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Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale

https://doi.org/10.1002/btpr.3264
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-0290(1999)66:3<171::aid-bit5>3.0.co;2-topenalex-snapshot
Control of pH in large-scale, free suspension animal cell bioreactors: Alkali addition and pH excursions
inferredcites →https://doi.org/10.1002/(sici)1097-0290(20000720)69:2<119::aid-bit1>3.0.co;2-9openalex-snapshot
Influence of scale-up on the quality of recombinant human growth hormone
inferredcites →https://doi.org/10.1002/9783527807833.ch2openalex-snapshot
Scale‐Down: Simulating Large‐Scale Cultures in the Laboratory
inferredcites →https://doi.org/10.1002/aic.13820openalex-snapshot
Coupling of biokinetic and population balance models to account for biological heterogeneity in bioreactors
inferredcites →https://doi.org/10.1002/aic.14238openalex-snapshot
A coupled population balance model and CFD approach for the simulation of mixing issues in lab‐scale and industrial bioreactors
inferredcites →https://doi.org/10.1002/biot.201000406openalex-snapshot
An industrial perspective on bioreactor scale‐down: What we can learn from combined large‐scale bioprocess and model fluid studies
inferredcites →https://doi.org/10.1002/biot.201100293openalex-snapshot
A two‐compartment bioreactor system made of commercial parts for bioprocess scale‐down studies: Impact of oscillations on Bacillus subtilis fed‐batch cultivations
inferredcites →https://doi.org/10.1002/biot.201600030openalex-snapshot
Combined metabolomics and proteomics reveals hypoxia as a cause of lower productivity on scale‐up to a 5000‐liter CHO bioprocess
inferredcites →https://doi.org/10.1002/biot.201600633openalex-snapshot
The impact of pH inhomogeneities on CHO cell physiology and fed‐batch process performance – two‐compartment scale‐down modelling and intracellular pH excursion
inferredcites →https://doi.org/10.1002/bit.10198openalex-snapshot
The response of GS‐NS0 myeloma cells to single and multiple pH perturbations
inferredcites →https://doi.org/10.1002/bit.1072openalex-snapshot
Scale‐down model to simulate spatial pH variations in large‐scale bioreactors
inferredcites →https://doi.org/10.1002/bit.1165openalex-snapshot
The response of GS‐NS0 myeloma cells to pH shifts and pH perturbations
inferredcites →https://doi.org/10.1002/bit.20232openalex-snapshot
Heterogeneous conditions in dissolved oxygen affect N‐glycosylation but not productivity of a monoclonal antibody in hybridoma cultures
inferredcites →https://doi.org/10.1002/bit.20353openalex-snapshot
Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0°C
inferredcites →https://doi.org/10.1002/bit.21013openalex-snapshot
Process parameter shifting: Part I. Effect of DOT, pH, and temperature on the performance of Epo‐Fc expressing CHO cells cultivated in controlled batch bioreactors
inferredcites →https://doi.org/10.1002/bit.22287openalex-snapshot
Scale‐up analysis for a CHO cell culture process in large‐scale bioreactors
inferredcites →https://doi.org/10.1002/bit.23200openalex-snapshot
Effects of cell culture conditions on antibody N ‐linked glycosylation—what affects high mannose 5 glycoform
inferredcites →https://doi.org/10.1002/bit.25543openalex-snapshot
Response of Corynebacterium glutamicum exposed to oscillating cultivation conditions in a two‐ and a novel three‐compartment scale‐down bioreactor
inferredcites →https://doi.org/10.1002/bit.25817openalex-snapshot
Physiological effects of pH gradients on Escherichia coli during plasmid DNA production
inferredcites →https://doi.org/10.1002/bit.260400207openalex-snapshot
Effect of feed zone in fed‐batch fermentations of Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1002/btpr.2489openalex-snapshot
A practical approach in bioreactor scale‐up and process transfer using a combination of constant P/V and vvm as the criterion
inferredcites →https://doi.org/10.1002/btpr.2620openalex-snapshot
Probing lactate metabolism variations in large‐scale bioreactors
inferredcites →https://doi.org/10.1002/btpr.2697openalex-snapshot
Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl‐drug conjugation process
inferredcites →https://doi.org/10.1002/btpr.3264openalex-snapshot
Development of a miniature bioreactor model to study the impact of pH and DOT fluctuations on CHO cell culture performance as a tool to understanding heterogeneity effects at large‐scale
inferredcites →https://doi.org/10.1002/btpr.522openalex-snapshot
A review of advanced small‐scale parallel bioreactor technology for accelerated process development: Current state and future need
