF-κB signaling pathway
inferredcites →https://doi.org/10.1038/srep40035openalex-snapshot
Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism
inferredcites →https://doi.org/10.1039/an9729700973openalex-snapshot
Spectrophotometric determination of diosgenin in Dioscorea composita following thin-layer chromatography
inferredcites →https://doi.org/10.1055/s-0033-1336521openalex-snapshot
Characterization of ADME Properties of Diosgenin and Dioscin: Bioactive Constituents of Dioscorea villosa (Wild yam)
inferredcites →https://doi.org/10.1055/s-0033-1350699openalex-snapshot
Characterization of in Vitro ADME Properties of Diosgenin and Dioscin from Dioscorea villosa
inferredcites →https://doi.org/10.1080/01635580802357352openalex-snapshot
Cancer Chemopreventive and Therapeutic Effects of Diosgenin, a Food Saponin
inferredcites →https://doi.org/10.1080/09168451.2015.1135040openalex-snapshot
Diosgenin effectively suppresses skin inflammation induced by phthalic anhydride in IL-4/Luc/CNS-1 transgenic mice
inferredcites →https://doi.org/10.1080/13880209.2021.1903047openalex-snapshot
Cytotoxic activity of standardized extracts, a fraction, and individual secondary metabolites from fenugreek seeds against SKOV-3, HeLa and MOLT-4 cell lines
inferredcites →https://doi.org/10.1080/14786419.2014.942661openalex-snapshot
Saponins: the phytochemical with an emerging potential for curing clinical depression
inferredcites →https://doi.org/10.1080/14786419.2015.1065493openalex-snapshot
Anti-inflammatory, antioxidant and antiangiogenic activities of diosgenin isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm
inferredcites →https://doi.org/10.1080/713605087openalex-snapshot
Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women
inferredcites →https://doi.org/10.1097/fjc.0000000000000308openalex-snapshot
Diosgenin Mitigates Streptozotocin Diabetes-induced Vascular Dysfunction of the Rat Aorta
inferredcites →https://doi.org/10.1111/1750-3841.14317openalex-snapshot
Quercetin in Food: Possible Mechanisms of Its Effect on Memory
inferredcites →https://doi.org/10.1111/1750-3841.14424openalex-snapshot
Identification of Polyphenols, Glycoalkaloids, and Saponins in Solanum scabrum Berries Using HPLC‐UV/Vis‐MS
inferredcites →https://doi.org/10.1128/mbio.01249-20openalex-snapshot
An Antivirulence Approach for Preventing Cryptococcus neoformans from Crossing the Blood-Brain Barrier via Novel Natural Product Inhibitors of a Fungal Metalloprotease
inferredcites →https://doi.org/10.1142/s0192415x09007296openalex-snapshot
Yam (Dioscorea pseudojaponicaYamamoto) Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose
inferredcites →https://doi.org/10.1142/s0192415x11009020openalex-snapshot
Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose
inferredcites →https://doi.org/10.1142/s0192415x20500202openalex-snapshot
Anti-Apoptotic Effects of Diosgenin in D-Galactose-Induced Aging Brain
inferredcites →https://doi.org/10.1155/2012/981675openalex-snapshot
Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway
inferredcites →https://doi.org/10.1155/2013/698190openalex-snapshot
Natural Bioactives and Phytochemicals Serve in Cancer Treatment and Prevention
inferredcites →https://doi.org/10.1155/2016/4156293openalex-snapshot
Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology
inferredcites →https://doi.org/10.1155/2020/3153082openalex-snapshot
Therapeutic Potential of Diosgenin and Its Major Derivatives against Neurological Diseases: Recent Advances
inferredcites →https://doi.org/10.1155/2020/6702314openalex-snapshot
Minireview on the Connections between the Neuropsychiatric and Dental Disorders: Current Perspectives and the Possible Relevance of Oxidative Stress and Other Factors
inferredcites →https://doi.org/10.1155/2020/8072639openalex-snapshot
Diosgenin Exerts Antitumor Activity via Downregulation of Skp2 in Breast Cancer Cells
inferredcites →https://doi.org/10.1155/2021/3687700openalex-snapshot
Paclitaxel: Application in Modern Oncology and Nanomedicine‐Based Cancer Therapy
inferredcites →https://doi.org/10.1155/2021/5905357openalex-snapshot
Tobacco Smoking and Liver Cancer Risk: Potential Avenues for Carcinogenesis
inferredcites →https://doi.org/10.1155/2021/9965916openalex-snapshot
The Involvement of the Oxidative Stress Status in Cancer Pathology: A Double View on the Role of the Antioxidants
inferredcites →https://doi.org/10.1155/2022/2910411openalex-snapshot
Nutraceutical Profiling, Bioactive Composition, and Biological Applications of Lepidium sativum L.
inferredcites →https://doi.org/10.1155/2022/3079577openalex-snapshot
Neurobiological Promises of the Bitter Diterpene Lactone Andrographolide
inferredcites →https://doi.org/10.1155/2022/4024331openalex-snapshot
Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications
inferredcites →https://doi.org/10.1155/2022/6025900openalex-snapshot
A Review of Recent Studies on the Antioxidant and Anti‐Infectious Properties of Senna Plants
inferredcites →https://doi.org/10.1155/2022/6727609openalex-snapshot
Ethnobotany, Phytochemistry, Biological Activities, and Health-Promoting Effects of the Genus Bulbophyllum
inferredcites →https://doi.org/10.1155/2022/8615242openalex-snapshot
[Retracted] Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects
inferredcites →https://doi.org/10.1159/000452662openalex-snapshot
The Impact of a Standardized Oral Multinutrient Supplementation on Embryo Quality in in vitro Fertilization/Intracytoplasmic Sperm Injection: A Prospective Randomized Trial
inferredcites →https://doi.org/10.1177/0300060516676724openalex-snapshot
Anti- trachea inflammatory effects of diosgenin from Dioscorea nipponica through interactions with glucocorticoid receptor α
inferredcites →https://doi.org/10.1186/s12906-016-1360-1openalex-snapshot
Dioscin inhibits gastric tumor growth through regulating the expression level of lncRNA HOTAIR
inferredcites →https://doi.org/10.1186/s12906-020-02930-7openalex-snapshot
Neuroprotective effect of diosgenin in a mouse model of diabetic peripheral neuropathy involves the Nrf2/HO-1 pathway
inferredcites →https://doi.org/10.1186/s12935-021-02025-4openalex-snapshot
Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment
inferredcites →https://doi.org/10.1248/bpb.25.193openalex-snapshot
Apoptosis Induced by Dioscin in Hela Cells.
