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Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer cells in undifferentiated and proliferative state

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/advs.202004850openalex-snapshot

An MST4‐pβ‐CateninThr40 Signaling Axis Controls Intestinal Stem Cell and Tumorigenesis

inferredcites →https://doi.org/10.1002/cac2.12149openalex-snapshot

Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway in colorectal cancer and is inhibited by hsa‐miR‐6887‐3p

inferredcites →https://doi.org/10.1002/ijc.24061openalex-snapshot

Characterization of a subpopulation of colon cancer cells with stem cell‐like properties

inferredcites →https://doi.org/10.1007/s10585-011-9407-7openalex-snapshot

Highly enriched CD133+CD44+ stem-like cells with CD133+CD44high metastatic subset in HCT116 colon cancer cells

inferredcites →https://doi.org/10.1016/j.bbamcr.2012.06.027openalex-snapshot

KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cells

inferredcites →https://doi.org/10.1016/j.cmet.2018.02.007openalex-snapshot

Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets

inferredcites →https://doi.org/10.1016/j.molcel.2021.04.009openalex-snapshot

The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

inferredcites →https://doi.org/10.1016/j.molmed.2005.09.008openalex-snapshot

Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease

inferredcites →https://doi.org/10.1016/j.radonc.2020.06.023openalex-snapshot

BMI1-KLF4 axis deficiency improves responses to neoadjuvant concurrent chemoradiotherapy in patients with rectal cancer

inferredcites →https://doi.org/10.1016/j.stem.2013.11.002openalex-snapshot

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

inferredcites →https://doi.org/10.1016/j.stem.2017.02.007openalex-snapshot

Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal Stem Cells

inferredcites →https://doi.org/10.1016/j.stem.2019.02.002openalex-snapshot

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

inferredcites →https://doi.org/10.1016/j.tcb.2019.10.003openalex-snapshot

Wnt Signaling in 3D: Recent Advances in the Applications of Intestinal Organoids

inferredcites →https://doi.org/10.1016/j.ydbio.2010.11.001openalex-snapshot

Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene

inferredcites →https://doi.org/10.1016/j.yexcr.2020.112191openalex-snapshot

MEX3A promotes triple negative breast cancer proliferation and migration via the PI3K/AKT signaling pathway

inferredcites →https://doi.org/10.1016/s0092-8674(00)81339-2openalex-snapshot

MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos

inferredcites →https://doi.org/10.1016/s0304-419x(02)00051-3openalex-snapshot

The genetics of the E2F family of transcription factors: shared functions and unique roles

inferredcites →https://doi.org/10.1038/nature07602openalex-snapshot

Crypt stem cells as the cells-of-origin of intestinal cancer

inferredcites →https://doi.org/10.1038/nature21713openalex-snapshot

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

inferredcites →https://doi.org/10.1038/nature22081openalex-snapshot

Visualization and targeting of LGR5+ human colon cancer stem cells

inferredcites →https://doi.org/10.1038/nrc.2017.103openalex-snapshot

Differentiation therapy revisited

inferredcites →https://doi.org/10.1038/nrc2419openalex-snapshot

Exploring the role of cancer stem cells in radioresistance

inferredcites →https://doi.org/10.1038/nrc2499openalex-snapshot

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

inferredcites →https://doi.org/10.1038/nrrheum.2009.137openalex-snapshot

Wnt and PPARγ signaling in osteoblastogenesis and adipogenesis

inferredcites →https://doi.org/10.1038/s41419-018-0556-3openalex-snapshot

HOXB9 promotes endometrial cancer progression by targeting E2F3

inferredcites →https://doi.org/10.1038/s41419-018-0919-9openalex-snapshot

Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells

inferredcites →https://doi.org/10.1038/s41419-020-02858-3openalex-snapshot

Mex3a interacts with LAMA2 to promote lung adenocarcinoma metastasis via PI3K/AKT pathway

inferredcites →https://doi.org/10.1038/s41419-021-03480-7openalex-snapshot

BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation

inferredcites →https://doi.org/10.1038/s41419-021-03971-7openalex-snapshot

Bcl-2/Bcl-xL inhibitor ABT-263 overcomes hypoxia-driven radioresistence and improves radiotherapy

inferredcites →https://doi.org/10.1038/s41467-020-20222-zopenalex-snapshot

The epigenetic regulator Mll1 is required for Wnt-driven intestinal tumorigenesis and cancer stemness

inferredcites →https://doi.org/10.1038/s41467-020-20636-9openalex-snapshot

CREPT is required for murine stem cell maintenance during intestinal regeneration

inferredcites →https://doi.org/10.1038/s41556-019-0408-0openalex-snapshot

A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

inferredcites →https://doi.org/10.1038/sj.onc.1209854openalex-snapshot

Role of E2F3 expression in modulating cellular proliferation rate in human bladder and prostate cancer cells