inferredcites →https://doi.org/10.1002/elsc.201900162openalex-snapshot
Scale‐down simulators for mammalian cell culture as tools to access the impact of inhomogeneities occurring in large‐scale bioreactors
inferredcites →https://doi.org/10.1007/bf00353919openalex-snapshot
Engineering challenges in high density cell culture systems
inferredcites →https://doi.org/10.1007/bf00353927openalex-snapshot
Homogenisation and oxygen transfer rates in large agitated and sparged animal cell bioreactors: Some implications for growth and production
inferredcites →https://doi.org/10.1007/s00449-018-1996-yopenalex-snapshot
pH excursions impact CHO cell culture performance and antibody N-linked glycosylation
inferredcites →https://doi.org/10.1007/s10616-006-9005-8openalex-snapshot
Reactor Engineering in Large Scale Animal Cell Culture
inferredcites →https://doi.org/10.1007/s10616-012-9446-1openalex-snapshot
Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors
inferredcites →https://doi.org/10.1007/s10616-015-9899-0openalex-snapshot
Equipment characterization to mitigate risks during transfers of cell culture manufacturing processes
inferredcites →https://doi.org/10.1016/j.bej.2013.04.011openalex-snapshot
The physical characterisation of a microscale parallel bioreactor platform with an industrial CHO cell line expressing an IgG4
inferredcites →https://doi.org/10.1016/j.bej.2017.12.004openalex-snapshot
Experimental and CFD physical characterization of animal cell bioreactors: From micro- to production scale
inferredcites →https://doi.org/10.1016/j.bej.2018.09.019openalex-snapshot
A systematic mass-transfer modeling approach for mammalian cell culture bioreactor scale-up
inferredcites →https://doi.org/10.1016/j.biologicals.2016.06.005openalex-snapshot
Determination of critical quality attributes for monoclonal antibodies using quality by design principles
inferredcites →https://doi.org/10.1016/j.biotechadv.2020.107660openalex-snapshot
Understanding gradients in industrial bioreactors
inferredcites →https://doi.org/10.1016/j.cej.2006.03.034openalex-snapshot
Modelling of the substrate heterogeneities experienced by a limited microbial population in scale-down and in large-scale bioreactors
inferredcites →https://doi.org/10.1016/j.ces.2006.03.003openalex-snapshot
Modeling the dynamics of E. coli populations in the three-dimensional turbulent field of a stirred-tank bioreactor—A structured–segregated approach
inferredcites →https://doi.org/10.1016/j.ces.2014.11.035openalex-snapshot
Investigating the interactions between physical and biological heterogeneities in bioreactors using compartment, population balance and metabolic models
inferredcites →https://doi.org/10.1016/j.ces.2015.05.045openalex-snapshot
Euler–Lagrange approach to model heterogeneities in stirred tank bioreactors – Comparison to experimental flow characterization and particle tracking
inferredcites →https://doi.org/10.1016/j.ces.2017.01.014openalex-snapshot
Euler-Lagrange analysis towards representative down-scaling of a 22 m3 aerobic S. cerevisiae fermentation
inferredcites →https://doi.org/10.1016/j.ces.2018.05.008openalex-snapshot
Hydrodynamic inhomogeneities in large scale stirred tanks – Influence on mixing time
inferredcites →https://doi.org/10.1016/j.cherd.2013.04.002openalex-snapshot
Scale-down studies for assessing the impact of different stress parameters on growth and product quality during animal cell culture
inferredcites →https://doi.org/10.1016/j.copbio.2010.02.001openalex-snapshot
Scale-down simulators for metabolic analysis of large-scale bioprocesses
inferredcites →https://doi.org/10.1016/j.jbiotec.2010.09.576openalex-snapshot
Scale down simulator for studying the impact of industrial scale inhomogeneities on Bacillus subtilis processes
inferredcites →https://doi.org/10.1016/j.jbiotec.2014.08.026openalex-snapshot
Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation
inferredcites →https://doi.org/10.1016/j.tibtech.2020.01.009openalex-snapshot
Developing a Computational Framework To Advance Bioprocess Scale-Up
inferredcites →https://doi.org/10.1016/s0168-1656(00)00365-5openalex-snapshot
Physiological responses to mixing in large scale bioreactors
inferredcites →https://doi.org/10.1252/jcej.08we317openalex-snapshot
Scale-Up Considerations Based on Studies at the Bench Scale in Stirred Bioreactors
inferredcites →https://doi.org/10.1371/journal.pone.0157111openalex-snapshot
Understanding and Controlling Sialylation in a CHO Fc-Fusion Process
inferredcites →https://doi.org/10.1385/mb:34:3:355openalex-snapshot
Living With Heterogeneities in Bioreactors: Understanding the Effects of Environmental Gradients on Cells