inferredcites →https://doi.org/10.1248/bpb.34.1493openalex-snapshot
Diosgenin from Dioscorea nipponica Ameliorates Diabetic Neuropathy by Inducing Nerve Growth Factor
inferredcites →https://doi.org/10.12965/jer.1836340.170openalex-snapshot
Diosgenin improves functional recovery from sciatic crushed nerve injury in rats
inferredcites →https://doi.org/10.1371/journal.pone.0020164openalex-snapshot
Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression
inferredcites →https://doi.org/10.1371/journal.pone.0106039openalex-snapshot
Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase
inferredcites →https://doi.org/10.2147/ott.s226261openalex-snapshot
Diosgenin Suppresses Cholangiocarcinoma Cells Via Inducing Cell Cycle Arrest And Mitochondria-Mediated Apoptosis
inferredcites →https://doi.org/10.3233/jad-180330openalex-snapshot
Diosgenin Attenuates Lipopolysaccharide-Induced Parkinson’s Disease by Inhibiting the TLR/NF-κB Pathway
inferredcites →https://doi.org/10.3389/fmolb.2019.00120openalex-snapshot
Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases
inferredcites →https://doi.org/10.3390/app9163387openalex-snapshot
Cucurbita Plants: From Farm to Industry
inferredcites →https://doi.org/10.3390/biom9010006openalex-snapshot
Epibatidine: A Promising Natural Alkaloid in Health
inferredcites →https://doi.org/10.3390/biomedicines6030082openalex-snapshot
Evidence for the Involvement of the Master Transcription Factor NF-κB in Cancer Initiation and Progression
inferredcites →https://doi.org/10.3390/diagnostics12030740openalex-snapshot
Post-Concussion Syndrome and Chronic Traumatic Encephalopathy: Narrative Review on the Neuropathology, Neuroimaging and Fluid Biomarkers
inferredcites →https://doi.org/10.3390/ijms150917130openalex-snapshot
High-Dose Diosgenin Reduces Bone Loss in Ovariectomized Rats via Attenuation of the RANKL/OPG Ratio
inferredcites →https://doi.org/10.3390/ijms19082274openalex-snapshot
Diosgenin Glucoside Protects against Spinal Cord Injury by Regulating Autophagy and Alleviating Apoptosis
inferredcites →https://doi.org/10.3390/ijms21010172openalex-snapshot
Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells
inferredcites →https://doi.org/10.3390/jcm10030381openalex-snapshot
ADORA2A rs5760423 and CYP1A2 rs762551 Polymorphisms as Risk Factors for Parkinson’s Disease
inferredcites →https://doi.org/10.3390/jcm10040624openalex-snapshot
A Novel Nutraceutical Formulation Can Improve Motor Activity and Decrease the Stress Level in a Murine Model of Middle-Age Animals
inferredcites →https://doi.org/10.3390/jcm9082395openalex-snapshot
The Treatment of Cognitive, Behavioural and Motor Impairments from Brain Injury and Neurodegenerative Diseases through Cannabinoid System Modulation—Evidence from In Vivo Studies
inferredcites →https://doi.org/10.3390/jpm11060494openalex-snapshot
Cannabinoids and Inflammations of the Gut-Lung-Skin Barrier
inferredcites →https://doi.org/10.3390/molecules21060730openalex-snapshot
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway
inferredcites →https://doi.org/10.3390/molecules24224025openalex-snapshot
Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis
inferredcites →https://doi.org/10.3390/nu10050645openalex-snapshot
Pro-Apoptotic and Anti-Cancer Properties of Diosgenin: A Comprehensive and Critical Review
inferredcites →https://doi.org/10.3390/nu7064938openalex-snapshot
In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity
inferredcites →https://doi.org/10.3390/nu9101160openalex-snapshot
Diosgenin-Rich Yam Extract Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind, Crossover Study of Healthy Adults
inferredcites →https://doi.org/10.3390/polym13081322openalex-snapshot
Synthesis and Characterization of Diosgenin Encapsulated Poly-ε-Caprolactone-Pluronic Nanoparticles and Its Effect on Brain Cancer Cells
inferredcites →https://doi.org/10.3785/j.issn.1008-9292.2016.09.02openalex-snapshot
[Protective effect of diosgenin on chondrocytes mediated by JAK2/STAT3 signaling pathway in mice with osteoarthritis].
inferredcites →https://doi.org/10.3892/etm.2017.4256openalex-snapshot
Pharmacological management of non-alcoholic fatty liver disease: Atorvastatin versus pentoxifylline
inferredcites →https://doi.org/10.3892/ijmm.2019.4191openalex-snapshot
Association of nutraceutical supplements with longer telomere length
inferredcites →https://doi.org/10.3892/ijo_00000601openalex-snapshot
Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells
inferredcites →https://doi.org/10.3892/mmr.2016.5750openalex-snapshot
Diosgenin-induced autophagy and apoptosis in a human prostate cancer cell line
inferredcites →https://doi.org/10.3892/mmr.2017.6280openalex-snapshot
Diosgenin inhibits angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts through regulating the TGF-β1/Smad3 signaling pathway
inferredcites →https://doi.org/10.3892/mmr.2017.6723openalex-snapshot
Diosgenin attenuates neuropathic pain in a rat model of chronic constriction injury
inferredcites →https://doi.org/10.3892/mmr.2017.7900openalex-snapshot
Dioscin inhibits ischemic stroke‑induced inflammation through inhibition of the TLR4/MyD88/NF‑κB signaling pathway in a rat model
inferredcites →https://doi.org/10.3892/ol.2019.9933openalex-snapshot
Molecular and cellular stratagem of brain metastases associated with melanoma (Review)
inferredcites →https://doi.org/10.4081/aiua.2018.1.59openalex-snapshot
The role of diallyl thiosulfinate associated with nuciferine and diosgenin in the treatment of premature ejaculation: A pilot study
inferredcites →https://doi.org/10.4161/cbt.13.3.18693openalex-snapshot
Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins
inferredcites →https://doi.org/10.5625/lar.2016.32.2.105openalex-snapshot
Beneficial effect of diosgenin as a stimulator of NGF on the brain with neuronal damage induced by Aβ-42 accumulation and neurotoxicant injection
inferredcites →https://doi.org/10.5772/63408openalex-snapshot
Colorectal Cancer and Inflammatory Bowel Disease
inferredcites →https://doi.org/10.7150/ijbs.18732openalex-snapshot
Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4481485openalex-extracted
