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High expression of STAT3 within the tumour‐associated stroma predicts poor outcome in breast cancer patients

https://doi.org/10.1002/cam4.6014
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cam4.6014openalex-snapshot
High expression of STAT3 within the tumour‐associated stroma predicts poor outcome in breast cancer patients
inferredcites →https://doi.org/10.1002/mc.20605openalex-snapshot
Stat3 is required for anchorage‐independent growth and metastasis but not for mammary tumor development downstream of the ErbB‐2 oncogene
inferredcites →https://doi.org/10.1007/s10549-020-05613-6openalex-snapshot
LLY17, a novel small molecule STAT3 inhibitor induces apoptosis and suppresses cell migration and tumor growth in triple-negative breast cancer
inferredcites →https://doi.org/10.1016/j.breast.2010.03.026openalex-snapshot
Management of triple negative breast cancer
inferredcites →https://doi.org/10.1016/j.ejso.2012.01.002openalex-snapshot
The prognostic value of tumour-stroma ratio in triple-negative breast cancer
inferredcites →https://doi.org/10.1016/j.intimp.2020.107186openalex-snapshot
JAK2 expression is correlated with the molecular and clinical features of breast cancer as a favorable prognostic factor
inferredcites →https://doi.org/10.1016/j.semcancer.2017.06.001openalex-snapshot
The JAK/STAT3 axis: A comprehensive drug target for solid malignancies
inferredcites →https://doi.org/10.1016/j.yexmp.2015.07.014openalex-snapshot
Molecular biomarkers for prediction of response to treatment and survival in triple negative breast cancer patients from Egypt
inferredcites →https://doi.org/10.1038/bjc.2014.279openalex-snapshot
The relationship between the tumour stroma percentage, clinicopathological characteristics and outcome in patients with operable ductal breast cancer
inferredcites →https://doi.org/10.1038/ni.3153openalex-snapshot
IL-6 as a keystone cytokine in health and disease
inferredcites →https://doi.org/10.1038/s41388-021-02172-yopenalex-snapshot
STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts
inferredcites →https://doi.org/10.1038/s41523-022-00487-xopenalex-snapshot
Ruxolitinib and exemestane for estrogen receptor positive, aromatase inhibitor resistant advanced breast cancer
inferredcites →https://doi.org/10.1038/s41568-018-0090-8openalex-snapshot
Therapeutically exploiting STAT3 activity in cancer — using tissue repair as a road map
inferredcites →https://doi.org/10.1038/sj.bjc.6603871openalex-snapshot
Expression levels of the JAK/STAT pathway in the transition from hormone-sensitive to hormone-refractory prostate cancer
inferredcites →https://doi.org/10.1038/sj.onc.1209306openalex-snapshot
A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells
inferredcites →https://doi.org/10.1053/j.gastro.2015.07.058openalex-snapshot
Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer
inferredcites →https://doi.org/10.1053/j.gastro.2022.07.076openalex-snapshot
Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer
inferredcites →https://doi.org/10.1155/2020/7656031openalex-snapshot
High JAK2 Protein Expression Predicts a Poor Prognosis in Patients with Resectable Pancreatic Ductal Adenocarcinoma
inferredcites →https://doi.org/10.1158/0008-5472.can-09-2840openalex-snapshot
Constitutively Active Stat3 Enhances Neu-Mediated Migration and Metastasis in Mammary Tumors via Upregulation of Cten
inferredcites →https://doi.org/10.1158/0008-5472.can-15-2770openalex-snapshot
STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis
inferredcites →https://doi.org/10.1158/0008-5472.can-18-0634openalex-snapshot
Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
inferredcites →https://doi.org/10.1158/1055-9965.epi-08-0089openalex-snapshot