inferredcites →https://doi.org/10.4236/abb.2012.37113openalex-snapshot
Assessment of AMBRTM as a model for high-throughput cell culture process development strategy
inferredcites →https://doi.org/10.7763/ijcea.2014.v5.355openalex-snapshot
CFD Prediction of Heterogeneities in the Scale up of Liquid-Liquid Dispersions

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4639441openalex-extracted
inferred← citeshttps://doi.org/10.1002/biot.70003openalex-snapshot
Rheology of CHO Cell Suspensions and Its Effects on High‐Density Cultivation Process and Bioreactor Design
inferred← citeshttps://doi.org/10.1002/bit.28647openalex-snapshot
Mimicking CHO large‐scale effects in the single multicompartment bioreactor: A new approach to access scale‐up behavior
inferred← citeshttps://doi.org/10.1007/978-3-032-22332-6_10openalex-snapshot
Advances in Miniaturized Bioreactors for Scalable Recombinant Protein Bioprocessing
inferred← citeshttps://doi.org/10.1007/978-3-032-22332-6_11openalex-snapshot
Innovations in Miniaturized Bioreactors for Commercial Applications
inferred← citeshttps://doi.org/10.1007/978-3-032-22332-6_12openalex-snapshot
Miniaturized Bioreactors: Bridging the Gap Between Small-Scale and Large-Scale Production Lines
inferred← citeshttps://doi.org/10.1007/978-3-032-22332-6_2openalex-snapshot
Miniatured Bioreactor in Microalgae Research for Sustainable Bioprocessing
inferred← citeshttps://doi.org/10.1007/978-3-032-22332-6_3openalex-snapshot
Miniaturized Bioreactors: Transforming Upstream Processing in Biopharmaceutical Production
inferred← citeshttps://doi.org/10.1007/s10616-025-00816-5openalex-snapshot
Impact of DO, agitation, aeration and copper concentration on lactate metabolism and charge heterogeneity for monoclonal antibody production by CHO cells in fed-batch culture
inferred← citeshttps://doi.org/10.1007/s44174-023-00142-4openalex-snapshot
Machine Learning Approaches to 3D Models for Drug Screening
inferred← citeshttps://doi.org/10.1016/j.checat.2022.09.037openalex-snapshot
Industrially useful enzymology: Translating biocatalysis from laboratory to process
inferred← citeshttps://doi.org/10.1016/j.cherd.2025.08.041openalex-snapshot
A novel model for the simulation of cell respiration in a mammalian cell culture process in an aerated stirred bioreactor
inferred← citeshttps://doi.org/10.1016/j.coche.2024.101044openalex-snapshot
End-to-end process flowsheet modeling for biopharmaceutical production: current state and future potential
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e25512openalex-snapshot
Evaluation of single-use optical and electrochemical pH sensors in upstream bioprocessing
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.09.010openalex-snapshot
Genome-scale metabolic analysis reveals enhanced metabolism and antioxidative stress response in perfusion cell culture under constant hyperosmotic stimulation
inferred← citeshttps://doi.org/10.1016/j.ymben.2026.102545openalex-snapshot
High-level terpene production via a novel Actinomycetota-derived MVA pathway in E. coli
inferred← citeshttps://doi.org/10.1038/s41540-026-00694-3openalex-snapshot
A double-staining automated flow cytometry method for real-time monitoring of bacteria in continuous bioreactors
inferred← citeshttps://doi.org/10.1080/10826068.2026.2654618openalex-snapshot
Impact of lactate metabolism on antibody production in Chinese hamster ovary cells during fed-batch culture
inferred← citeshttps://doi.org/10.1080/19420862.2026.2643039openalex-snapshot
Impact of process parameters on IgG glycosylation in CHO systems: a comprehensive quantitative analysis
inferred← citeshttps://doi.org/10.30895/1991-2919-2023-530openalex-snapshot
Block Copolymers of Ethylene Oxide and Propylene Oxide: Prospects for Medical and Pharmaceutical Application in Russia
inferred← citeshttps://doi.org/10.3389/fmedt.2023.1154653openalex-snapshot
Cytocentric measurement for regenerative medicine
inferred← citeshttps://doi.org/10.3390/applmicrobiol2040058openalex-snapshot
The Growth Medium Affects the Viability of IPEC-J2 Animal Cell Line in the Presence of Probiotic Bacteria
inferred← citeshttps://doi.org/10.3390/pr13040955openalex-snapshot
Comparison of Perfusion Culture Performance in Orbitally Shaken Bioreactors and Stirred Tank Bioreactors: A Spatiotemporal Dynamic Analysis of Shear Stress and Mass Transfer Based on Suspension Rheology
inferred← citeshttps://doi.org/10.3390/s26010010openalex-snapshot
Optical Fiber pH and Dissolved Oxygen Sensors for Bioreactor Monitoring: A Review
inferred← citeshttps://doi.org/10.3390/vaccines13070757openalex-snapshot
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