On the public citation graph

Small molecule inhibitors of ROR γt: Targeting T h17 cells and other applications

https://doi.org/10.1002/eji.201242740

0 signed · 217 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1016/j.autrev.2012.02.022openalex-snapshot

Effective treatment of rat adjuvant-induced arthritis by celastrol

inferredcites →https://doi.org/10.1016/j.bbmt.2011.10.001openalex-snapshot

The IL-17 Differentiation Pathway and Its Role in Transplant Outcome

inferredcites →https://doi.org/10.1016/j.cell.2006.06.050openalex-snapshot

Nuclear Receptor Expression Links the Circadian Clock to Metabolism

inferredcites →https://doi.org/10.1016/j.cell.2006.07.035openalex-snapshot

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

inferredcites →https://doi.org/10.1016/j.immuni.2007.11.016openalex-snapshot

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

inferredcites →https://doi.org/10.1016/j.immuni.2009.02.007openalex-snapshot

Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

inferredcites →https://doi.org/10.1016/j.immuni.2011.11.011openalex-snapshot

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

inferredcites →https://doi.org/10.1016/j.lfs.2007.03.013openalex-snapshot

The digitalis-like steroid hormones: New mechanisms of action and biological significance

inferredcites →https://doi.org/10.1016/j.taap.2012.01.011openalex-snapshot

Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ

inferredcites →https://doi.org/10.1016/s0021-9258(18)92752-3openalex-snapshot

Isolation of digoxin-like immunoreactive factors from mammalian adrenal cortex

inferredcites →https://doi.org/10.1016/s0140-6736(08)60725-4openalex-snapshot

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)

inferredcites →https://doi.org/10.1016/s0140-6736(08)60726-6openalex-snapshot

Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)

inferredcites →https://doi.org/10.1016/s0925-4773(97)00187-1openalex-snapshot

Orphan nuclear receptor RORα-deficient mice display the cerebellar defects of staggerer

inferredcites →https://doi.org/10.1021/bi00422a016openalex-snapshot

Structure-function relationships in the sodium-potassium ATPase .alpha. subunit: site-directed mutagenesis of glutamine-111 to arginine and asparagine-122 to aspartic acid generates a ouabain-resistant enzyme

inferredcites →https://doi.org/10.1021/cb200496yopenalex-snapshot

Identification of SR2211: A Potent Synthetic RORγ-Selective Modulator

inferredcites →https://doi.org/10.1038/nature06881openalex-snapshot

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

inferredcites →https://doi.org/10.1038/nature08114openalex-snapshot

The AP-1 transcription factor Batf controls TH17 differentiation

inferredcites →https://doi.org/10.1038/nature08922openalex-snapshot

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

inferredcites →https://doi.org/10.1038/nature09978openalex-snapshot

Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity

inferredcites →https://doi.org/10.1038/nature10075openalex-snapshot

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

inferredcites →https://doi.org/10.1038/ncpneph0848openalex-snapshot

Endogenous digitalis: pathophysiologic roles and therapeutic applications

inferredcites →https://doi.org/10.1038/ng.311openalex-snapshot

Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

inferredcites →https://doi.org/10.1038/ng.582openalex-snapshot

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

inferredcites →https://doi.org/10.1038/ni.1610openalex-snapshot

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

inferredcites →https://doi.org/10.1038/ni.1663openalex-snapshot

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

inferredcites →https://doi.org/10.1038/ni.1962openalex-snapshot

The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

inferredcites →https://doi.org/10.1038/ni1022openalex-snapshot

An essential function for the nuclear receptor RORγt in the generation of fetal lymphoid tissue inducer cells

inferredcites →https://doi.org/10.1038/ni1488openalex-snapshot

IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

inferredcites →https://doi.org/10.1053/j.gastro.2008.10.018openalex-snapshot

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

inferredcites →https://doi.org/10.1056/nejmoa1109997openalex-snapshot

Anti–Interleukin-17 Monoclonal Antibody Ixekizumab in Chronic Plaque Psoriasis

inferredcites →https://doi.org/10.1074/jbc.c111.250407openalex-snapshot

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein

inferredcites →https://doi.org/10.1074/jbc.m111.254003openalex-snapshot

Structural Basis of Digoxin That Antagonizes RORγt Receptor Activity and Suppresses Th17 Cell Differentiation and Interleukin (IL)-17 Production

