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Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

https://doi.org/10.4161/auto.9099
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THE IMPACT OF MICROGRAVITY ON DIFFERENT CELL SIGNALLING PATHWAYS
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CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy
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Expression profile and bioinformatics analysis of circular RNA in intestinal mucosal injury and repair after severe burns
inferred← citeshttps://doi.org/10.1002/ibd.21191openalex-snapshot
Cell death in the colonic epithelium during inflammatory bowel diseases
inferred← citeshttps://doi.org/10.1002/ijc.28301openalex-snapshot
Ursolic acid promotes cancer cell death by inducing Atg5‐dependent autophagy
inferred← citeshttps://doi.org/10.1002/jat.3049openalex-snapshot
Carnosic acid induces autophagic cell death through inhibition of the Akt/mTOR pathway in human hepatoma cells
inferred← citeshttps://doi.org/10.1002/jbm.a.35418openalex-snapshot
Necrotic cell death caused by exposure to graphitic carbon‐coated magnetic nanoparticles
inferred← citeshttps://doi.org/10.1002/stem.2808openalex-snapshot
Mesenchymal Stem Cells Protect Against Hypoxia-Ischemia Brain Damage by Enhancing Autophagy Through Brain Derived Neurotrophic Factor/Mammalin Target of Rapamycin Signaling Pathway
inferred← citeshttps://doi.org/10.1002/wrna.1719openalex-snapshot
Potential applications of N6‐methyladenosine modification in the prognosis and treatment of cancers via modulating apoptosis, autophagy, and ferroptosis
inferred← citeshttps://doi.org/10.1007/978-1-4614-6561-4_12openalex-snapshot
Autophagy and Cancer Drug Discovery
inferred← citeshttps://doi.org/10.1007/978-1-4614-8220-8_12openalex-snapshot
Autophagic Cell Death: A Real Killer, an Accomplice, or an Innocent Bystander?
inferred← citeshttps://doi.org/10.1007/978-1-4614-8220-8_13openalex-snapshot
Autophagy in Necrosis: A Force for Survival
inferred← citeshttps://doi.org/10.1007/978-1-4614-8220-8_17openalex-snapshot
Small-Molecule Inhibitors of Necroptosis
inferred← citeshttps://doi.org/10.1007/978-3-319-28305-0_13openalex-snapshot
Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide
inferred← citeshttps://doi.org/10.1007/978-3-319-42740-9_7openalex-snapshot
Role of Autophagy in Tumor Progression and Regression
inferred← citeshttps://doi.org/10.1007/978-981-15-4272-5_23openalex-snapshot
Autophagy and Tumor Cell Death
inferred← citeshttps://doi.org/10.1007/s00213-025-06834-7openalex-snapshot
Liraglutide improves depressive and cognitive deficits in a high-fat diet rat model of obesity: the role of hippocampal autophagy and the PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.1007/s10238-022-00839-8openalex-snapshot
Upregulation of necroptosis markers RIPK3/MLKL and their crosstalk with autophagy-related protein Beclin-1 in primary immune thrombocytopenia
inferred← citeshttps://doi.org/10.1007/s10495-017-1398-7openalex-snapshot
Autophagy inhibits high glucose induced cardiac microvascular endothelial cells apoptosis by mTOR signal pathway
inferred← citeshttps://doi.org/10.1007/s10571-020-00903-5openalex-snapshot
Therapeutic Potential of Berberine in the Treatment of Glioma: Insights into Its Regulatory Mechanisms
inferred← citeshttps://doi.org/10.1007/s11010-009-0377-xopenalex-snapshot
Ischemic post-conditioning reduces infarct size of the in vivo rat heart: role of PI3-K, mTOR, GSK-3β, and apoptosis
inferred← citeshttps://doi.org/10.1007/s11010-010-0638-8openalex-snapshot
Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts
inferred← citeshttps://doi.org/10.1007/s11010-016-2749-3openalex-snapshot
Salidroside protects cortical neurons against glutamate-induced cytotoxicity by inhibiting autophagy
inferred← citeshttps://doi.org/10.1007/s11357-019-00131-wopenalex-snapshot
The potential role of necroptosis in inflammaging and aging
inferred← citeshttps://doi.org/10.1007/s11802-019-3998-zopenalex-snapshot
The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy
inferred← citeshttps://doi.org/10.1007/s12020-025-04527-xopenalex-snapshot
The role of combined Metformin and pharmaceutical molecules with anti-androgenic properties in the therapy of PCOS in adult women
inferred← citeshttps://doi.org/10.1007/s13105-015-0384-1openalex-snapshot
Autophagy regulates insulin resistance following endoplasmic reticulum stress in diabetes
inferred← citeshttps://doi.org/10.1007/s13238-012-2047-0openalex-snapshot
New insight into the oncogenic mechanism of the retroviral oncoprotein Tax
