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The Tubulin Colchicine Domain: a Molecular Modeling Perspective

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1098-1128(199807)18:4<259::aid-med3>3.0.co;2-uopenalex-snapshot
Tubulin as a target for anticancer drugs: Agents which interact with the mitotic spindle
inferredcites →https://doi.org/10.1002/med.20097openalex-snapshot
Anti‐mitotic activity of colchicine and the structural basis for its interaction with tubulin
inferredcites →https://doi.org/10.1002/med.20242openalex-snapshot
Drugs that target dynamic microtubules: A new molecular perspective
inferredcites →https://doi.org/10.1007/128_2008_11openalex-snapshot
Microtubule-Destabilizing Agents: Structural and Mechanistic Insights from the Interaction of Colchicine and Vinblastine with Tubulin
inferredcites →https://doi.org/10.1007/bf01954881openalex-snapshot
Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4
inferredcites →https://doi.org/10.1007/s00249-006-0088-0openalex-snapshot
Homology modeling of tubulin: influence predictions for microtubule’s biophysical properties
inferredcites →https://doi.org/10.1007/s12539-010-0076-zopenalex-snapshot
Computer assisted design of second-generation colchicine derivatives
inferredcites →https://doi.org/10.1016/0014-5793(82)80619-4openalex-snapshot
Inhibition of microtubule assembly in vitro by TN‐16, a synthetic antitumor drug
inferredcites →https://doi.org/10.1016/0163-7258(93)90044-eopenalex-snapshot
Podophyllotoxin, steganacin and combretastatin: Natural products that bind at the colchicine site of tubulin
inferredcites →https://doi.org/10.1016/j.bmc.2007.11.076openalex-snapshot
Docking and hydropathic scoring of polysubstituted pyrrole compounds with antitubulin activity
inferredcites →https://doi.org/10.1016/j.bmc.2009.03.056openalex-snapshot
Mechanism of action of N-phenyl-N′-(2-chloroethyl)ureas in the colchicine-binding site at the interface between α- and β-tubulin
inferredcites →https://doi.org/10.1016/j.bmc.2009.07.012openalex-snapshot
Isocombretastatins A: 1,1-Diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds
inferredcites →https://doi.org/10.1016/j.bmc.2009.08.027openalex-snapshot
Design, synthesis and structure–activity relationship of 2-(3′,4′,5′-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization
inferredcites →https://doi.org/10.1016/j.bmc.2009.12.019openalex-snapshot
Design and pharmacophore modeling of biaryl methyl eugenol analogs as breast cancer invasion inhibitors
inferredcites →https://doi.org/10.1016/j.bmc.2010.04.091openalex-snapshot
Synthesis, molecular modeling and biological evaluation of dithiocarbamates as novel antitubulin agents
inferredcites →https://doi.org/10.1016/j.bmc.2010.07.072openalex-snapshot
Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents
inferredcites →https://doi.org/10.1016/j.bmc.2011.02.022openalex-snapshot
Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones
inferredcites →https://doi.org/10.1016/j.bmc.2011.06.088openalex-snapshot
Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents
inferredcites →https://doi.org/10.1016/j.bmcl.2006.08.087openalex-snapshot
Novel imidazole-based combretastatin A-4 analogues: Evaluation of their in vitro antitumor activity and molecular modeling study of their binding to the colchicine site of tubulin
inferredcites →https://doi.org/10.1016/j.ctrv.2008.11.001openalex-snapshot
Microtubule dynamics as a target in oncology
inferredcites →https://doi.org/10.1016/j.ejmech.2009.12.072openalex-snapshot
Novel derivatives of 1,3,4-oxadiazoles are potent mitostatic agents featuring strong microtubule depolymerizing activity in the sea urchin embryo and cell culture assays
inferredcites →https://doi.org/10.1016/j.ejmech.2011.05.020openalex-snapshot
Molecular modelling studies on Arylthioindoles as potent inhibitors of tubulin polymerization
inferredcites →https://doi.org/10.1016/s0021-9258(18)42215-6openalex-snapshot
Kinetics of colchicine binding to purified beta-tubulin isotypes from bovine brain.
inferredcites →https://doi.org/10.1016/s0021-9258(19)66927-9openalex-snapshot
Structure of the tubulin dimer.
inferredcites →https://doi.org/10.1016/s0092-8674(00)00069-6openalex-snapshot
The 4 Å X-Ray Structure of a Tubulin:Stathmin-like Domain Complex
inferredcites →https://doi.org/10.1016/s0165-6147(03)00161-5openalex-snapshot
Microtubule-interacting drugs for cancer treatment
inferredcites →https://doi.org/10.1016/s1040-8428(01)00183-4openalex-snapshot
Vinflunine, the latest Vinca alkaloid in clinical development
inferredcites →https://doi.org/10.1016/s1074-5521(02)00284-3openalex-snapshot
Small Molecules, Big Impact
inferredcites →https://doi.org/10.1016/s1470-2045(04)01411-1openalex-snapshot
Do β-tubulin mutations have a role in resistance to chemotherapy?
