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Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Part II. Overexpression ofbcl-2 family members enhances survival of mammalian cells in response to various culture insults
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Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells
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CHOgenome.org 2.0: Genome resources and website updates
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Metabolite profiling of CHO cells: Molecular reflections of bioprocessing effectiveness
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One‐step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment
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CRISPR/Cas9‐mediated genome engineering of CHO cell factories: Application and perspectives
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Cellular engineering for therapeutic protein production: product quality, host modification, and process improvement
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Virus susceptibility of Chinese hamster ovary (CHO) cells and detection of viral contaminations by adventitious agent testing
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Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production
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Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process
inferredcites →https://doi.org/10.1002/bit.24389openalex-snapshot
Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
inferredcites →https://doi.org/10.1002/bit.24445openalex-snapshot
Combined in silico modeling and metabolomics analysis to characterize fed‐batch CHO cell culture
inferredcites →https://doi.org/10.1002/bit.24496openalex-snapshot
Metabolite profiling of CHO cells with different growth characteristics
inferredcites →https://doi.org/10.1002/bit.24580openalex-snapshot
LC‐MS‐based metabolic characterization of high monoclonal antibody‐producing Chinese hamster ovary cells
inferredcites →https://doi.org/10.1002/bit.24728openalex-snapshot
Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption
inferredcites →https://doi.org/10.1002/bit.24826openalex-snapshot
Metabolic analysis of antibody producing CHO cells in fed‐batch production
inferredcites →https://doi.org/10.1002/bit.24841openalex-snapshot
An 'omics approach towards CHO cell engineering
inferredcites →https://doi.org/10.1002/bit.24858openalex-snapshot
Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed‐batch CHO cell culture
inferredcites →https://doi.org/10.1002/bit.24983openalex-snapshot
Metabolic signatures of GS‐CHO cell clones associated with butyrate treatment and culture phase transition
inferredcites →https://doi.org/10.1002/bit.25266openalex-snapshot
Metabolic responses of CHO cells to limitation of key amino acids
inferredcites →https://doi.org/10.1002/bit.25450openalex-snapshot
Amino acid and glucose metabolism in fed‐batch CHO cell culture affects antibody production and glycosylation
inferredcites →https://doi.org/10.1002/bit.25673openalex-snapshot
The use of ‘Omics technology to rationally improve industrial mammalian cell line performance
inferredcites →https://doi.org/10.1002/bit.260280912openalex-snapshot
Reduction of waste product excretion via nutrient control: Possible strategies for maximizing product and cell yields on serum in cultures of mammalian cells
inferredcites →https://doi.org/10.1002/bit.260390408openalex-snapshot
Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production
inferredcites →https://doi.org/10.1002/bit.26313openalex-snapshot
Identification and control of novel growth inhibitors in fed‐batch cultures of Chinese hamster ovary cells
inferredcites →https://doi.org/10.1002/bit.26316openalex-snapshot
Overexpression of the regulatory subunit of glutamate‐cysteine ligase enhances monoclonal antibody production in CHO cells
inferredcites →https://doi.org/10.1002/btpr.1868openalex-snapshot
Effects of copper on CHO cells: Insights from gene expression analyses
inferredcites →https://doi.org/10.1002/btpr.2004openalex-snapshot
Effects of copper on CHO cells: Cellular requirements and product quality considerations
inferredcites →https://doi.org/10.1002/btpr.238openalex-snapshot
A single nutrient feed supports both chemically defined NS0 and CHO fed‐batch processes: Improved productivity and lactate metabolism
inferredcites →https://doi.org/10.1002/jps.20319openalex-snapshot
Glycoengineering: The effect of glycosylation on the properties of therapeutic proteins
inferredcites →https://doi.org/10.1007/978-94-011-0437-1openalex-snapshot
Animal Cell Technology: Developments Towards the 21st Century
inferredcites →https://doi.org/10.1007/s00253-003-1385-5openalex-snapshot
Metabolic changes during cell growth inhibition by p27 overexpression
inferredcites →https://doi.org/10.1007/s00253-004-1751-yopenalex-snapshot
Glutathione: a review on biotechnological production
inferredcites →https://doi.org/10.1007/s00253-006-0654-5openalex-snapshot
Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
inferredcites →https://doi.org/10.1007/s00253-007-1041-6openalex-snapshot
Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44)
inferredcites →https://doi.org/10.1007/s00253-011-3758-5openalex-snapshot
CHO cells in biotechnology for production of recombinant proteins: current state and further potential
inferredcites →https://doi.org/10.1007/s00253-015-6514-4openalex-snapshot
Benchmarking of commercially available CHO cell culture media for antibody production
inferredcites →https://doi.org/10.1007/s00726-016-2181-8openalex-snapshot
Amino acids in the cultivation of mammalian cells
inferredcites →https://doi.org/10.1007/s10616-005-0301-5openalex-snapshot
Toxic Concentrations of Exogenously Supplied Methylglyoxal in Hybridoma Cell Culture
inferredcites →https://doi.org/10.1007/s10616-005-1920-6openalex-snapshot
Analysis of Methylglyoxal Metabolism in CHO Cells Grown in Culture
inferredcites →https://doi.org/10.1007/s10616-012-9508-4openalex-snapshot
Metabolomics profiling of extracellular metabolites in CHO-K1 cells cultured in different types of growth media
inferredcites →https://doi.org/10.1007/s12033-014-9762-0openalex-snapshot
Complete Knockout of the Lactate Dehydrogenase A Gene is Lethal in Pyruvate Dehydrogenase Kinase 1, 2, 3 Down-Regulated CHO Cells