Soybean Protein Based Diosgenin Nanoemulsions: Fabrication, Stability and in Vitro Study Using Caco-2 Cells
inferred← citeshttps://doi.org/10.2139/ssrn.4812410openalex-extracted
Diosgenin Attenuates Nonalcoholic Fatty Liver Disease Through the Hepatic Nlrp3 Inflammasome-Dependent Signaling Pathway
inferred← citeshttps://doi.org/10.1002/cam4.71519openalex-snapshot
Theranostic Nanoparticles in Prostate Cancer: Disrupting Hypoxia‐Induced Glycolysis by Targeting Hypoxia‐Inducible Factor‐1 Alpha and Downstream Metabolites
inferred← citeshttps://doi.org/10.1002/cbdv.202400444openalex-snapshot
In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin
inferred← citeshttps://doi.org/10.1002/cbdv.202401754openalex-snapshot
Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments
inferred← citeshttps://doi.org/10.1002/ddr.22180openalex-snapshot
A review of natural products and small‐molecule therapeutics acting on central nervous system malignancies: Approaches for drug development, targeting pathways, clinical trials, and challenges
inferred← citeshttps://doi.org/10.1002/pep2.70009openalex-snapshot
Exploring the Pharmacodynamic and Molecular Interactions of Diosgenin as a Multitarget Therapeutic Agent in Breast and Ovarian Cancer Pathways
inferred← citeshttps://doi.org/10.1002/ptr.8082openalex-snapshot
Phytochemicals in regulating PD ‐1/ PD‐L1 and immune checkpoint blockade therapy
inferred← citeshttps://doi.org/10.1002/slct.74768openalex-snapshot
Integrated Computational Drug Discovery of Diosgenin‐Based Analogues as PI3K‐Targeted Breast Cancer Inhibitors: QSAR, Molecular Docking, and Molecular Dynamics Insights
inferred← citeshttps://doi.org/10.1002/sscp.70167openalex-snapshot
Targeted Ultra‐High Performance Liquid Chromatography–Electrospray Ionization Triple Quadrupole Mass Spectrometry‐Based Quantification of Diosgenin in Hellenia speciosa for Its Wild Populations Screening: A Quality Control Assessment
inferred← citeshttps://doi.org/10.1007/978-3-031-29006-0_38-1openalex-snapshot
Bioactive Compounds and Biological Activities of Nepal Yam (Dioscorea deltoidea wall. Ex Griseb.)
inferred← citeshttps://doi.org/10.1007/978-3-031-30037-0_57-1openalex-snapshot
CRISPR-Cas-Mediated Optimization of Plant-Derived Natural Products of Biomedical Significance
inferred← citeshttps://doi.org/10.1007/978-3-031-44746-4_38openalex-snapshot
Bioactive Compounds and Biological Activities of Nepal Yam (Dioscorea deltoidea wall. Ex Griseb.)
inferred← citeshttps://doi.org/10.1007/978-3-031-51158-5_57openalex-snapshot
CRISPR-Cas-Mediated Optimization of Plant-Derived Natural Products of Biomedical Significance
inferred← citeshttps://doi.org/10.1007/978-981-95-8064-4_2openalex-snapshot
Clinical Evidence and Significance of Plant Secondary Metabolites in Anti-aging Therapies
inferred← citeshttps://doi.org/10.1007/s00210-026-05239-3openalex-snapshot
Diosgenin-loaded niosomes ameliorate cadmium-induced neurotoxicity and endocrine disruption in female rats through modulation of oxidative stress, apoptosis, and inflammatory markers
inferred← citeshttps://doi.org/10.1007/s00210-026-05263-3openalex-snapshot
Immunomodulatory and locomotor regulations via Diosgenin treatment in lipopolysaccharide-induced chronic fatigue syndrome (CFS)/ depressive despair symptom: an in vivo assessment
inferred← citeshttps://doi.org/10.1007/s00213-023-06509-1openalex-snapshot
Diosgenin alleviates alcohol-mediated escalation of social defeat stress and the neurobiological sequalae
inferred← citeshttps://doi.org/10.1007/s10072-024-07878-xopenalex-snapshot
The microbiota-gut-brain axis: a potential target in the small-molecule compounds and gene therapeutic strategies for Parkinson’s disease
inferred← citeshttps://doi.org/10.1007/s10722-025-02631-5openalex-snapshot
Paris polyphylla Sm. A threatened herb of the Himalayas: traditional knowledge, therapeutic significance and conservation urgency
inferred← citeshttps://doi.org/10.1007/s10787-026-02143-3openalex-snapshot
Dioscin-rich extract of Dioscorea floribunda ameliorates metabolic syndrome by improving inflammation-mediated gut, adipose and hepatic dysfunctions: a pre-clinical study
inferred← citeshttps://doi.org/10.1007/s11101-025-10107-8openalex-snapshot
Steroidal saponins: a treasure trove of natural resources that require urgent development
inferred← citeshttps://doi.org/10.1007/s11101-026-10322-xopenalex-snapshot
Plant-derived phytochemicals as immune checkpoint modulators: a systematic review of natural compounds targeting pd-1, pd-l1, ctla-4 and related mechanisms in cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/s11240-025-03022-5openalex-snapshot
Establishment of in vitro root cultures and hairy roots of Dioscorea composita for diosgenin production
inferred← citeshttps://doi.org/10.1007/s12032-025-02947-3openalex-snapshot
Role of diosgenin in gastrointestinal cancers: recent trends and future perspectives
inferred← citeshttps://doi.org/10.1007/s12161-026-03091-yopenalex-snapshot
Systematic Optimization of Acid Hydrolysis Parameters for Diosgenin Extraction Coupled with UHPLC-DAD Analysis
inferred← citeshttps://doi.org/10.1007/s12668-024-01383-3openalex-snapshot
Diosgenin-Conjugated Zinc Oxide Nanoparticles: A Sustainable Approach to Counter Antibiotic-Induced Oxidative Stress in the Aquatic Environment Using the in vivo Zebrafish Larvae Model (Danio rerio)
inferred← citeshttps://doi.org/10.1007/s13205-024-04017-3openalex-snapshot
Diosgenin intervention: targeting lipophagy to counter high glucose diet-induced lipid accumulation and lifespan reduction
inferred← citeshttps://doi.org/10.1007/s13668-025-00694-5openalex-snapshot
Shatavari (Asparagus racemosus): A Promising Ally for Fertility
inferred← citeshttps://doi.org/10.1007/s40203-026-00711-7openalex-snapshot
Identification of selective bioactive compounds from Fenugreek seed extracts by GC-MS analysis and their anti-tumoral potential via modulation of Parkin in oral cancer
inferred← citeshttps://doi.org/10.1007/s40883-025-00531-9openalex-snapshot
Evaluation of Diosgenin-Enhanced Gelatin/Hydroxyapatite Biomaterial for Bone Regeneration Using in Silico, in Vitro, and Zebrafish Models