inferredcites →https://doi.org/10.1021/bi00118a015openalex-snapshot
Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes
inferredcites →https://doi.org/10.1021/bi00313a026openalex-snapshot
Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles
inferredcites →https://doi.org/10.1021/bi00852a043openalex-snapshot
Colchicine-binding protein of mammalian brain and its relation to microtubules
inferredcites →https://doi.org/10.1021/bi060476gopenalex-snapshot
Interaction of 4-Arylcoumarin Analogues of Combretastatins with Microtubule Network of HBL100 Cells and Binding to Tubulin
inferredcites →https://doi.org/10.1021/cc800090dopenalex-snapshot
Solution-Phase Parallel Synthesis and Biological Evaluation of Combretatriazoles
inferredcites →https://doi.org/10.1021/ci800054nopenalex-snapshot
Free Energy Calculations on the Binding of Colchicine and Its Derivatives with the α/β-Tubulin Isoforms
inferredcites →https://doi.org/10.1021/jm030331xopenalex-snapshot
Structural Interaction Fingerprint (SIFt): A Novel Method for Analyzing Three-Dimensional Protein−Ligand Binding Interactions
inferredcites →https://doi.org/10.1021/jm050502topenalex-snapshot
A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach
inferredcites →https://doi.org/10.1021/jm050761iopenalex-snapshot
Design and Biological Evaluation of Novel Tubulin Inhibitors as Antimitotic Agents Using a Pharmacophore Binding Model with Tubulin
inferredcites →https://doi.org/10.1021/jm050809sopenalex-snapshot
New Arylthioindoles: Potent Inhibitors of Tubulin Polymerization. 2. Structure−Activity Relationships and Molecular Modeling Studies
inferredcites →https://doi.org/10.1021/jm0512903openalex-snapshot
Medicinal Chemistry of Combretastatin A4: Present and Future Directions
inferredcites →https://doi.org/10.1021/jm060355eopenalex-snapshot
Synthesis and Biological Evaluation of 2-Amino-3-(3‘,4‘,5‘-trimethoxybenzoyl)-5-aryl Thiophenes as a New Class of Potent Antitubulin Agents
inferredcites →https://doi.org/10.1021/jm1011947openalex-snapshot
Antitumor Agents. 284. New Desmosdumotin B Analogues with Bicyclic B-Ring as Cytotoxic and Antitubulin Agents
inferredcites →https://doi.org/10.1021/jm801569zopenalex-snapshot
Integration of Ligand and Structure-Based Virtual Screening for the Identification of the First Dual Targeting Agent for Heat Shock Protein 90 (Hsp90) and Tubulin
inferredcites →https://doi.org/10.1021/jm801649yopenalex-snapshot
Generation of Ligand-Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity
inferredcites →https://doi.org/10.1023/a:1022946305242openalex-snapshot
Different Effects of Vinblastine on the Polymerization of Isotypically Purified Tubulins from Bovine Brain
inferredcites →https://doi.org/10.1038/2171053a0openalex-snapshot
Amino-acid Composition of “Tubulin” constituting Microtubules of Sperm Flagella
inferredcites →https://doi.org/10.1038/34465openalex-snapshot
Structure of the αβ tubulin dimer by electron crystallography
inferredcites →https://doi.org/10.1038/embor.2008.171openalex-snapshot
Structural insight into the inhibition of tubulin by vinca domain peptide ligands
inferredcites →https://doi.org/10.1038/nature02393openalex-snapshot
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain
inferredcites →https://doi.org/10.1038/nature03566openalex-snapshot
Structural basis for the regulation of tubulin by vinblastine
inferredcites →https://doi.org/10.1038/nrc1317openalex-snapshot
Microtubules as a target for anticancer drugs
inferredcites →https://doi.org/10.1038/nrd3253openalex-snapshot
Microtubule-binding agents: a dynamic field of cancer therapeutics
inferredcites →https://doi.org/10.1038/sj.bjc.6605489openalex-snapshot
Class III β-tubulin expression and in vitro resistance to microtubule targeting agents
inferredcites →https://doi.org/10.1038/sj.cdd.4401088openalex-snapshot
The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet
inferredcites →https://doi.org/10.1056/nejm199504133321507openalex-snapshot
Paclitaxel (Taxol)
inferredcites →https://doi.org/10.1073/pnas.0904223106openalex-snapshot
Variations in the colchicine-binding domain provide insight into the structural switch of tubulin
inferredcites →https://doi.org/10.1073/pnas.68.8.1762openalex-snapshot
Are Cytoplasmic Microtubules Heteropolymers?
