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Analytical Methods for Extraction and Identification of Primary and Secondary Metabolites of Apple (Malus domestica) Fruits: A Review

https://doi.org/10.3390/separations8070091

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Fragmentation of the main triterpene acids of apple by LC‐APCI‐MS n

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Flavonoid and chlorogenic acid profiles of English cider apples

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inferredcites →https://doi.org/10.1007/s00217-013-1931-zopenalex-snapshot

Effect of l-ascorbic acid addition on quality, polyphenolic compounds and antioxidant capacity of cloudy apple juices

inferredcites →https://doi.org/10.1007/s10068-013-0212-8openalex-snapshot

Solvent and solvent to sample ratio as main parameters in the microwave-assisted extraction of polyphenolic compounds from apple pomace

inferredcites →https://doi.org/10.1007/s11032-015-0334-1openalex-snapshot

QTLs detected for individual sugars and soluble solids content in apple

inferredcites →https://doi.org/10.1007/s12161-020-01703-9openalex-snapshot

Determination of Major Phenolics Content in Dried Apples from Three New Cultivars (Malus domestica Borkh.) Using HPLC-UV-FL with Pentafluorophenyl Stationary Phase

inferredcites →https://doi.org/10.1007/s13580-018-0051-xopenalex-snapshot

Characterization of quercetin and its glycoside derivatives in Malus germplasm

inferredcites →https://doi.org/10.1016/b978-0-08-100596-5.22774-1openalex-snapshot

LC/MS Based Food Metabolomics

inferredcites →https://doi.org/10.1016/j.aca.2014.03.030openalex-snapshot

Multi-response optimization of the extraction and derivatization protocol of selected polar metabolites from apple fruit tissue for GC–MS analysis

inferredcites →https://doi.org/10.1016/j.arabjc.2016.12.009openalex-snapshot

Strategy for optimized use of LC-MS for determination of the polyphenolic profiles of apple peel, flesh and leaves

inferredcites →https://doi.org/10.1016/j.chroma.2004.06.077openalex-snapshot

On-line characterisation of apple polyphenols by liquid chromatography coupled with mass spectrometry and ultraviolet absorbance detection

inferredcites →https://doi.org/10.1016/j.chroma.2011.05.004openalex-snapshot

Hydrophilic interaction liquid chromatography in food analysis

inferredcites →https://doi.org/10.1016/j.chroma.2013.09.075openalex-snapshot

A new ultrahigh performance liquid chromatography with diode array detection coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry analytical strategy for fast analysis and improved characterization of phenolic compounds in apple products

inferredcites →https://doi.org/10.1016/j.chroma.2014.01.044openalex-snapshot

Ultra performance liquid chromatography analysis to study the changes in the carotenoid profile of commercial monovarietal fruit juices

inferredcites →https://doi.org/10.1016/j.chroma.2015.09.082openalex-snapshot

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inferredcites →https://doi.org/10.1016/j.chroma.2017.03.030openalex-snapshot

Development, validation and evaluation of an analytical method for the determination of monomeric and oligomeric procyanidins in apple extracts

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Method development and optimization for the determination of benzene, toluene, ethylbenzene and xylenes in water at trace levels by static headspace extraction coupled to gas chromatography–barrier ionization discharge detection

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The constitutive phenolic composition of two Malus×domestica genotypes is not responsible for their contrasted susceptibilities to fire blight

inferredcites →https://doi.org/10.1016/j.fbp.2008.03.004openalex-snapshot

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inferredcites →https://doi.org/10.1016/j.foodchem.2004.04.036openalex-snapshot