inferredcites →https://doi.org/10.1084/jem.20080034openalex-snapshot

In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells

inferredcites →https://doi.org/10.1126/science.1135245openalex-snapshot

A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

inferredcites →https://doi.org/10.1126/science.1223490openalex-snapshot

Interactions Between the Microbiota and the Immune System

inferredcites →https://doi.org/10.1126/science.6836275openalex-snapshot

Digoxin-Inactivating Bacteria: Identification in Human Gut Flora

inferredcites →https://doi.org/10.1128/aem.51.6.1300-1303.1986openalex-snapshot

Reduction of digoxin to 20R-dihydrodigoxin by cultures of Eubacterium lentum

inferredcites →https://doi.org/10.1152/physiolgenomics.00098.2007openalex-snapshot

Gene expression profiling reveals a regulatory role for RORα and RORγ in phase I and phase II metabolism

inferredcites →https://doi.org/10.1158/0008-5472.can-10-2907openalex-snapshot

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

inferredcites →https://doi.org/10.1172/jci21404openalex-snapshot

IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6

inferredcites →https://doi.org/10.1210/endo-125-5-2573openalex-snapshot

An Endogenous Digitalis-Like Factor Derived from the Adrenal Gland: Studies of Adrenal Tissue from Various Sources

inferredcites →https://doi.org/10.1210/me.2009-0507openalex-snapshot

Structural Basis for Hydroxycholesterols as Natural Ligands of Orphan Nuclear Receptor RORγ

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4047244openalex-extracted

inferred← citeshttps://doi.org/10.1002/cbdv.201800244openalex-snapshot

Structure‐Based Design and Synthesis of Fluorene Derivatives as Novel ROR γt Inverse Agonists

inferred← citeshttps://doi.org/10.1002/cmdc.201500432openalex-snapshot

Benzoxazepines Achieve Potent Suppression of IL‐17 Release in Human T‐Helper 17 (TH17) Cells through an Induced‐Fit Binding Mode to the Nuclear Receptor RORγ

inferred← citeshttps://doi.org/10.1002/cyto.a.24285openalex-snapshot

Little to no expression of angiotensin‐converting enzyme‐2 on most human peripheral blood immune cells but highly expressed on tissue macrophages

inferred← citeshttps://doi.org/10.1002/eji.201242872openalex-snapshot

Emerging new roles of Th17 cells

inferred← citeshttps://doi.org/10.1002/eji.201343875openalex-snapshot

To the Editor IL‐17, an important prognostic factor and potential therapeutic target for breast cancer?

inferred← citeshttps://doi.org/10.1002/eji.201545788openalex-snapshot

Metabolism of murine TH17 cells: Impact on cell fate and function

inferred← citeshttps://doi.org/10.1002/iid3.1112openalex-snapshot

Increased gene expression of CCR6 and RORγt in peripheral blood cells of rheumatoid arthritis patients and their correlation with anti‐cyclic citrullinated peptide and disease activity

inferred← citeshttps://doi.org/10.1002/jcb.25776openalex-snapshot

RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis

inferred← citeshttps://doi.org/10.1002/jlb.5mr0717-275rropenalex-snapshot

γδ cells and tumor microenvironment: A helpful or a dangerous liason?

inferred← citeshttps://doi.org/10.1007/978-3-030-51709-0_7openalex-snapshot

Bile Acids and Bilirubin in Liver Immunology

inferred← citeshttps://doi.org/10.1007/s00005-015-0344-zopenalex-snapshot

The Role of IL-17 and Th17 Lymphocytes in Autoimmune Diseases

inferred← citeshttps://doi.org/10.1007/s00018-016-2329-4openalex-snapshot

Nuclear receptor function in skin health and disease: therapeutic opportunities in the orphan and adopted receptor classes

inferred← citeshttps://doi.org/10.1007/s00281-018-0687-8openalex-snapshot

Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells

inferred← citeshttps://doi.org/10.1007/s10753-018-0875-7openalex-snapshot

Pharmacological Evaluation of TAK-828F, a Novel Orally Available RORγt Inverse Agonist, on Murine Colitis Model