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Growth behavior of Chinese hamster ovary cells in a compact loop bioreactor. 2. Effects of medium components and waste products
inferredcites →https://doi.org/10.1016/0168-1656(95)00196-4openalex-snapshot
The importance of ammonia in mammalian cell culture
inferredcites →https://doi.org/10.1016/b978-0-12-420117-0.00002-5openalex-snapshot
Emerging Regulatory Paradigms in Glutathione Metabolism
inferredcites →https://doi.org/10.1016/j.ab.2010.04.031openalex-snapshot
Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol
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The art of CHO cell engineering: A comprehensive retrospect and future perspectives
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A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism
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Metabolic Flux and the Regulation of Mammalian Cell Growth
inferredcites →https://doi.org/10.1016/j.copbio.2013.04.016openalex-snapshot
Metabolic flux rewiring in mammalian cell cultures
inferredcites →https://doi.org/10.1016/j.copbio.2014.06.004openalex-snapshot
Enhancement of production of protein biopharmaceuticals by mammalian cell cultures: the metabolomics perspective
inferredcites →https://doi.org/10.1016/j.jbiotec.2003.10.035openalex-snapshot
Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells
inferredcites →https://doi.org/10.1016/j.jbiotec.2005.02.003openalex-snapshot
Effects of amino acid additions on ammonium stressed CHO cells
inferredcites →https://doi.org/10.1016/j.jbiotec.2007.06.006openalex-snapshot
Engineering cell metabolism for high-density cell culture via manipulation of sugar transport
inferredcites →https://doi.org/10.1016/j.jbiotec.2010.03.018openalex-snapshot
Metabolomics-driven approach for the improvement of Chinese hamster ovary cell growth: Overexpression of malate dehydrogenase II
inferredcites →https://doi.org/10.1016/j.jbiotec.2010.12.010openalex-snapshot
Metabolomics-based identification of apoptosis-inducing metabolites in recombinant fed-batch CHO culture media
inferredcites →https://doi.org/10.1016/j.jbiotec.2011.03.003openalex-snapshot
Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
inferredcites →https://doi.org/10.1016/j.jbiotec.2012.08.021openalex-snapshot
Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator
inferredcites →https://doi.org/10.1016/j.mam.2008.08.009openalex-snapshot
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase
inferredcites →https://doi.org/10.1016/j.nbt.2012.05.021openalex-snapshot
Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity
inferredcites →https://doi.org/10.1016/j.procbio.2011.03.014openalex-snapshot
Optimizing amino acid composition of CHO cell culture media for a fusion protein production
inferredcites →https://doi.org/10.1016/j.tibtech.2004.03.007openalex-snapshot
Metabolomics by numbers: acquiring and understanding global metabolite data
inferredcites →https://doi.org/10.1016/j.tibtech.2010.06.005openalex-snapshot
Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways
inferredcites →https://doi.org/10.1016/j.tips.2009.04.007openalex-snapshot
Recombinant antibody therapeutics: the impact of glycosylation on mechanisms of action
inferredcites →https://doi.org/10.1016/j.yjmcc.2006.01.021openalex-snapshot
Asymmetric dimethylarginine induces apoptosis via p38 MAPK/caspase-3-dependent signaling pathway in endothelial cells
inferredcites →https://doi.org/10.1016/j.ymben.2005.10.002openalex-snapshot
Effects of elevated ammonium on glycosylation gene expression in CHO cells
inferredcites →https://doi.org/10.1016/j.ymben.2011.12.006openalex-snapshot
On metabolic shift to lactate consumption in fed-batch culture of mammalian cells
inferredcites →https://doi.org/10.1016/j.ymben.2012.10.001openalex-snapshot
Parallel labeling experiments with [1,2-13C]glucose and [U-13C]glutamine provide new insights into CHO cell metabolism
inferredcites →https://doi.org/10.1016/j.ymben.2017.01.008openalex-snapshot
Application of 13C flux analysis to identify high-productivity CHO metabolic phenotypes
inferredcites →https://doi.org/10.1016/s0021-9258(17)42703-7openalex-snapshot
Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits.
inferredcites →https://doi.org/10.1016/s0141-0229(00)00151-4openalex-snapshot
Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells
inferredcites →https://doi.org/10.1016/s0735-1097(00)01013-5openalex-snapshot
An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes
inferredcites →https://doi.org/10.1016/s0958-1669(00)00197-xopenalex-snapshot
Industrial choices for protein production by large-scale cell culture
inferredcites →https://doi.org/10.1021/bp9602360openalex-snapshot
Effects of Ammonium and Lactate on Growth and Metabolism of a Recombinant Chinese Hamster Ovary Cell Culture
inferredcites →https://doi.org/10.1021/pr501027copenalex-snapshot
High-Antibody-Producing Chinese Hamster Ovary Cells Up-Regulate Intracellular Protein Transport and Glutathione Synthesis
inferredcites →https://doi.org/10.1023/a:1007953628840openalex-snapshot
Incidence and potential implications of the toxic metabolite methylglyoxal in cell culture: A review
inferredcites →https://doi.org/10.1023/a:1008084622991openalex-snapshot
Effects of NH4+ and K+ on the energy metabolism in Sp2/0-Ag14 myeloma cells
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Applications of genome‐scale metabolic reconstructions
inferredcites →https://doi.org/10.1038/nbt.1932openalex-snapshot
The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
inferredcites →https://doi.org/10.1038/nbt0910-917openalex-snapshot
Biopharmaceutical benchmarks 2010
inferredcites →https://doi.org/10.1038/nbt1291-1347openalex-snapshot
The Oligosaccharides of Glycoproteins: Bioprocess Factors Affecting Oligosaccharide Structure and their Effect on Glycoprotein Properties
inferredcites →https://doi.org/10.1038/nbt799openalex-snapshot
Enhancement of therapeutic protein in vivo activities through glycoengineering
inferredcites →https://doi.org/10.1093/nar/gkj102openalex-snapshot
From genomics to chemical genomics: new developments in KEGG
inferredcites →https://doi.org/10.1093/nar/gkl923openalex-snapshot
HMDB: the Human Metabolome Database
inferredcites →https://doi.org/10.1093/nar/gkn810openalex-snapshot