Fibre concentrates from apple pomace and citrus peel as potential fibre sources for food enrichment

inferredcites →https://doi.org/10.1016/j.foodchem.2006.07.030openalex-snapshot

Chemical compositional characterization of some apple cultivars

inferredcites →https://doi.org/10.1016/j.foodchem.2010.05.053openalex-snapshot

Developmental changes of carbohydrates, organic acids, amino acids, and phenolic compounds in ‘Honeycrisp’ apple flesh

inferredcites →https://doi.org/10.1016/j.foodchem.2010.12.026openalex-snapshot

A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables

inferredcites →https://doi.org/10.1016/j.foodchem.2011.01.056openalex-snapshot

Effect of pectinase treatment on extraction of antioxidant phenols from pomace, for the production of puree-enriched cloudy apple juices

inferredcites →https://doi.org/10.1016/j.foodchem.2011.02.052openalex-snapshot

Total phenolics, flavonoids, anthocyanins and antioxidant activity following simulated gastro-intestinal digestion and dialysis of apple varieties: Bioaccessibility and potential uptake

inferredcites →https://doi.org/10.1016/j.foodchem.2012.06.068openalex-snapshot

Water at room temperature as a solvent for the extraction of apple pomace phenolic compounds

inferredcites →https://doi.org/10.1016/j.foodchem.2012.08.062openalex-snapshot

An improved mass spectrometric method for identification and quantification of phenolic compounds in apple fruits

inferredcites →https://doi.org/10.1016/j.foodchem.2013.08.135openalex-snapshot

Simultaneous separation and determination of fructose, sorbitol, glucose and sucrose in fruits by HPLC–ELSD

inferredcites →https://doi.org/10.1016/j.foodchem.2015.12.060openalex-snapshot

Simultaneous determination of glucose, fructose, sucrose and sorbitol in the leaf and fruit peel of different apple cultivars by the HPLC–RI optimized method

inferredcites →https://doi.org/10.1016/j.foodchem.2016.07.166openalex-snapshot

Identification/quantification of free and bound phenolic acids in peel and pulp of apples (Malus domestica) using high resolution mass spectrometry (HRMS)

inferredcites →https://doi.org/10.1016/j.foodchem.2016.10.029openalex-snapshot

Ursolic acid from apple pomace and traditional plants: A valuable triterpenoid with functional properties

inferredcites →https://doi.org/10.1016/j.foodchem.2017.09.091openalex-snapshot

Mass spectrometry-based phytochemical screening for hypoglycemic activity of Fagioli di Sarconi beans (Phaseolus vulgaris L.)

inferredcites →https://doi.org/10.1016/j.foodcont.2017.02.036openalex-snapshot

Volatile fraction analysis by HS-SPME/GC-MS and chemometric modeling for traceability of apples cultivated in the Northeast Italy

inferredcites →https://doi.org/10.1016/j.foodqual.2013.09.010openalex-snapshot

Preference mapping of apple varieties in Europe

inferredcites →https://doi.org/10.1016/j.foodres.2005.04.007openalex-snapshot

A review of the analytical methods to determine organic acids in grape juices and wines

inferredcites →https://doi.org/10.1016/j.foodres.2011.01.036openalex-snapshot

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inferredcites →https://doi.org/10.1016/j.foodres.2014.03.025openalex-snapshot

Chlorophyll and carotenoid pigments in the peel and flesh of commercial apple fruit varieties

inferredcites →https://doi.org/10.1016/j.foodres.2015.07.047openalex-snapshot

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inferredcites →https://doi.org/10.1016/j.jchromb.2014.01.009openalex-snapshot

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inferredcites →https://doi.org/10.1016/j.jclepro.2018.03.165openalex-snapshot