inferred← citeshttps://doi.org/10.1007/s42452-025-06646-6openalex-snapshot
Solanum incanum L.: an updated review of botany, traditional uses, phytochemistry, and pharmacology
inferred← citeshttps://doi.org/10.1007/s44371-026-00842-yopenalex-snapshot
Extraction techniques, mechanistic insights for gut health, microbiota modulation, and industrial applications of diosgenin
inferred← citeshttps://doi.org/10.1016/bs.armc.2023.10.002openalex-snapshot
The polypharmacology of natural products in drug discovery and development
inferred← citeshttps://doi.org/10.1016/j.abb.2023.109759openalex-snapshot
Diosgenin prevents dexamethasone-induced myotube atrophy in C2C12 cells
inferred← citeshttps://doi.org/10.1016/j.arabjc.2023.104680openalex-snapshot
Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications
inferred← citeshttps://doi.org/10.1016/j.bbapap.2025.141116openalex-snapshot
Molecular insights into diosgenin's role in preventing protein aggregation in neurodegenerative diseases
inferred← citeshttps://doi.org/10.1016/j.bbii.2024.100069openalex-snapshot
Exploring the therapeutic potential of dioscin and diosgenin in neurological disorders
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.118489openalex-snapshot
Trillin alleviates rheumatoid arthritis by inhibiting TXNIP-mediated mitochondrial damage and NLRP3-dependent pyroptosis
inferred← citeshttps://doi.org/10.1016/j.biocel.2026.107031openalex-snapshot
Diosgenin suppresses ALOX5 expression through Histone acetyltransferase KAT2A-mediated H3K27ac modification to attenuate macrophage ferroptosis and foam cell formation in atherosclerosis
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113555openalex-snapshot
Recent advances in the therapeutic potential of emodin for human health
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114332openalex-snapshot
Key oncologic pathways inhibited by Erinacine A: A perspective for its development as an anticancer molecule
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114687openalex-snapshot
RETRACTED: Rosmarinic acid and its derivatives: Current insights on anticancer potential and other biomedical applications
inferred← citeshttps://doi.org/10.1016/j.biortech.2025.133877openalex-snapshot
Efficient saponin glycosidases of Aspergillus tubingensis HG57 enable green diosgenin production using Dioscorea zingiberensis tubers
inferred← citeshttps://doi.org/10.1016/j.brainres.2024.148963openalex-snapshot
The neuroprotective effect of Diosgenin in the rat Valproic acid model of autism
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2023.140517openalex-snapshot
Rapid and sensitive electrochemical detection of oxidized form of glutathione in whole blood samples using Bi-metallic nanocomposites
inferred← citeshttps://doi.org/10.1016/j.compbiolchem.2025.108822openalex-snapshot
Diosgenin targets ITGA11-driven angiogenesis in hepatocellular carcinoma: Prognostic and mechanistic insights
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2025.110911openalex-snapshot
Antihypertensive potential of diosgenin: A comparative pharmacoinformatics study
inferred← citeshttps://doi.org/10.1016/j.cpan.2026.07.001openalex-snapshot
Research progresses on natural product monomers in the treatment of rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.csbj.2025.07.048openalex-snapshot
Diosgenin producing Bacillus sp. strain IRMC27M2 as a genome-mined weapon against multidrug-resistant Candidozyma (Candida) auris
inferred← citeshttps://doi.org/10.1016/j.ctmp.2024.200148openalex-snapshot
Adaptogenic action of diosgenin againsts chronic unpredictable mild stress-induced neuroimmune dysfunction of HPA axis reverses psychiatric behavior in mice
inferred← citeshttps://doi.org/10.1016/j.dscb.2024.100122openalex-snapshot
Containment of neuroimmune challenge by diosgenin confers amelioration of neurochemical and neurotrophic dysfunctions in ketamine-induced schizophrenia in mice
inferred← citeshttps://doi.org/10.1016/j.ecofro.2025.02.010openalex-snapshot
An overview of the nutritional composition, bioactivities and applications of Chinese yam (Dioscoreas Oppositae)
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116915openalex-snapshot
Plant based steroidal and triterpenoid sapogenins: Chemistry on diosgenin and biological aspects
inferred← citeshttps://doi.org/10.1016/j.fct.2023.113798openalex-snapshot
Dietary phytoestrogen diosgenin interrupts metabolism, physiology, and reproduction of Swiss albino mice: Possible mode of action as an emerging environmental contaminant, endocrine disruptor and reproductive toxicant
inferred← citeshttps://doi.org/10.1016/j.fitote.2024.105896openalex-snapshot
Bioactivities of morroniside: A comprehensive review of pharmacological properties and molecular mechanisms
inferred← citeshttps://doi.org/10.1016/j.fochx.2023.100982openalex-snapshot
Preparation, stability, and in vitro transport of soybean protein-based diosgenin nanoemulsions
inferred← citeshttps://doi.org/10.1016/j.foohum.2026.101449openalex-snapshot
Nature’s estrogen: Dioscorea and the emerging potential of β-selective estrogen receptor modulation in menopause
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e24350openalex-snapshot
Role of diosgenin extracted from Helicteres isora L in suppression of HIV-1 replication: An in vitro preclinical study
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.135788openalex-snapshot
Comparative transcriptomic and metabolomic analyses reveal key regulatory gene for methyl jasmonate-induced steroidal saponins synthesis in Dioscorea composita
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.138926openalex-snapshot
Diosgenin loaded-chitosan biodegradable nanoparticles ameliorate adjuvant-induced arthritis, pain, and peripheral neuropathy through moderation of inflammatory and oxidative stress biomarkers
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.139380openalex-snapshot
Evaluation of chitosan/diosgenin-infused manganese dioxide nanocomposite for highly effective photocatalytic and antibacterial activity
