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PERK Regulates the Sensitivity of Hepatocellular Carcinoma Cells to High-LET Carbon Ions via either Apoptosis or Ferroptosis

https://doi.org/10.7150/jca.61622
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ijc.26463openalex-snapshot
Expression of ER stress and autophagy‐related molecules in human non‐small cell lung cancer and premalignant lesions
inferredcites →https://doi.org/10.1002/ijc.28682openalex-snapshot
Radiosensitization by combining an aurora kinase inhibitor with radiotherapy in hepatocellular carcinoma through cell cycle interruption
inferredcites →https://doi.org/10.1007/978-3-319-98506-0_11openalex-snapshot
Hepatocellular Carcinoma
inferredcites →https://doi.org/10.1016/j.bbamcr.2013.07.024openalex-snapshot
When ER stress reaches a dead end
inferredcites →https://doi.org/10.1016/j.bbcan.2016.12.002openalex-snapshot
Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer
inferredcites →https://doi.org/10.1016/j.canlet.2010.07.016openalex-snapshot
Targeting ER stress induced apoptosis and inflammation in cancer
inferredcites →https://doi.org/10.1016/j.canlet.2019.02.049openalex-snapshot
P53 pathway is a major determinant in the radiosensitizing effect of Palbociclib: Implication in cancer therapy
inferredcites →https://doi.org/10.1016/j.canlet.2020.02.015openalex-snapshot
Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs
inferredcites →https://doi.org/10.1016/j.ccell.2019.04.002openalex-snapshot
Targeting Ferroptosis to Iron Out Cancer
inferredcites →https://doi.org/10.1016/j.cell.2012.03.042openalex-snapshot
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2018.05.074openalex-snapshot
The tumor suppressor protein p53 and the ferroptosis network
inferredcites →https://doi.org/10.1016/j.molcel.2006.12.009openalex-snapshot
Control of Macroautophagy by Calcium, Calmodulin-Dependent Kinase Kinase-β, and Bcl-2
inferredcites →https://doi.org/10.1016/j.molcel.2017.06.017openalex-snapshot
The Unfolded Protein Response and Cell Fate Control
inferredcites →https://doi.org/10.1016/j.radonc.2013.06.037openalex-snapshot
The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response
inferredcites →https://doi.org/10.1016/j.radonc.2014.11.033openalex-snapshot
Charged particle therapy versus photon therapy for patients with hepatocellular carcinoma: A systematic review and meta-analysis
inferredcites →https://doi.org/10.1016/j.radonc.2018.12.012openalex-snapshot
Patient specific outcomes of charged particle therapy for hepatocellular carcinoma – A systematic review and quantitative analysis
inferredcites →https://doi.org/10.1016/j.semcancer.2015.03.003openalex-snapshot
Controlling the unfolded protein response-mediated life and death decisions in cancer
inferredcites →https://doi.org/10.1016/j.tranon.2020.100843openalex-snapshot
Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite
inferredcites →https://doi.org/10.1016/j.trecan.2016.03.007openalex-snapshot
Endoplasmic Reticulum Stress and the Hallmarks of Cancer
inferredcites →https://doi.org/10.1016/j.ymeth.2014.11.021openalex-snapshot
LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells
inferredcites →https://doi.org/10.1016/s0140-6736(18)30010-2openalex-snapshot
Hepatocellular carcinoma
inferredcites →https://doi.org/10.1016/s1470-2045(14)70412-7openalex-snapshot
Carbon ion radiotherapy in Japan: an assessment of 20 years of clinical experience
inferredcites →https://doi.org/10.1038/41580.1471-0080openalex-snapshot
Nature Reviews Molecular Cell Biology
inferredcites →https://doi.org/10.1038/cdd.2015.158openalex-snapshot
Ferroptosis: process and function
inferredcites →https://doi.org/10.1038/cdd.2017.82openalex-snapshot
BCL-2 family: integrating stress responses at the ER to control cell demise
inferredcites →https://doi.org/10.1038/cr.2016.95openalex-snapshot
Ferroptosis is an autophagic cell death process
inferredcites →https://doi.org/10.1038/nature14344openalex-snapshot
Ferroptosis as a p53-mediated activity during tumour suppression
inferredcites →https://doi.org/10.1038/nature17041openalex-snapshot
Protein misfolding in the endoplasmic reticulum as a conduit to human disease
inferredcites →https://doi.org/10.1038/nrm2199openalex-snapshot
Signal integration in the endoplasmic reticulum unfolded protein response
inferredcites →https://doi.org/10.1038/s41420-019-0212-4openalex-snapshot
ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER–plasma membrane junctions
inferredcites →https://doi.org/10.1038/s41422-019-0263-3openalex-snapshot
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
inferredcites →https://doi.org/10.1038/s41571-020-00462-0openalex-snapshot
Broadening horizons: the role of ferroptosis in cancer
inferredcites →https://doi.org/10.1074/jbc.m509868200openalex-snapshot
Endoplasmic Reticulum Stress-induced Apoptosis
inferredcites →https://doi.org/10.1080/15548627.2019.1582973openalex-snapshot
Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy
inferredcites →https://doi.org/10.1111/cas.13260openalex-snapshot
Endoplasmic reticulum stress pathway PERK ‐ eIF 2α confers radioresistance in oropharyngeal carcinoma by activating NF ‐κB
inferredcites →https://doi.org/10.1111/cas.14646openalex-snapshot
Autophagy involvement in oncogenesis
inferredcites →https://doi.org/10.1126/science.1209038openalex-snapshot
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
inferredcites →https://doi.org/10.1269/jrr.10134openalex-snapshot
Radiosensitization by Inhibiting Survivin in Human Hepatoma HepG2 Cells to High-LET Radiation
inferredcites →https://doi.org/10.3389/fonc.2016.00030openalex-snapshot
Differential Superiority of Heavy Charged-Particle Irradiation to X-Rays: Studies on Biological Effectiveness and Side Effect Mechanisms in Multicellular Tumor and Normal Tissue Models
inferredcites →https://doi.org/10.3390/cancers10100344openalex-snapshot
The Unfolded Protein Response in Breast Cancer
inferredcites →https://doi.org/10.3978/j.issn.2305-5839.2015.12.18openalex-snapshot
Photon, light ion, and heavy ion cancer radiotherapy: paths from physics and biology to clinical practice.