Biorecovery of antioxidants from apple pomace by supercritical fluid extraction

inferredcites →https://doi.org/10.1016/j.jfca.2005.04.004openalex-snapshot

Analysis of carotenoids in vegetable and plasma samples: A review

inferredcites →https://doi.org/10.1016/j.jfca.2008.07.006openalex-snapshot

Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products

inferredcites →https://doi.org/10.1016/j.jfca.2010.12.012openalex-snapshot

Phenolic and polysaccharidic composition of applesauce is close to that of apple flesh

inferredcites →https://doi.org/10.1016/j.jfca.2013.05.012openalex-snapshot

Polyphenolic characterisation of old local apple varieties from Southeastern European region

inferredcites →https://doi.org/10.1016/j.jfca.2014.05.004openalex-snapshot

Phenolic and mineral profiles of four Balkan indigenous apple cultivars monitored at two different maturity stages

inferredcites →https://doi.org/10.1016/j.jfda.2019.10.003openalex-snapshot

Gas chromatography-mass spectrometry-based analytical strategies for fatty acid analysis in biological samples

inferredcites →https://doi.org/10.1016/j.jff.2009.12.004openalex-snapshot

Characterization of traditional and exotic apple varieties from Portugal. Part 1 – Nutritional, phytochemical and sensory evaluation

inferredcites →https://doi.org/10.1016/j.jff.2015.02.041openalex-snapshot

Comparison of phenolic compounds and antioxidant potential between selected edible fruits and their leaves

inferredcites →https://doi.org/10.1016/j.jfoodeng.2012.01.026openalex-snapshot

Lab and pilot-scale ultrasound-assisted water extraction of polyphenols from apple pomace

inferredcites →https://doi.org/10.1016/j.postharvbio.2005.10.003openalex-snapshot

Instrumental measurement of apple texture: A comparison of the single-edge notched bend test and the penetrometer

inferredcites →https://doi.org/10.1016/j.scienta.2007.05.004openalex-snapshot

Parameters of inner quality of the apple scab resistant and susceptible apple cultivars (Malus domestica Borkh.)

inferredcites →https://doi.org/10.1016/j.scienta.2009.01.038openalex-snapshot

Cultivar variation in apple peel and whole fruit phenolic composition

inferredcites →https://doi.org/10.1016/j.scienta.2009.06.012openalex-snapshot

Physico-chemical and antioxidant properties of six apple cultivars (Malus domestica Borkh) grown in southern Brazil

inferredcites →https://doi.org/10.1016/j.scienta.2015.01.001openalex-snapshot

Analytical methods for determination of sugars and sweetness of horticultural products—A review

inferredcites →https://doi.org/10.1016/j.scitotenv.2018.08.150openalex-snapshot

CO2 and N2O from water resource recovery facilities: Evaluation of emissions from biological treatment, settling, disinfection, and receiving water body

inferredcites →https://doi.org/10.1016/j.talanta.2020.121862openalex-snapshot

Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues

inferredcites →https://doi.org/10.1016/j.tifs.2015.06.003openalex-snapshot

Metabolomics of carotenoids: The challenges and prospects – A review

inferredcites →https://doi.org/10.1016/j.trac.2016.12.006openalex-snapshot

Trends in LC-MS and LC-HRMS analysis and characterization of polyphenols in food

inferredcites →https://doi.org/10.1016/j.trac.2017.08.011openalex-snapshot

Recent chemometrics advances for foodomics

inferredcites →https://doi.org/10.1016/s0003-2670(02)00397-5openalex-snapshot

Analysis of fatty acids by gas chromatography, and its relevance to research on health and nutrition

inferredcites →https://doi.org/10.1016/s0021-9673(00)00921-3openalex-snapshot

Analytical-scale microwave-assisted extraction

inferredcites →https://doi.org/10.1016/s0021-9673(01)96512-4openalex-snapshot

Determination of organic acids in sugar cane process juice by high-performance liquid chromatography: improved resolution using dual aminex HPX-87H cation-exchange columns equilibrated to different temperatures

inferredcites →https://doi.org/10.1016/s0165-9936(98)00109-5openalex-snapshot

Solid-phase microextraction

inferredcites →https://doi.org/10.1016/s0925-5214(03)00098-xopenalex-snapshot

Fatty acids as precursors for aroma volatile biosynthesis in pre-climacteric and climacteric apple fruit

inferredcites →https://doi.org/10.1016/s0963-9969(00)00068-5openalex-snapshot

Review on polyphenols in Theobroma cacao: changes in composition during the manufacture of chocolate and methodology for identification and quantification