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111270openalex-snapshot
Diosgenin alters LPS-induced macrophage polarization by activating PPARγ/NF-κB signaling pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112581openalex-snapshot
Diosgenin attenuates metabolic-associated fatty liver disease through the hepatic NLRP3 inflammasome-dependent signaling pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.117337openalex-snapshot
The role and mechanism of diosgenin glucoside in modulating megakaryopoiesis through promotion of autophagy via the AMPK/mTOR/ULK1 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.jarmap.2024.100596openalex-snapshot
Diosgenin production from Dioscorea zingiberensis tubers by novel pressurized hydrolysis in acidic ionic liquids
inferred← citeshttps://doi.org/10.1016/j.jddst.2025.107468openalex-snapshot
Formulation of a novel diosgenin-loaded nanoemulsion and its evaluation for improved brain bioavailability in the management of cerebral ischemia
inferred← citeshttps://doi.org/10.1016/j.jep.2026.121747openalex-snapshot
Diosgenin alleviates hepatic fibrosis via PI3K/Akt/mTOR mediated fatty acid metabolic reprogramming and NF-κB activation
inferred← citeshttps://doi.org/10.1016/j.jksus.2024.103238openalex-snapshot
Exploring the therapeutic potential of Cynanchum tunicatum (Retz.) Alston- assessment of phytochemicals and biological activities
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2025.109886openalex-snapshot
Diosgenin alleviates lipid accumulation in NAFLD through the pathways of ferroptosis defensive and executive system
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.122033openalex-snapshot
Regulation of cytokinesis and necroptosis pathways by diosgenin inhibits the proliferation of NCI-H460 lung cancer cells
inferred← citeshttps://doi.org/10.1016/j.mam.2026.101514openalex-snapshot
Harnessing Nature's Arsenal: The multitarget anticancer and antidiabetic networks of saponins
inferred← citeshttps://doi.org/10.1016/j.molimm.2025.10.005openalex-snapshot
Diosgenin ameliorates CLP-induced sepsis in mice via suppressing inflammatory responses and preserving intestinal mucosal barrier integrity
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.140086openalex-snapshot
Spectroscopic, DFT and molecular docking studies of novel diosgenin NSAID conjugates and their in vitro evaluation as potential anti-cancer agents against SiHa cells
inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.144413openalex-snapshot
Fluorescence enhancement and quenching study: Interaction of diosgenin with biologically significant macromolecules
inferred← citeshttps://doi.org/10.1016/j.nanoso.2025.101556openalex-snapshot
Diosgenin-based nanomedicine: Advances in formulation strategies, biomedical applications, and translational challenges
inferred← citeshttps://doi.org/10.1016/j.neurot.2026.e01046openalex-snapshot
Diosgenin enhances transplanted human oligodendrocyte precursor cell-mediated myelination in preterm white matter injury by inhibiting matrix metalloproteinase-9–driven TGF-β/Smad2/3 signaling
inferred← citeshttps://doi.org/10.1016/j.nexres.2026.101457openalex-snapshot
Herbal intervention targeting NLRP3 inflammasome in the treatment of liver diseases
inferred← citeshttps://doi.org/10.1016/j.obmed.2026.100712openalex-snapshot
Nanotechnology-enabled targeted delivery of incretin therapies for the treatment of obesity and metabolic disorders
inferred← citeshttps://doi.org/10.1016/j.onano.2025.100274openalex-snapshot
Diosgenin-functionalized zinc oxide nanoparticles produced using Hibiscus tiliaceus leaf extract: evaluation of anticancer and antibacterial activities
inferred← citeshttps://doi.org/10.1016/j.pharma.2026.07.008openalex-snapshot
A highly-sensitive and selective LC–MS/MS platform for quantitative determination of diosgenin in mice plasma with comprehensive bioanalytical validation and pharmacokinetic study
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155299openalex-snapshot
Diosgenin as a substitute for cholesterol alleviates NAFLD by affecting CYP7A1 and NPC1L1-related pathway
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.157605openalex-snapshot
Diosgenin ameliorates colitis by inhibiting mitochondrial DNA synthesis in macrophages via STAT2-CMPK2 pathway
inferred← citeshttps://doi.org/10.1016/j.phyplu.2023.100497openalex-snapshot
Paris polyphylla Sm. extract enriched with diosgenin as an antidiabetic agent: In vitro and in vivo study
inferred← citeshttps://doi.org/10.1016/j.phyplu.2024.100540openalex-snapshot
Recent advances in phytosomes for the safe management of cancer
inferred← citeshttps://doi.org/10.1016/j.phyplu.2025.100833openalex-snapshot
Diosgenin mitigates oxidative stress and inflammation within the hepatorenal system associated with epilepsy and alcohol use disorders in murine models
inferred← citeshttps://doi.org/10.1016/j.plana.2025.100161openalex-snapshot
Nanomaterials for delivery of medicinal plant extracts and phytochemicals: Potential applications and future perspectives
inferred← citeshttps://doi.org/10.1016/j.plaphy.2026.111227openalex-snapshot
The gasotransmitters hydrogen sulfide and nitric oxide independently regulate growth, physiology, and secondary metabolism in fenugreek (Trigonella foenum-graecum L.)
inferred← citeshttps://doi.org/10.1016/j.prenap.2026.100525openalex-snapshot
Therapeutic potential of gallic acid and diosgenin in metabolic dysfunction-associated steatotic liver disease (MASLD) and non-alcoholic fatty liver disease (NAFLD): A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.saa.2024.125349openalex-snapshot
Exploring the potential of diosgenin as a promising antitumor agent through comprehensive spectroscopic characterization, solvent–solute interactions, topological properties, Hirshfeld surface, and molecular docking interactions with 2NZT and 2I1V proteins
inferred← citeshttps://doi.org/10.1016/j.sciaf.2025.e02941openalex-snapshot
Historical and ethnopharmacological perspectives on African medicinal plants: From traditional remedies to computational drug discovery