HMDB: a knowledgebase for the human metabolome
inferredcites →https://doi.org/10.1093/nar/gks1065openalex-snapshot
HMDB 3.0—The Human Metabolome Database in 2013
inferredcites →https://doi.org/10.1093/nar/gkv1070openalex-snapshot
KEGG as a reference resource for gene and protein annotation
inferredcites →https://doi.org/10.1093/nar/gkv1351openalex-snapshot
The Reactome pathway Knowledgebase
inferredcites →https://doi.org/10.1093/nar/gkw1092openalex-snapshot
KEGG: new perspectives on genomes, pathways, diseases and drugs
inferredcites →https://doi.org/10.1126/science.123.3191.309openalex-snapshot
On the Origin of Cancer Cells
inferredcites →https://doi.org/10.1126/science.291.5512.2364openalex-snapshot
Intracellular Functions of N-Linked Glycans
inferredcites →https://doi.org/10.1371/journal.pone.0121561openalex-snapshot
Multiplicity of Steady States in Glycolysis and Shift of Metabolic State in Cultured Mammalian Cells
inferredcites →https://doi.org/10.1371/journal.pone.0143516openalex-snapshot
Livelihoods and Fisheries Governance in a Contemporary Pacific Island Setting
inferredcites →https://doi.org/10.2225/vol16-issue3-fulltext-2openalex-snapshot
Advances in improving mammalian cells metabolism for recombinant protein production
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Glutathione levels in human tumors
inferredcites →https://doi.org/10.3389/fphar.2017.00001openalex-snapshot
Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy
inferredcites →https://doi.org/10.4155/pbp.13.5openalex-snapshot
High expression of the aspartate–glutamate carrier Aralar1 favors lactate consumption in CHO cell culture
inferredcites →https://doi.org/10.4155/pbp.13.56openalex-snapshot
The use of glutamine synthetase as a selection marker: recent advances in Chinese hamster ovary cell line generation processes
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Carbon Quantum Dots Codoped with Nitrogen and Lanthanides for Multimodal Imaging
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Mechanistic Insights Into Plasma‐Activated Hydrogel: RONS Transport, Storage, and Bactericidal Synergy
inferred← citeshttps://doi.org/10.1002/aic.18602openalex-snapshot
Productive CHO cell lines selection in biopharm process development through machine learning on metabolomic dynamics
inferred← citeshttps://doi.org/10.1002/amp2.10180openalex-snapshot
Two scale‐down tools for the optimization of perfusion bioreactors for the manufacture of biopharmaceuticals
inferred← citeshttps://doi.org/10.1002/biot.201700221openalex-snapshot
The Expression Pattern of the Phosphoproteome Is Significantly Changed During the Growth Phases of Recombinant CHO Cell Culture
inferred← citeshttps://doi.org/10.1002/biot.201800077openalex-snapshot
Enhancing CHO by Systems Biotechnology
inferred← citeshttps://doi.org/10.1002/biot.201800352openalex-snapshot
Multi‐Omics Study on the Impact of Cysteine Feed Level on Cell Viability and mAb Production in a CHO Bioprocess
inferred← citeshttps://doi.org/10.1002/biot.202000350openalex-snapshot
Subcloning induces changes in the DNA‐methylation pattern of outgrowing Chinese hamster ovary cell colonies
inferred← citeshttps://doi.org/10.1002/biot.202000464openalex-snapshot
Effect of vitamins and metal ions on productivity and charge heterogeneity of IgG1 expressed in CHO cells
inferred← citeshttps://doi.org/10.1002/biot.202000629openalex-snapshot
Longitudinal monitoring of cell metabolism in biopharmaceutical production using label‐free fluorescence lifetime imaging microscopy
inferred← citeshttps://doi.org/10.1002/biot.202100019openalex-snapshot
An integrated modular framework for modeling the effect of ammonium on the sialylation process of monoclonal antibodies produced by CHO cells
inferred← citeshttps://doi.org/10.1002/biot.202100098openalex-snapshot
Transient ammonia stress on Chinese hamster ovary (CHO) cells yield alterations to alanine metabolism and IgG glycosylation profiles
inferred← citeshttps://doi.org/10.1002/biot.202100325openalex-snapshot
Capillary and microchip electrophoresis method development for amino acid monitoring during biopharmaceutical cultivation
inferred← citeshttps://doi.org/10.1002/biot.202100395openalex-snapshot
Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using Raman spectroscopy
inferred← citeshttps://doi.org/10.1002/biot.202200243openalex-snapshot
Cottonseed hydrolysate supplementation alters metabolic and proteomics responses in Chinese hamster ovary cell cultures
inferred← citeshttps://doi.org/10.1002/biot.202200616openalex-snapshot
1H NMR‐based process understanding and biochemical marker identification methodology for monitoring CHO cell culture process during commercial‐scale manufacturing
inferred← citeshttps://doi.org/10.1002/biot.202300338openalex-snapshot
Amino acid degradation pathway inhibitory by‐products trigger apoptosis in CHO cells
inferred← citeshttps://doi.org/10.1002/biot.202300395openalex-snapshot
Development of an in‐line Raman analytical method for commercial‐scale CHO cell culture process monitoring: Influence of measurement channels and batch number on model performance
inferred← citeshttps://doi.org/10.1002/biot.202300495openalex-snapshot
Exploring metabolic responses and pathway changes in CHO‐K1 cells under varied aeration conditions and copper supplementations using 1H NMR‐based metabolomics
inferred← citeshttps://doi.org/10.1002/biot.202400251openalex-snapshot
Advances in serum‐free media for CHO cells: From traditional serum substitutes to microbial‐derived substances
inferred← citeshttps://doi.org/10.1002/biot.202400624openalex-snapshot
Time‐Resolved Hierarchical Modeling Highlights Metabolites Influencing Productivity and Cell Death in Chinese Hamster Ovary Cells
inferred← citeshttps://doi.org/10.1002/biot.70041openalex-snapshot
Replacement of Isoleucine and Leucine by their Keto Acids leads to increased formation of α‐Hydroxy Acids in Chinese Hamster Ovary cells
inferred← citeshttps://doi.org/10.1002/biot.70087openalex-snapshot
Uncovering Growth‐Inhibitory Metabolic Byproducts in HEK293 Fed‐Batch Cultures and Strategies for Their Control
inferred← citeshttps://doi.org/10.1002/bit.26858openalex-snapshot
Metabolic flux balance analysis during lactate and glucose concomitant consumption in HEK293 cell cultures
inferred← citeshttps://doi.org/10.1002/bit.27247openalex-snapshot