inferredcites →https://doi.org/10.1021/jf010021sopenalex-snapshot

Determination of Polyphenolic Profiles of Basque Cider Apple Varieties Using Accelerated Solvent Extraction

inferredcites →https://doi.org/10.1021/jf0346298openalex-snapshot

Polyphenolic Profiles in Eight Apple Cultivars Using High-Performance Liquid Chromatography (HPLC)

inferredcites →https://doi.org/10.1021/jf035416lopenalex-snapshot

Polyphenolic Profiles of Basque Cider Apple Cultivars and Their Technological Properties

inferredcites →https://doi.org/10.1021/jf040482oopenalex-snapshot

Major Phytochemicals in Apple Cultivars: Contribution to Peroxyl Radical Trapping Efficiency

inferredcites →https://doi.org/10.1021/jf049317zopenalex-snapshot

Quantitation of Polyphenols in Different Apple Varieties

inferredcites →https://doi.org/10.1021/jf049577gopenalex-snapshot

Optimization of Extraction of Apple Aroma by Dynamic Headspace and Influence of Saliva on Extraction of Volatiles

inferredcites →https://doi.org/10.1021/jf052889eopenalex-snapshot

Comparison of the HPLC Method and FT-NIR Analysis for Quantification of Glucose, Fructose, and Sucrose in Intact Apple Fruits

inferredcites →https://doi.org/10.1021/jf203970jopenalex-snapshot

Apple Peels, from Seven Cultivars, Have Lipase-Inhibitory Activity and Contain Numerous Ursenoic Acids As Identified by LC-ESI-QTOF-HRMS

inferredcites →https://doi.org/10.1021/jf3028446openalex-snapshot

Identification and Quantitation of Carotenoids and Tocopherols in Seed Oils Recovered from Different Rosaceae Species

inferredcites →https://doi.org/10.1021/jf403064popenalex-snapshot

Changes in Primary Metabolites and Polyphenols in the Peel of “Braeburn” Apples (Malus domesticaBorkh.) during Advanced Maturation

inferredcites →https://doi.org/10.1021/jf500336vopenalex-snapshot

Polyphenol Profiling of a Red-Fleshed Apple Cultivar and Evaluation of the Color Extractability and Stability in the Juice

inferredcites →https://doi.org/10.1021/jf800510jopenalex-snapshot

Polyphenolic Compounds and Antioxidant Activity of New and Old Apple Varieties

inferredcites →https://doi.org/10.1021/jf9608229openalex-snapshot

Rapid Analysis of Volatile Flavor Compounds in Apple Fruit Using SPME and GC/Time-of-Flight Mass Spectrometry

inferredcites →https://doi.org/10.1021/jf970832popenalex-snapshot

Reversed-Phase HPLC following Thiolysis for Quantitative Estimation and Characterization of the Four Main Classes of Phenolic Compounds in Different Tissue Zones of a French Cider Apple Variety (Malus domestica Var. Kermerrien)

inferredcites →https://doi.org/10.1021/jf990563yopenalex-snapshot

Polyphenol Profiles of French Cider Apple Varieties ( Malus domestica sp.)

inferredcites →https://doi.org/10.1038/hortres.2014.19openalex-snapshot

Effects of location within the tree canopy on carbohydrates, organic acids, amino acids and phenolic compounds in the fruit peel and flesh from three apple (Malus × domestica) cultivars

inferredcites →https://doi.org/10.1038/s41598-020-63817-8openalex-snapshot

Application of in vivo solid phase microextraction (SPME) in capturing metabolome of apple (Malus ×domestica Borkh.) fruit

inferredcites →https://doi.org/10.1061/(asce)ee.1943-7870.0001538openalex-snapshot