inferredcites →https://doi.org/10.7150/jca.27943openalex-snapshot
Autophagy Plays a Critical Role in Insulin Resistance- Mediated Chemoresistance in Hepatocellular Carcinoma Cells by Regulating the ER Stress
inferredcites →https://doi.org/10.7150/jca.29421openalex-snapshot
Unravel the molecular mechanism of XBP1 in regulating the biology of cancer cells
inferredcites →https://doi.org/10.7554/elife.02523openalex-snapshot
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4641193openalex-extracted
Visualizing the Role of ER Stress in Diabetic Cardiomyopathy: A Bibliometric Analysis
inferred← citeshttps://doi.org/10.1002/cac2.12520openalex-snapshot
Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy
inferred← citeshttps://doi.org/10.1002/mnfr.202300343openalex-snapshot
Ethanol‐Induced Hepatic Ferroptosis Is Mediated by PERK‐Dependent MAMs Formation: Preventive Role of Quercetin
inferred← citeshttps://doi.org/10.1007/s00066-023-02158-7openalex-snapshot
High-LET charged particles: radiobiology and application for new approaches in radiotherapy
inferred← citeshttps://doi.org/10.1007/s00210-025-03791-yopenalex-snapshot
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy
inferred← citeshttps://doi.org/10.1007/s11010-023-04893-yopenalex-snapshot
Ferroptosis: a new promising target for hepatocellular carcinoma therapy
inferred← citeshttps://doi.org/10.1007/s11010-025-05240-zopenalex-snapshot
STAT1 increases the sensitivity of lung adenocarcinoma to carbon ion irradiation via HO-1-mediated ferroptosis
inferred← citeshttps://doi.org/10.1007/s12265-025-10590-6openalex-snapshot
The link between ferroptosis and autophagy in myocardial ischemia/reperfusion injury: new directions for therapy
inferred← citeshttps://doi.org/10.1007/s43188-023-00201-4openalex-snapshot
Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2023.01.001openalex-snapshot
Are charged particles a good match for combination with immunotherapy? Current knowledge and perspectives
inferred← citeshttps://doi.org/10.1016/j.bbcan.2022.188848openalex-snapshot
Ferroptosis and its interaction with tumor immune microenvironment in liver cancer
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.116722openalex-snapshot
Ferroptosis in ulcerative colitis: Potential mechanisms and promising therapeutic targets
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Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma: Emphasis on cell death mechanism crosstalk
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.104773openalex-snapshot
Radiosensitization strategies for hepatocellular carcinoma: Mechanisms, therapeutic advances, and clinical perspectives
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109901openalex-snapshot
Crosstalk of non-apoptotic RCD panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization
inferred← citeshttps://doi.org/10.1016/j.jddst.2024.106426openalex-snapshot
3-Bromopyruvate modified with cholesterol enhances anti-hepatoma activity by inducing ferroptosis and apoptosis
inferred← citeshttps://doi.org/10.1016/j.neo.2026.101329openalex-snapshot
Inhibition of PERK signaling suppresses tumor progression and blocks GP73-GRP78-dependent stromal activation in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107332openalex-snapshot
Regulation mechanism of endoplasmic reticulum stress on metabolic enzymes in liver diseases
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102833openalex-snapshot
Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.yexcr.2025.114725openalex-snapshot
PERK suppression induces susceptibility to ferroptosis in lupus nephritis
inferred← citeshttps://doi.org/10.1038/s41416-022-01998-xopenalex-snapshot
Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy
inferred← citeshttps://doi.org/10.1038/s41419-022-05408-1openalex-snapshot
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
inferred← citeshttps://doi.org/10.1038/s41419-022-05444-xopenalex-snapshot
Endoplasmic reticulum stress-mediated cell death in liver injury
inferred← citeshttps://doi.org/10.1038/s41420-023-01645-1openalex-snapshot
Regulation of m6A modification on ferroptosis and its potential significance in radiosensitization
inferred← citeshttps://doi.org/10.1038/s41420-025-02761-wopenalex-snapshot