Oxidative stress‐alleviating strategies to improve recombinant protein production in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.27439openalex-snapshot
Overexpression of the mitochondrial pyruvate carrier reduces lactate production and increases recombinant protein productivity in CHO cells
inferred← citeshttps://doi.org/10.1002/bit.27693openalex-snapshot
Application of metabolic modeling for targeted optimization of high seeding density processes
inferred← citeshttps://doi.org/10.1002/bit.27704openalex-snapshot
In‐silico media optimization for continuous cultures using genome scale metabolic networks: The case of CHO‐K1
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Scale‐up economics for cultured meat
inferred← citeshttps://doi.org/10.1002/bit.27942openalex-snapshot
Production of butyrate and branched‐chain amino acid catabolic byproducts by CHO cells in fed‐batch culture enhances their specific productivity
inferred← citeshttps://doi.org/10.1002/bit.27947openalex-snapshot
Modular development enables rapid design of media for alternative hosts
inferred← citeshttps://doi.org/10.1002/bit.27998openalex-snapshot
Using MVDA with stoichiometric balances to optimize amino acid concentrations in chemically defined CHO cell culture medium for improved culture performance
inferred← citeshttps://doi.org/10.1002/bit.28104openalex-snapshot
Combined multivariate statistical and flux balance analyses uncover media bottlenecks to the growth and productivity of Chinese hamster ovary cell cultures
inferred← citeshttps://doi.org/10.1002/bit.28397openalex-snapshot
Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments
inferred← citeshttps://doi.org/10.1002/bit.28403openalex-snapshot
Addressing amino acid‐derived inhibitory metabolites and enhancing CHO cell culture performance through DOE‐guided media modifications
inferred← citeshttps://doi.org/10.1002/bit.28412openalex-snapshot
Critical challenges and advances in recombinant adeno‐associated virus (rAAV) biomanufacturing
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Precision fermentation with mass spectrometry‐based spent media analysis
inferred← citeshttps://doi.org/10.1002/bit.28459openalex-snapshot
CHOmpact: A reduced metabolic model of Chinese hamster ovary cells with enhanced interpretability
inferred← citeshttps://doi.org/10.1002/bit.28605openalex-snapshot
Developing an ultra‐intensified fed‐batch cell culture process with greatly improved performance and productivity
inferred← citeshttps://doi.org/10.1002/bit.28613openalex-snapshot
Harnessing metabolic plasticity in CHO cells for enhanced perfusion cultivation
inferred← citeshttps://doi.org/10.1002/bit.28777openalex-snapshot
Metabolomic characterization of monoclonal antibody‐producing Chinese hamster lung (CHL)‐YN cells in glucose‐controlled serum‐free fed‐batch operation
inferred← citeshttps://doi.org/10.1002/bit.28982openalex-snapshot
Flux Sampling Suggests Metabolic Signatures of High Antibody‐Producing CHO Cells
inferred← citeshttps://doi.org/10.1002/bit.70205openalex-snapshot
Multi‐Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions
inferred← citeshttps://doi.org/10.1002/bit.70206openalex-snapshot
Intracellular Lactate Modulation Alters Histone Modifications and CHO Cell Performance in Fed‐Batch Culture
inferred← citeshttps://doi.org/10.1002/bit.70287openalex-snapshot
Metabolic Flux Analysis Reveals Cell Line‐Specific Rewiring in CHO Cells Following TCA Cycle Intermediate Feeding for Bioprocess pH Control
inferred← citeshttps://doi.org/10.1002/bit.70290openalex-snapshot
Microbial Hydrolysates as Amino Acid Source in Cell Culture Media for Cellular Agriculture
inferred← citeshttps://doi.org/10.1002/bmc.5348openalex-snapshot
LC‐HRMS‐based targeted metabolomics for high‐throughput and quantitative analysis of 21 growth inhibition‐related metabolites in Chinese hamster ovary cell fed‐batch cultures
inferred← citeshttps://doi.org/10.1002/btpr.3365openalex-snapshot
Use of single analytic tool to quantify both absolute N‐glycosylation and glycan distribution in monoclonal antibodies
inferred← citeshttps://doi.org/10.1002/btpr.3507openalex-snapshot
CHO stable pool fed‐batch process development of SARS ‐ CoV ‐2 spike protein production: Impact of aeration conditions and feeding strategies
inferred← citeshttps://doi.org/10.1002/btpr.70071openalex-snapshot
Secondary feed filtration and storage conditions influence trace element availability and process performance at 2000 L scale
inferred← citeshttps://doi.org/10.1002/btpr.70080openalex-snapshot
Dynamic pH profiles drive higher cell‐specific and volumetric productivity
inferred← citeshttps://doi.org/10.1002/btpr.70082openalex-snapshot
Optimization of amino acid composition in CHO cell perfusion medium using definitive screening design and 1 H NMR ‐based consumption profiling
inferred← citeshttps://doi.org/10.1002/btpr.88557openalex-snapshot
Evaluation of media intensification strategies in perfusion
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_16openalex-snapshot
Monitoring Tools for the Development of High Cell Density Culture Strategies
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An Omic’s Data-Driven Approach Towards Engineering Mammalian Cell Factories and Bioprocesses for Biopharmaceutical Production
inferred← citeshttps://doi.org/10.1007/978-3-030-79871-0_7openalex-snapshot
Next-Generation Cell Engineering Platform for Improving Recombinant Protein Production in Mammalian Cells
inferred← citeshttps://doi.org/10.1007/978-3-031-45669-5_4openalex-snapshot
Continuous Bioprocessing for Upstream Process: Perfusion Process
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Nutrient Absorption Dynamics and Food Contamination
inferred← citeshttps://doi.org/10.1007/s00216-023-04725-4openalex-snapshot
Protein overproduction alters exosome secretion in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1007/s00216-025-05845-9openalex-snapshot
Quantitative 1H NMR optimization for high-throughput metabolite analysis in industrial bioprocess monitoring
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A new strategy for fed-batch process control of HEK293 cell cultures based on alkali buffer addition monitoring: comparison with O.U.R. dynamic method
inferred← citeshttps://doi.org/10.1007/s00253-019-10020-zopenalex-snapshot