Toward a New Plant-Wide Experimental and Modeling Approach for Reduction of Greenhouse Gas Emission from Wastewater Treatment Plants

inferredcites →https://doi.org/10.1080/00032719.2014.886694openalex-snapshot

Determination of the Volatile Components of Apple Juice Using Solid Phase Microextraction and Gas Chromatography–Mass Spectrometry

inferredcites →https://doi.org/10.1080/01496395.2016.1165253openalex-snapshot

Ultrasonic assisted extraction of ursolic acid from apple pomace: A novel and facile technique

inferredcites →https://doi.org/10.1080/10942912.2018.1506478openalex-snapshot

Detection and analysis of triterpenic compounds in apple extracts

inferredcites →https://doi.org/10.1093/chromsci/41.6.331openalex-snapshot

Comparison of Different Extraction and Detection Methods for Sugars Using Amino-Bonded Phase HPLC

inferredcites →https://doi.org/10.1093/jxb/ers134openalex-snapshot

Metabolic and gene expression analysis of apple (Malus × domestica) carotenogenesis

inferredcites →https://doi.org/10.1104/pp.112.208249openalex-snapshot

Functional Genomics Reveals That a Compact Terpene Synthase Gene Family Can Account for Terpene Volatile Production in Apple

inferredcites →https://doi.org/10.1111/1750-3841.13277openalex-snapshot

Phenolic Profiles and Contribution of Individual Compounds to Antioxidant Activity of Apple Powders

inferredcites →https://doi.org/10.1111/j.1365-2621.2003.tb07038.xopenalex-snapshot

Representativeness of Apple Aroma Extract Obtained by Vacuum Hydrodistillation: Comparison of Two Concentration Techniques

inferredcites →https://doi.org/10.1111/j.1750-3841.2009.01356.xopenalex-snapshot

Phenolic Profiles and Antioxidant Properties of Apple Skin Extracts

inferredcites →https://doi.org/10.1111/j.1750-3841.2010.01823.xopenalex-snapshot

Impact of Shelf Life on Content of Primary and Secondary Metabolites in Apple ( Malus domestica Borkh.)

inferredcites →https://doi.org/10.1111/j.1750-3841.2011.02406.xopenalex-snapshot

Determination of Volatile Compounds in Apple Pomace by Stir Bar Sorptive Extraction and Gas Chromatography‐Mass Spectrometry (SBSE‐GC‐MS)

inferredcites →https://doi.org/10.1111/j.1750-3841.2012.02896.xopenalex-snapshot

Composition of Sugars, Organic Acids, and Total Phenolics in 25 Wild or Cultivated Berry Species

inferredcites →https://doi.org/10.1155/2014/542121openalex-snapshot

Application of an Optimized HPLC Method for the Detection of Various Phenolic Compounds in Apples from Lithuanian Cultivars

inferredcites →https://doi.org/10.1155/2016/6705431openalex-snapshot

Analysis of Polyphenolic Compounds in Extracts from Leaves of SomeMalus domesticaCultivars: Antiradical and Antimicrobial Analysis of These Extracts

inferredcites →https://doi.org/10.1155/2020/4264815openalex-snapshot

Pistacia lentiscus Hydrosol: Untargeted Metabolomic Analysis and Anti-Inflammatory Activity Mediated by NF-κB and the Citrate Pathway

inferredcites →https://doi.org/10.1177/1934578x1701200111openalex-snapshot

Characterization of the Polyphenolic Profiles of Peel, Flesh and Leaves of Malus domestica Cultivars Using UHPLC-DAD-HESI-MS n

inferredcites →https://doi.org/10.1186/1752-153x-8-45openalex-snapshot

Polyphenols profile and antioxidant activity of skin and pulp of a rare apple from Marche region (Italy)

inferredcites →https://doi.org/10.1263/jbb.100.347openalex-snapshot

Plant metabolomics: potential for practical operation

inferredcites →https://doi.org/10.13080/z-a.2018.105.010openalex-snapshot

Triterpenic acid content in the fruit peel of Malus × domestica Borkh. depends on the growing technology

