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Microenvironmental modulation of the developing tumour: an immune‐stromal dialogue

https://doi.org/10.1002/1878-0261.12773
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inferredcites →https://doi.org/10.1016/j.canlet.2011.12.020openalex-snapshot
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Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis
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Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
inferredcites →https://doi.org/10.1016/j.ccr.2005.08.010openalex-snapshot
Tensional homeostasis and the malignant phenotype
inferredcites →https://doi.org/10.1016/j.ccr.2005.10.012openalex-snapshot
TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance
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Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling
inferredcites →https://doi.org/10.1016/j.ccr.2009.06.017openalex-snapshot
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inferredcites →https://doi.org/10.1016/j.ccr.2011.08.012openalex-snapshot
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Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
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Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
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Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis
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ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis
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CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
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Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts
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Tenascin-C Downregulates Wnt Inhibitor Dickkopf-1, Promoting Tumorigenesis in a Neuroendocrine Tumor Model
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Global Reorganization of the Nuclear Landscape in Senescent Cells
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Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
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IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development
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Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment
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Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
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Tumor-Induced IL-6 Reprograms Host Metabolism to Suppress Anti-tumor Immunity
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Tumor-associated macrophages in breast cancer: Innocent bystander or important player?
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Regulatory T Cells Reversibly Suppress Cytotoxic T Cell Function Independent of Effector Differentiation
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NKG2D-Deficient Mice Are Defective in Tumor Surveillance in Models of Spontaneous Malignancy
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STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
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Interleukin-4 Receptor α Signaling in Myeloid Cells Controls Collagen Fibril Assembly in Skin Repair
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Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition
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Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency
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Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression
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NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis
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The Immune Landscape of Cancer
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Transforming Growth Factor-β Signaling in Immunity and Cancer
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Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation
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Inflammation and Cancer: Triggers, Mechanisms, and Consequences
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IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance
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Cancer Immunoediting by Innate Lymphoid Cells
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Deep immune profiling by mass cytometry links human T and NK cell differentiation and cytotoxic molecule expression patterns
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Tissue-Infiltrating Neutrophils Constitute the Major In Vivo Source of Angiogenesis-Inducing MMP-9 in the Tumor Microenvironment
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Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer
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Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors
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CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα
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A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis
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The Multiple Layers of the Tumor Environment
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Immunodepression and Malignancy