inferredcites →https://doi.org/10.1073/pnas.96.10.5686openalex-snapshot
Selective, covalent modification of β-tubulin residue Cys-239 by T138067, an antitumor agent with in vivo efficacy against multidrug-resistant tumors
inferredcites →https://doi.org/10.1074/jbc.m005299200openalex-snapshot
Mapping the Binding Site of Colchicinoids on β-Tubulin
inferredcites →https://doi.org/10.1074/jbc.m110.141929openalex-snapshot
Stathmin and Interfacial Microtubule Inhibitors Recognize a Naturally Curved Conformation of Tubulin Dimers
inferredcites →https://doi.org/10.1074/jbc.m900167200openalex-snapshot
Molecular Basis for Class V β-Tubulin Effects on Microtubule Assembly and Paclitaxel Resistance
inferredcites →https://doi.org/10.1088/0957-4484/17/4/014openalex-snapshot
Comparative modelling of human β tubulin isotypes and implications for drug binding
inferredcites →https://doi.org/10.1089/thy.2008.0321openalex-snapshot
A Phase II Trial of Fosbretabulin in Advanced Anaplastic Thyroid Carcinoma and Correlation of Baseline Serum-Soluble Intracellular Adhesion Molecule-1 with Outcome
inferredcites →https://doi.org/10.1093/jnci/92.3.182openalex-snapshot
Tubulin/Microtubules: Still a Promising Target for New Chemotherapeutic Agents
inferredcites →https://doi.org/10.1097/jto.0b013e318174e01fopenalex-snapshot
A Phase II Study of ABT-751 in Patients with Advanced Non-small Cell Lung Cancer
inferredcites →https://doi.org/10.1111/j.1432-1033.1997.00420.xopenalex-snapshot
Interactions of a Bicyclic Analog of Colchicine with β‐Tubulin Isoforms αβII, αβIII and αβIV
inferredcites →https://doi.org/10.1186/1476-4598-9-131openalex-snapshot
Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives
inferredcites →https://doi.org/10.1200/jco.2003.05.185openalex-snapshot
Phase I Clinical Trial of Weekly Combretastatin A4 Phosphate: Clinical and Pharmacokinetic Results
inferredcites →https://doi.org/10.1200/jco.2003.12.986openalex-snapshot
Phase I Trial of the Antivascular Agent Combretastatin A4 Phosphate on a 5-Day Schedule to Patients With Cancer: Magnetic Resonance Imaging Evidence for Altered Tumor Blood Flow
inferredcites →https://doi.org/10.1242/jcs.102.3.401openalex-snapshot
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles : Implications for the role of microtubule dynamics in mitosis
inferredcites →https://doi.org/10.1592/phco.23.2.165.32088openalex-snapshot
2‐Methoxyestradiol, a Promising Anticancer Agent
inferredcites →https://doi.org/10.2174/1381612023394043openalex-snapshot
Epothilones: A Novel Class of Non-taxane Microtubule-stabilizing Agents
inferredcites →https://doi.org/10.2174/1381612053764733openalex-snapshot
The Chemistry and Biology of Antimitotic Chalcones and Related Enone Systems
inferredcites →https://doi.org/10.2174/1568011053352569openalex-snapshot
Targeting Microtubules for Cancer Chemotherapy

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Discovery and Mechanistic Insights into Thieno[3,2-D]Pyrimidine and Heterocyclic Fused Pyrimidines Inhibitors Targeting Tubulin for Cancer Therapy
inferred← citeshttps://doi.org/10.2139/ssrn.4814175openalex-extracted
Discovery of Colchicine Aryne Cyclo-Adduct as a Potent Molecule for the Abrogation of Epithelial to Mesenchymal Transition Via Modulating Cell Cycle Regulatory Cdk-2 and Cdk-4 Kinases
inferred← citeshttps://doi.org/10.1002/ange.202100273openalex-snapshot
Comprehensive Analysis of Binding Sites in Tubulin
inferred← citeshttps://doi.org/10.1002/anie.202100273openalex-snapshot
Comprehensive Analysis of Binding Sites in Tubulin
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inferred← citeshttps://doi.org/10.1002/chin.201213277openalex-snapshot
ChemInform Abstract: The Tubulin Colchicine Domain: A Molecular Modeling Perspective
inferred← citeshttps://doi.org/10.1002/cmdc.201200561openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/cmdc.201402310openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/cmdc.201800641openalex-snapshot
Synthesis, Biological Evaluation, and Molecular Docking of Combretastatin and Colchicine Derivatives and their hCE1‐Activated Prodrugs as Antiviral Agents
inferred← citeshttps://doi.org/10.1002/em.21986openalex-snapshot
The adverse outcome pathway ( AOP ) for chemical binding to tubulin in oocytes leading to aneuploid offspring
inferred← citeshttps://doi.org/10.1002/med.21541openalex-snapshot
Antitubulin sulfonamides: The successful combination of an established drug class and a multifaceted target
inferred← citeshttps://doi.org/10.1002/prp2.616openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/slct.201800402openalex-snapshot
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Selective Functionalization of Benzo‐Fused N ‐Heterocycles by Using In Situ Trapping Metalations
inferred← citeshttps://doi.org/10.1002/slct.202003170openalex-snapshot
Design and Synthesis of New Tubulin Polymerization Inhibitors Inspired from Combretastatin A‐4: An Anticancer Agent