inferred← citeshttps://doi.org/10.1016/j.steroids.2023.109218openalex-snapshot
Production of encapsulated (25R)-Spirost-5-en-3β-ol powder with composite coating material and its characterization
inferred← citeshttps://doi.org/10.1016/j.steroids.2023.109256openalex-snapshot
Epoxide of diosgenin acetate synthesis: DoE for diastereoselective yield optimization, antimicroibial, antioxidant and antiproliferative effects
inferred← citeshttps://doi.org/10.1016/j.steroids.2024.109393openalex-snapshot
Potential targets of diosgenin for the treatment of oral squamous cell carcinoma and their bioinformatics and transcriptional profiling analyses
inferred← citeshttps://doi.org/10.1016/j.steroids.2025.109602openalex-snapshot
BSS-4, a diosgenin analogue, reduces carrageenan-induced paw inflammation in rat
inferred← citeshttps://doi.org/10.1016/j.transproceed.2024.11.007openalex-snapshot
Diosgenin Mediated JAK/STAT Signal Channel Improving SD Rat Renal Ischemia-Reperfusion
inferred← citeshttps://doi.org/10.1016/j.waojou.2026.101412openalex-snapshot
Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markers
inferred← citeshttps://doi.org/10.1016/j.ydbio.2025.11.008openalex-snapshot
Evaluation of molecular interaction studies of khellin on bovine serum albumin through various biophysical approaches
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6c00721openalex-snapshot
Hydroxypheophytin a Stereoisomers as Principal Bioactive Compounds from Spirulina for the Reduction of Lipids and Appetite
inferred← citeshttps://doi.org/10.1021/acs.joc.4c01756openalex-snapshot
Insight into the Course of the Ferrier Rearrangement Used to Obtain Untypical Diosgenyl Saponins
inferred← citeshttps://doi.org/10.1021/acsami.4c13445openalex-snapshot
Construction of an Innovative Nanogel and Its Applications for Achieving Chemo-Immunotherapy of Tumors
inferred← citeshttps://doi.org/10.1021/acsomega.5c00981openalex-snapshot
AI-Driven Multiscale Study on the Mechanism of Polygonati Rhizoma in Regulating Immune Function in STAD
inferred← citeshttps://doi.org/10.1021/acsomega.6c00145openalex-snapshot
Scale-Up Isolation of High-Purity Shatavarins from Asparagus racemosus via Flash Chromatography with Bioavailability and Pharmacological Insights
inferred← citeshttps://doi.org/10.1038/s41598-026-35006-6openalex-snapshot
Structural basis for diosgenin as an inverse agonist of retinoic acid receptor-related orphan receptor γ
inferred← citeshttps://doi.org/10.1038/s41598-026-35751-8openalex-snapshot
Mechanism of Babao Dan on fluorouracil-induced bone marrow suppression and T cell immune disorder through MAPK pathway
inferred← citeshttps://doi.org/10.1039/d4ra03249gopenalex-snapshot
Phytofabricated ZnO-NPs mediated by Hibiscus tiliaceus leaf extract and its potential as a diosgenin delivery vehicle
inferred← citeshttps://doi.org/10.1039/d6cc02702dopenalex-snapshot
Biocatalytic strategies for steroid synthesis: from side-chain remodeling to precision scaffold functionalization
inferred← citeshttps://doi.org/10.1055/a-1874-9617openalex-snapshot
Phytotherapeutika zur Behandlung von vasomotorischen Symptomen im Klimakterium
inferred← citeshttps://doi.org/10.1055/a-2263-1329openalex-snapshot
Therapeutic Potential of Diosgenin in Amelioration of Carbon Tetrachloride-Induced Murine Liver Injury
inferred← citeshttps://doi.org/10.1055/s-0045-1807269openalex-snapshot
Exploring the Mechanism of Yougui Pill against Aging Based on Network Pharmacology and Molecular Docking Study
inferred← citeshttps://doi.org/10.1063/5.0258681openalex-snapshot
Comparative estimation of ROS levels in zebrafish larvae on the treatment of diosgenin and doxorubicin under stress conditions for antioxidant property
inferred← citeshttps://doi.org/10.1080/07391102.2022.2122568openalex-snapshot
Anti-angiogenic potential of bioactive phytochemicals from Helicteres isora targeting VEGFR-2 to fight cancer through molecular docking and molecular dynamics simulation
inferred← citeshttps://doi.org/10.1080/07391102.2025.2458334openalex-snapshot
Identification of potential therapeutic phytocompounds targeting the G-glycoprotein of Nipah Virus: an in-silico study
inferred← citeshttps://doi.org/10.1080/10942912.2023.2243050openalex-snapshot
Advances in Alzheimer’s disease therapeutics: biochemistry, exploring bioactive compounds and novel approaches
inferred← citeshttps://doi.org/10.1080/14786419.2026.2683704openalex-snapshot
Assessment of the diosgenin content of various accessions and the epicarp, pulp, and seed kernels of Balanites roxhburghii Planch
inferred← citeshttps://doi.org/10.1080/15376516.2025.2567419openalex-snapshot
Potential of Fenfuro ® , a novel, standardized Trigonella foenum-graecum (Fenugreek) seed extract, in ameliorating glycation-mediated amyloidogenesis
inferred← citeshttps://doi.org/10.1080/15502783.2025.2540408openalex-snapshot
How reliable is the labeling of a commercial phytosteroid product? A 12-week randomized double-blind training study
inferred← citeshttps://doi.org/10.1080/17435889.2026.2734068openalex-snapshot
Preclinical advances on diosgenin-loaded nanomedicines
inferred← citeshttps://doi.org/10.1080/17512433.2025.2517748openalex-snapshot
Hormonal contraception, past, present, and future part 1: the early path – facts, stories, and controversies
inferred← citeshttps://doi.org/10.1089/jop.2023.0089openalex-snapshot
Solanum nigrum Toxicity and Its Neuroprotective Effect Against Retinal Ganglion Cell Death Through Modulation of Extracellular Matrix in a Glaucoma Rat Model
inferred← citeshttps://doi.org/10.1111/jnc.16033openalex-snapshot
Gut microbiota modification by diosgenin mediates antiepileptic effects in a mouse model of epilepsy
inferred← citeshttps://doi.org/10.1155/2022/5628601openalex-snapshot
Artemisia spp.: An Update on Its Chemical Composition, Pharmacological and Toxicological Profiles
inferred← citeshttps://doi.org/10.1155/2022/8002766openalex-snapshot
Cytotoxic and Antioxidant Properties of Natural Bioactive Monoterpenes Nerol, Estragole, and 3,7-Dimethyl-1-Octanol
inferred← citeshttps://doi.org/10.1167/iovs.67.6.10openalex-snapshot