inferred← citeshttps://doi.org/10.1016/b978-0-12-812005-7.00006-0openalex-snapshot
Autophagy and Novel Therapeutic Strategies in Neuroblastoma
inferred← citeshttps://doi.org/10.1016/j.aquaculture.2021.737182openalex-snapshot
Deoxynivalenol induces carp neutrophil apoptosis and necroptosis via CYP450s/ROS/PI3K/AKT pathway
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102842openalex-snapshot
Bidirectional regulation of neuronal autophagy in ischemic stroke: Mechanisms and therapeutic potential
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2013.06.001openalex-snapshot
Crosstalk between apoptosis, necrosis and autophagy
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2013.10.021openalex-snapshot
The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer
inferred← citeshttps://doi.org/10.1016/j.bbcan.2010.07.003openalex-snapshot
Autophagy is a therapeutic target in anticancer drug resistance
inferred← citeshttps://doi.org/10.1016/j.bbr.2016.11.053openalex-snapshot
Autophagy and Akt/CREB signalling play an important role in the neuroprotective effect of nimodipine in a rat model of vascular dementia
inferred← citeshttps://doi.org/10.1016/j.bbrc.2016.03.017openalex-snapshot
FGFR antagonist induces protective autophagy in FGFR1-amplified breast cancer cell
inferred← citeshttps://doi.org/10.1016/j.bcp.2013.09.020openalex-snapshot
A novel binuclear palladacycle complex inhibits melanoma growth in vitro and in vivo through apoptosis and autophagy
inferred← citeshttps://doi.org/10.1016/j.bcp.2014.02.019openalex-snapshot
Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116277openalex-snapshot
Risk factors of using late-autophagy inhibitors: Aspects to consider when combined with anticancer therapies
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117781openalex-snapshot
Cannabinoids and the autophagy-related signaling in brain tumors: from mechanistic insights to therapeutic frontiers in glioblastoma
inferred← citeshttps://doi.org/10.1016/j.biopha.2016.04.002openalex-snapshot
Procyanidins, from Castanea mollissima Bl. shell, induces autophagy following apoptosis associated with PI3K/AKT/mTOR inhibition in HepG2 cells
inferred← citeshttps://doi.org/10.1016/j.biopha.2016.08.035openalex-snapshot
Fisetin inhibits laryngeal carcinoma through regulation of AKT/NF-κB/mTOR and ERK1/2 signaling pathways
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.08.125openalex-snapshot
RETRACTED: Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.112577openalex-snapshot
HDAC inhibitor cowanin extracted from G. fusca induces apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathways in Jurkat cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2018.05.026openalex-snapshot
Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells
inferred← citeshttps://doi.org/10.1016/j.canlet.2021.05.015openalex-snapshot
The E2F1/USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK/mTOR pathway
inferred← citeshttps://doi.org/10.1016/j.canlet.2021.08.023openalex-snapshot
Peroxiredoxin 1 is essential for natamycin-triggered apoptosis and protective autophagy in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.cbi.2018.11.022openalex-snapshot
Anti-proliferative and cytotoxic activities of the flavonoid isoliquiritigenin in the human neuroblastoma cell line SH-SY5Y
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111886openalex-snapshot
5-Hydroxymethylfurfural triggers autophagy and apoptosis in sertoli and spermatogonial cells via suppression of the PI3K/AKT/mTOR pathway
inferred← citeshttps://doi.org/10.1016/j.celbio.2026.100382openalex-snapshot
Piezo-mediated inhibition of ferroptosis alleviates acute liver injury
inferred← citeshttps://doi.org/10.1016/j.dci.2020.103637openalex-snapshot
MicroRNA expression profiling of caudal fin cell of C. auratus gibelio upon cyprinid herpesvirus 2 infection
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2021.113050openalex-snapshot
Ochratoxin A induces NLRP3 inflammasome-mediated pyroptosis via activation of ROS modulated by autophagy in vitro
inferred← citeshttps://doi.org/10.1016/j.ejcb.2016.10.005openalex-snapshot
Autophagy and the invisible line between life and death
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.175621openalex-snapshot
Galangin alleviated myocardial ischemia-reperfusion injury by enhancing autophagic flux and inhibiting inflammation
inferred← citeshttps://doi.org/10.1016/j.envpol.2017.03.083openalex-snapshot
Crotonaldehyde induces autophagy-mediated cytotoxicity in human bronchial epithelial cells via PI3K, AMPK and MAPK pathways