inferredcites →https://doi.org/10.1371/journal.pone.0053725openalex-snapshot

Apple Peel Polyphenols and Their Beneficial Actions on Oxidative Stress and Inflammation

inferredcites →https://doi.org/10.1371/journal.pone.0141916openalex-snapshot

Cultivar and Year Rather than Agricultural Practices Affect Primary and Secondary Metabolites in Apple Fruit

inferredcites →https://doi.org/10.15414/jmbfs.2018.8.1.721-725openalex-snapshot

IN-VITRO ANTIBACTERIAL, PHYTOCHEMICAL, ANTIMYCOBACTERIAL ACTIVITIES AND GC-MS ANALYSES OF Bidens pilosa LEAF EXTRACT

inferredcites →https://doi.org/10.15835/nbha4229715openalex-snapshot

Determination of Major-to-Trace Minerals and Polyphenols in Different Apple Cultivars

inferredcites →https://doi.org/10.1631/jzus.2004.0651openalex-snapshot

Measurement of sugar content in Fuji apples by FT-NIR spectroscopy

inferredcites →https://doi.org/10.21273/hortsci.48.2.193openalex-snapshot

Influence of Phostrade Ca on Color Development and Anthocyanin Content of ‘Braeburn’ Apple (Malus domestica Borkh.)

inferredcites →https://doi.org/10.2478/fhort-2019-0019openalex-snapshot

Bio-chemical properties and susceptibility to fire blight ( Erwinia amylovora Burrill) of scab-resistant apple cultivars ( Malus domestica Borkh.)

inferredcites →https://doi.org/10.2478/s11696-012-0200-0openalex-snapshot

Changes in lipid composition of apple surface layer during long-term storage in controlled atmosphere

inferredcites →https://doi.org/10.3389/fpls.2019.00157openalex-snapshot

Root Exudation of Primary Metabolites: Mechanisms and Their Roles in Plant Responses to Environmental Stimuli

inferredcites →https://doi.org/10.3390/antiox2030181openalex-snapshot

Phenolic Compounds in Apple (Malus x domestica Borkh.): Compounds Characterization and Stability during Postharvest and after Processing

inferredcites →https://doi.org/10.3390/antiox7010020openalex-snapshot

Polyphenolic Compounds Analysis of Old and New Apple Cultivars and Contribution of Polyphenolic Profile to the In Vitro Antioxidant Capacity

inferredcites →https://doi.org/10.3390/antiox9060479openalex-snapshot

Determination of Polyphenols Using Liquid Chromatography–Tandem Mass Spectrometry Technique (LC–MS/MS): A Review

inferredcites →https://doi.org/10.3390/antiox9070567openalex-snapshot

Antioxidant Activity Modulated by Polyphenol Contents in Apple and Leaves during Fruit Development and Ripening

inferredcites →https://doi.org/10.3390/biom10060853openalex-snapshot

Oenological Characteristics of Fermented Apple Musts and Volatile Profile of Brandies Obtained from Different Apple Cultivars

inferredcites →https://doi.org/10.3390/foods7020015openalex-snapshot

Polyphenolic Characterization and Antioxidant Activity of Malus domestica and Prunus domestica Cultivars from Costa Rica

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Volatile Metabolites

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inferredcites →https://doi.org/10.4236/ajac.2017.86032openalex-snapshot

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Variation of Ursolic and Betulinic Acid in Five Malus χ domestica clones from Southern Brazil

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Additional file 1 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

inferred← citeshttps://doi.org/10.6084/m9.figshare.25414996openalex-snapshot

Additional file 2 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

inferred← citeshttps://doi.org/10.6084/m9.figshare.26693368openalex-snapshot

Additional file 3 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

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Additional file 4 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

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Additional file 5 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

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Additional file 6 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

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Additional file 7 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

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Additional file 8 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

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Additional file 9 of Multi-omics provide insights into the regulation of DNA methylation in pear fruit metabolism

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