inferred← citeshttps://doi.org/10.1007/s10787-019-00643-zopenalex-snapshot

VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease

inferred← citeshttps://doi.org/10.1007/s11684-015-0388-9openalex-snapshot

Th17 cells in autoimmune diseases

inferred← citeshttps://doi.org/10.1007/s12016-020-08823-4openalex-snapshot

IL-23/IL-17 Axis in Inflammatory Rheumatic Diseases

inferred← citeshttps://doi.org/10.1007/s12026-021-09204-5openalex-snapshot

5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivative attenuates lupus nephritis with less effect to thymocyte development

inferred← citeshttps://doi.org/10.1007/s12272-019-01146-9openalex-snapshot

T helper 17 (Th17) cells and interleukin-17 (IL-17) in cancer

inferred← citeshttps://doi.org/10.1007/s13205-018-1337-5openalex-snapshot

Role of nitric oxide-scavenging activity of Karanjin and Pongapin in the treatment of Psoriasis

inferred← citeshttps://doi.org/10.1007/s40674-015-0017-4openalex-snapshot

How Can We Manipulate the IL-23/IL-17 Axis?

inferred← citeshttps://doi.org/10.1016/b978-0-12-417150-3.00012-0openalex-snapshot

Targeting the Nuclear Hormone Receptor RORγt for the Treatment of Autoimmune and Inflammatory Disorders

inferred← citeshttps://doi.org/10.1016/b978-0-323-75978-6.00011-xopenalex-snapshot

Inflammation in Keratoconus

inferred← citeshttps://doi.org/10.1016/bs.acr.2015.04.014openalex-snapshot

Tumor-Elicited Inflammation and Colorectal Cancer

inferred← citeshttps://doi.org/10.1016/j.antiviral.2023.105769openalex-snapshot

Validation of nuclear receptor RORγ isoform 1 as a novel host-directed antiviral target based on the modulation of cholesterol levels

inferred← citeshttps://doi.org/10.1016/j.apsb.2026.03.003openalex-snapshot

Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)

inferred← citeshttps://doi.org/10.1016/j.bbrc.2014.09.037openalex-snapshot

CD4 aptamer–RORγt shRNA chimera inhibits IL-17 synthesis by human CD4+ T cells

inferred← citeshttps://doi.org/10.1016/j.bbrc.2018.02.110openalex-snapshot

Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains

inferred← citeshttps://doi.org/10.1016/j.bcp.2015.12.006openalex-snapshot

Targeting transcription factors by small compounds—Current strategies and future implications

inferred← citeshttps://doi.org/10.1016/j.bcp.2018.01.023openalex-snapshot

Pharmacological inhibitory profile of TAK-828F, a potent and selective orally available RORγt inverse agonist

inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103077openalex-snapshot

5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives as inhibitors of full-length RORγt

inferred← citeshttps://doi.org/10.1016/j.biopha.2017.04.133openalex-snapshot

Bupleurum chinense extract ameliorates an OVA-induced murine allergic asthma through the reduction of the Th2 and Th17 cytokines production by inactivation of NFκB pathway

inferred← citeshttps://doi.org/10.1016/j.bmc.2013.12.021openalex-snapshot

Discovery of novel N-(5-(arylcarbonyl)thiazol-2-yl)amides and N-(5-(arylcarbonyl)thiophen-2-yl)amides as potent RORγt inhibitors

inferred← citeshttps://doi.org/10.1016/j.bmc.2015.07.068openalex-snapshot

Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists

inferred← citeshttps://doi.org/10.1016/j.bmc.2017.12.006openalex-snapshot

Discovery of orally efficacious RORγt inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds

inferred← citeshttps://doi.org/10.1016/j.bmc.2018.02.018openalex-snapshot

Targeting RORs nuclear receptors by novel synthetic steroidal inverse agonists for autoimmune disorders

inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.10.054openalex-snapshot

Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc

inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.03.038openalex-snapshot

Identification of tertiary sulfonamides as RORc inverse agonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2014.06.048openalex-snapshot

Reduction in lipophilicity improved the solubility, plasma–protein binding, and permeability of tertiary sulfonamide RORc inverse agonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.05.026openalex-snapshot

Discovery of biaryl carboxylamides as potent RORγ inverse agonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.05.028openalex-snapshot

