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Protein-Peptide Interactions Revolutionize Drug Development
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Outgoing claims: the papers this work cites, builds on, or argues with.
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SH3 domains and drug design: Ligands, structure, and biological function
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Apoptosis. Its significance in cancer and cancer Therapy
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Nucleic Acid and Peptide Aptamers: Fundamentals and Bioanalytical Aspects
inferredcites →https://doi.org/10.1002/cbic.201000717openalex-snapshot
Peptides and Proteins as a Continuing Exciting Source of Inspiration for Peptidomimetics
inferredcites →https://doi.org/10.1002/cmdc.200800390openalex-snapshot
Development and Characterization of Peptidic Fusion Inhibitors Derived from HIV‐1 gp41 with Partial D ‐Amino Acid Substitutions
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Can we trust docking results? Evaluation of seven commonly used programs on PDBbind database
inferredcites →https://doi.org/10.1002/prot.22629openalex-snapshot
DynaDock: A new molecular dynamics‐based algorithm for protein–peptide docking including receptor flexibility
inferredcites →https://doi.org/10.1002/prot.22716openalex-snapshot
Sub-angstrom modeling of complexes between flexible peptides and globular proteins
inferredcites →https://doi.org/10.1002/prot.22785openalex-snapshot
Can self‐inhibitory peptides be derived from the interfaces of globular protein–protein interactions?
inferredcites →https://doi.org/10.1006/bbrc.1996.1413openalex-snapshot
Inhibition of Alzheimer's Amyloidosis by Peptides That Prevent β-Sheet Conformation
inferredcites →https://doi.org/10.1006/viro.1996.0178openalex-snapshot
Inhibition of HIV Infection by Pseudopeptides Blocking Viral Envelope Glycoprotein-Mediated Membrane Fusion and Cell Death
inferredcites →https://doi.org/10.1007/978-1-59745-419-3_10openalex-snapshot
Serum Stability of Peptides
inferredcites →https://doi.org/10.1007/978-1-60327-394-7_6openalex-snapshot
Rapid Identification of Linear Protein Domain Binding Motifs Using Peptide SPOT Arrays
inferredcites →https://doi.org/10.1007/978-1-61779-043-0_8openalex-snapshot
SPOT Synthesis as a Tool to Study Protein–Protein Interactions
inferredcites →https://doi.org/10.1007/bf02189111openalex-snapshot
The molecular significance of amyloid β-peptide for Alzheimer's disease
inferredcites →https://doi.org/10.1007/s00216-008-2463-4openalex-snapshot
Analytical characterization of chitosan nanoparticles for peptide drug delivery applications
inferredcites →https://doi.org/10.1007/s00726-005-0289-3openalex-snapshot
Strategies to improve plasma half life time of peptide and protein drugs
inferredcites →https://doi.org/10.1016/b978-0-12-391860-4.00015-xopenalex-snapshot
Chitosan-Coated Solid Lipid Nanoparticles for Insulin Delivery
inferredcites →https://doi.org/10.1016/j.addr.2009.11.009openalex-snapshot
Chitosan-based delivery systems for protein therapeutics and antigens
inferredcites →https://doi.org/10.1016/j.bbamem.2006.05.013openalex-snapshot
Structure–activity relationship study of the cell-penetrating peptide pVEC
inferredcites →https://doi.org/10.1016/j.bbamem.2009.09.014openalex-snapshot
Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate
inferredcites →https://doi.org/10.1016/j.bbamem.2010.02.009openalex-snapshot
Cell biology meets biophysics to unveil the different mechanisms of penetratin internalization in cells
inferredcites →https://doi.org/10.1016/j.cbpa.2004.03.002openalex-snapshot
Developments in peptide and amide synthesis
inferredcites →https://doi.org/10.1016/j.cbpa.2004.08.007openalex-snapshot
Peptide arrays: towards routine implementation
inferredcites →https://doi.org/10.1016/j.cbpa.2008.08.019openalex-snapshot
Contemporary strategies for the stabilization of peptides in the α-helical conformation
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ArfGAP family proteins in cell adhesion, migration and tumor invasion
inferredcites →https://doi.org/10.1016/j.drudis.2006.08.005openalex-snapshot
Is the oral route possible for peptide and protein drug delivery?
