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Recapitulating the α-Helix: Nonpeptidic, Low-Molecular-Weight Ligands for the Modulation of Helix-Mediated Protein–Protein Interactions

https://doi.org/10.4155/fmc.13.176

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Design of a Protein Surface Antagonist Based on α-Helix Mimicry: Inhibition of gp41 Assembly and Viral Fusion We thank the National Institutes of Health for support of this work and the Deutsche Forschungsgemeinschaft (DFG) for a research fellowship to O.K.

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Strategies for Targeting Protein–Protein Interactions With Synthetic Agents

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Structure and Function of Benzoylurea‐Derived α‐Helix Mimetics Targeting the Bcl‐xL/Bak Binding Interface

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Modular Synthesis of Triazole‐Containing Triaryl α‐Helix Mimetics

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Modular Solid‐Phase Synthesis of Teroxazoles as a Class of α‐Helix Mimetics

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Protein–protein interaction networks and subnetworks in the biology of disease

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Phospholipid Catalysis of Diabetic Amyloid Assembly

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Conformational properties of O-alkylated benzamides

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Facile synthesis of benzamides to mimic an α-helix

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Protein β-turn mimetics I. Design, synthesis, and evaluation in model cyclic peptides.

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Features of protein–protein interactions that translate into potent inhibitors: topology, surface area and affinity

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Comprehensive Peptidomimetic Libraries Targeting Protein–Protein Interactions

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inferredcites →https://doi.org/10.1021/ol901785vopenalex-snapshot

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inferredcites →https://doi.org/10.1038/nchem.1568openalex-snapshot

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inferredcites →https://doi.org/10.1038/npp.2008.151openalex-snapshot

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inferredcites →https://doi.org/10.1039/b608043jopenalex-snapshot

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inferredcites →https://doi.org/10.1039/b712606aopenalex-snapshot

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2-O-Alkylated para-benzamide α-helix mimetics: the role of scaffold curvature

inferredcites →https://doi.org/10.1073/pnas.84.24.8898openalex-snapshot

Helix stabilization by Glu-...Lys+ salt bridges in short peptides of de novo design.

inferredcites →https://doi.org/10.1073/pnas.95.26.15613openalex-snapshot

Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target

inferredcites →https://doi.org/10.1074/jbc.m110.203638openalex-snapshot

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inferredcites →https://doi.org/10.1111/j.1747-0285.2006.00365.xopenalex-snapshot

Substituted 1,4‐Benzodiazepine‐2,5‐diones as α‐Helix Mimetic Antagonists of the HDM2‐p53 Protein–Protein Interaction

inferredcites →https://doi.org/10.1126/science.1092472openalex-snapshot

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

inferredcites →https://doi.org/10.1126/science.281.5381.1322openalex-snapshot

The Bcl-2 Protein Family: Arbiters of Cell Survival

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The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein–protein interactions with Bak

inferredcites →https://doi.org/10.1515/bc.2002.150openalex-snapshot

Dimerization Inhibitors of HIV-1 Protease

inferredcites →https://doi.org/10.2174/138161211798220972openalex-snapshot

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Pancreatic duodenal homeobox factor-1and diabetes mellitus type 2 (Review)

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Selective Pyridine-Directed C-H Activations Enabled Synthesis of Pyridine-Pyridone Α-Helix Mimics

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