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Cancer as a robust system: implications for anticancer therapy

https://doi.org/10.1038/nrc1300
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Outgoing claims: the papers this work cites, builds on, or argues with.

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inferredcites →https://doi.org/10.1038/16483openalex-snapshot
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The microenvironment of the tumour–host interface
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Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
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Cancer robustness: Tumour tactics
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Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
inferredcites →https://doi.org/10.1038/ng0103-5openalex-snapshot
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inferredcites →https://doi.org/10.1038/ng1055openalex-snapshot
A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity
inferredcites →https://doi.org/10.1038/nm0295-117openalex-snapshot
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inferredcites →https://doi.org/10.1038/nm0295-149openalex-snapshot
Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
inferredcites →https://doi.org/10.1038/nm0597-505openalex-snapshot
Cancer dormancy: Opportunities for new therapeutic approaches
inferredcites →https://doi.org/10.1038/nm0696-689openalex-snapshot
Angiostatin induces and sustains dormancy of human primary tumors in mice
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Targeting HIF-1 for cancer therapy
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Hypoxia — a key regulatory factor in tumour growth
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Chemokines: agents for the immunotherapy of cancer?
inferredcites →https://doi.org/10.1038/scientificamerican0793-42openalex-snapshot
Viral Quasispecies
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Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
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Immediate Local and Regional Recurrence After the Excision of a Polypoid Melanoma: Tumor Dormancy or Tumor Activation?
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Complexity and robustness
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Multiple mutations and cancer
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inferredcites →https://doi.org/10.1073/pnas.212514799openalex-snapshot
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Stochastic mechanisms in gene expression
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Tumor Dormancy Induced by Downregulation of Urokinase Receptor in Human Carcinoma Involves Integrin and MAPK Signaling
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Urokinase Receptor and Fibronectin Regulate the ERKMAPK to p38MAPK Activity Ratios That Determine Carcinoma Cell Proliferation or Dormancy In Vivo
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Robustness of a gene regulatory circuit
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'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally
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Tumor Hypoxia: Definitions and Current Clinical, Biologic, and Molecular Aspects
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Phase II study of combining vinblastine and cyclosporin-A to circumvent multidrug resistance in renal cell cancer
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The complexity of p53 modulation: emerging patterns from divergent signals
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Sir2 links chromatin silencing, metabolism, and aging
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Highly optimized tolerance: A mechanism for power laws in designed systems
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Analysis of switched and hybrid systems - beyond piecewise quadratic methods
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Introducing SOSTOOLS: a general purpose sum of squares programming solver
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Tumor hypoxia: A target for selective cancer therapy
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Clinical Resistance to STI-571 Cancer Therapy Caused by BCR-ABL Gene Mutation or Amplification
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Systems Biology: A Brief Overview
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Reverse Engineering of Biological Complexity
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Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
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Addiction to Oncogenes--the Achilles Heal of Cancer
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Roots of Clinical Resistance to STI-571 Cancer Therapy
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Dynamic Heterogeneity: Rapid Generation of Metastatic Variants in Mouse B16 Melanoma Cells
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Phase transitions in unstable cancer cell populations
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SIMULATION OF PROKARYOTIC GENETIC CIRCUITS
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Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans
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MDM2 Oncogene as a Novel Target for Human Cancer Therapy
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DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance

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The Continuous π-Calculus: A Process Algebra for Biochemical Modelling