inferredcites →https://doi.org/10.1016/j.drudis.2009.10.009openalex-snapshot
Synthetic therapeutic peptides: science and market
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A comparative study of chitosan and chitosan/cyclodextrin nanoparticles as potential carriers for the oral delivery of small peptides☆
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Selectivity and promiscuity in the interaction network mediated by protein recognition modules
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Chitosan/cyclodextrin nanoparticles as macromolecular drug delivery system
inferredcites →https://doi.org/10.1016/j.ijpharm.2008.01.046openalex-snapshot
Inhalable liposomal formulation for vasoactive intestinal peptide
inferredcites →https://doi.org/10.1016/j.ijpharm.2008.11.013openalex-snapshot
Chitosan–aprotinin coated liposomes for oral peptide delivery: Development, characterisation and in vivo evaluation
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Chitosan–PEG nanocapsules as new carriers for oral peptide delivery
inferredcites →https://doi.org/10.1016/j.jim.2004.04.006openalex-snapshot
Binding proteins from alternative scaffolds
inferredcites →https://doi.org/10.1016/j.jmb.2005.08.001openalex-snapshot
Design and Validation of a Neutral Protein Scaffold for the Presentation of Peptide Aptamers
inferredcites →https://doi.org/10.1016/j.molcel.2006.06.001openalex-snapshot
The Human and Mouse Complement of SH2 Domain Proteins—Establishing the Boundaries of Phosphotyrosine Signaling
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Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery
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Exchange-transferred NOE spectroscopy and bound ligand structure determination
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Peptides in the treatment of AIDS
inferredcites →https://doi.org/10.1016/j.str.2009.06.013openalex-snapshot
Protein-Peptide Interactions Adopt the Same Structural Motifs as Monomeric Protein Folds
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The Structural Basis of Peptide-Protein Binding Strategies
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The expanding scope of antimicrobial peptide structures and their modes of action
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Interaction domains: from simple binding events to complex cellular behavior
inferredcites →https://doi.org/10.1016/s0021-9258(17)34080-2openalex-snapshot
The third helix of the Antennapedia homeodomain translocates through biological membranes.
inferredcites →https://doi.org/10.1016/s0021-9258(18)31593-xopenalex-snapshot
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.
inferredcites →https://doi.org/10.1016/s0022-1759(02)00137-0openalex-snapshot
The SPOT-synthesis technique
inferredcites →https://doi.org/10.1016/s0026-0495(99)90090-2openalex-snapshot
Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide
inferredcites →https://doi.org/10.1016/s0040-4020(01)85612-xopenalex-snapshot
Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
inferredcites →https://doi.org/10.1016/s0092-8674(00)81307-0openalex-snapshot
Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ
inferredcites →https://doi.org/10.1016/s0092-8674(00)81430-0openalex-snapshot
HIV Entry and Its Inhibition
inferredcites →https://doi.org/10.1016/s0378-5173(02)00337-xopenalex-snapshot
Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms
inferredcites →https://doi.org/10.1016/s0955-0674(00)00189-7openalex-snapshot
Phosphoserine/threonine-binding domains
inferredcites →https://doi.org/10.1016/s0959-440x(02)00283-xopenalex-snapshot
Unraveling hot spots in binding interfaces: progress and challenges
inferredcites →https://doi.org/10.1017/s096183680000331xopenalex-snapshot
Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies
inferredcites →https://doi.org/10.1021/bc050125zopenalex-snapshot
Cell Transduction Pathways of Transportans
inferredcites →https://doi.org/10.1021/bi048582aopenalex-snapshot
Inhibition of Islet Amyloid Polypeptide Fibril Formation: A Potential Role for Heteroaromatic Interactions
inferredcites →https://doi.org/10.1021/bi0619371openalex-snapshot
Structure-Guided Peptidomimetic Design Leads to Nanomolar β-Hairpin Inhibitors of the Tat−TAR Interaction of Bovine Immunodeficiency Virus,