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Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence: an 11-year follow-up study of a general population
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Matrix metal loproteinases and the development of cancer
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
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Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
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Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
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IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
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Cancer-associated fibroblasts induce epithelial–mesenchymal transition of breast cancer cells through paracrine TGF-β signalling
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TAMeless traitors: macrophages in cancer progression and metastasis
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Activated macrophages promote Wnt signalling through tumour necrosis factor‐α in gastric tumour cells
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Human macrophages induce CD4+Foxp3+ regulatory T cells via binding and re‐release of TGF‐β
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TGFβ1-Induced Inflammation in Premalignant Epidermal Squamous Lesions Requires IL-17
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Stromal fibroblasts in cancer initiation and progression
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Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
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The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
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BRAFE600-associated senescence-like cell cycle arrest of human naevi
inferredcites →https://doi.org/10.1038/nature06309openalex-snapshot
Adaptive immunity maintains occult cancer in an equilibrium state
inferredcites →https://doi.org/10.1038/nature06348openalex-snapshot
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
inferredcites →https://doi.org/10.1038/nature07445openalex-snapshot
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
inferredcites →https://doi.org/10.1038/nature07765openalex-snapshot
A mechanosensitive transcriptional mechanism that controls angiogenesis
inferredcites →https://doi.org/10.1038/nature10803openalex-snapshot
Expression of tumour-specific antigens underlies cancer immunoediting
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Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
inferredcites →https://doi.org/10.1038/nature25501openalex-snapshot
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
inferredcites →https://doi.org/10.1038/ncb1658openalex-snapshot
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
inferredcites →https://doi.org/10.1038/ncb2756openalex-snapshot
Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts
inferredcites →https://doi.org/10.1038/ncb3015openalex-snapshot
The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis
inferredcites →https://doi.org/10.1038/ncb3041openalex-snapshot
A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
inferredcites →https://doi.org/10.1038/ncb3157openalex-snapshot
Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway
inferredcites →https://doi.org/10.1038/ncb3228openalex-snapshot
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
inferredcites →https://doi.org/10.1038/ncb3400openalex-snapshot
A single dividing cell population with imbalanced fate drives oesophageal tumour growth
inferredcites →https://doi.org/10.1038/ncomms10204openalex-snapshot
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
inferredcites →https://doi.org/10.1038/ncomms12630openalex-snapshot
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
inferredcites →https://doi.org/10.1038/ncomms13050openalex-snapshot
Cancer-associated fibroblast-secreted CXCL16 attracts monocytes to promote stroma activation in triple-negative breast cancers
inferredcites →https://doi.org/10.1038/ncomms4472openalex-snapshot
Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling
inferredcites →https://doi.org/10.1038/ncomms9280openalex-snapshot
NCR+ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures
inferredcites →https://doi.org/10.1038/ng.3013openalex-snapshot
Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis
inferredcites →https://doi.org/10.1038/ng.3225openalex-snapshot
Stromal gene expression defines poor-prognosis subtypes in colorectal cancer
inferredcites →https://doi.org/10.1038/ng.3967openalex-snapshot
Patient-derived xenografts undergo mouse-specific tumor evolution
inferredcites →https://doi.org/10.1038/ng1054openalex-snapshot
High frequency of BRAF mutations in nevi
inferredcites →https://doi.org/10.1038/ni.1947openalex-snapshot
IL-12 initiates tumor rejection via lymphoid tissue–inducer cells bearing the natural cytotoxicity receptor NKp46
inferredcites →https://doi.org/10.1038/ni.2077openalex-snapshot
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
inferredcites →https://doi.org/10.1038/ni.2499openalex-snapshot
Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells
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Tumor-induced stromal reprogramming drives lymph node transformation
inferredcites →https://doi.org/10.1038/ni.3800openalex-snapshot
Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