inferred← citeshttps://doi.org/10.1016/j.etp.2014.01.004openalex-snapshot
Autophagy in arsenic carcinogenesis
inferred← citeshttps://doi.org/10.1016/j.exger.2021.111406openalex-snapshot
Sargahydroquinoic acid (SHQA) suppresses cellular senescence through Akt/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1016/j.fct.2014.01.014openalex-snapshot
Dihydromyricetin induces autophagy in HepG2 cells involved in inhibition of mTOR and regulating its upstream pathways
inferred← citeshttps://doi.org/10.1016/j.fct.2018.09.070openalex-snapshot
Ochratoxin A induces cytoprotective autophagy via blocking AKT/mTOR signaling pathway in PK-15 cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2010.04.014openalex-snapshot
Selective induction of catalase-mediated autophagy by dihydrocapsaicin in lung cell lines
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2013.08.003openalex-snapshot
Implications of autophagy for vascular smooth muscle cell function and plasticity
inferred← citeshttps://doi.org/10.1016/j.ghir.2025.101668openalex-snapshot
Growth hormone - releasing hormone antagonists induce autophagy in cancer cells
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2018.07.188openalex-snapshot
Migration inhibition of water stress proteins from Nostoc commune Vauch. via activation of autophagy in DLD-1 cells
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.141501openalex-snapshot
Co-delivery of hsa-miR-34a and 3-methyl adenine by a self-assembled cellulose-based nanocarrier for enhanced anti-tumor effects in HCC
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.147547openalex-snapshot
RETRACTED: Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.109785openalex-snapshot
Provocative non-canonical roles of p53 and AKT signaling: A role for Thymosin β4 in medulloblastoma
inferred← citeshttps://doi.org/10.1016/j.jbo.2022.100448openalex-snapshot
RNA 5-methylcytosine status is associated with DNMT2/TRDMT1 nuclear localization in osteosarcoma cell lines
inferred← citeshttps://doi.org/10.1016/j.jep.2020.112611openalex-snapshot
The Chinese herbal prescription JZ-1 induces autophagy to protect against herpes simplex Virus-2 in human vaginal epithelial cells by inhibiting the PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2018.10.007openalex-snapshot
Methylmercury-induced testis damage is associated with activation of oxidative stress and germ cell autophagy
inferred← citeshttps://doi.org/10.1016/j.jmb.2016.06.011openalex-snapshot
Molecular Functions of Glycoconjugates in Autophagy
inferred← citeshttps://doi.org/10.1016/j.jprot.2019.103401openalex-snapshot
iTRAQ-based quantitative proteomic analysis provides insights into strong broodiness in Muscovy duck (Cairina moschata) combined with metabolomics analysis
inferred← citeshttps://doi.org/10.1016/j.kint.2015.11.021openalex-snapshot
Autophagy in acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119507openalex-snapshot
Modulation of autophagy and transient receptor potential vanilloid 4 channels by montelukast in a rat model of hemorrhagic cystitis
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.120095openalex-snapshot
A 1,10-phenanthroline derivative selectively targeting telomeric G-quadruplex induces cytoprotective autophagy, causing apoptosis of gastric cancer cells
inferred← citeshttps://doi.org/10.1016/j.lungcan.2021.05.018openalex-snapshot
High proportion of tumor necrosis predicts poor survival in surgically resected high-grade neuroendocrine carcinoma of the lung
inferred← citeshttps://doi.org/10.1016/j.mcn.2018.08.004openalex-snapshot
Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation
inferred← citeshttps://doi.org/10.1016/j.micpath.2025.107816openalex-snapshot
The beneficial role of probiotics and gut microbiota in signaling pathways, immunity, apoptosis, autophagy, and intestinal barrier for effective wound healing post-burn injury
inferred← citeshttps://doi.org/10.1016/j.nbd.2015.10.001openalex-snapshot
mTOR pathway inhibition prevents neuroinflammation and neuronal death in a mouse model of cerebral palsy
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.05.042openalex-snapshot
Influence of Tau on Neurotoxicity and Cerebral Vasculature Impairment Associated with Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1016/j.phymed.2018.09.017openalex-snapshot
Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154212openalex-snapshot
The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy
inferred← citeshttps://doi.org/10.1016/j.placenta.2012.04.011openalex-snapshot
Survival by self-destruction: A role for autophagy in the placenta?