Diosgenin Attenuates Photoreceptor Degeneration in an N-Methyl-N-Nitrosourea–Induced Mouse Model of Retinal Degeneration
inferred← citeshttps://doi.org/10.1177/10915818261469132openalex-snapshot
Acute and Chronic Toxicity Assessment of Diosgenin Polyethylene Glycol Succinate in Wistar Rats: Safety Evaluation of a Novel Universal Solubilizer
inferred← citeshttps://doi.org/10.1186/s12870-024-05133-1openalex-snapshot
Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study
inferred← citeshttps://doi.org/10.1186/s12934-025-02910-xopenalex-snapshot
Functional characterization of a novel β-glucosidase converting trillin to diosgenin from Enterococcus faecalis
inferred← citeshttps://doi.org/10.1186/s12935-022-02663-2openalex-snapshot
Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
inferred← citeshttps://doi.org/10.1186/s12935-022-02666-zopenalex-snapshot
Targeting Ras-ERK cascade by bioactive natural products for potential treatment of cancer: an updated overview
inferred← citeshttps://doi.org/10.1186/s12935-022-02706-8openalex-snapshot
Recent advances and limitations of mTOR inhibitors in the treatment of cancer
inferred← citeshttps://doi.org/10.1186/s12935-022-02721-9openalex-snapshot
Sesquiterpenoid lactones as potential anti-cancer agents: an update on molecular mechanisms and recent studies
inferred← citeshttps://doi.org/10.1186/s12935-022-02806-5openalex-snapshot
Natural essential oils as a new therapeutic tool in colorectal cancer
inferred← citeshttps://doi.org/10.1186/s12964-023-01109-0openalex-snapshot
Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy
inferred← citeshttps://doi.org/10.1186/s13020-023-00727-7openalex-snapshot
A comprehensive review on traditional uses, phytochemistry and pharmacological properties of Paeonia emodi Wall. ex Royle: current landscape and future perspectives
inferred← citeshttps://doi.org/10.1186/s13058-024-01868-9openalex-snapshot
Epigallocatechin gallate and curcumin inhibit Bcl-2: a pharmacophore and docking based approach against cancer
inferred← citeshttps://doi.org/10.1186/s40001-026-04168-4openalex-snapshot
Protective effects of diosgenin against non-alcoholic fatty liver disease through inhibiting the STING-dependent inflammatory pathway
inferred← citeshttps://doi.org/10.1186/s40816-025-00394-1openalex-snapshot
Tupistra Nutans:A comprehensive review of morphology, phytochemical profile, and Pharmacological activity”
inferred← citeshttps://doi.org/10.1246/bcsj.20230166openalex-snapshot
NMR Studies on the Structure and Functions of Small Biomolecules with Highly Flexible Conformation
inferred← citeshttps://doi.org/10.12677/acm.2025.151085openalex-snapshot
Exploring the Mechanism of Sishen Decoction in Intervening Diarrhea-Predominant Irritable Bowel Syndrome with Depression Based on Network Pharmacology
inferred← citeshttps://doi.org/10.13057/asianjagric/g090118openalex-snapshot
Tuber diversity of Dioscorea hispida from Muna Island, Indonesia, for potential microencapsulated bioherbicide agents
inferred← citeshttps://doi.org/10.1371/journal.pone.0342058openalex-snapshot
In-silico identification of anti-cholera phytochemicals from Indian medicinal plants
inferred← citeshttps://doi.org/10.1515/znc-2022-0076openalex-snapshot
Santalum Genus: phytochemical constituents, biological activities and health promoting-effects
inferred← citeshttps://doi.org/10.15379/ijmst.v10i4.3634openalex-snapshot
Preparation Of Diosgenin-Encapsulated Microspheres By Spray Drying Technique
inferred← citeshttps://doi.org/10.1590/1519-6984.271619openalex-snapshot
Antioxidants from different citrus peels provide protection against cancer
inferred← citeshttps://doi.org/10.18370/2309-4117.2023.69.104-112openalex-snapshot
Phytocompositions of ayurvedic medicine in the restoration of menstrual health in women of early reproductive age who have survived moderate and severe form of COVID-19
inferred← citeshttps://doi.org/10.20944/preprints202401.0362.v1openalex-snapshot
Telomerase Inhibition Potential of Natural Compounds in Leukemia Treatment
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5661693/v1openalex-snapshot
Exploration of Potential Therapeutic Targets of Diosgenin in Pulmonary Fibrosis through Network Pharmacology and Mendelian Randomization
inferred← citeshttps://doi.org/10.2147/dddt.s577261openalex-snapshot
Synergistic Enhancement of Diosgenin Dissolution and Bioavailability via Ternary Solid Dispersions and Self-Assembled Polymeric Micelles
inferred← citeshttps://doi.org/10.2174/0113816128348771240925100639openalex-snapshot
Herbal Remedies for Hepatic Inflammation: Unravelling Pathways and Mechanisms for Therapeutic Intervention
inferred← citeshttps://doi.org/10.2174/0113862073331615241018081811openalex-snapshot
Potential Cardiovascular Disease Treatment by Natural Drugs Targeting the HIF-1α Factor and its Pathway
inferred← citeshttps://doi.org/10.2174/0115734072334775241209052941openalex-snapshot
Botanical Bounty: Exploring Aphrodisiac Drug Discovery and Development from Nature's Pharmacy
inferred← citeshttps://doi.org/10.2174/0115748855399874250726091823openalex-snapshot
Novel Granular Formulation of Solanum nigrum and Cichorium intybus Leaf Juice Hepatoprotective Effects Against Paracetamol-induced Toxicity in Rats
inferred← citeshttps://doi.org/10.22541/au.168478029.91639355/v1openalex-snapshot
Library-based UHPLC-Q-Exactive-Orbitrap-MS Putative Identification of Isomeric and Non-isomeric Compounds from Shenling Baizhu Granule and its Pharmacopoeia Quality-marker Chemistry
inferred← citeshttps://doi.org/10.23736/s2724-542x.22.02946-7openalex-snapshot
Neuroprotective effect of curcumin and curcumin-integrated nanocarriers in stroke: from mechanisms to therapeutic opportunities
inferred← citeshttps://doi.org/10.31632/ijalsr.2025.v08i02.013openalex-snapshot
Antioxidant Activity Test and Antibacterial Gel Formulation of Ethanol Extract of Black Ginger (Curcuma aeruginosa Roxb.) Rhizome
inferred← citeshttps://doi.org/10.32859/era.24.15.1-16openalex-snapshot
Ethnomedicinal and traditional application of Allium wallichii Kunth (Himalayan Onion): An unexplored and underutilized nutraceutical plant foods from Himalayan regions.