inferredcites →https://doi.org/10.1021/cb100388jopenalex-snapshot
Discovery of Cyclotides in the Fabaceae Plant Family Provides New Insights into the Cyclization, Evolution, and Distribution of Circular Proteins
inferredcites →https://doi.org/10.1021/ja039565wopenalex-snapshot
Photolithographic Synthesis of Peptoids
inferredcites →https://doi.org/10.1021/ja202946kopenalex-snapshot
Design and Structure of Stapled Peptides Binding to Estrogen Receptors
inferredcites →https://doi.org/10.1021/ja2068752openalex-snapshot
Protein–Ligand Interactions: Thermodynamic Effects Associated with Increasing Nonpolar Surface Area
inferredcites →https://doi.org/10.1021/ja910535jopenalex-snapshot
Constraining Binding Hot Spots: NMR and Molecular Dynamics Simulations Provide a Structural Explanation for Enthalpy−Entropy Compensation in SH2−Ligand Binding
inferredcites →https://doi.org/10.1021/jm901105kopenalex-snapshot
Structure−Affinity Relationships of Glutamine Mimics Incorporated into Phosphopeptides Targeted to the SH2 Domain of Signal Transducer and Activator of Transcription 3
inferredcites →https://doi.org/10.1021/mp200264mopenalex-snapshot
Chitosan Microparticles and Nanoparticles as Biocompatible Delivery Vehicles for Peptide and Protein-Based Immunocontraceptive Vaccines
inferredcites →https://doi.org/10.1021/ol9012662openalex-snapshot
Synthesis of Phosphatase-Stable, Cell-Permeable Peptidomimetic Prodrugs That Target the SH2 Domain of Stat3
inferredcites →https://doi.org/10.1038/3293openalex-snapshot
Potent suppression of HIV-1 replication in humans by T-20, a peptide inhibitor of gp41-mediated virus entry
inferredcites →https://doi.org/10.1038/35065138openalex-snapshot
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
inferredcites →https://doi.org/10.1038/372375a0openalex-snapshot
Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains
inferredcites →https://doi.org/10.1038/373573a0openalex-snapshot
Protein modules and signalling networks
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Genetic selection of peptide aptamers that recognize and inhibit cyclin-dependent kinase 2
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Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement
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The multiple‐specificity landscape of modular peptide recognition domains
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Optimization of specificity in a cellular protein interaction network by negative selection
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Individually addressable parallel peptide synthesis on microchips
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Nucleation of huntingtin aggregation in cells
inferredcites →https://doi.org/10.1038/nm0798-822openalex-snapshot
β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy
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Incretin-based therapies for type 2 diabetes mellitus
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Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities
inferredcites →https://doi.org/10.1039/b415578eopenalex-snapshot
Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy
inferredcites →https://doi.org/10.1056/nejm200105103441904openalex-snapshot
Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis
inferredcites →https://doi.org/10.1073/pnas.0509166103openalex-snapshot
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
inferredcites →https://doi.org/10.1073/pnas.0706574105openalex-snapshot
Molecular dynamics simulations suggest a mechanism for translocation of the HIV-1 TAT peptide across lipid membranes
inferredcites →https://doi.org/10.1073/pnas.221467298openalex-snapshot
The anti-HIV pentameric pseudopeptide HB-19 is preferentially taken up in vivo by lymphoid organs where it forms a complex with nucleolin
inferredcites →https://doi.org/10.1073/pnas.79.15.4815openalex-snapshot
Opiate antagonistic properties of an octapeptide somatostatin analog.
inferredcites →https://doi.org/10.1073/pnas.89.21.10537openalex-snapshot
A synthetic peptide inhibitor of human immunodeficiency virus replication: correlation between solution structure and viral inhibition.
inferredcites →https://doi.org/10.1073/pnas.92.17.7819openalex-snapshot
The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.