Prognostic Value of Signal Transducers and Activators of Transcription 3 in Breast Cancer
inferredcites →https://doi.org/10.1158/1078-0432.ccr-04-1752openalex-snapshot
Persistent Activation of Stat3 Signaling Induces Survivin Gene Expression and Confers Resistance to Apoptosis in Human Breast Cancer Cells
inferredcites →https://doi.org/10.1158/1078-0432.ccr-16-1416openalex-snapshot
Signal Transduction and Activator of Transcription-3 (STAT3) in Patients with Colorectal Cancer: Associations with the Phenotypic Features of the Tumor and Host
inferredcites →https://doi.org/10.1186/s13046-021-02215-yopenalex-snapshot
The CD70-CD27 axis in oncology: the new kids on the block
inferredcites →https://doi.org/10.1371/journal.pone.0212031openalex-snapshot
Extraction-free whole transcriptome gene expression analysis of FFPE sections and histology-directed subareas of tissue
inferredcites →https://doi.org/10.2147/cmar.s225376openalex-snapshot
EGFR Promotes the Development of Triple Negative Breast Cancer Through JAK/STAT3 Signaling
inferredcites →https://doi.org/10.26508/lsa.202201460openalex-snapshot
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer
inferredcites →https://doi.org/10.3892/ol.2017.6690openalex-snapshot
Activation of Janus kinase 1 confers poor prognosis in patients with non-small cell lung cancer
inferredcites →https://doi.org/10.3892/ol.2019.10059openalex-snapshot
Inhibition of tumor growth and angiogenesis of tamoxifen‑resistant breast cancer cells by ruxolitinib, a selective JAK2 inhibitor

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4808568openalex-extracted
Constructing a Risk Scoring Model for Breast Cancer: Focusing on Mitochondrial Energy Metabolism and Cellular Senescence Gene Features
inferred← citeshttps://doi.org/10.1002/cam4.71815openalex-snapshot
High Expression of PAPP ‐A Predicts Poor Outcomes in Oestrogen Receptor‐Positive Breast Cancer Patients
inferred← citeshttps://doi.org/10.1002/ctd2.70116openalex-snapshot
Toward precision oncology: An integrative multi‐omics approach for prognosis prediction and inferred immunotherapy responsiveness in breast cancer
inferred← citeshttps://doi.org/10.1002/mc.70005openalex-snapshot
MAZ Coordinates With HDAC1 to Promote Hepatocarcinoma Proliferation and Metastasis Through Transcriptional Repression of CSK
inferred← citeshttps://doi.org/10.1002/pros.24820openalex-snapshot
pSTAT3 Expression is Increased in Advanced Prostate Cancer in Post‐Initiation of Androgen Deprivation Therapy
inferred← citeshttps://doi.org/10.1007/s12672-024-01527-7openalex-snapshot
Pan-cancer analysis of STAT3 indicates its potential prognostic value and correlation with immune cell infiltration in prostate cancer
inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.111679openalex-snapshot
IL6 mediated cFLIP downregulation increases the migratory and invasive potential of triple negative breast cancer cell
inferred← citeshttps://doi.org/10.1016/j.ctrv.2025.103026openalex-snapshot
Emerging mechanisms of triple-negative breast cancer radioresistance: Interplay between cancer cell mechanisms and the tumor immune microenvironment
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e32904openalex-snapshot
NFκB signalling in colorectal cancer: Examining the central dogma of IKKα and IKKβ signalling
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116730openalex-snapshot
MAL/SPP1 axis drives tumor proliferation and immune evasion via JAK2/STAT3 and MHC class Ib in breast cancer
inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.146076openalex-snapshot
Design, synthesis, and evaluation of novel C6-substituted purine-isoxazole derivatives and their Re(I) tricarbonyl complexes: antiproliferative activity and integrated in silico study
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.157485openalex-snapshot