inferred← citeshttps://doi.org/10.1007/s00044-025-03519-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.addr.2022.114138openalex-snapshot
Destruction of tumor vasculature by vascular disrupting agents in overcoming the limitation of EPR effect
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Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain
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Potent colchicine-site ligands with improved intrinsic solubility by replacement of the 3,4,5-trimethoxyphenyl ring with a 2-methylsulfanyl-6-methoxypyridine ring
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.106282openalex-snapshot
Novel amino analogs of the trimethoxyphenyl ring in potent colchicine site ligands improve solubility by the masked polar group incorporation (MPGI) strategy
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Unveiling the anti-cancer potentiality of phthalimide-based Analogues targeting tubulin polymerization in MCF-7 cancerous Cells: Rational design, chemical Synthesis, and Biological-coupled Computational investigation
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A potent Bioorganic azapodophyllotoxin derivative Suppresses tumor Progression in Triple negative breast Cancer: An Insight into its Inhibitory effect on tubulin polymerization and Disruptive effect on microtubule assembly
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The stilbene and dibenzo[b,f]oxepine derivatives as anticancer compounds
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inferred← citeshttps://doi.org/10.1016/j.bmc.2013.03.049openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bmc.2013.09.046openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bmc.2013.12.030openalex-snapshot
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Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function
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inferred← citeshttps://doi.org/10.1016/j.bmc.2020.115874openalex-snapshot
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Anti-tumor activity evaluation of novel tubulin and HDAC dual-targeting inhibitors
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A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity
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Chemical mechanisms involved during the biosynthesis of tropolones
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VISAGE Reveals a Targetable Mitotic Spindle Vulnerability in Cancer Cells
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Podophyllotoxin derivatives targeting tubulin: An update (2017–2022)
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In vitro and in vivo biological evaluation of new 4,5-disubstituted 1,2,3-triazoles as cis-constrained analogs of combretastatin A4
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(E)-4-Aryl-4-oxo-2-butenoic acid amides, chalcone–aroylacrylic acid chimeras: Design, antiproliferative activity and inhibition of tubulin polymerization
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Structural factors affecting affinity of cytotoxic oxathiole-fused chalcones toward tubulin
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Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins
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Synthesis and cytostatic properties of polyfunctionalized furanoallocolchicinoids
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β-Lactam analogues of combretastatin A-4 prevent metabolic inactivation by glucuronidation in chemoresistant HT-29 colon cancer cells
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Conformation impacts on the bioactivities of SMART analogues
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Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain
inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.03.045openalex-snapshot
Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop
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Design, synthesis and bio-evaluation of novel 2-aryl-4-(3,4,5-trimethoxy-benzoyl)-5-substituted-1,2,3-triazoles as the tubulin polymerization inhibitors
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Methylsulfanylpyridine based diheteroaryl isocombretastatin analogs as potent anti-proliferative agents
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Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities
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A comprehensive assessment of a new series of 5′,6′-difluorobenzotriazole-acrylonitrile derivatives as microtubule targeting agents (MTAs)
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The discovery of water-soluble indazole derivatives as potent microtubule polymerization inhibitors
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Promising anti-proliferative indolic benzenesulfonamides alter mechanisms with sulfonamide nitrogen substituents