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Lipid accumulation and dendritic cell dysfunction in cancer
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Molecular imaging using fluorescent lectins permits rapid endoscopic identification of dysplasia in Barrett's esophagus
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Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
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Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
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High-frequency microrheology reveals cytoskeleton dynamics in living cells
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Targeting neoantigens to augment antitumour immunity
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Microenvironmental regulation of tumour angiogenesis
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Radical causes of cancer
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Cancer as a robust system: implications for anticancer therapy
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Patient-derived tumour xenografts as models for oncology drug development
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Targeting the IL-6/JAK/STAT3 signalling axis in cancer
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Immunogenic cell death in cancer and infectious disease
inferredcites →https://doi.org/10.1038/nri.2017.74openalex-snapshot
Mechanical forces in the immune system
inferredcites →https://doi.org/10.1038/nri2852openalex-snapshot
The impact of the extracellular matrix on inflammation
inferredcites →https://doi.org/10.1038/nrm3904openalex-snapshot
Remodelling the extracellular matrix in development and disease
inferredcites →https://doi.org/10.1038/nrurol.2017.65openalex-snapshot
The potential of organoids in urological cancer research
inferredcites →https://doi.org/10.1038/onc.2008.270openalex-snapshot
The Janus face of dendritic cells in cancer
inferredcites →https://doi.org/10.1038/onc.2009.463openalex-snapshot
Heterogeneity of gene expression in stromal fibroblasts of human breast carcinomas and normal breast
inferredcites →https://doi.org/10.1038/onc.2013.191openalex-snapshot
Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression
inferredcites →https://doi.org/10.1038/onc.2015.254openalex-snapshot
Integrin α11β1 regulates cancer stromal stiffness and promotes tumorigenicity and metastasis in non-small cell lung cancer
inferredcites →https://doi.org/10.1038/onc.2016.217openalex-snapshot
TNFα-activated mesenchymal stromal cells promote breast cancer metastasis by recruiting CXCR2+ neutrophils
inferredcites →https://doi.org/10.1038/onc.2016.288openalex-snapshot
Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma
inferredcites →https://doi.org/10.1038/onc.2017.65openalex-snapshot
Fibroblasts drive an immunosuppressive and growth-promoting microenvironment in breast cancer via secretion of Chitinase 3-like 1
inferredcites →https://doi.org/10.1038/s41388-018-0593-5openalex-snapshot
Stromal Gas6 promotes the progression of premalignant mammary cells
inferredcites →https://doi.org/10.1038/s41467-017-02186-9openalex-snapshot
Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer
inferredcites →https://doi.org/10.1038/s41467-017-02481-5openalex-snapshot
Macrophages orchestrate breast cancer early dissemination and metastasis
inferredcites →https://doi.org/10.1038/s41467-017-02696-6openalex-snapshot
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy
inferredcites →https://doi.org/10.1038/s41467-018-03347-0openalex-snapshot
Cancer-associated fibroblasts induce antigen-specific deletion of CD8 + T Cells to protect tumour cells
inferredcites →https://doi.org/10.1038/s41467-018-03348-zopenalex-snapshot
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
inferredcites →https://doi.org/10.1038/s41467-018-07582-3openalex-snapshot
Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing
inferredcites →https://doi.org/10.1038/s41467-018-07987-0openalex-snapshot
Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts
inferredcites →https://doi.org/10.1038/s41467-019-09484-4openalex-snapshot
A clinically translatable hyperspectral endoscopy (HySE) system for imaging the gastrointestinal tract
inferredcites →https://doi.org/10.1038/s41467-019-10968-6openalex-snapshot
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
inferredcites →https://doi.org/10.1038/s41467-019-12370-8openalex-snapshot
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
inferredcites →https://doi.org/10.1038/s41568-019-0222-9openalex-snapshot
How the ageing microenvironment influences tumour progression
inferredcites →https://doi.org/10.1038/s41577-018-0061-zopenalex-snapshot
Natural killer cells and other innate lymphoid cells in cancer
inferredcites →https://doi.org/10.1038/s41577-019-0221-9openalex-snapshot
Defining ‘T cell exhaustion’
inferredcites →https://doi.org/10.1038/s41580-018-0007-0openalex-snapshot
Contextual determinants of TGFβ action in development, immunity and cancer
inferredcites →https://doi.org/10.1038/s41588-018-0331-5openalex-snapshot
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic
inferredcites →https://doi.org/10.1038/s41591-020-0892-6openalex-snapshot
Systemic dysfunction and plasticity of the immune macroenvironment in cancer models
inferredcites →https://doi.org/10.1038/sj.bjc.6605196openalex-snapshot
Angiogenesis is associated with the onset of hyperplasia in human ductal breast disease