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.03.109openalex-snapshot

Discovery of biaryls as RORγ inverse agonists by using structure-based design

inferred← citeshttps://doi.org/10.1016/j.cbpa.2014.08.013openalex-snapshot

Small-molecule control of cytokine function: new opportunities for treating immune disorders

inferred← citeshttps://doi.org/10.1016/j.cell.2019.03.010openalex-snapshot

A Multiscale Map of the Stem Cell State in Pancreatic Adenocarcinoma

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111314openalex-snapshot

Pathobiont-responsive Th17 cells in gut-mouth axis provoke inflammatory oral disease and are modulated by intestinal microbiome

inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114951openalex-snapshot

Distinct RORγt-dependent Th17 immune responses are required for autoimmune pathogenesis and protection against bacterial infection

inferred← citeshttps://doi.org/10.1016/j.chom.2021.11.001openalex-snapshot

Human Gut Bacterial Metabolism Drives Th17 Activation and Colitis

inferred← citeshttps://doi.org/10.1016/j.clim.2015.01.011openalex-snapshot

Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

inferred← citeshttps://doi.org/10.1016/j.csbj.2020.06.034openalex-snapshot

Structural change of retinoic-acid receptor-related orphan receptor induced by binding of inverse-agonist: Molecular dynamics and ab initio molecular orbital simulations

inferred← citeshttps://doi.org/10.1016/j.cyto.2015.02.002openalex-snapshot

The role and modulation of CCR6+ Th17 cell populations in rheumatoid arthritis

inferred← citeshttps://doi.org/10.1016/j.cyto.2018.12.021openalex-snapshot

IL-17 and colorectal cancer: From carcinogenesis to treatment

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2016.07.004openalex-snapshot

Post-translational regulation of RORγt—A therapeutic target for the modulation of interleukin-17-mediated responses in autoimmune diseases

inferred← citeshttps://doi.org/10.1016/j.drudis.2014.04.012openalex-snapshot

Inhibiting RORγt/Th17 axis for autoimmune disorders

inferred← citeshttps://doi.org/10.1016/j.ejmech.2014.03.065openalex-snapshot

Discovery of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives as new RORγ inhibitors using virtual screening, synthesis and biological evaluation

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.02.050openalex-snapshot

Discovery of carbazole carboxamides as novel RORγt inverse agonists

inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.111984openalex-snapshot

Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.112536openalex-snapshot

Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists

inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115472openalex-snapshot

Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of RORγ antagonists

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.08.026openalex-snapshot

Oxidative stress modulates the cytokine response of differentiated Th17 and Th1 cells

inferred← citeshttps://doi.org/10.1016/j.gene.2017.01.016openalex-snapshot

Interluekin-17A (IL17A)

inferred← citeshttps://doi.org/10.1016/j.gene.2019.01.048openalex-snapshot

The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2018.07.021openalex-snapshot

Protein biomarker for psoriasis: A systematic review on their role in the pathomechanism, diagnosis, potential targets and treatment of psoriasis

inferred← citeshttps://doi.org/10.1016/j.immuni.2014.04.005openalex-snapshot

The Emerging Landscape of RORγt Biology

inferred← citeshttps://doi.org/10.1016/j.intimp.2018.10.010openalex-snapshot

21‑Benzylidene digoxin, a novel digoxin hemi-synthetic derivative, presents an anti-inflammatory activity through inhibition of edema, tumour necrosis factor alpha production, inducible nitric oxide synthase expression and leucocyte migration

inferred← citeshttps://doi.org/10.1016/j.intimp.2019.02.025openalex-snapshot

Gallic acid alleviates nasal inflammation via activation of Th1 and inhibition of Th2 and Th17 in a mouse model of allergic rhinitis

inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107788openalex-snapshot

Traffic-related PM2.5 and diverse constituents disturb the balance of Th17/Treg cells by STAT3/RORγt-STAT5/Foxp3 signaling pathway in a rat model of asthma

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110254openalex-snapshot

PM2.5 exposure regulates Th1/Th2/Th17 cytokine production through NF-κB signaling in combined allergic rhinitis and asthma syndrome