inferred← citeshttps://doi.org/10.1016/j.prp.2026.156363openalex-snapshot
OXPHOS inhibitor IACS010759 suppresses tumor growth by modulating autophagy in esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.psj.2025.105895openalex-snapshot
Review: Research progress on broodiness behavior and its molecular mechanisms in poultry
inferred← citeshttps://doi.org/10.1016/j.redox.2020.101458openalex-snapshot
Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery
inferred← citeshttps://doi.org/10.1016/j.reprotox.2025.109110openalex-snapshot
Protective effects of rutin against docetaxel-induced testicular damage in rats: Effects on antioxidant defence, apoptosis and autophagy
inferred← citeshttps://doi.org/10.1016/j.semcancer.2013.08.008openalex-snapshot
Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics
inferred← citeshttps://doi.org/10.1016/j.semcancer.2021.03.022openalex-snapshot
The role of autophagy in metal-induced urogenital carcinogenesis
inferred← citeshttps://doi.org/10.1016/j.tice.2026.103378openalex-snapshot
Mechanism of endoplasmic reticulum stress: Insights for potential therapeutic benefits in burns
inferred← citeshttps://doi.org/10.1016/j.tox.2025.154091openalex-snapshot
6PPD induces apoptosis and autophagy in SH-SY5Y cells via ROS-mediated PI3K/AKT/mTOR pathway: In vitro and in silico approaches
inferred← citeshttps://doi.org/10.1016/j.toxlet.2020.06.006openalex-snapshot
Autophagy mediates bronchial cell malignant transformation induced by chronic arsenic exposure via MEK/ERK1/2 pathway
inferred← citeshttps://doi.org/10.1016/j.yexcr.2012.02.006openalex-snapshot
Autophagy is a survival force via suppression of necrotic cell death
inferred← citeshttps://doi.org/10.1016/j.yexcr.2014.01.001openalex-snapshot
Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2016.11.002openalex-snapshot
Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia–reperfusion injury
inferred← citeshttps://doi.org/10.1038/aps.2012.194openalex-snapshot
Coordination of autophagy with other cellular activities
inferred← citeshttps://doi.org/10.1038/cdd.2010.72openalex-snapshot
zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway
inferred← citeshttps://doi.org/10.1038/cdd.2013.45openalex-snapshot
Obatoclax (GX15-070) triggers necroptosis by promoting the assembly of the necrosome on autophagosomal membranes
inferred← citeshttps://doi.org/10.1038/cddis.2013.533openalex-snapshot
Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress
inferred← citeshttps://doi.org/10.1038/cddis.2014.361openalex-snapshot
Peroxisome proliferator-activated receptor α activation attenuates the inflammatory response to protect the liver from acute failure by promoting the autophagy pathway
inferred← citeshttps://doi.org/10.1038/cddis.2016.144openalex-snapshot
Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells
inferred← citeshttps://doi.org/10.1038/jcbfm.2011.131openalex-snapshot
Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice
inferred← citeshttps://doi.org/10.1038/s41392-026-02583-xopenalex-snapshot
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications
inferred← citeshttps://doi.org/10.1038/s41419-018-1052-5openalex-snapshot
Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation
inferred← citeshttps://doi.org/10.1038/s41419-019-1798-4openalex-snapshot
Homocysteine enhances neural stem cell autophagy in in vivo and in vitro model of ischemic stroke
inferred← citeshttps://doi.org/10.1038/s41419-020-2270-1openalex-snapshot
miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells
inferred← citeshttps://doi.org/10.1038/s41420-018-0067-0openalex-snapshot
Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation
inferred← citeshttps://doi.org/10.1038/s41420-022-01170-7openalex-snapshot
ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling
inferred← citeshttps://doi.org/10.1038/s41421-021-00339-1openalex-snapshot
LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation
inferred← citeshttps://doi.org/10.1038/s41423-024-01253-8openalex-snapshot