inferredcites →https://doi.org/10.1038/srep02038openalex-snapshot
MiR-21/Smad 7 signaling determines TGF-β1-induced CAF formation
inferredcites →https://doi.org/10.1038/srep11924openalex-snapshot
TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT
inferredcites →https://doi.org/10.1038/srep38408openalex-snapshot
Cancer-associated fibroblasts treated with cisplatin facilitates chemoresistance of lung adenocarcinoma through IL-11/IL-11R/STAT3 signaling pathway
inferredcites →https://doi.org/10.1046/j.1440-1746.2003.03018.xopenalex-snapshot
Tumor progression in hepatocellular carcinoma: Relationship with tumor stroma and parenchymal disease
inferredcites →https://doi.org/10.1053/j.gastro.2016.03.040openalex-snapshot
Mounting Pressure in the Microenvironment: Fluids, Solids, and Cells in Pancreatic Ductal Adenocarcinoma
inferredcites →https://doi.org/10.1055/s-0043-124080openalex-snapshot
Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue
inferredcites →https://doi.org/10.1056/nejm198612253152606openalex-snapshot
Tumors: Wounds That Do Not Heal
inferredcites →https://doi.org/10.1073/pnas.0408197102openalex-snapshot
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
inferredcites →https://doi.org/10.1073/pnas.0503681102openalex-snapshot
Synergy between interstitial flow and VEGF directs capillary morphogenesis in vitro through a gradient amplification mechanism
inferredcites →https://doi.org/10.1073/pnas.0509182102openalex-snapshot
Intraepithelial CD8 + tumor-infiltrating lymphocytes and a high CD8 + /regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
inferredcites →https://doi.org/10.1073/pnas.0601807103openalex-snapshot
Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis
inferredcites →https://doi.org/10.1073/pnas.0906481106openalex-snapshot
Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity
inferredcites →https://doi.org/10.1073/pnas.1103581108openalex-snapshot
Interstitial flow influences direction of tumor cell migration through competing mechanisms
inferredcites →https://doi.org/10.1073/pnas.1114718109openalex-snapshot
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
inferredcites →https://doi.org/10.1073/pnas.1308887110openalex-snapshot
Modulation of macrophage phenotype by cell shape
inferredcites →https://doi.org/10.1073/pnas.1320318110openalex-snapshot
Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti–PD-L1 immunotherapy in pancreatic cancer
inferredcites →https://doi.org/10.1073/pnas.1600363113openalex-snapshot
Tumor-associated fibroblasts predominantly come from local and not circulating precursors
showing the first 200 of 400

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4628680openalex-extracted
Disruption of CD47-SIRPα Signalling Restores Inflammatory Function in Tumour-Associated Myeloid Derived Suppressor Cells
inferred← citeshttps://doi.org/10.1007/978-3-030-80962-1_62-1openalex-snapshot
Immune Compartments and Extracellular Matrix Crosstalk Involved in Tumor Dissemination
inferred← citeshttps://doi.org/10.1007/978-3-032-00759-9_62openalex-snapshot
Immune Compartments and Extracellular Matrix Crosstalk Involved in Tumor Dissemination
inferred← citeshttps://doi.org/10.1016/j.addr.2024.115485openalex-snapshot
Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication
inferred← citeshttps://doi.org/10.1016/j.gene.2025.149917openalex-snapshot
Dynamic tumor microenvironment remodeling from laryngeal leukoplakia to carcinoma revealed by single-cell transcriptomics
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e23601openalex-snapshot
Single-cell RNA sequencing reveals the immune microenvironment landscape of osteosarcoma before and after chemotherapy
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109546openalex-snapshot
Disruption of CD47-SIRPα signaling restores inflammatory function in tumor-associated myeloid-derived suppressor cells
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155608openalex-snapshot
Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms
inferred← citeshttps://doi.org/10.1038/s41598-025-03499-2openalex-snapshot
NOX4 as an emerging prognostic and immunological biomarker across pan-cancer analyses
inferred← citeshttps://doi.org/10.1111/imr.12972openalex-snapshot
Fibroblasts as confederates of the immune system
inferred← citeshttps://doi.org/10.15407/exp-oncology.2023.01.051openalex-snapshot
ROLE OF STROMAL MICROENVIRONMENT IN THE FORMATION OF INVASIVE, ANGIOGENIC, AND METASTATIC POTENTIAL OF ENDOMETRIOID CARCINOMA OF ENDOMETRIUM
inferred← citeshttps://doi.org/10.17650/2313-805x-2023-10-4-8-20openalex-snapshot
Cellular microenvironment as an object of targeted therapy for malignant neoplasms
inferred← citeshttps://doi.org/10.18632/oncotarget.27921openalex-snapshot
The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia
inferred← citeshttps://doi.org/10.3390/cancers15245757openalex-snapshot
Interleukin-6 Induces Stem Cell Propagation through Liaison with the Sortilin–Progranulin Axis in Breast Cancer
inferred← citeshttps://doi.org/10.3390/diagnostics12092166openalex-snapshot
Endorectal Ultrasound Shear-Wave Elastography of Complex Rectal Adenoma and Early Rectal Cancer
inferred← citeshttps://doi.org/10.3390/ijms23168940openalex-snapshot
Microenvironment in Oral Potentially Malignant Disorders: Multi-Dimensional Characteristics and Mechanisms of Carcinogenesis
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