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110326openalex-snapshot

The effect of lymphocyte immunotherapy (LIT) in modulating immune responses in patients with recurrent pregnancy loss (RPL)

inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113263openalex-snapshot

SO2 activates Th17 cells through the JAK1,2/STAT3 signaling pathway

inferred← citeshttps://doi.org/10.1016/j.intimp.2025.115331openalex-snapshot

Protein targets & therapeutics in psoriasis: toward personalization

inferred← citeshttps://doi.org/10.1016/j.isci.2025.112675openalex-snapshot

Fungal pathogen-responsive Th17 cells in gut-mouth axis enhance protection against oropharyngeal candidiasis

inferred← citeshttps://doi.org/10.1016/j.it.2021.09.005openalex-snapshot

RORγt protein modifications and IL-17-mediated inflammation

inferred← citeshttps://doi.org/10.1016/j.jaci.2017.11.024openalex-snapshot

TNF-α–induced protein 3 (TNFAIP3)/A20 acts as a master switch in TNF-α blockade–driven IL-17A expression

inferred← citeshttps://doi.org/10.1016/j.jep.2018.02.023openalex-snapshot

Restoring Th17/Treg balance via modulation of STAT3 and STAT5 activation contributes to the amelioration of chronic obstructive pulmonary disease by Bufei Yishen formula

inferred← citeshttps://doi.org/10.1016/j.jep.2020.112760openalex-snapshot

The anti-TH17 polarization effect of Indigo naturalis and tryptanthrin by differentially inhibiting cytokine expression

inferred← citeshttps://doi.org/10.1016/j.jep.2023.116719openalex-snapshot

Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma

inferred← citeshttps://doi.org/10.1016/j.jep.2023.116931openalex-snapshot

Qingre Lishi Decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated DC maturation

inferred← citeshttps://doi.org/10.1016/j.molimm.2017.11.002openalex-snapshot

IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis

inferred← citeshttps://doi.org/10.1016/j.nmd.2014.06.432openalex-snapshot

The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications

inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155663openalex-snapshot

The potential application and molecular mechanisms of natural products in the treatment of allergic rhinitis: A review

inferred← citeshttps://doi.org/10.1016/j.semradonc.2014.07.005openalex-snapshot

Radiotherapy and Immunogenic Cell Death

inferred← citeshttps://doi.org/10.1016/j.taap.2013.11.012openalex-snapshot

Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice

inferred← citeshttps://doi.org/10.1016/j.tox.2015.01.007openalex-snapshot

Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ

inferred← citeshttps://doi.org/10.1016/j.vetimm.2026.111078openalex-snapshot

Interleukin- 17A as an Immunomodulatory Cytokine in Animal Health and Diseases: A Systematic Review

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01992openalex-snapshot

Tricyclic-Carbocyclic RORγt Inverse Agonists—Discovery of BMS-986313

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01314openalex-snapshot

Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Agonists as Potential Small Molecule Therapeutics for Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b01369openalex-snapshot

Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt—Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy

inferred← citeshttps://doi.org/10.1021/acschembio.8b00260openalex-snapshot

Small Molecule and Pooled CRISPR Screens Investigating IL17 Signaling Identify BRD2 as a Novel Contributor to Keratinocyte Inflammatory Responses

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.0c00063openalex-snapshot

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORγt Inverse Agonist

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5b00122openalex-snapshot

Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors

inferred← citeshttps://doi.org/10.1021/acsmedchemlett.7b00476openalex-snapshot

From RORγt Agonist to Two Types of RORγt Inverse Agonists

inferred← citeshttps://doi.org/10.1021/cr400161bopenalex-snapshot

Retinoic Acid Actions through Mammalian Nuclear Receptors

inferred← citeshttps://doi.org/10.1021/jacs.5c02724openalex-snapshot

Spontaneous Generation of an Endogenous RORγt Agonist

inferred← citeshttps://doi.org/10.1021/jacs.5c08613openalex-snapshot

Eggerthella lenta Produces a Cryptic Pro-inflammatory Lipid

inferred← citeshttps://doi.org/10.1021/jm401901dopenalex-snapshot

Modulators of the Nuclear Receptor Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc)

inferred← citeshttps://doi.org/10.1021/ml300286hopenalex-snapshot

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors

inferred← citeshttps://doi.org/10.1021/ml4003875openalex-snapshot

Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists

inferred← citeshttps://doi.org/10.1038/aps.2016.32openalex-snapshot

Discovery and structural optimization of 4-(4-(benzyloxy)phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists

inferred← citeshttps://doi.org/10.1038/icb.2017.26openalex-snapshot

Follistatin‐like protein 1 modulates IL‐17 signaling via IL‐17RC regulation in stromal cells