Nelfinavir triggers ferroptosis by inducing ER stress mediated downregulation of GPX4/GSH system, upregulation of NRF2/HO-1 axis, and mitochondrial impairment in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1038/s41467-024-48330-0openalex-snapshot
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
inferred← citeshttps://doi.org/10.1097/hep.0000000000000893openalex-snapshot
ER stress signaling at the interphase between MASH and HCC
inferred← citeshttps://doi.org/10.1097/md.0000000000039567openalex-snapshot
Spotlight on endoplasmic reticulum stress in acute kidney injury: A bibliometric analysis and visualization from 1997 to 2024
inferred← citeshttps://doi.org/10.1101/2023.03.28.534659openalex-snapshot
PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)
inferred← citeshttps://doi.org/10.1159/000545341openalex-snapshot
Endoplasmic Reticulum Stress Modulates Therapeutic Responses in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.1186/s11658-026-00895-yopenalex-snapshot
Targeting dormant cancer cells: ferroptosis as a precision therapeutic strategy
inferred← citeshttps://doi.org/10.1186/s12935-025-03947-zopenalex-snapshot
The endoplasmic reticulum stress-ferroptosis reciprocal signaling orchestrates anti-tumor effect of anlotinib in anaplastic thyroid cancer
inferred← citeshttps://doi.org/10.1186/s13014-025-02647-2openalex-snapshot
Carbon ion irradiation mobilizes antitumor immunity: from concept to the clinic
inferred← citeshttps://doi.org/10.1186/s40104-025-01196-8openalex-snapshot
Gut microbiota modulate intestinal inflammation by endoplasmic reticulum stress-autophagy-cell death signaling axis
inferred← citeshttps://doi.org/10.1186/s40164-023-00427-wopenalex-snapshot
Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy
inferred← citeshttps://doi.org/10.12677/wjcr.2023.132005openalex-snapshot
Research Progress of Endoplasmic Reticulum Stress in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3389/fcell.2022.882571openalex-snapshot
The Critical Role of Ferroptosis in Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3389/fcell.2026.1742297openalex-snapshot
Endoplasmic reticulum stress-mediated cell death in spinal cord injury: from molecular mechanisms to therapeutic applications
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1424954openalex-snapshot
Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs
inferred← citeshttps://doi.org/10.3389/fmed.2025.1592116openalex-snapshot
Carbon-ion radiotherapy induces ferroptosis and M1 macrophage polarization to inhibit the development of gastric cancer by downregulating DHODH
inferred← citeshttps://doi.org/10.3389/fmicb.2026.1781245openalex-snapshot
Cosmic silence and viral noise: transcriptomic crosstalk in Caenorhabditis elegans under simulated space conditions
inferred← citeshttps://doi.org/10.3389/fphar.2025.1605363openalex-snapshot
The protective effect and mechanism of dexmedetomidine in inhibiting ferroptosis
inferred← citeshttps://doi.org/10.3389/fphar.2025.1615974openalex-snapshot
Potential value and cardiovascular risks of programmed cell death in cancer treatment
inferred← citeshttps://doi.org/10.3389/fphar.2026.1785916openalex-snapshot
Natural products in treating sepsis-associated lung and liver injuries by mediating ferroptosis, current progress, and future perspective
inferred← citeshttps://doi.org/10.3390/antiox14030307openalex-snapshot
The PERK-eIF2α-ATF4 Axis Is Involved in Mediating ER-Stress-Induced Ferroptosis via DDIT4-mTORC1 Inhibition and Acetaminophen-Induced Hepatotoxicity
inferred← citeshttps://doi.org/10.3390/ph18030325openalex-snapshot
Therapeutic Approaches with Iron Oxide Nanoparticles to Induce Ferroptosis and Overcome Radioresistance in Cancers
inferred← citeshttps://doi.org/10.3390/toxics10080436openalex-snapshot
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate
inferred← citeshttps://doi.org/10.3748/wjg.v31.i32.108654openalex-snapshot
Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism
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Role of CELF2 in ferroptosis: Potential targets for cancer therapy (Review)
inferred← citeshttps://doi.org/10.5483/bmbrep.2023-0247openalex-snapshot
Increased ER stress by depletion of PDIA6 impairs primary ciliogenesis and enhances sensitivity to ferroptosis in kidney cells
inferred← citeshttps://doi.org/10.62347/sigp9279openalex-snapshot
Potential therapies for HCC involving targeting the ferroptosis pathway
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