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Modeling and Robustness Analysis of Biochemical Networks of Glycerol Metabolism by Klebsiella Pneumoniae
inferred← citeshttps://doi.org/10.1007/978-3-642-04590-5_16openalex-snapshot
Ontological Enrichment of the Genes-to-Systems Breast Cancer Database
inferred← citeshttps://doi.org/10.1007/978-3-642-15102-6_4openalex-snapshot
Signal Transduction in Biological Systems and its Possible Uses in Computation and Communication Systems
inferred← citeshttps://doi.org/10.1007/978-3-642-17943-3_17openalex-snapshot
A New Approach to Estimation of Protein Networks for Cell Cycle Based on Least-Squares Method
inferred← citeshttps://doi.org/10.1007/978-3-642-34070-3_48openalex-snapshot
Morphogenesis and Complexity of the Tumor Patterns
inferred← citeshttps://doi.org/10.1007/978-3-642-38951-1_11openalex-snapshot
Computational Systems Biology Approaches for Deciphering Traditional Chinese Medicine
inferred← citeshttps://doi.org/10.1007/978-3-7643-7567-6_10openalex-snapshot
Biological robustness in complex host-pathogen systems
inferred← citeshttps://doi.org/10.1007/978-81-322-0843-3_17openalex-snapshot
Systems Biology and Integrative Omics in Breast Cancer
inferred← citeshttps://doi.org/10.1007/978-90-313-8935-3_15openalex-snapshot
Lage energie laser en de behandeling van orale mucositis
inferred← citeshttps://doi.org/10.1007/978-94-007-1567-7_1openalex-snapshot
Introduction to Systems Approaches to Cancer
inferred← citeshttps://doi.org/10.1007/978-94-007-1567-7_10openalex-snapshot
Systems Biology Analysis of Cell Death Pathways in Cancer: How Collaborative and Interdisciplinary Research Helps
inferred← citeshttps://doi.org/10.1007/978-94-007-1567-7_17openalex-snapshot
Cancer Robustness and Therapy Strategies
inferred← citeshttps://doi.org/10.1007/978-94-007-1567-7_18openalex-snapshot
Synthetic Biology and Perspectives
inferred← citeshttps://doi.org/10.1007/978-94-007-4819-4_15openalex-snapshot
Relevance of Network Hierarchy in Cancer Drug-Target Selection
inferred← citeshttps://doi.org/10.1007/978-94-007-6803-1_14openalex-snapshot
Computational Tools and Resources for Integrative Modeling in Systems Biology
inferred← citeshttps://doi.org/10.1007/978-94-024-0865-2_5openalex-snapshot
Towards a Relational Ontology for Cancer
inferred← citeshttps://doi.org/10.1007/b137124openalex-snapshot
Scientific and technical challenges for systems biology
inferred← citeshttps://doi.org/10.1007/b138746openalex-snapshot
A modular systems biology analysis of cell cycle entrance into S-phase
inferred← citeshttps://doi.org/10.1007/bf03256319openalex-snapshot
Clinical Biomarkers in Oncology
inferred← citeshttps://doi.org/10.1007/bf03256688openalex-snapshot
Challenges in Combinational Oncology Studies
inferred← citeshttps://doi.org/10.1007/s00285-015-0883-2openalex-snapshot
From invasion to latency: intracellular noise and cell motility as key controls of the competition between resource-limited cellular populations
inferred← citeshttps://doi.org/10.1007/s00335-007-9044-2openalex-snapshot
From mouse genetics to systems biology
inferred← citeshttps://doi.org/10.1007/s00449-013-1037-9openalex-snapshot
Complex metabolic network of 1,3-propanediol transport mechanisms and its system identification via biological robustness
inferred← citeshttps://doi.org/10.1007/s00520-007-0238-7openalex-snapshot
A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation
inferred← citeshttps://doi.org/10.1007/s00520-007-0245-8openalex-snapshot
Oral cryotherapy reduces mucositis and opioid use after myeloablative therapy—a randomized controlled trial
inferred← citeshttps://doi.org/10.1007/s00520-009-0637-zopenalex-snapshot
Oral mucositis in patients receiving reduced-intensity regimens for allogeneic hematopoietic cell transplantation: comparison with conventional regimen
inferred← citeshttps://doi.org/10.1007/s00520-010-1002-yopenalex-snapshot
Progress of oral care and reduction of oral mucositis—a pilot study in a hematopoietic stem cell transplantation ward
inferred← citeshttps://doi.org/10.1007/s10441-008-9047-8openalex-snapshot
Beyond the Oncogene Paradigm: Understanding Complexity in Cancerogenesis
inferred← citeshttps://doi.org/10.1007/s10555-013-9441-9openalex-snapshot
Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review
inferred← citeshttps://doi.org/10.1007/s10916-016-0678-zopenalex-snapshot
Building a Personalized Cancer Treatment System
inferred← citeshttps://doi.org/10.1007/s11060-017-2732-1openalex-snapshot
Analysis of immunobiologic markers in primary and recurrent glioblastoma
inferred← citeshttps://doi.org/10.1007/s11424-013-2040-6openalex-snapshot
Solvability and control design for synchronization of Boolean networks
inferred← citeshttps://doi.org/10.1007/s11432-020-3136-3openalex-snapshot
Stabilization of Boolean control networks with state-triggered impulses
inferred← citeshttps://doi.org/10.1007/s11626-014-9751-4openalex-snapshot
Comparison of some antioxidant properties of plant extracts from Origanum vulgare, Salvia officinalis, Eleutherococcus senticosus and Stevia rebaudiana
inferred← citeshttps://doi.org/10.1007/s12013-012-9447-xopenalex-snapshot
Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status
inferred← citeshttps://doi.org/10.1007/s12094-006-0194-6openalex-snapshot
Bioinformatics and cancer: an essential alliance
inferred← citeshttps://doi.org/10.1007/s12609-014-0143-2openalex-snapshot
Understanding Drug Resistance in Breast Cancer with Mathematical Oncology
inferred← citeshttps://doi.org/10.1007/s13194-021-00371-8openalex-snapshot
How is cancer complex?