inferredcites →https://doi.org/10.1056/nejmc1908886openalex-snapshot

Clinical and Therapeutic Implications of Cancer Stem Cells

inferredcites →https://doi.org/10.1056/nejmra1804280openalex-snapshot

Clinical and Therapeutic Implications of Cancer Stem Cells

inferredcites →https://doi.org/10.1073/pnas.0405928102openalex-snapshot

The Wnt/β-catenin signaling pathway targets PPARγ activity in colon cancer cells

inferredcites →https://doi.org/10.1073/pnas.0907916106openalex-snapshot

RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3

inferredcites →https://doi.org/10.1073/pnas.94.19.10330openalex-snapshot

β-Catenin mutations in cell lines established from human colorectal cancers

inferredcites →https://doi.org/10.1093/nar/gkm016openalex-snapshot

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

inferredcites →https://doi.org/10.1093/nar/gkx1090openalex-snapshot

LinkedOmics: analyzing multi-omics data within and across 32 cancer types

inferredcites →https://doi.org/10.1126/science.1122491openalex-snapshot

Translational Regulators Maintain Totipotency in the Caenorhabditis elegans Germline

inferredcites →https://doi.org/10.1128/mcb.00063-09openalex-snapshot

KLF4 Interacts with β-Catenin/TCF4 and Blocks p300/CBP Recruitment by β-Catenin

inferredcites →https://doi.org/10.1128/mcb.00938-09openalex-snapshot

E2F3 Is a Mediator of DNA Damage-Induced Apoptosis

inferredcites →https://doi.org/10.1146/annurev-physiol-021119-034500openalex-snapshot

BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract

inferredcites →https://doi.org/10.1158/0008-5472.can-18-0043openalex-snapshot

SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium

inferredcites →https://doi.org/10.1158/1541-7786.mcr-15-0410openalex-snapshot

KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis

inferredcites →https://doi.org/10.1186/s12943-019-0962-xopenalex-snapshot

Stem cells in homeostasis and cancer of the gut

inferredcites →https://doi.org/10.1186/s12943-020-01232-3openalex-snapshot

A novel LncRNA transcript, RBAT1, accelerates tumorigenesis through interacting with HNRNPL and cis-activating E2F3

inferredcites →https://doi.org/10.1242/dev.129.11.2619openalex-snapshot

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon

inferredcites →https://doi.org/10.1242/dev.150136openalex-snapshot

BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice

inferredcites →https://doi.org/10.15252/embr.201948938openalex-snapshot

MEX3A regulates Lgr5+ stem cell maintenance in the developing intestinal epithelium

inferredcites →https://doi.org/10.3322/caac.21660openalex-snapshot

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

inferredcites →https://doi.org/10.3389/fcell.2020.549533openalex-snapshot

The Stemness Gene Mex3A Is a Key Regulator of Neuroblast Proliferation During Neurogenesis

inferredcites →https://doi.org/10.3892/etm.2021.10778openalex-snapshot

MEX3A knockdown inhibits the tumorigenesis of colorectal cancer via modulating CDK2 expression

inferredcites →https://doi.org/10.4103/1477-3163.78279openalex-snapshot

The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies

inferredcites →https://doi.org/10.7717/peerj.8562openalex-snapshot

The E2F family as potential biomarkers and therapeutic targets in colon cancer

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4750448openalex-extracted

Histone Lactylation-Mediated PRRC2A Overexpression Promotes Colorectal Cancer Progression in M6A Modification-Dependent Manner

inferred← citeshttps://doi.org/10.1002/advs.202406935openalex-snapshot

m6A Reader PRRC2A Promotes Colorectal Cancer Progression via CK1ε‐Mediated Activation of WNT and YAP Signaling Pathways

inferred← citeshttps://doi.org/10.1002/cam4.71498openalex-snapshot

Krüppel‐Like Factor 4, a Hub Gate for Cell Crosstalk in Tumor Microenvironment

inferred← citeshttps://doi.org/10.1002/path.70106openalex-snapshot

Heterozygous germline deletion in Hif3a exacerbates esophageal squamous cell carcinoma development

inferred← citeshttps://doi.org/10.1007/s00432-024-05845-9openalex-snapshot

MEX3A promotes colorectal cancer migration, invasion and EMT via regulating the Wnt/β-catenin signaling pathway

inferred← citeshttps://doi.org/10.1007/s10620-024-08473-yopenalex-snapshot

KLF4 Induces Colorectal Cancer by Promoting EMT via STAT3 Activation

inferred← citeshttps://doi.org/10.1016/j.bcp.2026.118462openalex-snapshot

MEX3A mediates DHRS3 instability to relieve G0/G1 arrest and facilitate hepatocellular carcinoma tumorigenesis and progression