Cell-associated galectin 9 interacts with cytotoxic T cells confers resistance to tumor killing in nasopharyngeal carcinoma through autophagy activation
inferred← citeshttps://doi.org/10.1038/s41556-018-0065-8openalex-snapshot
CK1α suppresses lung tumour growth by stabilizing PTEN and inducing autophagy
inferred← citeshttps://doi.org/10.1038/s41598-017-00689-5openalex-snapshot
Chemically different non-thermal plasmas target distinct cell death pathways
inferred← citeshttps://doi.org/10.1038/s41598-019-39559-7openalex-snapshot
Low density lipoprotein mimics insulin action on autophagy and glucose uptake in endothelial cells
inferred← citeshttps://doi.org/10.1038/s41598-024-57680-0openalex-snapshot
Exploring the potential of Ziziphus nummularia and luteolin-7-O-glucoside as tubulin inhibitors in cancer therapy and survival
inferred← citeshttps://doi.org/10.1055/a-2119-3301openalex-snapshot
Insulin Inhibits Autophagy by Inhibiting the Binding of FoXO1 to the Promoter Region of GABARAPL1
inferred← citeshttps://doi.org/10.1074/jbc.m109.080796openalex-snapshot
Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase
inferred← citeshttps://doi.org/10.1080/07391102.2022.2048077openalex-snapshot
Neem and Turmeric in the management of Covid Associated Mucormycosis (CAM) derived through network pharmacology
inferred← citeshttps://doi.org/10.1080/07853890.2025.2593151openalex-snapshot
Comprehensive analysis suggests CRIF1 is a potential target in breast cancer associated with prognosis and immune infiltration
inferred← citeshttps://doi.org/10.1080/10799893.2016.1247862openalex-snapshot
Regulation of dendritic cell function by insulin/IGF-1/PI3K/Akt signaling through klotho expression
inferred← citeshttps://doi.org/10.1080/15548627.2015.1034411openalex-snapshot
Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy
inferred← citeshttps://doi.org/10.1080/15548627.2021.1934271openalex-snapshot
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation
inferred← citeshttps://doi.org/10.1080/15548627.2024.2353497openalex-snapshot
SCF FBXW5 -mediated degradation of AQP3 suppresses autophagic cell death through the PDPK1-AKT-MTOR axis in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1080/17435390.2017.1343874openalex-snapshot
Oral subchronic exposure to silver nanoparticles causes renal damage through apoptotic impairment and necrotic cell death
inferred← citeshttps://doi.org/10.1080/17435390.2018.1466932openalex-snapshot
The protective role of autophagy in nephrotoxicity induced by bismuth nanoparticles through AMPK/mTOR pathway
inferred← citeshttps://doi.org/10.1083/jcb.201801151openalex-snapshot
Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1
inferred← citeshttps://doi.org/10.1093/abbs/gmv111openalex-snapshot
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy
inferred← citeshttps://doi.org/10.1093/cvr/cvr321openalex-snapshot
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy
inferred← citeshttps://doi.org/10.1093/cvr/cvr358openalex-snapshot
Autophagy as a therapeutic target for ischaemia /reperfusion injury? Concepts, controversies, and challenges
inferred← citeshttps://doi.org/10.1093/humrep/dead250openalex-snapshot
ROS-induced oxidative stress is a major contributor to sperm cryoinjury
inferred← citeshttps://doi.org/10.1093/toxsci/kfs240openalex-snapshot
Autophagy Is a Cell Self-Protective Mechanism Against Arsenic-Induced Cell Transformation
inferred← citeshttps://doi.org/10.1097/fjc.0b013e318291c094openalex-snapshot
Neuregulin-1 Attenuates Doxorubicin-induced Autophagy in Neonatal Rat Cardiomyocytes
inferred← citeshttps://doi.org/10.1101/2025.05.09.25327290openalex-snapshot
Tracing the Benign Nature of Pilocytic Astrocytoma with a Focus on How Gliogenic Regulators Impact its Tumorigenesis: a systematic review
inferred← citeshttps://doi.org/10.1111/bph.70181openalex-snapshot
Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology
inferred← citeshttps://doi.org/10.1111/brv.12177openalex-snapshot
Transcription factors and cognate signalling cascades in the regulation of autophagy