inferredcites →https://doi.org/10.1073/pnas.93.24.13555openalex-snapshot
Light-directed synthesis of high-density oligonucleotide arrays using semiconductor photoresists
inferredcites →https://doi.org/10.1074/jbc.271.15.8545openalex-snapshot
Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand
inferredcites →https://doi.org/10.1074/jbc.272.25.16010openalex-snapshot
A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus
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A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
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Structural, Functional, and Bioinformatic Studies Demonstrate the Crucial Role of an Extended Peptide Binding Site for the SH3 Domain of Yeast Abp1p
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Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis
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Distinct Peptide Binding Specificities of Src Homology 3 (SH3) Protein Domains Can Be Determined by Modulation of Local Energetics across the Binding Interface
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Peptides from Second Extracellular Loop of C-C Chemokine Receptor Type 5 (CCR5) Inhibit Diverse Strains of HIV-1
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Pharmacological Profiles of Peptide Drug Candidates for the Treatment of Alzheimer's Disease
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Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold
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A Trimeric Structural Subdomain of the HIV-1 Transmembrane Glycoprotein
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Muco-adhesive multivesicular liposomes as an effective carrier for transmucosal insulin delivery
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Peptide aptamers: Tools for biology and drug discovery
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ADAN: a database for prediction of protein–protein interaction of modular domains mediated by linear motifs
inferredcites →https://doi.org/10.1093/bioinformatics/btr498openalex-snapshot
PepCrawler: a fast RRT-based algorithm for high-resolution refinement and binding affinity estimation of peptide inhibitors
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The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase Gcn5p
inferredcites →https://doi.org/10.1093/nar/26.2.623openalex-snapshot
Green fluorescent protein as a scaffold for intracellular presentation of peptides
inferredcites →https://doi.org/10.1093/nar/gkp893openalex-snapshot
PepX: a structural database of non-redundant protein–peptide complexes
inferredcites →https://doi.org/10.1096/fj.01-0841fjeopenalex-snapshot
Reduction of amyloid load and cerebral damage in transgenic mouse model of Alzheimer's disease by treatment with a β‐sheet breaker peptide
inferredcites →https://doi.org/10.1096/fj.07-8582comopenalex-snapshot
Demonstrating the C‐terminal boundary of the HIV 1 fusion conformation in a dynamic ongoing fusion process and implication for fusion inhibition
inferredcites →https://doi.org/10.1097/00006254-200110000-00018openalex-snapshot
Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women With Osteoporosis
inferredcites →https://doi.org/10.1107/s0907444905014356openalex-snapshot
Structure of the wild-type TEM-1 β-lactamase at 1.55 Å and the mutant enzyme Ser70Ala at 2.1 Å suggest the mode of noncovalent catalysis for the mutant enzyme
inferredcites →https://doi.org/10.1111/j.1742-4658.2010.07906.xopenalex-snapshot
Novel peptide inhibiting both TEM‐1 β‐lactamase and penicillin‐binding proteins
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Proceedings of the National Academy of Sciences of the United States of America
inferredcites →https://doi.org/10.1126/science.1059796openalex-snapshot
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
inferredcites →https://doi.org/10.1126/science.1083653openalex-snapshot
Assembly of Cell Regulatory Systems Through Protein Interaction Domains
inferredcites →https://doi.org/10.1126/science.1990438openalex-snapshot
Light-Directed, Spatially Addressable Parallel Chemical Synthesis
inferredcites →https://doi.org/10.1126/science.271.5257.1854openalex-snapshot
Identification of d -Peptide Ligands Through Mirror-Image Phage Display
inferredcites →https://doi.org/10.1126/science.285.5427.591openalex-snapshot
Genetic Selection of Peptide Inhibitors of Biological Pathways
inferredcites →https://doi.org/10.1126/science.7527937openalex-snapshot
An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins
inferredcites →https://doi.org/10.1126/science.8438166openalex-snapshot
Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site
inferredcites →https://doi.org/10.1126/scisignal.1792003re8openalex-snapshot
The Structure and Function of Proline Recognition Domains
inferredcites →https://doi.org/10.1126/stke.2003.179.re8openalex-snapshot
The Structure and Function of Proline Recognition Domains
inferredcites →https://doi.org/10.1128/mcb.19.12.8226openalex-snapshot
Dissection of the LXXLL Nuclear Receptor-Coactivator Interaction Motif Using Combinatorial Peptide Libraries: Discovery of Peptide Antagonists of Estrogen Receptors α and β
inferredcites →https://doi.org/10.1136/bmj.295.6606.1084openalex-snapshot
Gonadotrophin hormone releasing analogues open new doors in cancer treatment.
inferredcites →https://doi.org/10.1136/bmj.295.6612.1565-bopenalex-snapshot
Gonadotrophin hormone releasing analogues open new doors in cancer treatment.