Clonal variations in CHO IGF signaling investigated by SILAC-based phosphoproteomics and LFQ-MS
inferred← citeshttps://doi.org/10.1007/s00253-020-10916-1openalex-snapshot
Metabolic understanding of disulfide reduction during monoclonal antibody production
inferred← citeshttps://doi.org/10.1007/s00253-021-11755-4openalex-snapshot
Valine feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of CHO cells
inferred← citeshttps://doi.org/10.1007/s00253-023-12997-0openalex-snapshot
Exploring metabolic effects of dipeptide feed media on CHO cell cultures by in silico model-guided flux analysis
inferred← citeshttps://doi.org/10.1007/s00253-024-13008-6openalex-snapshot
Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells
inferred← citeshttps://doi.org/10.1007/s00253-026-13912-zopenalex-snapshot
Multi-omics reveal molecular changes during suspension adaptation of HEK293 cells
inferred← citeshttps://doi.org/10.1007/s00253-026-13994-9openalex-snapshot
Chemometric analysis shows compositional variability in cotton hydrolysates that impacts antibody productivity and glycosylation of CHO cells
inferred← citeshttps://doi.org/10.1007/s00449-019-02075-zopenalex-snapshot
Process intensification for the production of rituximab by an inducible CHO cell line
inferred← citeshttps://doi.org/10.1007/s00449-020-02332-6openalex-snapshot
A metabolic network-based approach for developing feeding strategies for CHO cells to increase monoclonal antibody production
inferred← citeshttps://doi.org/10.1007/s00449-020-02429-yopenalex-snapshot
Feedback control of two supplemental feeds during fed-batch culture on a platform process using inline Raman models for glucose and phenylalanine concentration
inferred← citeshttps://doi.org/10.1007/s00449-022-02795-9openalex-snapshot
Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis
inferred← citeshttps://doi.org/10.1007/s00449-023-02912-2openalex-snapshot
Automated Raman feed-back control of multiple supplemental feeds to enable an intensified high inoculation density fed-batch platform process
inferred← citeshttps://doi.org/10.1007/s00449-025-03142-4openalex-snapshot
Bioprocess biomarker identification and diagnosis for industrial mAb production based on metabolic profiling and multivariate data analysis
inferred← citeshttps://doi.org/10.1007/s10529-020-02953-7openalex-snapshot
LC-MS/MS-based quantitative proteomic and phosphoproteomic analysis of CHO-K1 cells adapted to growth in glutamine-free media
inferred← citeshttps://doi.org/10.1007/s10529-024-03499-8openalex-snapshot
Machine learning: an advancement in biochemical engineering
inferred← citeshttps://doi.org/10.1007/s10529-025-03609-0openalex-snapshot
Application of aurintricarboxylic acid to boost CHO cell performance
inferred← citeshttps://doi.org/10.1007/s10616-022-00554-yopenalex-snapshot
Comparative study of commercial media to improve GMP manufacturing of recombinant human interferon β-1a by CHO cells in perfusion bioreactor
inferred← citeshttps://doi.org/10.1007/s10616-024-00669-4openalex-snapshot
Enhancing monoclonal antibody production efficiency using CHO-MK cells and specific media in a conventional fed-batch culture
inferred← citeshttps://doi.org/10.1007/s10616-024-00690-7openalex-snapshot
Evaluating the impact of media and feed combinations on CHO cell culture performance and monoclonal antibody (trastuzumab) production
inferred← citeshttps://doi.org/10.1007/s11095-026-04016-4openalex-snapshot
Evaluation of Low-Field NMR as a PAT Technology for Upstream Bioprocess Monitoring
inferred← citeshttps://doi.org/10.1007/s11814-022-1062-yopenalex-snapshot
Energy metabolism in Chinese hamster ovary (CHO) cells: Productivity and beyond
inferred← citeshttps://doi.org/10.1007/s12247-026-11120-wopenalex-snapshot
Multi-component Monitoring of CHO Cell Culture Processes Using Benchtop NMR Spectroscopy Combined with Machine Learning
inferred← citeshttps://doi.org/10.1007/s12257-026-00306-1openalex-snapshot
Purine precursor supplementation increases productivity of antibody-expressing Chinese Hamster Ovary cells by elevating intracellular ATP level
inferred← citeshttps://doi.org/10.1007/s43393-024-00280-wopenalex-snapshot
Recycling spent animal cell culture media using the thermally resistant microalga Chlorella sorokiniana
inferred← citeshttps://doi.org/10.1016/b978-0-443-18748-3.00004-4openalex-snapshot
Biological systems for therapeutic protein production
inferred← citeshttps://doi.org/10.1016/bs.mie.2021.05.005openalex-snapshot
Method to transfer Chinese hamster ovary (CHO) batch shake flask experiments to large-scale, computer-controlled fed-batch bioreactors
inferred← citeshttps://doi.org/10.1016/bs.pmbts.2025.11.001openalex-snapshot
High-throughput screening of biomolecules using cell-free systems
inferred← citeshttps://doi.org/10.1016/j.bej.2020.107624openalex-snapshot
Identifying metabolic features and engineering targets for productivity improvement in CHO cells by integrated transcriptomics and genome-scale metabolic model
inferred← citeshttps://doi.org/10.1016/j.bej.2020.107638openalex-snapshot
CHO cell productivity improvement by genome-scale modeling and pathway analysis: Application to feed supplements
inferred← citeshttps://doi.org/10.1016/j.bej.2020.107870openalex-snapshot
Scale-down cultivation in mammalian cell bioreactors—The effect of bioreactor mixing time on the response of CHO cells to dissolved oxygen gradients
inferred← citeshttps://doi.org/10.1016/j.bej.2021.108224openalex-snapshot
Determination of culture design spaces in shaken disposable cultivation systems for CHO suspension cell cultures
inferred← citeshttps://doi.org/10.1016/j.bej.2022.108763openalex-snapshot
Automated assembly of hybrid dynamic models for CHO cell culture processes
inferred← citeshttps://doi.org/10.1016/j.bej.2023.108836openalex-snapshot
A feed enrichment strategy targeting the tricarboxylic acid cycle for increasing monoclonal antibody production and alleviating ammonia accumulation in Chinese hamster ovary cell culture
inferred← citeshttps://doi.org/10.1016/j.bej.2023.109184openalex-snapshot
Elucidating lactate metabolism in industrial CHO cultures through the combined use of flux balance and principal component analyses
inferred← citeshttps://doi.org/10.1016/j.bej.2024.109279openalex-snapshot
Current strategies for the development of high-yield HEK293 cell lines