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Discovery and mechanistic insights into thieno[3,2-d]pyrimidine and heterocyclic fused pyrimidines inhibitors targeting tubulin for cancer therapy
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Verubulin and its derivatives: Progress and promise in tubulin-targeted cancer therapy
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2-Naphthyl tetrazoles are potent antiproliferative and apoptotic inducers with different tubulin polymerization dynamics inhibitory activity
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Identification of novel αβ-tubulin modulators with antiproliferative activity directed to cancer therapy using ligand and structure-based virtual screening
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Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum
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Drug resistance in liver flukes
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New diarylsulfonamide inhibitors of Leishmania infantum amastigotes
inferred← citeshttps://doi.org/10.1016/j.jarmap.2022.100388openalex-snapshot
Diversity assessment of Gloriosa superba accessions from Western Ghats of India based on morphological traits, ISSR markers and metabolite content
inferred← citeshttps://doi.org/10.1016/j.jmgm.2016.10.007openalex-snapshot
A comparative study based on docking and molecular dynamics simulations over HDAC-tubulin dual inhibitors
inferred← citeshttps://doi.org/10.1016/j.matchemphys.2021.124381openalex-snapshot
Novel topical and transdermal delivery of colchicine with chitosan based biocomposite nanofiberous system; formulation, optimization, characterization, ex vivo skin deposition/permeation, and anti-melanoma evaluation
inferred← citeshttps://doi.org/10.1016/j.molliq.2018.02.001openalex-snapshot
Rational design of imidazolium based salts as anthelmintic agents
inferred← citeshttps://doi.org/10.1016/j.molliq.2018.07.029openalex-snapshot
Deciphering the anthelmintic activity of benzimidazolium salts by experimental and in-silico studies
inferred← citeshttps://doi.org/10.1016/j.molstruc.2020.128025openalex-snapshot
Synthesis, biological evaluation, and modeling studies of 1,3-disubstituted cyclobutane-containing analogs of combretastatin A4
inferred← citeshttps://doi.org/10.1016/j.molstruc.2021.131702openalex-snapshot
Novel derivatives of aroylacrylic acid phenylamides as inducers of apoptosis through the ROS-mediated pathway in several cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.132723openalex-snapshot
Microtubules destabilizing agents binding sites in tubulin
inferred← citeshttps://doi.org/10.1016/j.rechem.2024.101539openalex-snapshot
Design, stereoselective synthesis, and antitumoral activity of combretastatin A-4 analogs
inferred← citeshttps://doi.org/10.1016/j.semarthrit.2015.06.013openalex-snapshot
Colchicine—Update on mechanisms of action and therapeutic uses
inferred← citeshttps://doi.org/10.1016/j.tcb.2018.05.001openalex-snapshot
Microtubule-Targeting Agents: Strategies To Hijack the Cytoskeleton
inferred← citeshttps://doi.org/10.1016/j.tet.2016.05.005openalex-snapshot
Synthesis of derivatives of methoxydibenzo[ b, f ]oxepine in the presence of sodium azide
inferred← citeshttps://doi.org/10.1016/j.tranon.2020.100917openalex-snapshot
Cross-resistance of cisplatin selected cells to anti-microtubule agents: Role of general survival mechanisms
inferred← citeshttps://doi.org/10.1021/acs.biochem.5b00146openalex-snapshot
Investigating the Structural Variability and Binding Modes of the Glioma Targeting NFL-TBS.40–63 Peptide on Tubulin
inferred← citeshttps://doi.org/10.1021/acs.biochem.6b00988openalex-snapshot
Mobility and Core-Protein Binding Patterns of Disordered C-Terminal Tails in β-Tubulin Isotypes
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.9b00051openalex-snapshot
Phospholipidic Colchicinoids as Promising Prodrugs Incorporated into Enzyme-Responsive Liposomes: Chemical, Biophysical, and Enzymological Aspects
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00222openalex-snapshot
Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01208openalex-snapshot
Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01775openalex-snapshot
PM534, an Optimized Target-Protein Interaction Strategy through the Colchicine Site of Tubulin
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00155openalex-snapshot
Design, Synthesis, in Vitro, and in Vivo Anticancer and Antiangiogenic Activity of Novel 3-Arylaminobenzofuran Derivatives Targeting the Colchicine Site on Tubulin
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02701openalex-snapshot
Tubulin Zone Occupancy by PDB-Deposited Colchicine Binding Site Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00071openalex-snapshot
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00237openalex-snapshot
Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00463openalex-snapshot
Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01644openalex-snapshot
Bifidenone: Structure–Activity Relationship and Advanced Preclinical Candidate
inferred← citeshttps://doi.org/10.1021/acsami.5c01405openalex-snapshot
Modulating the Curvature of Protein Self-Assembled Spiral Nanotubules
inferred← citeshttps://doi.org/10.1021/acsomega.2c02933openalex-snapshot
Synthesis, Biological Evaluation, and Molecular Modeling Studies of 1-Aryl-1 H -pyrazole-Fused Curcumin Analogues as Anticancer Agents
inferred← citeshttps://doi.org/10.1021/ci300302copenalex-snapshot
Discovery of Novel Tubulin Inhibitors via Structure-Based Hierarchical Virtual Screening
inferred← citeshttps://doi.org/10.1021/jm300388hopenalex-snapshot
Discovery and Optimization of a Series of 2-Aryl-4-Amino-5-(3′,4′,5′-trimethoxybenzoyl)Thiazoles as Novel Anticancer Agents
inferred← citeshttps://doi.org/10.1021/jm400043dopenalex-snapshot
Synthesis and Biological Evaluation of 2-(Alkoxycarbonyl)-3-Anilinobenzo[b]thiophenes and Thieno[2,3-b]pyridines as New Potent Anticancer Agents
inferred← citeshttps://doi.org/10.1021/jm400954hopenalex-snapshot
How to Deal with Low-Resolution Target Structures: Using SAR, Ensemble Docking, Hydropathic Analysis, and 3D-QSAR to Definitively Map the αβ-Tubulin Colchicine Site
inferred← citeshttps://doi.org/10.1021/jm4013938openalex-snapshot
Concise Synthesis and Biological Evaluation of 2-Aroyl-5-Amino Benzo[b]thiophene Derivatives As a Novel Class of Potent Antimitotic Agents
inferred← citeshttps://doi.org/10.1021/jm500034jopenalex-snapshot
Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors
inferred← citeshttps://doi.org/10.1021/jm500561aopenalex-snapshot
New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer
inferred← citeshttps://doi.org/10.1021/jm5016389openalex-snapshot
Design, Synthesis, and Biological Evaluation of Combretabenzodiazepines: A Novel Class of Anti-Tubulin Agents
inferred← citeshttps://doi.org/10.1038/s41598-017-09491-9openalex-snapshot
Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer properties
inferred← citeshttps://doi.org/10.1038/s41598-018-22382-xopenalex-snapshot
High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
inferred← citeshttps://doi.org/10.1038/s41598-021-03076-3openalex-snapshot
Characterization of a recently synthesized microtubule-targeting compound that disrupts mitotic spindle poles in human cells
inferred← citeshttps://doi.org/10.1038/srep14814openalex-snapshot
Comparison of carbon-sulfur and carbon-amine bond in therapeutic drug: 4β-S-aromatic heterocyclic podophyllum derivatives display antitumor activity
inferred← citeshttps://doi.org/10.1039/c3md00357dopenalex-snapshot
Combretastatin A-4 inspired novel 2-aryl-3-arylamino-imidazo-pyridines/pyrazines as tubulin polymerization inhibitors, antimitotic and anticancer agents
inferred← citeshttps://doi.org/10.1039/c5ra26807aopenalex-snapshot
Targeting the colchicine site in tubulin through cyclohexanedione derivatives
inferred← citeshttps://doi.org/10.1039/c6ob02610aopenalex-snapshot
Synthesis, SAR and biological studies of sugar amino acid-based almiramide analogues: N-methylation leads the way
inferred← citeshttps://doi.org/10.1039/c7md00227kopenalex-snapshot
Recent advances in combretastatin based derivatives and prodrugs as antimitotic agents
inferred← citeshttps://doi.org/10.1039/c7ra02720fopenalex-snapshot
Synthesis and antiproliferative activity of 2-aryl-4-(3,4,5-trimethoxybenzoyl)-1,2,3-triazol derivatives as microtubule-destabilizing agents
inferred← citeshttps://doi.org/10.1039/d1md00392eopenalex-snapshot
Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking
inferred← citeshttps://doi.org/10.1039/d2ra03312gopenalex-snapshot
Synthesis and biological activity, and molecular modelling studies of potent cytotoxic podophyllotoxin-naphthoquinone compounds
inferred← citeshttps://doi.org/10.1039/d3ra07396copenalex-snapshot
Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents
inferred← citeshttps://doi.org/10.1039/d4ra07810aopenalex-snapshot
Design, synthesis, molecular docking and anticancer activity of benzothiazolecarbohydrazide–sulfonate conjugates: insights into ROS-induced DNA damage and tubulin polymerization inhibition
inferred← citeshttps://doi.org/10.1039/d5cb00321kopenalex-snapshot
Illuminating microtubule functions with small molecules: past, present and future of fluorescent tubulin-binding probes
inferred← citeshttps://doi.org/10.1063/5.0068469openalex-snapshot
Modeling the antitubulin activity of benzimidazol-2-yl carbamates: Mini-review
inferred← citeshttps://doi.org/10.1080/07391102.2014.1000377openalex-snapshot
Integrating docking and molecular dynamics approaches for a series of proline-based 2,5-diketopiperazines as novel αβ-tubulin inhibitors
inferred← citeshttps://doi.org/10.1080/07391102.2022.2109063openalex-snapshot