inferredcites →https://doi.org/10.1155/2011/414729openalex-snapshot
Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
inferredcites →https://doi.org/10.1158/1078-0432.ccr-07-2184openalex-snapshot
The Challenge of Drugging Undruggable Targets in Cancer: Lessons Learned from Targeting BCL-2 Family Members
inferredcites →https://doi.org/10.1208/s12249-011-9716-9openalex-snapshot
Preparation, Statistical Optimization, and In vitro Characterization of Insulin Nanoparticles Composed of Quaternized Aromatic Derivatives of Chitosan
inferredcites →https://doi.org/10.1212/wnl.45.7.1268openalex-snapshot
Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis
inferredcites →https://doi.org/10.1242/jcs.114.7.1253openalex-snapshot
SH3 domains: complexity in moderation
inferredcites →https://doi.org/10.1371/journal.pbio.1000218openalex-snapshot
Bayesian Modeling of the Yeast SH3 Domain Interactome Predicts Spatiotemporal Dynamics of Endocytosis Proteins
inferredcites →https://doi.org/10.1371/journal.pcbi.0030042openalex-snapshot
Deciphering Protein–Protein Interactions. Part I. Experimental Techniques and Databases
inferredcites →https://doi.org/10.1371/journal.pone.0014360openalex-snapshot
Grifonin-1: A Small HIV-1 Entry Inhibitor Derived from the Algal Lectin, Griffithsin
inferredcites →https://doi.org/10.1371/journal.pone.0026684openalex-snapshot
PLGA, PLGA-TMC and TMC-TPP Nanoparticles Differentially Modulate the Outcome of Nasal Vaccination by Inducing Tolerance or Enhancing Humoral Immunity
inferredcites →https://doi.org/10.1517/14712598.5.6.783openalex-snapshot
Peptide aptamers: recent developments for cancer therapy
inferredcites →https://doi.org/10.1529/biophysj.106.100198openalex-snapshot
Mechanism of the Cell-Penetrating Peptide Transportan 10 Permeation of Lipid Bilayers
inferredcites →https://doi.org/10.1530/jrf.0.0640529openalex-snapshot
Use of analogues of luteinizing hormone-releasing hormone for the treatment of cancer
inferredcites →https://doi.org/10.2174/138161207779313722openalex-snapshot
HIV Entry Inhibitors Targeting gp41: From Polypeptides to Small-Molecule Compounds
inferredcites →https://doi.org/10.2174/1386207043328517openalex-snapshot
Recent Advances in Peptide-Based Microarray Technologies
inferredcites →https://doi.org/10.2174/1389450043345290openalex-snapshot
β-Sheet Breakers for Alzheimers Disease Therapy
inferredcites →https://doi.org/10.2174/1566524043360519openalex-snapshot
Peptide Aptamers: Specific Inhibitors of Protein Function
inferredcites →https://doi.org/10.2337/diab.5.1.69openalex-snapshot
Pancreatic Extracts in The Treatment of Diabetes Mellitus
inferredcites →https://doi.org/10.2337/diabetes.47.5.764openalex-snapshot
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.
inferredcites →https://doi.org/10.2337/diacare.25.5.869openalex-snapshot
Inhibition of Dipeptidyl Peptidase IV Improves Metabolic Control Over a 4-Week Study Period in Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diacare.28.5.1092openalex-snapshot
Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes
inferredcites →https://doi.org/10.3109/13506129.2011.582902openalex-snapshot
The generic amyloid formation inhibition effect of a designed small aromatic β-breaking peptide
inferredcites →https://doi.org/10.3390/molecules16010857openalex-snapshot
Peptide Phage Display as a Tool for Drug Discovery: Targeting Membrane Receptors
inferredcites →https://doi.org/10.4155/fmc.10.259openalex-snapshot
Design and Development of Peptides and Peptide Mimetics as Antagonists for Therapeutic Intervention
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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In Silico Analysis of Peptide Macrocycle–Protein Interactions
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Identification of putative bone anabolic peptides targeting adherent plasma membrane
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Development of peptide inhibitors of HIV transmission
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Modeling of protein–peptide interactions using the CABS-dock web server for binding site search and flexible docking
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A New Mixed All-Atom/Coarse-Grained Model: Application to Melittin Aggregation in Aqueous Solution
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Influenza Viral Hemagglutinin Peptide Inhibits Influenza Viral Entry by Shielding the Host Receptor
inferred← citeshttps://doi.org/10.1093/bioinformatics/btx614openalex-snapshot
Structure-based prediction of protein– peptide binding regions using Random Forest
inferred← citeshttps://doi.org/10.1111/jdi.12358openalex-snapshot
Peptide modulators of alpha‐glucosidase
inferred← citeshttps://doi.org/10.1155/2013/851915openalex-snapshot
The Uptake Mechanism of the Cell‐Penetrating pVEC Peptide
inferred← citeshttps://doi.org/10.3389/fphar.2025.1707377openalex-snapshot
Optimisation of peptides targeting reverse transcriptase HIV-1 using QSAR, machine learning, and computational approaches
inferred← citeshttps://doi.org/10.4172/2161-0444.1000344openalex-snapshot
Interface Peptide Mimetics-Rationale and Application as Therapeutic Agents
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