inferred← citeshttps://doi.org/10.1016/j.bej.2025.110013openalex-snapshot
Investigating the effect of media composition on growth and mAb production in CHO cells using a piecewise hybrid dFBA-PLS framework
inferred← citeshttps://doi.org/10.1016/j.bej.2026.110404openalex-snapshot
Impact of dipeptide media supplements on critical quality attributes of a monoclonal antibody produced in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2024.108506openalex-snapshot
HEK-omics: The promise of omics to optimize HEK293 for recombinant adeno-associated virus (rAAV) gene therapy manufacturing
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2026.108866openalex-snapshot
Amino acid metabolism, demand and supply in Chinese Hamster ovary cell culture – A comprehensive literature review
inferred← citeshttps://doi.org/10.1016/j.btre.2021.e00640openalex-snapshot
Generic and specific recurrent neural network models: Applications for large and small scale biopharmaceutical upstream processes
inferred← citeshttps://doi.org/10.1016/j.btre.2026.e00968openalex-snapshot
Biochemical and functional benchmarking of plant protein hydrolysates in serum-reduced adherent CHO-K1 cell culture
inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462336openalex-snapshot
A rapid, simple and sensitive microfluidic chip electrophoresis mass spectrometry method for monitoring amino acids in cell culture media
inferred← citeshttps://doi.org/10.1016/j.coche.2018.10.004openalex-snapshot
Process and metabolic engineering perspectives of lactate production in mammalian cell cultures
inferred← citeshttps://doi.org/10.1016/j.coche.2021.100688openalex-snapshot
From omics to cellular mechanisms in mammalian cell factory development
inferred← citeshttps://doi.org/10.1016/j.copbio.2021.06.018openalex-snapshot
Knowing more from less: miniaturization of ligand-binding assays and electrophoresis as new paradigms for at-line monitoring and control of mammalian cell bioprocesses
inferred← citeshttps://doi.org/10.1016/j.dche.2023.100137openalex-snapshot
Predictive models for upstream mammalian cell culture development - A review
inferred← citeshttps://doi.org/10.1016/j.fbio.2026.109783openalex-snapshot
Recent advances in heterologous lactoprotein expression: from host engineering to downstream processing
inferred← citeshttps://doi.org/10.1016/j.foodres.2024.114138openalex-snapshot
Metabolomic changes in culture media with varying passage numbers of pig muscle stem cell culture for cultured meat production
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2025.126522openalex-snapshot
Assessing effects of leachables in single-use systems used in cell therapy manufacture
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2023.12.013openalex-snapshot
Development of a novel tyrosine-based selection system for generation of recombinant Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1016/j.jbiosc.2025.12.002openalex-snapshot
Sequential active learning for medium optimization in mAb production
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2019.04.005openalex-snapshot
Assessment of fed-batch cultivation strategies for an inducible CHO cell line
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2019.08.014openalex-snapshot
Comparing two automated high throughput viable-cell counting systems for cell culture applications
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.01.008openalex-snapshot
Investigating the metabolic load of monoclonal antibody production conveyed to an inducible CHO cell line using a transfer-rate online monitoring system
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.10.003openalex-snapshot
Beyond tyrosine feeding: A novel fed-batch cultivation strategy based on tyrosine metabolic engineering in recombinant CHO cells
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2026.01.002openalex-snapshot
Two industrial media reveal a mitochondrial disfunction in CHO cell cultures co-fed with glucose and lactic acid
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2026.06.011openalex-snapshot
Run-to-run optimization of CHO cell culture media using high-throughput microscale bioreactor system and a hybrid modeling approach
inferred← citeshttps://doi.org/10.1016/j.jpba.2022.114973openalex-snapshot
High sensitivity and high-confidence compound identification with a flexible BoxCar acquisition method
inferred← citeshttps://doi.org/10.1016/j.jprot.2026.105655openalex-snapshot
Proteomic analysis of ammonia-induced stress in Chinese hamster ovary (CHO) cell cultures
inferred← citeshttps://doi.org/10.1016/j.jtice.2021.03.040openalex-snapshot
Enhancing the yield and activity of defucosylated antibody produced by CHO-K1 cells using Cas13d-mediated multiplex gene targeting
inferred← citeshttps://doi.org/10.1016/j.matpr.2023.08.031openalex-snapshot
Sequential adaptation to serum-free medium for Vero cells cultivation on ultraviolet/ozone (UVO) treated microcarrier
inferred← citeshttps://doi.org/10.1016/j.mec.2019.e00097openalex-snapshot
Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers
inferred← citeshttps://doi.org/10.1016/j.mec.2021.e00182openalex-snapshot
Identification of novel inhibitory metabolites and impact verification on growth and protein synthesis in mammalian cells
inferred← citeshttps://doi.org/10.1016/j.mec.2024.e00232openalex-snapshot
Building blocks needed for mechanistic modeling of bioprocesses: A critical review based on protein production by CHO cells
inferred← citeshttps://doi.org/10.1016/j.nbt.2022.02.004openalex-snapshot
Combination of sodium butyrate and decitabine promotes transgene expression in CHO cells via apoptosis inhibition
inferred← citeshttps://doi.org/10.1016/j.nbt.2025.07.006openalex-snapshot
Biology-aware machine learning for culture medium optimization
inferred← citeshttps://doi.org/10.1016/j.pep.2022.106130openalex-snapshot
Kinetic modeling: A tool for temperature shift and feeding optimization in cell culture process development
inferred← citeshttps://doi.org/10.1016/j.procbio.2019.03.020openalex-snapshot
An investigation of nucleotide sugar dynamics under the galactose supplementation in CHO cell culture
inferred← citeshttps://doi.org/10.1016/j.tifs.2023.06.031openalex-snapshot
Cell culture medium cycling in cultured meat: Key factors and potential strategies
inferred← citeshttps://doi.org/10.1016/j.tiv.2020.105054openalex-snapshot