inferred← citeshttps://doi.org/10.1111/cns.12005openalex-snapshot
A Double‐Edged Sword with Therapeutic Potential: An Updated Role of Autophagy in Ischemic Cerebral Injury
inferred← citeshttps://doi.org/10.1111/jcmm.14310openalex-snapshot
The role of autophagy in the pathogenesis of exposure keratitis
inferred← citeshttps://doi.org/10.1111/mpp.70259openalex-snapshot
A Plant Virus Glycoprotein Induces Autophagy by Activating the Toll7 Immune Pathway in Its Insect Vector
inferred← citeshttps://doi.org/10.1117/12.876042openalex-snapshot
Combination of PI3K/Akt/mTOR inhibitors and PDT in endothelial and tumor cells
inferred← citeshttps://doi.org/10.1124/jpet.113.206714openalex-snapshot
Regulation of Death Induction and Chemosensitizing Action of 3-Bromopyruvate in Myeloid Leukemia Cells: Energy Depletion, Oxidative Stress, and Protein Kinase Activity Modulation
inferred← citeshttps://doi.org/10.1134/s1607672921060065openalex-snapshot
Inhibition of Liver Cancer Cell Growth by Triethylsilyl Resveratrol through Targeting Phosphoinositide-3 Kinase Pathway
inferred← citeshttps://doi.org/10.1134/s1607672923600525openalex-snapshot
Inhibition of Liver Cancer Cell Viability by Triazole through Up-regulation of p38 Phosphorylation and Targeting the Activation of p-ERK1/2 and Akt Protein Expression
inferred← citeshttps://doi.org/10.1134/s1607672923600537openalex-snapshot
The 3,3'-dimethoxy-4,4'-dihydroxy-stilbene Triazole (STT) Inhibits Liver Cancer Cell Growth by Targeting Akt/mTOR Pathway
inferred← citeshttps://doi.org/10.1136/annrheumdis-2018-214656openalex-snapshot
mTOR inhibition by metformin impacts monosodium urate crystal–induced inflammation and cell death in gout: a prelude to a new add-on therapy?
inferred← citeshttps://doi.org/10.1142/s0192415x18500350openalex-snapshot
The Polyphenolic Compound Curcumin Conjugation with an Alkyne Moiety in the Process of Autophagy
inferred← citeshttps://doi.org/10.1152/ajpendo.00603.2014openalex-snapshot
(Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose
inferred← citeshttps://doi.org/10.1152/ajprenal.00596.2015openalex-snapshot
Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy
inferred← citeshttps://doi.org/10.1155/2014/498083openalex-snapshot
The Regulation of Autophagy by Influenza A Virus
inferred← citeshttps://doi.org/10.1155/2017/6965739openalex-snapshot
Hongjingtian Injection Attenuates Myocardial Oxidative Damage via Promoting Autophagy and Inhibiting Apoptosis
inferred← citeshttps://doi.org/10.1155/2017/8519169openalex-snapshot
ROS‐Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A‐Sonodynamic Therapy in THP‐1 Macrophages
inferred← citeshttps://doi.org/10.1155/2021/5472605openalex-snapshot
Inhibition of PTEN Ameliorates Secondary Hippocampal Injury and Cognitive Deficits after Intracerebral Hemorrhage: Involvement of AKT/FoxO3a/ATG‐Mediated Autophagy
inferred← citeshttps://doi.org/10.1155/2021/6662225openalex-snapshot
Impaired Autophagy Induced by oxLDL/ β 2GPI/anti‐ β 2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction
inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-21-0277openalex-snapshot
Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway
inferred← citeshttps://doi.org/10.1165/rcmb.2019-0050ocopenalex-snapshot
PI3K Catalytic Subunits α and β Modulate Cell Death and IL-6 Secretion Induced by Talc Particles in Human Lung Carcinoma Cells
inferred← citeshttps://doi.org/10.1177/0960327119883409openalex-snapshot
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway
inferred← citeshttps://doi.org/10.1177/15353702231191117openalex-snapshot
Fluoride induces osteoblast autophagy by inhibiting the PI3K/AKT/mTOR signaling pathway in vivo and in vitro
inferred← citeshttps://doi.org/10.1186/s12883-018-1083-7openalex-snapshot
Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway
inferred← citeshttps://doi.org/10.1186/s12906-017-1575-9openalex-snapshot
Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy
inferred← citeshttps://doi.org/10.1186/s12906-017-2017-4openalex-snapshot