inferred← citeshttps://doi.org/10.3389/fcell.2022.1005910openalex-snapshot
Recent updates on anticancer mechanisms of polyphenols
inferred← citeshttps://doi.org/10.3389/fnut.2024.1280100openalex-snapshot
Fenugreek derived diosgenin as an emerging source for diabetic therapy
inferred← citeshttps://doi.org/10.3389/fnut.2026.1903508openalex-snapshot
Effects of oral fenugreek-derived preparations on testosterone-related outcomes in adult men: a systematic review and meta-analysis of randomized placebo-controlled trials
inferred← citeshttps://doi.org/10.3389/fphar.2023.1226548openalex-snapshot
Literature review on hepatoprotective effects of diosgenin: possible mechanisms of action
inferred← citeshttps://doi.org/10.3389/fphar.2023.1232088openalex-snapshot
Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress
inferred← citeshttps://doi.org/10.3389/fphar.2025.1555849openalex-snapshot
Modulating the gut microbiota and inflammation is involved in the effect of diosgenin against diabetic nephropathy in rat
inferred← citeshttps://doi.org/10.3390/antiox13040427openalex-snapshot
Telomerase Inhibition in the Treatment of Leukemia: A Comprehensive Review
inferred← citeshttps://doi.org/10.3390/biomedicines11061611openalex-snapshot
Therapeutic Approaches in Pancreatic Cancer: Recent Updates
inferred← citeshttps://doi.org/10.3390/cancers18030458openalex-snapshot
Risks, Benefits, and Molecular Targets of Fenugreek Administration in the Treatment of Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3390/cosmetics13010044openalex-snapshot
Fenugreek as a Versatile Cosmetic Ingredient: Phytochemical Profile, Skin–Hair Benefits and Formulation Opportunities
inferred← citeshttps://doi.org/10.3390/foods15183178openalex-snapshot
Agro-Industrial Potential of Yam (Dioscorea spp.): From Biological and Chemical Characterization to Industrial Applications and Valorization
inferred← citeshttps://doi.org/10.3390/ijms232415854openalex-snapshot
Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain
inferred← citeshttps://doi.org/10.3390/ijms24055049openalex-snapshot
Effect of Chitosan-Diosgenin Combination on Wound Healing
inferred← citeshttps://doi.org/10.3390/ijms24098430openalex-snapshot
The Functional Characterization of DzCYP72A12-4 Related to Diosgenin Biosynthesis and Drought Adaptability in Dioscorea zingiberensis
inferred← citeshttps://doi.org/10.3390/ijms25168588openalex-snapshot
Correlation between Molecular Docking and the Stabilizing Interaction of HOMO-LUMO: Spirostans in CHK1 and CHK2, an In Silico Cancer Approach
inferred← citeshttps://doi.org/10.3390/ijms252413399openalex-snapshot
Protective Effects of Dioscin and Diosgenin on Plateau Hyperuricemia by Attenuating Renal Inflammation via EPHX2
inferred← citeshttps://doi.org/10.3390/ijms26136335openalex-snapshot
Inhibition of (p)ppGpp Synthesis and Membrane Fluidity Modulation by Diosgenin: A Strategy to Suppress Staphylococcus aureus Persister Cells
inferred← citeshttps://doi.org/10.3390/ijms27198624openalex-snapshot
Diosgenin Alleviates Neuropathic Pain Associated with Alterations in Spinal Mitochondrial and ER Stress-Related Factors in CCI Mice
inferred← citeshttps://doi.org/10.3390/jpm12091515openalex-snapshot
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
inferred← citeshttps://doi.org/10.3390/ma16093492openalex-snapshot
Polygonum cuspidatum Loaded Nanostructured Lipid Carriers for Dual Inhibition of TNF-α- and IL-6 Cytokines and Free Radical Species
inferred← citeshttps://doi.org/10.3390/metabo15110701openalex-snapshot
Geographical Variation Shapes Nutritional Metabolite Profile and Food Functionality of Houttuynia cordata
inferred← citeshttps://doi.org/10.3390/molecules28031486openalex-snapshot
Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/molecules28073093openalex-snapshot
Characterization and Biological Activities of Four Biotransformation Products of Diosgenin from Rhodococcus erythropolis
inferred← citeshttps://doi.org/10.3390/molecules31040693openalex-snapshot
Harnessing Endophytic Fungi as a Sustainable Source of Novel Anticancer Agents: Opportunities, Challenges, and Future Directions
inferred← citeshttps://doi.org/10.3390/molecules31173046openalex-snapshot
Comparative Transcriptomic Analysis Provides Insights into PSK-α-Mediated Regulation of Diosgenin Biosynthesis in Trigonella foenum-graecum
inferred← citeshttps://doi.org/10.3390/nu15173677openalex-snapshot
Dietary Supplements for Erectile Dysfunction: Analysis of Marketed Products, Systematic Review, Meta-Analysis and Rational Use
inferred← citeshttps://doi.org/10.3390/nu15234951openalex-snapshot
Safety of Innovative Nanotechnology Oral Formulations Loaded with Bioactive Menopause Molecules: Influence of Genotoxicity and Biochemical Parameters on a Menopausal Rat Model
inferred← citeshttps://doi.org/10.3390/nu17233695openalex-snapshot
The Combination of Diosgenin, Vitamin D, and α-Lactalbumin Normalizes the Menstrual Cycle in Women with PCOS of Phenotype D: A Pilot Clinical Study
inferred← citeshttps://doi.org/10.3390/plants11141885openalex-snapshot
Anticancer Potential and Other Pharmacological Properties of Prunus armeniaca L.: An Updated Overview
inferred← citeshttps://doi.org/10.3390/plants12173024openalex-snapshot
Integrative Approach to Identifying System-Level Mechanisms of Chung-Sang-Bo-Ha-Hwan’s Influence on Respiratory Tract Diseases: A Network Pharmacological Analysis with Experimental Validation
inferred← citeshttps://doi.org/10.3390/sci6020036openalex-snapshot
Anti-Aging Potential of Bioactive Phytoconstituents Found in Edible Medicinal Plants: A Review
inferred← citeshttps://doi.org/10.3390/separations9110326openalex-snapshot
Multidimensional Chromatography and Its Applications in Food Products, Biological Samples and Toxin Products: A Comprehensive Review
inferred← citeshttps://doi.org/10.52768/epidemiology/1022openalex-snapshot
Review of Saponins in Treating Heart Failure
inferred← citeshttps://doi.org/10.53555/jrtdd.v6i1.2573openalex-snapshot
Formulation And Evaluation Of Diosgenin Gel For Its In Vivo Anti-Skin Cancer Activity
inferred← citeshttps://doi.org/10.5530/pres.20252199openalex-snapshot
Development and Validation of an HPLC Method for Diosgenin, A Bioactive Compound in the Rhizomes of Chamaecostus cuspidatus
inferred← citeshttps://doi.org/10.6084/m9.figshare.26733540openalex-snapshot
Additional file 1 of Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26733543openalex-snapshot
Additional file 2 of Identification of genetic variants controlling diosgenin content in Dioscorea zingiberensis tuber by genome-wide association study
inferred← citeshttps://doi.org/10.6084/m9.figshare.26746118openalex-snapshot
Additional file 1 of Epigallocatechin gallate and curcumin inhibit Bcl-2: a pharmacophore and docking based approach against cancer
inferred← citeshttps://doi.org/10.9734/irjpac/2024/v25i4866openalex-snapshot
Proximate, Selected Elements and Bioactive Compounds in Jatropha tanjorensis and Bryophyllum pinnatum Leaves
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