Integration of transcriptomic, proteomic and metabolomic data to reveal the biological mechanisms of AAI injury in renal epithelial cells
inferred← citeshttps://doi.org/10.1016/j.xphs.2026.104306openalex-snapshot
A multi-dimensional modeling framework integrating metabolomics analysis and process modeling for bioprocess characterization
inferred← citeshttps://doi.org/10.1016/j.ymben.2018.09.009openalex-snapshot
Application of a curated genome-scale metabolic model of CHO DG44 to an industrial fed-batch process
inferred← citeshttps://doi.org/10.1016/j.ymben.2019.03.001openalex-snapshot
Metabolic engineering of Chinese hamster ovary cells towards reduced biosynthesis and accumulation of novel growth inhibitors in fed-batch cultures
inferred← citeshttps://doi.org/10.1016/j.ymben.2022.07.003openalex-snapshot
Data-driven and model-guided systematic framework for media development in CHO cell culture
inferred← citeshttps://doi.org/10.1016/j.ymben.2024.06.003openalex-snapshot
Metabolic engineering of CHO cells towards cysteine prototrophy and systems analysis of the ensuing phenotype
inferred← citeshttps://doi.org/10.1016/j.ymben.2024.07.009openalex-snapshot
Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks
inferred← citeshttps://doi.org/10.1016/j.ymben.2025.03.010openalex-snapshot
NEXT-FBA: A hybrid stoichiometric/data-driven approach to improve intracellular flux predictions
inferred← citeshttps://doi.org/10.1016/s1875-5364(21)60027-4openalex-snapshot
Polyphyllin I promotes cell death via suppressing UPR-mediated CHOP ubiquitination and degradation in non-small cell lung cancer
inferred← citeshttps://doi.org/10.1021/acs.jafc.6c02313openalex-snapshot
Rewiring Amino Acid Flux for Efficient Transglutaminase Production in Streptomyces mobaraensis
inferred← citeshttps://doi.org/10.1021/acs.jproteome.0c00106openalex-snapshot
S-Trap Eliminates Cell Culture Media Polymeric Surfactants for Effective Proteomic Analysis of Mammalian Cell Bioreactor Supernatants
inferred← citeshttps://doi.org/10.1021/acsomega.2c05257openalex-snapshot
Flavin Mononucleotide-Dependent l ‑Lactate Dehydrogenases: Expanding the Toolbox of Enzymes for l ‑Lactate Biosensors
inferred← citeshttps://doi.org/10.1021/acsomega.3c00861openalex-snapshot
Fast-Training Deep Learning Algorithm for Multiplex Quantification of Mammalian Bioproduction Metabolites via Contactless Short-Wave Infrared Hyperspectral Sensing
inferred← citeshttps://doi.org/10.1021/acsomega.4c01897openalex-snapshot
More Than One Enzyme: Exploring Alternative FMN-Dependent L-Lactate Oxidases for Biosensor Development
inferred← citeshttps://doi.org/10.1021/cbe.6c00077openalex-snapshot
Strategies for High-Titer and High-Quality Monoclonal Antibody Production: Cell Line Construction, Culture Medium Development, and Process Regulation in Bioreactors
inferred← citeshttps://doi.org/10.1038/s41540-023-00284-7openalex-snapshot
Employing active learning in the optimization of culture medium for mammalian cells
inferred← citeshttps://doi.org/10.1038/s41598-022-09887-2openalex-snapshot
Engineering and validation of a dual luciferase reporter system for quantitative and systematic assessment of regulatory sequences in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1038/s41598-023-27962-0openalex-snapshot
Microevolutionary dynamics of eccDNA in Chinese hamster ovary cells grown in fed-batch cultures under control and lactate-stressed conditions
inferred← citeshttps://doi.org/10.1038/s41598-026-46901-3openalex-snapshot
Extracellular vesicle delivery of Myricetin suppresses ovarian cancer through mitochondrial dynamics by downregulating the ECM1/NF-κB/TGFβ signaling pathway
inferred← citeshttps://doi.org/10.1038/s42003-021-01903-xopenalex-snapshot
Coagulation factor IX analysis in bioreactor cell culture supernatant predicts quality of the purified product
inferred← citeshttps://doi.org/10.1038/s42003-025-07596-wopenalex-snapshot
Accelerating biopharmaceutical cell line selection with label-free multimodal nonlinear optical microscopy and machine learning
inferred← citeshttps://doi.org/10.1039/d4cc04925jopenalex-snapshot
A user-friendly fluorescent biosensor for precise lactate detection and quantification in vitro
inferred← citeshttps://doi.org/10.1080/07388551.2022.2036691openalex-snapshot
Recent advances in the production of recombinant factor IX: bioprocessing and cell engineering
inferred← citeshttps://doi.org/10.1080/10826068.2026.2654618openalex-snapshot
Impact of lactate metabolism on antibody production in Chinese hamster ovary cells during fed-batch culture
inferred← citeshttps://doi.org/10.1080/10826068.2026.2661959openalex-snapshot
Controlled vs. non-controlled culture systems for SARS-CoV-2 VLP production using the baculovirus/SF9 platform
inferred← citeshttps://doi.org/10.1080/19420862.2022.2060724openalex-snapshot
Upstream cell culture process characterization and in-process control strategy development at pandemic speed
inferred← citeshttps://doi.org/10.1089/omi.2020.0112openalex-snapshot
Biotherapeutic Products, Cellular Factories, and Multiomics Integration in Metabolic Engineering
inferred← citeshttps://doi.org/10.1093/etojnl/vgaf208openalex-snapshot
Optimization of the RTgill-W1 assay for commercial testing applications
inferred← citeshttps://doi.org/10.1101/2025.09.23.677837openalex-snapshot
Inferring the Metabolic Objectives of Mammalian Cells via Inverse Modeling of Fluxomics and Metabolomics
inferred← citeshttps://doi.org/10.1109/lsens.2023.3300799openalex-snapshot
Multiplexed Sensing Probe for Bioreactors for Cellular Agriculture
inferred← citeshttps://doi.org/10.1111/1541-4337.70255openalex-snapshot
Heterologous Expression, Digestive Stability, and Emerging Trends of Lactoferrin
inferred← citeshttps://doi.org/10.1146/annurev-animal-021022-055132openalex-snapshot
Advances and Challenges in Cell Biology for Cultured Meat
inferred← citeshttps://doi.org/10.1146/annurev-chembioeng-092220-125832openalex-snapshot
Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions
inferred← citeshttps://doi.org/10.11606/d.60.2020.tde-22092021-084330openalex-snapshot
Produção do fator VII da coagulação sanguínea recombinante em células humanas
inferred← citeshttps://doi.org/10.1186/s12896-020-00667-2openalex-snapshot