Pulchinenoside E2: A dual-functional STAT3 and autophagy inhibitor with potent anti-metastatic activity in triple-negative breast cancer
inferred← citeshttps://doi.org/10.1016/j.phymed.2026.157819openalex-snapshot
Quercetin targets IL6/JAK1/STAT3/MMP9 signaling to attenuate breast cancer progression in diabetic comorbidity: A multi-omics and experimental study
inferred← citeshttps://doi.org/10.1016/j.tranon.2024.102064openalex-snapshot
TAK1 expression is associated with increased PD-L1 and decreased cancer-specific survival in microsatellite-stable colorectal cancer
inferred← citeshttps://doi.org/10.1038/s41598-025-28439-yopenalex-snapshot
Stromal transcriptomics uncover LIF as a key effector in high tumor budding triple-negative breast cancer
inferred← citeshttps://doi.org/10.1038/s44276-025-00139-0openalex-snapshot
IL-6R expression is an independent prognostic factor in high-grade serous ovarian cancer
inferred← citeshttps://doi.org/10.1080/08977194.2025.2484007openalex-snapshot
Expression of DDX49 in breast cancer and its mechanism regulating the proliferation and metastasis of breast cancer cells
inferred← citeshttps://doi.org/10.1080/14737159.2025.2482639openalex-snapshot
Multi-omic profiling in breast cancer: utility for advancing diagnostics and clinical care
inferred← citeshttps://doi.org/10.1134/s0026893325604963openalex-snapshot
SPATIAL TRANSCRIPTOMICS FOR MOLECULAR DISSECTING OF THE TUMOR IMMUNE MICROENVIRONMENT: COMPARISON OF COMMERCIALLY AVAILABLE PLATFORMS
inferred← citeshttps://doi.org/10.1177/03009858251338851openalex-snapshot
Prognostic significance of pSTAT3 expression in feline mammary carcinomas
inferred← citeshttps://doi.org/10.1186/s10020-024-00827-6openalex-snapshot
Extracellular matrix marker LAMC2 targets ZEB1 to promote TNBC malignancy via up-regulating CD44/STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1186/s13058-025-02074-xopenalex-snapshot
Cancer-associated fibroblast driven paracrine IL-6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma
inferred← citeshttps://doi.org/10.1371/journal.pone.0320862openalex-snapshot
TempO-seq and RNA-seq gene expression levels are highly correlated for most genes: A comparison using 39 human cell lines
inferred← citeshttps://doi.org/10.2147/bctt.s593138openalex-snapshot
Peripheral Blood IL-6 and STAT3 Gene Expression as Biomarkers Associated with Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer: A Prospective Cross-Sectional Study
inferred← citeshttps://doi.org/10.3389/fimmu.2024.1513421openalex-snapshot
Patterns of immune evasion in triple-negative breast cancer and new potential therapeutic targets: a review
inferred← citeshttps://doi.org/10.3389/fmolb.2026.1931263openalex-snapshot
Copper complexes in the triple-negative breast cancer landscape: advances and opportunities
inferred← citeshttps://doi.org/10.3390/biom14121629openalex-snapshot
IL6 and IL6R as Prognostic Biomarkers in Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/cancers16091615openalex-snapshot
Multiplex Digital Spatial Profiling in Breast Cancer Research: State-of-the-Art Technologies and Applications across the Translational Science Spectrum
inferred← citeshttps://doi.org/10.3390/cancers17050755openalex-snapshot
Targeting STAT3 for Cancer Therapy: Focusing on Y705, S727, or Dual Inhibition?
inferred← citeshttps://doi.org/10.6084/m9.figshare.25852964openalex-snapshot
Additional file 1 of Extracellular matrix marker LAMC2 targets ZEB1 to promote TNBC malignancy via up-regulating CD44/STAT3 signaling pathway
inferred← citeshttps://doi.org/10.7759/cureus.85288openalex-snapshot
Comprehensive Cytokine Gene Expression and Multiplex Analysis in Breast Cancer Patients: Insights Into Immune Profiles and Prognostic Factors’ Association
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