Spectrin: an alternate target for cytoskeletal drugs
inferred← citeshttps://doi.org/10.1080/1061186x.2024.2315474openalex-snapshot
Plant-based natural products in cancer therapeutics
inferred← citeshttps://doi.org/10.1097/cad.0000000000000464openalex-snapshot
Potential anticancer role of colchicine-based derivatives
inferred← citeshttps://doi.org/10.1101/2020.08.14.251058openalex-snapshot
A novel compound that disrupts mitotic spindle poles in human cells
inferred← citeshttps://doi.org/10.1101/2020.12.27.424481openalex-snapshot
Deciphering colchicine like actions of clerodin in terms of microtubule destabilization based mitotic abnormalities, G2/M-phase arrest, and plant polyploidy
inferred← citeshttps://doi.org/10.1111/cbdd.12776openalex-snapshot
Influence of S ‐Oxidation on Cytotoxic Activity of Oxathiole‐Fused Chalcones
inferred← citeshttps://doi.org/10.1111/cbdd.13052openalex-snapshot
Design, synthesis, and biological evaluation of a new class of benzo[b]furan derivatives as antiproliferative agents, with in silico predicted antitubulin activity
inferred← citeshttps://doi.org/10.1155/2013/843748openalex-snapshot
Comparative Analyses of theβ-Tubulin Gene and Molecular Modeling Reveal Molecular Insight into the Colchicine Resistance in Kinetoplastids Organisms
inferred← citeshttps://doi.org/10.11606/t.76.2021.tde-17022022-110839openalex-snapshot
Estudos de modelagem molecular na caracterização da interação entre o domínio de ligação da colchicina da αβ-tubulina e agentes antitumorais
inferred← citeshttps://doi.org/10.11606/t.76.2024.tde-18062024-093531openalex-snapshot
Investigação de moduladores da tubulina com propriedades anticâncer
inferred← citeshttps://doi.org/10.1186/1471-2164-15-s9-s3openalex-snapshot
Fragment based group QSAR and molecular dynamics mechanistic studies on arylthioindole derivatives targeting the α-β interfacial site of human tubulin
inferred← citeshttps://doi.org/10.12998/wjcc.v13.i31.110123openalex-snapshot
Role of anti-inflammatory agent colchicine in atherosclerotic cardiovascular disease
inferred← citeshttps://doi.org/10.1371/journal.pone.0182022openalex-snapshot
Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity
inferred← citeshttps://doi.org/10.14201/gredos.127298openalex-snapshot
Análogos de fenstatinas e isocombretastatinas basados en piridina
inferred← citeshttps://doi.org/10.1517/13543776.2014.859247openalex-snapshot
Tubulin inhibitors: a patent review
inferred← citeshttps://doi.org/10.15252/emmm.202013818openalex-snapshot
Inhibiting parasite proliferation using a rationally designed anti‐tubulin agent
inferred← citeshttps://doi.org/10.15826/chimtech.2024.11.1.04openalex-snapshot
Development of A. solani β-tubulin models and comparison of docking results for benzo[d]azoles derivatives as potential antifungal agents
inferred← citeshttps://doi.org/10.17776/csj.1063966openalex-snapshot
Molecular Docking and Drug-likeness Prediction of New Potent Tubulin Colchicine Binding Site Inhibitors for Potential Antitumor Drug
inferred← citeshttps://doi.org/10.18002/10612/5144openalex-snapshot
Actividad y modo de acción leishmanicida de nuevos derivados de la podofilotoxina y quinonas = Activity and target of new leishmanicide podophyllotoxin derivatives and quinones
inferred← citeshttps://doi.org/10.18632/oncotarget.14980openalex-snapshot
Mitotic cell death induction by targeting the mitotic spindle with tubulin-inhibitory indole derivative molecules
inferred← citeshttps://doi.org/10.2174/0929867322666150114163732openalex-snapshot
Tubulin Colchicine Binding Site Inhibitors as Vascular Disrupting Agents in Clinical Developments
inferred← citeshttps://doi.org/10.2174/092986732311160420104823openalex-snapshot
Pyridine Based Antitumour Compounds Acting at the Colchicine Site
inferred← citeshttps://doi.org/10.2174/1568026613666131216110417openalex-snapshot
Reviewing Colchicaceae Alkaloids – Perspectives of Evolution on Medicinal Chemistry
inferred← citeshttps://doi.org/10.2174/1871520620666200925102940openalex-snapshot
Synthesis and Preclinical Evaluation of Indole Triazole Conjugates as Microtubule Targeting Agents that are Effective against MCF-7 Breast Cancer Cell Lines
inferred← citeshttps://doi.org/10.2174/1871520621666211026102307openalex-snapshot
Synthesis, Molecular Docking, and Biological Evaluation of 2,3-Diphenylquinoxaline Derivatives as a Tubulin’s Colchicine Binding Site Inhibitor Based on Primary Virtual Screening
inferred← citeshttps://doi.org/10.2478/s11658-013-0094-zopenalex-snapshot
Tubulin-interactive stilbene derivatives as anticancer agents
inferred← citeshttps://doi.org/10.26434/chemrxiv-2023-d5lcgopenalex-snapshot
C-4 analogs of podophyllotoxin as tubulin inhibitors: Synthesis, biological evaluation, and structure-activity relationship
inferred← citeshttps://doi.org/10.26434/chemrxiv-2024-rs3lhopenalex-snapshot