The inhibitory effects of compound Muniziqi granule against B16 cells and harmine induced autophagy and apoptosis by inhibiting Akt/mTOR pathway
inferred← citeshttps://doi.org/10.1186/s12906-025-04747-8openalex-snapshot
Protective mechanism of safflower yellow injection on myocardial ischemia-reperfusion injury in rats by activating NLRP3 inflammasome
inferred← citeshttps://doi.org/10.1186/s12933-016-0484-4openalex-snapshot
Exercise mediated protection of diabetic heart through modulation of microRNA mediated molecular pathways
inferred← citeshttps://doi.org/10.1186/s13046-024-03071-2openalex-snapshot
Protein homeostasis maintained by HOOK1 levels promotes the tumorigenic and stemness properties of ovarian cancer cells through reticulum stress and autophagy
inferred← citeshttps://doi.org/10.1186/s13195-023-01334-2openalex-snapshot
PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1186/s43556-026-00556-8openalex-snapshot
miR-486-5p suppresses autophagy in hepatocellular carcinoma via activation of the AKT/mTOR signalling pathway
inferred← citeshttps://doi.org/10.1200/po.18.00043openalex-snapshot
Translating Gene Signatures Into a Pathologic Feature: Tumor Necrosis Predicts Disease Relapse in Operable and Stage I Lung Adenocarcinoma
inferred← citeshttps://doi.org/10.12659/msm.920785openalex-snapshot
Hydroxypyridinone-Coumarin Inhibits the Proliferation of MHCC97 and HepG2 Human Hepatocellular Carcinoma Cells and Down-Regulates the Phosphoinositide-3 Kinase Pathway
inferred← citeshttps://doi.org/10.1371/journal.pone.0056576openalex-snapshot
Akt Regulates TNFα Synthesis Downstream of RIP1 Kinase Activation during Necroptosis
inferred← citeshttps://doi.org/10.1371/journal.pone.0094634openalex-snapshot
Regulator of G-Protein Signaling 19 (RGS19) and Its Partner Gα-Inhibiting Activity Polypeptide 3 (GNAI3) Are Required for zVAD-Induced Autophagy and Cell Death in L929 Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0103364openalex-snapshot
Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0141110openalex-snapshot
Downregulation of Choline Kinase-Alpha Enhances Autophagy in Tamoxifen-Resistant Breast Cancer Cells
inferred← citeshttps://doi.org/10.1371/journal.pone.0210200openalex-snapshot
Trichloroethene metabolite dichloroacetyl chloride induces apoptosis and compromises phagocytosis in Kupffer Cells: Activation of inflammasome and MAPKs
inferred← citeshttps://doi.org/10.1507/endocrj.ej21-0480openalex-snapshot
Metformin ameliorates polycystic ovary syndrome in a rat model by decreasing excessive autophagy in ovarian granulosa cells via the PI3K/AKT/mTOR pathway
inferred← citeshttps://doi.org/10.1523/jneurosci.2922-20.2021openalex-snapshot
Sustained ErbB Activation Causes Demyelination and Hypomyelination by Driving Necroptosis of Mature Oligodendrocytes and Apoptosis of Oligodendrocyte Precursor Cells
inferred← citeshttps://doi.org/10.1530/rep-13-0386openalex-snapshot
AKT is involved in granulosa cell autophagy regulation via mTOR signaling during rat follicular development and atresia
inferred← citeshttps://doi.org/10.1530/rep-16-0643openalex-snapshot
Hypoxia-inducible factor-1α promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis
inferred← citeshttps://doi.org/10.18632/aging.203445openalex-snapshot
NPAS2 ameliorates myocardial ischaemia/reperfusion injury in rats via CX3CL1 pathways and regulating autophagy
inferred← citeshttps://doi.org/10.18632/aging.203795openalex-snapshot
Deglycosylated EpCAM regulates proliferation by enhancing autophagy of breast cancer cells via PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.18632/oncotarget.3353openalex-snapshot
PTPRO-mediated autophagy prevents hepatosteatosis and tumorigenesis
inferred← citeshttps://doi.org/10.18632/oncotarget.3357openalex-snapshot
Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling
inferred← citeshttps://doi.org/10.18632/oncotarget.4767openalex-snapshot
Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells
inferred← citeshttps://doi.org/10.18926/amo/52006openalex-snapshot
Oncolytic adenovirus-induced autophagy: tumor-suppressive effect and molecular basis.