inferred← citeshttps://doi.org/10.1038/mi.2015.143openalex-snapshot

Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease

inferred← citeshttps://doi.org/10.1038/mi.2016.86openalex-snapshot

RORγt, a multitask nuclear receptor at mucosal surfaces

inferred← citeshttps://doi.org/10.1038/ncomms13048openalex-snapshot

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

inferred← citeshttps://doi.org/10.1038/ni.3832openalex-snapshot

A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development

inferred← citeshttps://doi.org/10.1038/nm.4046openalex-snapshot

Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells

inferred← citeshttps://doi.org/10.1038/s41401-022-01042-xopenalex-snapshot

Ginseng-derived panaxadiol ameliorates STZ-induced type 1 diabetes through inhibiting RORγ/IL-17A axis

inferred← citeshttps://doi.org/10.1038/s41467-018-07203-zopenalex-snapshot

Sumoylation of RORγt regulates TH17 differentiation and thymocyte development

inferred← citeshttps://doi.org/10.1038/s41586-019-1785-zopenalex-snapshot

Bile acid metabolites control TH17 and Treg cell differentiation

inferred← citeshttps://doi.org/10.1038/s41586-022-04480-zopenalex-snapshot

Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

inferred← citeshttps://doi.org/10.1039/c9fo03019kopenalex-snapshot

Eriodictyol suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis

inferred← citeshttps://doi.org/10.1042/bsr20201643openalex-snapshot

Chlorogenic acid ameliorated allergic rhinitis-related symptoms in mice by regulating Th17 cells

inferred← citeshttps://doi.org/10.1073/pnas.1919893117openalex-snapshot

Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

inferred← citeshttps://doi.org/10.1080/13543784.2018.1506764openalex-snapshot

Investigational drugs in phase I and phase II clinical trials targeting interleukin 23 (IL23) for the treatment of Crohn’s disease

inferred← citeshttps://doi.org/10.1080/21645515.2015.1057363openalex-snapshot

Small molecule drugs with immunomodulatory effects in cancer

inferred← citeshttps://doi.org/10.1093/abbs/gmy137openalex-snapshot

Th17 cells were recruited and accumulated in the cerebrospinal fluid and correlated with the poor prognosis of anti-NMDAR encephalitis

inferred← citeshttps://doi.org/10.1093/jb/mvw092openalex-snapshot

The retinoic acid receptor-related orphan receptor α positively regulates tight junction protein claudin domain-containing 1 mRNA expression in human brain endothelial cells

inferred← citeshttps://doi.org/10.1093/nar/gkt447openalex-snapshot

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors - and -mediated transactivation

inferred← citeshttps://doi.org/10.1093/nar/gku766openalex-snapshot

Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes

inferred← citeshttps://doi.org/10.1096/fj.13-242040openalex-snapshot

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20‐hydroxy‐ and 20,23‐dihydroxyvitamin D

inferred← citeshttps://doi.org/10.1096/fj.202000415ropenalex-snapshot

Soluble epoxide hydrolase inhibitor, TPPU, increases regulatory T cells pathway in an arthritis model

inferred← citeshttps://doi.org/10.1101/2020.07.18.210120openalex-snapshot

High expression of angiotensin-converting enzyme-2 (ACE2) on tissue macrophages that may be targeted by virus SARS-CoV-2 in COVID-19 patients

inferred← citeshttps://doi.org/10.1101/465344openalex-snapshot

Bile acid metabolites control Th17 and Treg cell differentiation

inferred← citeshttps://doi.org/10.1101/766899openalex-snapshot

A diet-dependent enzyme from the human gut microbiome promotes Th17 cell accumulation and colitis

inferred← citeshttps://doi.org/10.1111/bph.13453openalex-snapshot

Digoxin reduces atherosclerosis in apolipoprotein E‐deficient mice

inferred← citeshttps://doi.org/10.1111/bph.15023openalex-snapshot

JQ1, a bromodomain inhibitor, suppresses Th17 effectors by blocking p300‐mediated acetylation of RORγt

inferred← citeshttps://doi.org/10.1111/cea.12378openalex-snapshot

Th17 response and its regulation in inflammatory upper airway diseases

inferred← citeshttps://doi.org/10.1111/febs.15711openalex-snapshot

Rationalizing heptadecaphobia: TH17 cells and associated cytokines in cancer and metastasis