Characterization of metabolic responses, genetic variations, and microsatellite instability in ammonia-stressed CHO cells grown in fed-batch cultures
inferred← citeshttps://doi.org/10.1186/s13568-022-01398-7openalex-snapshot
Development of a perfusion process for serum-free adenovirus vector herpes zoster vaccine production
inferred← citeshttps://doi.org/10.1186/s13568-026-02050-4openalex-snapshot
Eicosadienoic acid enhances antibody production in CHO cells by prolonging culture longevity and attenuating apoptosis
inferred← citeshttps://doi.org/10.1186/s40643-025-00907-3openalex-snapshot
Current breakthroughs and advances in atmospheric room temperature plasma (ARTP) technology for biomanufacturing
inferred← citeshttps://doi.org/10.13005/bpj/3198openalex-snapshot
Development of Serum-Free Medium and Suspension Culture for HEK293 Cells Using Systematic Optimization Strategies
inferred← citeshttps://doi.org/10.1371/journal.pone.0265886openalex-snapshot
Population balance modelling captures host cell protein dynamics in CHO cell cultures
inferred← citeshttps://doi.org/10.1371/journal.pone.0266921openalex-snapshot
Conversion of mammalian cell culture media waste to microbial fermentation feed efficiently supports production of recombinant protein by Escherichia coli
inferred← citeshttps://doi.org/10.1515/psr-2022-0113openalex-snapshot
Process intensification in biopharmaceutical process development and production – an industrial perspective
inferred← citeshttps://doi.org/10.18174/585711openalex-snapshot
Process intensification for CHO cell biomanufacturing
inferred← citeshttps://doi.org/10.20631/bigaku.33.3_45openalex-snapshot
ミケランジェロとフィグーラ・セルペンティナータ(美学会第三十三回全国大会報告)
inferred← citeshttps://doi.org/10.21203/rs.3.rs-8498955/v1openalex-snapshot
Phenotypes and Multi-omics Reveal Changes and Molecular Mechanism of Suspension Adaptation of HEK293 Cells: Structural Remodelling, Metabolic Reconstruction and Stress Resistance
inferred← citeshttps://doi.org/10.21203/rs.3.rs-918138/v1openalex-snapshot
Amino acid feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of CHO cells
inferred← citeshttps://doi.org/10.22541/au.161100207.71294164/v1openalex-snapshot
Lactate Control Enhances Growth Advantage in Fed-batch Cultures of Metabolically Engineered CHO Cells with Reduced Novel Growth-inhibitory Compound Formation
inferred← citeshttps://doi.org/10.22541/au.164864667.70266203/v1openalex-snapshot
CRISPR-Cas13d for CHO Cell Engineering and Antibody Production
inferred← citeshttps://doi.org/10.31224/osf.io/795suopenalex-snapshot
Scale-Up Economics for Cultured Meat: Techno-Economic Analysis and Due Diligence
inferred← citeshttps://doi.org/10.3389/fbioe.2019.00195openalex-snapshot
Oxygen Uptake Rate Soft-Sensing via Dynamic kLa Computation: Cell Volume and Metabolic Transition Prediction in Mammalian Bioprocesses
inferred← citeshttps://doi.org/10.3389/fbioe.2021.646363openalex-snapshot
Serum-Free Medium for Recombinant Protein Expression in Chinese Hamster Ovary Cells
inferred← citeshttps://doi.org/10.3389/fbioe.2022.964397openalex-snapshot
The impact of serum-free culture on HEK293 cells: From the establishment of suspension and adherent serum-free adaptation cultures to the investigation of growth and metabolic profiles
inferred← citeshttps://doi.org/10.3389/fbioe.2023.1106292openalex-snapshot
Boosting Productivity for Advanced Biomanufacturing by Re-Using Viable Cells
inferred← citeshttps://doi.org/10.3389/fbioe.2023.1211410openalex-snapshot
A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing
inferred← citeshttps://doi.org/10.3389/fbioe.2024.1347138openalex-snapshot
Advancements in CHO metabolomics: techniques, current state and evolving methodologies
inferred← citeshttps://doi.org/10.3389/fbioe.2024.1479633openalex-snapshot
Cell clone selection—impact of operation modes and medium exchange strategies on clone ranking
inferred← citeshttps://doi.org/10.3389/fbioe.2025.1546105openalex-snapshot
mAb production kinetics in CHO batch culture: exploring extracellular and intracellular dynamics
inferred← citeshttps://doi.org/10.3389/fbioe.2025.1615263openalex-snapshot
Dual formation mechanisms of acidic variants in cysteine-engineered antibodies and strategies for their reduction
inferred← citeshttps://doi.org/10.3389/fbioe.2026.1716758openalex-snapshot
Whole-genome DNA methylation analysis of Chinese hamster ovary cells undergoing media adaptation
inferred← citeshttps://doi.org/10.3389/fbioe.2026.1750646openalex-snapshot
Towards a cleaner CHO chassis: systematic knockout of host cell proteins for efficient biopharmaceutical manufacturing
inferred← citeshttps://doi.org/10.3390/cells11121929openalex-snapshot
Metabolic Profiling of CHO Cells during the Production of Biotherapeutics
inferred← citeshttps://doi.org/10.3390/cells9071572openalex-snapshot
Progressively De-Differentiated Pancreatic Cancer Cells Shift from Glycolysis to Oxidative Metabolism and Gain a Quiescent Stem State
inferred← citeshttps://doi.org/10.3390/fermentation10050234openalex-snapshot
Machine Learning and Deep Learning Strategies for Chinese Hamster Ovary Cell Bioprocess Optimization
inferred← citeshttps://doi.org/10.3390/genes14081576openalex-snapshot
Dynamics of Amino Acid Metabolism, Gene Expression, and Circulomics in a Recombinant Chinese Hamster Ovary Cell Line Adapted to Moderate and High Levels of Extracellular Lactate
inferred← citeshttps://doi.org/10.3390/ijms20215464openalex-snapshot
Computer-Aided Strategies for Determining the Amino Acid Composition of Medium for Chinese Hamster Ovary Cell-Based Biomanufacturing Platforms
inferred← citeshttps://doi.org/10.3390/ijms24098144openalex-snapshot
CRISPR Technologies in Chinese Hamster Ovary Cell Line Engineering
inferred← citeshttps://doi.org/10.3390/ijms241914709openalex-snapshot
Novel Approaches to the Establishment of Local Microenvironment from Resorbable Biomaterials in the Brain In Vitro Models
inferred← citeshttps://doi.org/10.3390/metabo10050199openalex-snapshot
Using Metabolomics to Identify Cell Line-Independent Indicators of Growth Inhibition for Chinese Hamster Ovary Cell-Based Bioprocesses
inferred← citeshttps://doi.org/10.3390/metabo10080301openalex-snapshot
Comprehensive Vitamer Profiling of Folate Mono- and Polyglutamates in Baker’s Yeast (Saccharomyces cerevisiae) as a Function of Different Sample Preparation Procedures
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