inferred← citeshttps://doi.org/10.21037/atm-20-3768openalex-snapshot
Beta carotene protects H9c2 cardiomyocytes from advanced glycation end product-induced endoplasmic reticulum stress, apoptosis, and autophagy via the PI3K/Akt/mTOR signaling pathway
inferred← citeshttps://doi.org/10.2147/cmar.s204472openalex-snapshot
Protective autophagy or autophagic death: effects of BEZ235 on chronic myelogenous leukemia
inferred← citeshttps://doi.org/10.2174/1389450120666191112155654openalex-snapshot
The Therapeutic Potential of Quercetin in Parkinson’s Disease: Insights into its Molecular and Cellular Regulation
inferred← citeshttps://doi.org/10.2174/1574884716666210726110021openalex-snapshot
Targeting Abnormal PI3K/AKT/mTOR Signaling in Intracerebral Hemorrhage: A Systematic Review on Potential Drug Targets and Influences of Signaling Modulators on Other Neurological Disorders
inferred← citeshttps://doi.org/10.2217/fnl.12.72openalex-snapshot
A Critical Kinase Cascade In Neurological Disorders: Pi3K, Akt and Mtor
inferred← citeshttps://doi.org/10.31362/patd.1709595openalex-snapshot
Immunohistochemical demonstration of mTOR and p-mTOR expression in frozen and thawed ovarian tissue
inferred← citeshttps://doi.org/10.3382/ps/pew006openalex-snapshot
Goose broodiness is involved in granulosa cell autophagy and homeostatic imbalance of follicular hormones
inferred← citeshttps://doi.org/10.3389/fcell.2019.00140openalex-snapshot
On the Fly: Recent Progress on Autophagy and Aging in Drosophila
inferred← citeshttps://doi.org/10.3389/fcell.2021.662597openalex-snapshot
Proliferation of Lung Epithelial Cells Is Regulated by the Mechanisms of Autophagy Upon Exposure of Soots
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1074271openalex-snapshot
Identification of immune infiltration and cuproptosis-related subgroups in Crohn’s disease
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1345734openalex-snapshot
Metabolomics-transcriptomics joint analysis: unveiling the dysregulated cell death network and developing a diagnostic model for high-grade neuroblastoma
inferred← citeshttps://doi.org/10.3389/fnins.2019.00491openalex-snapshot
Insulin and Autophagy in Neurodegeneration
inferred← citeshttps://doi.org/10.3389/fonc.2023.1106667openalex-snapshot
A triple-drug combination induces apoptosis in cervical cancer-derived cell lines
inferred← citeshttps://doi.org/10.3389/fonc.2024.1383805openalex-snapshot
Research status and development trends of omics in neuroblastoma a bibliometric and visualization analysis
inferred← citeshttps://doi.org/10.3389/fphys.2018.00441openalex-snapshot
Severe Burn-Induced Intestinal Epithelial Barrier Dysfunction Is Associated With Endoplasmic Reticulum Stress and Autophagy in Mice
inferred← citeshttps://doi.org/10.3390/biom15050640openalex-snapshot
Baicalin Relieves Glaesserella parasuis-Triggered Immunosuppression Through Polarization via MIF/CD74 Signaling Pathway in Piglets
inferred← citeshttps://doi.org/10.3390/cells10092475openalex-snapshot
Autophagy Promotes the Survival of Adipose Mesenchymal Stem/Stromal Cells and Enhances Their Therapeutic Effects in Cisplatin-Induced Liver Injury via Modulating TGF-β1/Smad and PI3K/AKT Signaling Pathways
inferred← citeshttps://doi.org/10.3390/cells14181474openalex-snapshot
PF-04691502, a PI3K/mTOR Dual Inhibitor, Ameliorates AD-like Pathology in a Mouse Model of AD
inferred← citeshttps://doi.org/10.3390/cimb46110782openalex-snapshot
Selenized Yeast Protects Against Cadmium-Induced Follicular Atresia in Laying Hens by Reducing Autophagy in Granulosa Cells
inferred← citeshttps://doi.org/10.3390/ijms21176109openalex-snapshot
Lamin A/C and the Immune System: One Intermediate Filament, Many Faces
inferred← citeshttps://doi.org/10.3390/ijms21249409openalex-snapshot
Reactive Oxygen Species-Mediated Autophagy by Ursolic Acid Inhibits Growth and Metastasis of Esophageal Cancer Cells
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