inferred← citeshttps://doi.org/10.1111/his.12156openalex-snapshot

Interleukin‐17‐producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor

inferred← citeshttps://doi.org/10.1111/imm.12575openalex-snapshot

T‐bet as a key regulator of mucosal immunity

inferred← citeshttps://doi.org/10.1111/imm.12926openalex-snapshot

Deficient arginase II expression without alteration in arginase I expression attenuated experimental autoimmune encephalomyelitis in mice

inferred← citeshttps://doi.org/10.1111/imr.12039openalex-snapshot

CD 4+ T‐cell subsets in intestinal inflammation

inferred← citeshttps://doi.org/10.11131/2015/101185openalex-snapshot

Retinoic Acid-Related Orphan Receptors (RORs): Regulatory Functions in Immunity, Development, Circadian Rhythm, and Metabolism

inferred← citeshttps://doi.org/10.1124/pharmrev.121.000436openalex-snapshot

International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023

inferred← citeshttps://doi.org/10.1126/sciadv.adc9221openalex-snapshot

Decoupling the role of RORγt in the differentiation and effector function of T H 17 cells

inferred← citeshttps://doi.org/10.1126/scitranslmed.aat0797openalex-snapshot

A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans

inferred← citeshttps://doi.org/10.1146/annurev-pharmtox-010919-023711openalex-snapshot

(Inverse) Agonists of Retinoic Acid–Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease

inferred← citeshttps://doi.org/10.1155/2015/290657openalex-snapshot

Targeting Th17 Cells with Small Molecules and Small Interference RNA

inferred← citeshttps://doi.org/10.1155/2019/6471815openalex-snapshot

Louqin Zhisou Decoction Inhibits Mucus Hypersecretion for Acute Exacerbation of Chronic Obstructive Pulmonary Disease Rats by Suppressing EGFR-PI3K-AKT Signaling Pathway and Restoring Th17/Treg Balance

inferred← citeshttps://doi.org/10.1172/jci.insight.91127openalex-snapshot

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations

inferred← citeshttps://doi.org/10.1210/endocr/bqaa198openalex-snapshot

Antifibrogenic Activities of CYP11A1-derived Vitamin D3-hydroxyderivatives Are Dependent on RORγ

inferred← citeshttps://doi.org/10.1371/journal.pone.0137711openalex-snapshot

Identification of Tetraazacyclic Compounds as Novel Potent Inhibitors Antagonizing RORγt Activity and Suppressing Th17 Cell Differentiation

inferred← citeshttps://doi.org/10.1371/journal.pone.0137955openalex-snapshot

Phosphoenolpyruvate Carboxykinase, a Key Enzyme That Controls Blood Glucose, Is a Target of Retinoic Acid Receptor-Related Orphan Receptor α

inferred← citeshttps://doi.org/10.1371/journal.pone.0180088openalex-snapshot

T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab

inferred← citeshttps://doi.org/10.1517/14728222.2016.1086751openalex-snapshot

Are Th17 cells and their cytokines a therapeutic target in Guillain–Barré syndrome?

inferred← citeshttps://doi.org/10.2174/1570180820666230217123456openalex-snapshot

Thiazole Derivatives as RORγt Inhibitors: Synthesis, Biological Evaluation, and Docking Analysis

inferred← citeshttps://doi.org/10.2217/imt-2019-0190openalex-snapshot

Small-Molecule-Based Immunotherapy for Immunologically Mediated Skin Conditions

inferred← citeshttps://doi.org/10.3109/08830185.2013.821118openalex-snapshot

Inhibition of IL-17 as a Pharmacological Approach for IBD

inferred← citeshttps://doi.org/10.3109/08830185.2014.911858openalex-snapshot

Signaling Pathways and Epigenetic Regulations in the Control ofRORγtExpression in T Helper 17 Cells

inferred← citeshttps://doi.org/10.3109/08958378.2015.1066905openalex-snapshot

A mechanistic review of silica-induced inhalation toxicity

inferred← citeshttps://doi.org/10.32604/oncologie.2021.018532openalex-snapshot

Synthesis, Pharmacological Evaluation, and In-Silico Studies of Thiophene Derivatives