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116625openalex-snapshot

CD8+MT+ effector T cells from enlarged tumor-draining lymph nodes enhanced anti-tumor immunity and improved prognosis in colorectal cancer

inferred← citeshttps://doi.org/10.1016/j.curgen.2026.09.008openalex-snapshot

Single-Cell Atlas of Nasopharyngeal Carcinoma Reveals Epithelial Heterogeneity and Immune Evasion Networks

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117004openalex-snapshot

Cadmium exposure promotes inflammation through the PPAR signaling pathway in the small intestine and colon of Hu sheep

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2025.118861openalex-snapshot

Epiberberine alleviates cadmium-induced duodenal inflammation in Hu sheep by inhibiting HIF-1 signaling pathway

inferred← citeshttps://doi.org/10.1016/j.gendis.2026.102236openalex-snapshot

Context-dependent regulation of stemness programs: MEX3A provides a flourishing source for both normal and tumor tissues by regulating cellular stemness

inferred← citeshttps://doi.org/10.1016/j.jcmgh.2026.101771openalex-snapshot

MEX3A Modulates PPARγ Pathway Activity and Colorectal Cancer Growth

inferred← citeshttps://doi.org/10.1016/j.repbio.2024.100876openalex-snapshot

Circ_0001495 influences the development of endometriosis through the miRNA-34c-5p/E2F3 axis

inferred← citeshttps://doi.org/10.1038/s41392-024-01787-3openalex-snapshot

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

inferred← citeshttps://doi.org/10.1038/s41467-025-56444-2openalex-snapshot

ROS-induced cytosolic release of mitochondrial PGAM5 promotes colorectal cancer progression by interacting with MST3

inferred← citeshttps://doi.org/10.1042/bsr20240367openalex-snapshot

Dexamethasone–tamoxifen combination exerts synergistic therapeutic effects in tamoxifen-resistance breast cancer cells

inferred← citeshttps://doi.org/10.1093/nar/gkag048openalex-snapshot

Novel intermolecular zinc fingers and redox-driven conformational changes dictate tumor suppressor ZMYND11’s role in cooperative recognition of diverse targets

inferred← citeshttps://doi.org/10.1101/2025.01.13.632758openalex-snapshot

Intestinal stem cell marker MEX3A regulates PPARγ expression with functional impact in colorectal carcinogenesis

inferred← citeshttps://doi.org/10.1101/gr.279709.124openalex-snapshot

Homozygous editing of multiple genes for accelerated generation of xenotransplantation pigs

inferred← citeshttps://doi.org/10.1186/s12935-024-03465-4openalex-snapshot

Characterization of the stem cell landscape and identification of a stemness-associated prognostic signature in bladder cancer

inferred← citeshttps://doi.org/10.1186/s13046-024-03193-7openalex-snapshot

Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling

inferred← citeshttps://doi.org/10.18632/aging.204744openalex-snapshot

Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway

inferred← citeshttps://doi.org/10.2139/ssrn.4890934openalex-snapshot

Cadmium Exposure Promotes Inflammation Through the Ppar Signalling Pathway in the Small Intestine and Colon of Sheep

inferred← citeshttps://doi.org/10.3389/fimmu.2025.1514780openalex-snapshot

KLF4: a multifunctional nexus connecting tumor progression and immune regulation

inferred← citeshttps://doi.org/10.3390/cancers15092430openalex-snapshot

Krüppel-like Factors 4 and 5 in Colorectal Tumorigenesis

inferred← citeshttps://doi.org/10.3390/cancers17132135openalex-snapshot

Diagnostic and Therapeutic Potential of Selected microRNAs in Colorectal Cancer: A Literature Review

inferred← citeshttps://doi.org/10.3390/ijms27010205openalex-snapshot

RNA-Binding Proteins: Modulators of Canonical Wnt Signaling Pathway

inferred← citeshttps://doi.org/10.3390/ph17081048openalex-snapshot

The Pivotal Role of Preclinical Animal Models in Anti-Cancer Drug Discovery and Personalized Cancer Therapy Strategies

inferred← citeshttps://doi.org/10.3892/ijmm.2025.5579openalex-snapshot

Role of MEX3A in tumorigenesis: Mechanisms, tumor‑specific effects and therapeutic implications (Review)

inferred← citeshttps://doi.org/10.6084/m9.figshare.27140773openalex-snapshot

Additional file 1 of Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling

inferred← citeshttps://doi.org/10.64898/2025.12.26.696633openalex-snapshot

Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons

inferred← citeshttps://doi.org/10.7554/elife.110809openalex-snapshot

Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons

inferred← citeshttps://doi.org/10.7554/elife.110809.1openalex-snapshot

Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons

inferred← citeshttps://doi.org/10.7717/peerj.16159openalex-snapshot

Murine models of colorectal cancer: the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of colitis-associated cancer

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