inferred← citeshttps://doi.org/10.1007/s13721-018-0165-1openalex-snapshot
Cancer drug target identification and node-level analysis of the network of MAPK pathways
inferred← citeshttps://doi.org/10.1007/s13752-022-00398-xopenalex-snapshot
A New Paradigm for Cancer?
inferred← citeshttps://doi.org/10.1016/b978-0-12-385075-1.00007-xopenalex-snapshot
Design and Connection of Robust Genetic Circuits
inferred← citeshttps://doi.org/10.1016/b978-0-12-385944-0.00024-1openalex-snapshot
Cancer Systems Biology
inferred← citeshttps://doi.org/10.1016/b978-0-12-809479-2.00010-xopenalex-snapshot
Big Evolutionary Mechanisms of Network Robustness and Signaling Transductivity in Aging and Carcinogenic Process by System Modeling and Database Mining
inferred← citeshttps://doi.org/10.1016/b978-0-12-814072-7.00010-3openalex-snapshot
Evolutionary Game Strategy of an Evolutionary Biological Network of Somatic Cells in the Organ Carcinogenesis and Aging Process
inferred← citeshttps://doi.org/10.1016/b978-0-12-814072-7.09991-5openalex-snapshot
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Translational strategies for development of monoclonal antibodies from discovery to the clinic
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Modeling the effects of vasculature evolution on early brain tumor growth
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Control of Boolean networks: Hardness results and algorithms for tree structured networks
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Robustness and state-space structure of Boolean gene regulatory models
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Cancer stem cells as the engine of unstable tumor progression
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Comparable ecological dynamics underlie early cancer invasion and species dispersal, involving self-organizing processes
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Pathway knockout and redundancy in metabolic networks
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Optimization aspects of carcinogenesis
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High-glycolytic cancers and their interplay with the body’s glucose demand and supply cycle
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Obesity-associated mechanisms of hepatocarcinogenesis
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Somatic evolution of head and neck cancer — Biological robustness and latent vulnerability
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A drug-delivery strategy for overcoming drug resistance in breast cancer through targeting of oncofetal fibronectin
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On the origin of cancer: Can we ignore coherence?
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Dynamics of P53 in response to DNA damage: Mathematical modeling and perspective
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Cancer as a form of life: Musings of the cancer and evolution symposium
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Structure and dynamics of molecular networks: A novel paradigm of drug discovery
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Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia
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Analysis of the impact degree distribution in metabolic networks using branching process approximation
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Thermodynamics and cancer stationary states
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Identification of critical regulatory genes in cancer signaling network using controllability analysis
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Integrative radiation carcinogenesis: interactions between cell and tissue responses to DNA damage
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Adaptation and learning of molecular networks as a description of cancer development at the systems-level: Potential use in anti-cancer therapies
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Cancer stem cells display extremely large evolvability: alternating plastic and rigid networks as a potential Mechanism
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Drug repurposing for cancer therapy, easier said than done
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Systems biology and the integration of mechanistic explanation and mathematical explanation
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Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system
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Nutrient Exploitation within the Tumor–Stroma Metabolic Crosstalk
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What keeps us ticking: a funny current, a calcium clock, or both?
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Changes in gene expression variability reveal a stable synthetic lethal interaction network in BRCA2−ovarian cancers
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Philosophy of Immunology
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Transcriptomic Integration Analyses Uncover Common Bisphenol A Effects Across Species and Tissues Primarily Mediated by Disruption of JUN/FOS, EGFR, ER, PPARG, and P53 Pathways
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Diverse array-designed modes of combination therapies in Fangjiomics
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Mathematics for Understanding Disease
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Towards a theory of biological robustness
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Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy
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Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML
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Network modeling links breast cancer susceptibility and centrosome dysfunction
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Models, mechanisms and clinical evidence for cancer dormancy
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Toll-like receptors and cancer
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A robustness-based approach to systems-oriented drug design
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Biological robustness
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Modulating the dynamics of NFκB and PI3K enhances the ensemble-level TNFR1 signaling mediated apoptotic response
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Angiogenesis in human brain tumors: screening of drug response through a patient-specific cell platform for personalized therapy
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Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis
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Hypergraph geometry reflects higher-order dynamics in protein interaction networks
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Predicting cancer stages from tissue energy dissipation
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Barium nanoparticles enhance efficacy of external beam radiation therapy in a preclinical basal-like mammary cancer mouse model
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Enhanced therapeutic efficacy of IL-12, but not GM-CSF, expressing oncolytic herpes simplex virus for transgenic mouse derived prostate cancers
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Ras-dependent carbon metabolism and transformation in mouse fibroblasts
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Graph Curvature for Differentiating Cancer Networks
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A streamlined search technology for identification of synergistic drug combinations
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Understanding cancer complexome using networks, spectral graph theory and multilayer framework
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