Silicon-tethered colchicine aryne cyclo-adduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases
inferred← citeshttps://doi.org/10.26686/wgtn.17011898openalex-snapshot
Resistance to microtubule-stabilising agents following point mutation of human βI-tubulin
inferred← citeshttps://doi.org/10.26686/wgtn.17011898.v1openalex-snapshot
Resistance to microtubule-stabilising agents following point mutation of human βI-tubulin
inferred← citeshttps://doi.org/10.26686/wgtn.17142671openalex-snapshot
Characterisation of Zampanolide as a Microtubule-Stabilizing Agent
inferred← citeshttps://doi.org/10.26686/wgtn.17142671.v1openalex-snapshot
Characterisation of Zampanolide as a Microtubule-Stabilizing Agent
inferred← citeshttps://doi.org/10.3389/fcimb.2013.00002openalex-snapshot
Management of familial Mediterranean fever by colchicine does not normalize the altered profile of microbial long chain fatty acids in the human metabolome
inferred← citeshttps://doi.org/10.3390/app13074471openalex-snapshot
Therapeutic Targets in the Virological Mechanism and in the Hyperinflammatory Response of Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2)
inferred← citeshttps://doi.org/10.3390/biom13050834openalex-snapshot
Structural Changes, Biological Consequences, and Repurposing of Colchicine Site Ligands
inferred← citeshttps://doi.org/10.3390/cancers13225650openalex-snapshot
Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles
inferred← citeshttps://doi.org/10.3390/ijms222011033openalex-snapshot
Synthesis and Investigations of Building Blocks with Dibenzo[b,f] Oxepine for Use in Photopharmacology
inferred← citeshttps://doi.org/10.3390/ijms23073448openalex-snapshot
Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function
inferred← citeshttps://doi.org/10.3390/ijms241311093openalex-snapshot
Novel Tetrazole Derivatives Targeting Tubulin Endowed with Antiproliferative Activity against Glioblastoma Cells
inferred← citeshttps://doi.org/10.3390/ijms242417474openalex-snapshot
Frentizole, a Nontoxic Immunosuppressive Drug, and Its Analogs Display Antitumor Activity via Tubulin Inhibition
inferred← citeshttps://doi.org/10.3390/ijms26157652openalex-snapshot
Microtubule-Targeting Agents: Advances in Tubulin Binding and Small Molecule Therapy for Gliomas and Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3390/jfb14030135openalex-snapshot
A Molecular Docking Study Reveals That Short Peptides Induce Conformational Changes in the Structure of Human Tubulin Isotypes αβI, αβII, αβIII and αβIV
inferred← citeshttps://doi.org/10.3390/molecules21111468openalex-snapshot
Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis
inferred← citeshttps://doi.org/10.3390/molecules25163705openalex-snapshot
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells
inferred← citeshttps://doi.org/10.3390/molecules27185836openalex-snapshot
Synthesis and Study of Dibenzo[b, f]oxepine Combined with Fluoroazobenzenes—New Photoswitches for Application in Biological Systems
inferred← citeshttps://doi.org/10.3390/molecules28083558openalex-snapshot
Systematic Studies on Anti-Cancer Evaluation of Stilbene and Dibenzo[b,f]oxepine Derivatives
inferred← citeshttps://doi.org/10.3390/molecules30163314openalex-snapshot
Recent Advances in Microtubule Targeting Agents for Cancer Therapy
inferred← citeshttps://doi.org/10.3390/molecules31020362openalex-snapshot
Synthesis and Study of Substituted Chalcones Combined with Fluoroazobenzenes—New Photoswitches for Application in Biological Systems
inferred← citeshttps://doi.org/10.3390/pharmaceutics15061698openalex-snapshot
Potent and Selective Benzothiazole-Based Antimitotics with Improved Water Solubility: Design, Synthesis, and Evaluation as Novel Anticancer Agents
inferred← citeshttps://doi.org/10.3390/pharmaceutics18091064openalex-snapshot
Small Molecule Drug Conjugate Hybrids of Naphthalene Sulfonamide and Phospholipid Conjugates Are Microtubule-Disrupting Antitumor Agents
inferred← citeshttps://doi.org/10.3390/su14031327openalex-snapshot
The Assessment of Morphological Diversity of Colchicum luteum L., an Economically Important Threatened Medicinal Plant of Kashmir Himalaya
inferred← citeshttps://doi.org/10.4155/fmc-2017-0324openalex-snapshot
Design, Synthesis and Biological Evaluation of Chromenopyrimidines as Potential Cytotoxic Agents
inferred← citeshttps://doi.org/10.56588/iabcd.v2i2.97openalex-snapshot
COMPUTATIONAL ANALYSIS OF TRANSCRIPTION FACTORS AS CANCER DRUG TARGETS WITH POTENTIAL INHIBITORS FROM THE NPACT DATABASE
inferred← citeshttps://doi.org/10.56588/iabcd.v3i1.198openalex-snapshot
EXPLORING THE ANTI-CANCER POTENTIAL OF PHYTOCHEMICALS FROM SPECIFIC PLANTS: EXAMINING AND VALIDATING THROUGH MOLECULAR DOCKING AND MD SIMULATIONS
inferred← citeshttps://doi.org/10.64898/2026.02.24.707696openalex-snapshot
Ligand Binding Free Energy Landscapes at the Tubulin Colchicine Site from Coarse-Grained Metadynamics
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