inferred← citeshttps://doi.org/10.3389/fendo.2013.00001openalex-snapshot

Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity

inferred← citeshttps://doi.org/10.3389/fimmu.2017.01549openalex-snapshot

Exploring Non-Metabolic Functions of Glycolytic Enzymes in Immunity

inferred← citeshttps://doi.org/10.3389/fimmu.2020.623324openalex-snapshot

T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells

inferred← citeshttps://doi.org/10.3389/fimmu.2021.760198openalex-snapshot

Sustained Post-Developmental T-Bet Expression Is Critical for the Maintenance of Type One Innate Lymphoid Cells In Vivo

inferred← citeshttps://doi.org/10.3389/fphar.2022.1039441openalex-snapshot

The regulation of T helper cell polarization by the diterpenoid fraction of Rhododendron molle based on the JAK/STAT signaling pathway

inferred← citeshttps://doi.org/10.3390/biom9040145openalex-snapshot

Essential Kinases and Transcriptional Regulators and Their Roles in Autoimmunity

inferred← citeshttps://doi.org/10.3390/biomedicines10092076openalex-snapshot

Identification of the Natural Steroid Sapogenin Diosgenin as a Direct Dual-Specific RORα/γ Inverse Agonist

inferred← citeshttps://doi.org/10.3390/cells13030239openalex-snapshot

Novel Vitamin D3 Hydroxymetabolites Require Involvement of the Vitamin D Receptor or Retinoic Acid-Related Orphan Receptors for Their Antifibrogenic Activities in Human Fibroblasts

inferred← citeshttps://doi.org/10.3390/ijms20225780openalex-snapshot

The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT

inferred← citeshttps://doi.org/10.3390/ijms21103547openalex-snapshot

RORγt Inhibitor-SR1001 Halts Retinal Inflammation, Capillary Degeneration, and the Progression of Diabetic Retinopathy

inferred← citeshttps://doi.org/10.3390/ijms21218011openalex-snapshot

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

inferred← citeshttps://doi.org/10.3390/ijms23031906openalex-snapshot

Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORγT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity

inferred← citeshttps://doi.org/10.3390/ijms24021762openalex-snapshot

Neural Networks in the Design of Molecules with Affinity to Selected Protein Domains

inferred← citeshttps://doi.org/10.3390/ijms24087647openalex-snapshot

Leveraging Exosomes as the Next-Generation Bio-Shuttles: The Next Biggest Approach against Th17 Cell Catastrophe

inferred← citeshttps://doi.org/10.4049/jimmunol.1302190openalex-snapshot

Pharmacologic Inhibition of RORγt Regulates Th17 Signature Gene Expression and Suppresses Cutaneous Inflammation In Vivo

inferred← citeshttps://doi.org/10.4049/jimmunol.1401093openalex-snapshot

PLZF Regulates CCR6 and Is Critical for the Acquisition and Maintenance of the Th17 Phenotype in Human Cells

inferred← citeshttps://doi.org/10.4049/jimmunol.1600548openalex-snapshot

Ubiquitination of RORγt at Lysine 446 Limits Th17 Differentiation by Controlling Coactivator Recruitment

inferred← citeshttps://doi.org/10.4049/jimmunol.1700457openalex-snapshot

Regulation of Th17 Differentiation by IKKα-Dependent and -Independent Phosphorylation of RORγt

inferred← citeshttps://doi.org/10.4049/jimmunol.1801187openalex-snapshot

SRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development

inferred← citeshttps://doi.org/10.4049/jimmunol.1900656openalex-snapshot

Nrf2 through Aryl Hydrocarbon Receptor Regulates IL-22 Response in CD4+ T Cells

inferred← citeshttps://doi.org/10.4161/hv.27910openalex-snapshot

Emerging immunotherapies for rheumatoid arthritis

inferred← citeshttps://doi.org/10.4172/2155-9899.1000e111openalex-snapshot

Small Molecule Inhibitors Targeting the Th17 Cell Transcription Factor RORγt for the Treatment of Autoimmune Diseases

inferred← citeshttps://doi.org/10.4236/jct.2020.1110005openalex-snapshot

IL-17A in Ovarian Cancer

inferred← citeshttps://doi.org/10.4236/wjcd.2019.94024openalex-snapshot

Targeting the Inflammation Culprit in Patients with Psoriasis/Psoriatic Arthritis and Associated Cardiovascular Comorbidities. Is the IL-17 Inhibitor the New Kid on the Block?

inferred← citeshttps://doi.org/10.4993/acrt.27.59openalex-snapshot

IL-17A in oncology

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.